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  1. Article: Examining the Association Between Serum Leptin and Sarcopenic Obesity.

    Yang, Zhe-Yu / Chen, Wei-Liang

    Journal of inflammation research

    2021  Volume 14, Page(s) 3481–3487

    Abstract: Objective: Sarcopenic obesity is an emerging geriatric syndrome among elderly individuals. Studies revealed a complicated pathogenesis between sarcopenia and obesity. Leptin, a proinflammatory adipokine, has been implicated in the mechanism of ... ...

    Abstract Objective: Sarcopenic obesity is an emerging geriatric syndrome among elderly individuals. Studies revealed a complicated pathogenesis between sarcopenia and obesity. Leptin, a proinflammatory adipokine, has been implicated in the mechanism of sarcopenic obesity. This study investigated the relationship between serum leptin level and sarcopenic obesity.
    Methods: The study included 4063 participants aged 60 years and older from the NHANES III database. Sarcopenia was defined as a skeletal muscle index (SMI) less than one standard deviation below the young adult value. Obesity was defined as a body mass index (BMIF) over 30 kg/m
    Results: In adjusted models, serum leptin level was positively correlated with BMI (β: 1.33, p value < 0.001) and negatively correlated with SMI (β: -0.091, p value = 0.001). A significant association between serum leptin level and sarcopenic obesity was found in multivariate analysis (β: 4.011, p value=0.014).
    Conclusion: Our study demonstrated that serum leptin level was related to an increased risk of sarcopenic obesity. This epidemiologic finding suggests that leptin may play a role in sarcopenic obesity.
    Language English
    Publishing date 2021-07-22
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S320445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prognostic significance of subjective oral dysfunction on the all-cause mortality.

    Yang, Zhe-Yu / Chen, Wei-Liang

    Journal of oral rehabilitation

    2021  Volume 49, Issue 3, Page(s) 337–343

    Abstract: Background: As the proportion of elderly population grows, it raises concern about impaired oral health which has been reported to be associated with increased risk of numerous adverse health events. Emerging study defined oral frailty as poor oral ... ...

    Abstract Background: As the proportion of elderly population grows, it raises concern about impaired oral health which has been reported to be associated with increased risk of numerous adverse health events. Emerging study defined oral frailty as poor oral health accumulation and demonstrated that oral frailty was a risk factor of disability, physical frailty and mortality. In this study, we examined the association between subjective oral dysfunction and all-cause mortality in the United States.
    Methods: In this cross-sectional observational study, a total of 7827 participants who completed oral functions data from 1999 to 2002 NHANES database were recruited. Subjective oral dysfunction included 3 components: limited eating ability, dry mouth and difficult swallowing, which were obtained from self-reported questionnaire. For primary outcome, all-cause mortality was followed from baseline to death or 2006. The relationship of subjective oral dysfunction and all-cause mortality was assessed by Cox regression model.
    Results: A statistically significant relationship between subjective oral dysfunction and all-cause mortality was observed in fully adjusted model. Participants with more components of subjective oral dysfunction had worse risk of all-cause mortality. Limited eating ability was inversely associated with muscle strength.
    Conclusion: Subjective oral dysfunction which was obtained from an easy self-assessment survey might be a potential risk factor for all-cause mortality and could be used for initial screening during general health examination.
    MeSH term(s) Aged ; Cross-Sectional Studies ; Frail Elderly ; Frailty ; Humans ; Nutrition Surveys ; Prognosis
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 187079-8
    ISSN 1365-2842 ; 0305-182X
    ISSN (online) 1365-2842
    ISSN 0305-182X
    DOI 10.1111/joor.13281
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Physiological significance of link between polycyclic aromatic hydrocarbons and serum nutritional biomarkers.

    Yang, Zhe-Yu / Chen, Wei-Liang

    Food chemistry

    2021  Volume 353, Page(s) 129445

    Abstract: It is well-known that exposure to polycyclic aromatic hydrocarbons (PAH) may cause adverse health impacts. However, there are few investigations assessing the association between PAH exposure and the nutritional status of the general population. Thus, ... ...

