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Book ; Online: Poetry, History, Memory

Yang, Zhiyi

Wang Jingwei and China in Dark Times

2023

Keywords	Literature: history & criticism ; Asian history ; Poetry ; Literature: history and criticism;Asian history;Poetry
Language	English
Size	1 electronic resource (351 pages)
Publisher	University of Michigan Press
Document type	Book ; Online
Note	English
HBZ-ID	HT030611500
ISBN	9780472056507 ; 0472056506
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Dialectics of Spontaneity

Yang, Zhiyi

2015

Abstract: In Dialectics of Spontaneity, Zhiyi Yang examines the aesthetic and ethical theories of Su Shi, the primary poet, artist, and statesman of Northern Song. Readership: All interested in Chinese literature, aesthetics and ethics, in particular Su Shi, in ... ...

Abstract	In Dialectics of Spontaneity, Zhiyi Yang examines the aesthetic and ethical theories of Su Shi, the primary poet, artist, and statesman of Northern Song. Readership: All interested in Chinese literature, aesthetics and ethics, in particular Su Shi, in the comparative discussion about spontaneity, and those concerned with the reception history of Tao Qian or with inner alchemy
Keywords	Literature (General)
Size	1 electronic resource (248 pages)
Publisher	Brill
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020481586
ISBN	9789004298538 ; 9004298533
DOI	10.1163/9789004298538
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Alzheimer's disease cerebrospinal fluid biomarkers and kidney function in normal and cognitively impaired older adults.

Hajjar, Ihab / Neal, Reem / Yang, Zhiyi / Lah, James J

Alzheimer's & dementia (Amsterdam, Netherlands)

2024 Volume 16, Issue 2, Page(s) e12581

Abstract: Introduction: Recent Alzheimer's disease (AD) clinical trials have used cerebrospinal fluid (CSF) biomarker levels for screening and enrollment. Preliminary evidence suggests that AD risk is related to impaired renal function. The impact of kidney ... ...

Abstract	Introduction: Recent Alzheimer's disease (AD) clinical trials have used cerebrospinal fluid (CSF) biomarker levels for screening and enrollment. Preliminary evidence suggests that AD risk is related to impaired renal function. The impact of kidney function on commonly used AD biomarkers remains unknown. Methods: Participants in studies conducted at the Goizueta Alzheimer's Disease Research Center ( Results: Lower estimated glomerular filtration rate (eGFR) was associated with lower amyloid beta (Aβ)42/tau ratio ( Discussion: The association between eGFR and CSF AD biomarkers has a significant impact that varies by cognitive status. Future studies exploring this impact on the pathogenesis of AD and related biomarkers are needed. Highlights: There is a significant association between Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers and both estimated glomerular filtration rate (eGFR) and mild cognitive impairment (MCI).Kidney function influences CSF biomarker levels in individuals with normal cognitive function and those with MCI.The impact of kidney function on AD biomarker levels is more pronounced in individuals with cognitive impairment.The variation in CSF tau levels is independent of cardiovascular factors and is likely directly related to kidney function.Tau may have a possible role in both kidney and cognitive function.
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12581
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unlocking the Molecular Variations of a Micron-Scale Amyloid Plaque in an Early Stage Alzheimer's Disease by a Cellular-Resolution Mass Spectrometry Imaging Platform.

Lv, Yueguang / Yan, Shuxiong / Deng, Ka / Chen, Zhiyu / Yang, Zhiyi / Li, Fang / Luo, Qian

ACS chemical neuroscience

2024 Volume 15, Issue 2, Page(s) 337–345

Abstract: Uncovering the molecular changes at the site where Aβ is deposited plays a critical role in advancing the diagnosis and treatment of Alzheimer's disease. However, there is currently a lack of a suitable label-free imaging method with a high spatial ... ...

