Article: Examining the Association Between Serum Leptin and Sarcopenic Obesity.
Journal of inflammation research
2021 Volume 14, Page(s) 3481–3487
Abstract: Objective: Sarcopenic obesity is an emerging geriatric syndrome among elderly individuals. Studies revealed a complicated pathogenesis between sarcopenia and obesity. Leptin, a proinflammatory adipokine, has been implicated in the mechanism of ... ...
Abstract | Objective: Sarcopenic obesity is an emerging geriatric syndrome among elderly individuals. Studies revealed a complicated pathogenesis between sarcopenia and obesity. Leptin, a proinflammatory adipokine, has been implicated in the mechanism of sarcopenic obesity. This study investigated the relationship between serum leptin level and sarcopenic obesity. Methods: The study included 4063 participants aged 60 years and older from the NHANES III database. Sarcopenia was defined as a skeletal muscle index (SMI) less than one standard deviation below the young adult value. Obesity was defined as a body mass index (BMIF) over 30 kg/m Results: In adjusted models, serum leptin level was positively correlated with BMI (β: 1.33, p value < 0.001) and negatively correlated with SMI (β: -0.091, p value = 0.001). A significant association between serum leptin level and sarcopenic obesity was found in multivariate analysis (β: 4.011, p value=0.014). Conclusion: Our study demonstrated that serum leptin level was related to an increased risk of sarcopenic obesity. This epidemiologic finding suggests that leptin may play a role in sarcopenic obesity. |
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Language | English |
Publishing date | 2021-07-22 |
Publishing country | New Zealand |
Document type | Journal Article |
ZDB-ID | 2494878-0 |
ISSN | 1178-7031 |
ISSN | 1178-7031 |
DOI | 10.2147/JIR.S320445 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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