    Abstract It is well-known that exposure to polycyclic aromatic hydrocarbons (PAH) may cause adverse health impacts. However, there are few investigations assessing the association between PAH exposure and the nutritional status of the general population. Thus, the purpose of this investigation was to assess the correlation between PAH metabolites and nutritional biomarkers in the U.S. general population. From the 2003-2006 National Health and Nutrition Examination Survey, 4,545 eligible participants were included in this cross-sectional study. To assess PAH exposure, ten urinary PAH metabolites were measured. Eleven serum nutritional biomarkers including carotenoids and vitamins were measured. The association between PAH metabolites and serum nutritional biomarkers was investigated using multivariate linear regression models. Increased 2-hydroxyfluorene was inversely correlated with elven serum nutritional biomarkers: α-carotene (β = -0.529, p < 0.001), β-cryptoxanthin (β = -0.968, p < 0.001), cis-β carotene (β = -0.149, p < 0.001), lutein and zeaxanthin (β = -1.188, p < 0.001), retinyl palmitate (β = -0.145, p < 0.001), retinyl stearate (β = -0.025, p = 0.006), total lycopene (β = -1.074, p < 0.001), trans-β carotene (β = -2.268, p < 0.001), trans-lycopene (β = -0.466, p < 0.003), retinol (β = -0.694, p = 0.004) and 25-hydroxyvitamin D (β = -1.247, p = 0.007). Increased 3-hydroxyfluorene was inversely correlated with eleven serum nutritional biomarkers: α-carotene (β = -0.740, p < 0.001), β-cryptoxanthin (β = -1.377, p < 0.001), cis-β carotene (β = -0.205, p < 0.001), lutein and zeaxanthin (β = -1.521, p < 0.001), retinyl palmitate (β = -0.209, p < 0.001), retinyl stearate (β = -0.034, p = 0.014), total lycopene (β = -1.20, p = 0.007), trans-β carotene (β = -3.185, p < 0.001), trans-lycopene (β = -0.490, p = 0.039), retinol (β = -1.366, p < 0.001) and 25-hydroxyvitamin D (β = -2.483, p < 0.001). Increased 1-hydroxypyrene was inversely correlated with eight serum nutritional biomarkers: α-carotene (β = -0.601, p = 0.001), β-cryptoxanthin (β = -1.071, p = 0.001), cis-β carotene (β = -0.170, p = 0.001), lutein and zeaxanthin (β = -1.074, p < 0.001), retinyl palmitate (β = -0.214, p = 0.005), retinyl stearate (β = -0.041, p = 0.043), total lycopene (β = -1.664, p = 0.011) and retinol (β = -1.381, p = 0.011). These results demonstrate that PAH exposure is significantly correlated with decreased levels of serum nutritional biomarkers.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Carotenoids/blood ; Cross-Sectional Studies ; Diterpenes/blood ; Environmental Exposure/analysis ; Female ; Humans ; Lutein/blood ; Lycopene/blood ; Male ; Middle Aged ; Nutrition Surveys ; Nutritional Status/physiology ; Polycyclic Aromatic Hydrocarbons/metabolism ; Polycyclic Aromatic Hydrocarbons/toxicity ; Polycyclic Aromatic Hydrocarbons/urine ; Retinyl Esters/blood ; Vitamin A/blood ; Zeaxanthins/blood ; beta Carotene/blood
    Chemical Substances Biomarkers ; Diterpenes ; Polycyclic Aromatic Hydrocarbons ; Retinyl Esters ; Zeaxanthins ; beta Carotene (01YAE03M7J) ; Vitamin A (11103-57-4) ; retinol palmitate (1D1K0N0VVC) ; Carotenoids (36-88-4) ; alpha-carotene (45XWE1Z69V) ; retinyl stearate (631-87-8) ; Lycopene (SB0N2N0WV6) ; Lutein (X72A60C9MT)
    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2021.129445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Central and lateral neck involvement in papillary thyroid carcinoma patients with or without thyroid capsular invasion: A multi-center analysis.

    Yang, Zheyu / Heng, Yu / Zhou, Jian / Tao, Lei / Cai, Wei

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1138085

    Abstract: Purposes: To quantitatively predict the probability of cervical lymph node metastasis for papillary thyroid carcinomas (PTC) patients with or without thyroid capsular invasion (TCI), to guide the decision-making of management strategies for neck regions. ...

    Abstract Purposes: To quantitatively predict the probability of cervical lymph node metastasis for papillary thyroid carcinomas (PTC) patients with or without thyroid capsular invasion (TCI), to guide the decision-making of management strategies for neck regions.
    Methods: A total of 998 PTC patients from three medical centers were retrospectively analyzed.
    Results: Patients with positive TCI (TCI group) exhibited higher risks for both CLNM and LLNM than those with negative TCI (no-TCI group). Patients receiving lateral lymph node dissection showed significantly higher incidence of relatively severe postoperative complications. For no-TCI group, factors including age less than 55 years old, male, the presence of bilateral disease and multifocality, and maximum tumor diameter (MTD)>=0.5cm were confirmed to be independent risk factors for CLNM, while the presence of bilateral disease and ipsilateral nodular goiter (iNG), and maximum positive CLN diameter (MCLND)>1.0cm independent factors for LLNM. Independent risk factors of LLNM for patients within the TCI group included MCLND>1.0cm, positive CLN number>=3, and the presence of iNG. Predictive models of CLNM and LLNM were established based on the aforementioned risk factors for patients within no-TCI and TCI groups. A meticulous and comprehensive risk stratification flow chart was established for a more accurate evaluation of central neck involvement including both CLNM and LLNM risk in PTC patients.
    Conclusions: A meticulous and comprehensive stratification flow chart for PTC patients for quantitatively evaluating both CLNM and LLNM was constructed.
    MeSH term(s) Humans ; Male ; Middle Aged ; Thyroid Cancer, Papillary/secondary ; Thyroid Neoplasms/complications ; Thyroid Neoplasms/surgery ; Thyroid Neoplasms/pathology ; Retrospective Studies ; Carcinoma, Papillary/pathology
    Language English
    Publishing date 2023-03-09
    Publishing country Switzerland
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1138085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial: Community series in the role of angiogenesis and immune response in tumor microenvironment of solid tumor: volume II.

    Li, Haosheng / Yang, Zheyu / Lu, Xin / Zhao, Ren / Cheng, Xi

    Frontiers in immunology

    2023  Volume 14, Page(s) 1332519

    MeSH term(s) Humans ; Tumor Microenvironment ; Angiogenesis ; Cardiovascular Physiological Phenomena ; Neoplasms ; Immunity
    Language English
    Publishing date 2023-11-22
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1332519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The association between dietary fiber intake and sarcopenia

    Kao, Chia-Chun / Yang, Zhe-Yu / Chen, Wei-Liang

    Journal of Functional Foods. 2023 Mar., v. 102 p.105437-

    2023  

    Abstract: The study aims to understand the effects of dietary fiber on muscle quality parameters and sarcopenia. Study data were collected from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2000 and 2001 to 2002. We enrolled a ... ...

    Abstract The study aims to understand the effects of dietary fiber on muscle quality parameters and sarcopenia. Study data were collected from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2000 and 2001 to 2002. We enrolled a total of 2492 eligible participants and conducted logistic regression and multivariate regression analysis to interpret the relationship between dietary fiber and sarcopenia. In the measure of association between dietary fiber intake and sarcopenia, the crude odds ratio (OR) was 0.972. After adjustment for age, sex, and race/ethnicity, the OR was 0.977. In the fully adjusted model, the OR was 0.968. In addition, increased dietary fiber intake had significant positive correlations with all three muscle quality parameters, including muscle strength, skeletal muscle index, and gait speed. Adequate intake of dietary fiber is advised for the sarcopenia prevalent geriatric population.
    Keywords Adequate Intakes ; National Health and Nutrition Examination Survey ; dietary fiber ; elderly ; gait ; models ; muscle strength ; muscles ; nationalities and ethnic groups ; odds ratio ; regression analysis ; sarcopenia ; skeletal muscle ; Gut-muscle axis ; Muscle ; Geriatric ; ASM ; AUROC ; BMI ; CI ; DXA ; EWGSOP ; IRB ; MEC ; NCHS ; NHANES ; OR ; ROC ; SD ; SMI
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2511964-3
    ISSN 1756-4646
    ISSN 1756-4646
    DOI 10.1016/j.jff.2023.105437
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Cervical Lymph Node Metastasis Differences in Patients with Unilateral or Bilateral Papillary Thyroid Microcarcinoma: A Multi-Center Analysis.

    Yang, Zheyu / Heng, Yu / Qiu, Weihua / Tao, Lei / Cai, Wei

    Journal of clinical medicine

    2022  Volume 11, Issue 16

    Abstract: Purposes: To quantitatively predict the risk of neck lymph node metastasis for unilateral and bilateral papillary thyroid microcarcinomas (PTMC) that may guide individual treatment strategies for the neck region. Methods: A total of 717 PTMC patients ... ...

    Abstract Purposes: To quantitatively predict the risk of neck lymph node metastasis for unilateral and bilateral papillary thyroid microcarcinomas (PTMC) that may guide individual treatment strategies for the neck region. Methods: A total of 717 PTMC patients from three medical centers were enrolled for analysis. Results: Bilateral PTMCs were demonstrated to be more aggressive with a much higher cervical lymph node metastasis rate including for both central (CLNM) and lateral lymph node metastasis (LLNM) when being compared to unilateral PTMCs. In unilateral PTMC, five (age < 55 years old, male, maximum tumor diameter (MTD) ≥ 0.5 cm, and the presence of thyroid capsular invasion (TCI) and multifocality) and three (maximum diameter of positive CLN (MDCLN) > 0.5 cm, the presence of multifocality and nodular goiter, iNG) factors were identified as independent risk factors for CLNM and LLNM, respectively. In bilateral PTMC, three (age < 55 and presence of TCI and multifocality in at least one side of thyroid lobe) and two (MDCLN > 0.5 cm and presence of nodular goiter (iNG)) factors were identified as independent factors for CLNM and LLNM, respectively. Predictive models of CLNM and LLNM for patients with unilateral disease and of CLNM for patients with the bilateral disease were established based on the described risk factors. Bilateral patients with positive CLNM were also stratified into different subgroups according to the presence and absence of independent risk factors. Conclusion: An evaluation system based on independent factors of CLNM and LLNM for PTMC patients with bilateral and unilateral disease was established. Our newly established evaluation system can efficaciously quantify risks of CLNM and LLNM for PTMC patients with bilateral and unilateral disease and may guide individual treatment strategy including both surgical and postoperative adjuvant treatment of the neck region for these patients.
    Language English
    Publishing date 2022-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11164929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Lateral Involvement in Different Sized Papillary Thyroid Carcinomas Patients with Central Lymph Node Metastasis: A Multi-Center Analysis.

    Heng, Yu / Yang, Zheyu / Cao, Pengyu / Cheng, Xi / Tao, Lei

    Journal of clinical medicine

    2022  Volume 11, Issue 17

    Abstract: Objective: To quantitatively predict the probability of lateral lymph node metastasis (LLNM) for papillary thyroid carcinomas (PTC) patients with central lymph node metastasis (CLNM) in order to guide postoperative adjuvant treatment. Methods: Five ... ...

    Abstract Objective: To quantitatively predict the probability of lateral lymph node metastasis (LLNM) for papillary thyroid carcinomas (PTC) patients with central lymph node metastasis (CLNM) in order to guide postoperative adjuvant treatment. Methods: Five hundred and three PTC patients with CLNM from three medical centers were retrospectively analyzed. Results: The LLNM rate for all patients was 23.9% (120 in 503), with 15.5% (45 in 291) and 35.4% (75 in 212) for patients with papillary thyroid microcarcinoma (PTMC) and large papillary thyroid carcinoma (LPTC), respectively. Patients with no fewer than five positive central lymph nodes (CLN) exhibited a higher risk of LLNM. For patients with fewer than five positive CLN, a maximum diameter of positive CLN > 0.5 cm and the presence of ipsilateral nodular goiter were identified as independent risk factors of LLNM for papillary thyroid microcarcinoma (PTMC) patients. The independent risk factors of LLNM for large papillary thyroid carcinoma (LPTC) patients included a tumor located in the upper portion of thyroid, maximum tumor diameter ≥ 2.0 cm, maximum diameter of positive CLN > 0.5 cm, and the presence of thyroid capsular invasion. Predictive nomograms were established based on these risk factors for PTMC and LPTC patients, respectively. The accuracy and validity of our newly built models were verified by C-index and calibration curves. PTMC and LPTC patients with fewer than five positive CLN were each stratified into three subgroups based on their nomogram risk scores, and a detailed risk stratification flow chart was established for a more accurate evaluation of LLNM risk in PTC patients. Conclusions: A detailed stratification flow chart for PTC patients with CLNM to quantitatively assess LLNM risk was established, which may aid in clinical decision-making for those patients.
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11174975
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  9. Article ; Online: Exploring the relationship between trans fatty acids and body fat distribution.

    Kao, Chia-Chun / Yang, Zhe-Yu / Chen, Wei-Liang

    Polish archives of internal medicine

    2021  Volume 132, Issue 3

    Abstract: Introduction: The importance of fat distribution is well established. Nevertheless, the mechanism by which fat is distributed throughout the trunk and limbs remains unclear.: Objectives: The aim of this study was to uncover the relationship between 4 ...

    Abstract Introduction: The importance of fat distribution is well established. Nevertheless, the mechanism by which fat is distributed throughout the trunk and limbs remains unclear.
    Objectives: The aim of this study was to uncover the relationship between 4 trans fatty acids (TFAs) and body fat distribution in the trunk and limbs.
    Patients and methods: The study examined 1467 participants registered in the National Health and Nutrition Examination Survey database between 1999 and 2000. A cross‑sectional analysis was conducted to evaluate the relationship between TFA and body fat distribution over the trunk and limbs.
    Results: In the unadjusted model for men, trunk fat percentage was significantly associated with trans 9‑hexadecenoic acid (β = 0.250; 95% CI, 0.187-0.313; P <0.01), trans 11‑octadecenoic acid (β = 0.927; 95% CI, 0.499-1.356; P <0.01), trans 9‑octadecenoic acid (β = 1.028; 95% CI, 0.654-1.402; P <0.01), and trans 9, trans 12‑octadienoic acid (β = 0.078; 95% CI, 0.054-0.103; P <0.01). No significant association was found between limb fat percentage and TFA.
    Conclusions: Our study demonstrated that increased TFA concentration was associated with fat deposition predominantly in the trunk rather than in the limbs. Further research is needed to investigate the role of TFA in different body fat distributions.
    MeSH term(s) Body Fat Distribution ; Cross-Sectional Studies ; Humans ; Male ; Nutrition Surveys ; Trans Fatty Acids/analysis
    Chemical Substances Trans Fatty Acids
    Language English
    Publishing date 2021-12-15
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16174
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association between protoporphyrin IX and sarcopenia: a cross sectional study.

    Kao, Chia-Chun / Yang, Zhe-Yu / Chen, Wei-Liang

    BMC geriatrics

    2021  Volume 21, Issue 1, Page(s) 384

    Abstract: Background: According to the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia primarily focused on low muscle strength with the detection of low muscle quality and quantity as confirming index. Many studies had ... ...

    Abstract Background: According to the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia primarily focused on low muscle strength with the detection of low muscle quality and quantity as confirming index. Many studies had identified mitochondrial dysfunction as one of the multifactorial etiologies of sarcopenia. Yet, no study had investigated the role of biosynthetic pathway intermediate, which was found in mitochondria, in the development of sarcopenia. This study aimed to examine the association between protoporphyrin IX (PPIX) and components of sarcopenia.
    Method: The present study enrolled 1172 participants without anemia between 1999 to 2002 from the National Health and Nutrition Examination Survey (NHANES) database. We employed the multivariable-logistic regression model to examine the relationship between PPIX and sarcopenia. Covariate adjustments were designated to each of the three models for further analysis of the relationship.
    Results: In the unadjusted model, PPIX was significantly associated with sarcopenia (OR = 3.910, 95% CI = 2.375, 6.439, P value < 0.001). The significance persisted after covariate adjustments as observed in the fully adjusted model (OR = 2.537, 95% CI = 1.419, 4.537, P value = 0.002).
    Conclusions: The findings of this study suggested statistically significant association between PPIX and sarcopenia. Our study disclosed the potential of PPIX as a valuable indicator of sarcopenia.
    MeSH term(s) Aged ; Cross-Sectional Studies ; Hand Strength ; Humans ; Nutrition Surveys ; Prevalence ; Protoporphyrins ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology
    Chemical Substances Protoporphyrins ; protoporphyrin IX (C2K325S808)
    Language English
    Publishing date 2021-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-021-02331-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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