Abstract	Uncovering the molecular changes at the site where Aβ is deposited plays a critical role in advancing the diagnosis and treatment of Alzheimer's disease. However, there is currently a lack of a suitable label-free imaging method with a high spatial resolution for brain tissue analysis. In this study, we propose a modified desorption electrospray ionization (DESI) mass spectrometry imaging (MSI) method, called segmented temperature-controlled DESI (STC-DESI), to achieve high-resolution and high-sensitivity spatial metabolomics observation by precisely controlling desorption and ionization temperatures. By concentrating the spray plume and accelerating solvent evaporation at different temperatures, we achieved an impressive spatial resolution of 20 μm that enables direct observation of the heterogeneity around a single cell or an individual Aβ plaque and an exciting sensitivity that allows a variety of low-abundance metabolites and less ionizable neutral lipids to be detected. We applied this STC-DESI method to analyze the brains of transgenic AD mice and identified molecular changes associated with individual Aβ aggregates. More importantly, our study provides the first evidence that carnosine is significantly depleted and 5-caffeoylquinic acid (5-CQA) levels rise sharply around Aβ deposits. These observations highlight the potential of carnosine as a sensitive molecular probe for clinical magnetic resonance imaging diagnosis and the potential of 5-CQA as an efficient therapeutic strategy for Aβ clearance in the early AD stage. Overall, our findings demonstrate the effectiveness of our STC-DESI method and shed light on the potential roles of these molecules in AD pathology, specifically in cellular endocytosis, gray matter network disruption, and paravascular Aβ clearance.
MeSH term(s)	Mice ; Animals ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Plaque, Amyloid/metabolism ; Carnosine ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Mice, Transgenic ; Brain/metabolism ; Spectrometry, Mass, Electrospray Ionization
Chemical Substances	Amyloid beta-Peptides ; Carnosine (8HO6PVN24W)
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.3c00660
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification of a conservative site in the African swine fever virus p54 protein and its preliminary application in a serological assay.

Xu, Lingyu / Cao, Chenfu / Yang, Zhiyi / Jia, Weixin

Journal of veterinary science

2022 Volume 23, Issue 4, Page(s) e55

Abstract: Background: ASF was first reported in Kenya in 1910 in 1921. In China, ASF spread to 31 provinces including Henan and Jiangsu within six months after it was first reported on August 3, 2018. The epidemic almost affected the whole China, causing direct ... ...

Abstract	Background: ASF was first reported in Kenya in 1910 in 1921. In China, ASF spread to 31 provinces including Henan and Jiangsu within six months after it was first reported on August 3, 2018. The epidemic almost affected the whole China, causing direct economic losses of tens of billions of yuan. Cause great loss to our pig industry. As ELISA is cheap and easy to operate, OIE regards it as the preferred serological method for ASF detection. P54 protein has good antigenicity and is an ideal antigen for detection. Objective: To identify a conservative site in the African swine fever virus (ASFV) p54 protein and perform a Cloth-enzyme-linked immunosorbent assay (ELISA) for detecting the ASFV antibody in order to reduce risks posed by using the live virus in diagnostic assays. Method: We used bioinformatics methods to predict the antigen epitope of the ASFV p54 protein in combination with the antigenic index and artificially synthesized the predicted antigen epitope peptides. Using ASFV-positive serum and specific monoclonal antibodies (mAbs), we performed indirect ELISA and blocking ELISA to verify the immunological properties of the predicted epitope polypeptide. Results: The results of our prediction revealed that the possible antigen epitope regions were A23-29, A36-45, A72-94, A114-120, A124-130, and A137-150. The indirect ELISA showed that the peptides A23-29, A36-45, A72-94, A114-120, and A137-150 have good antigenicity. Moreover, the A36-45 polypeptide can react specifically with the mAb secreted by hybridoma cells, and its binding site contains a minimum number of essential amino acids in the sequence 37DIQFINPY44. Conclusions: Our study confirmed a conservative antigenic site in the ASFV p54 protein and its amino acid sequence. A competitive ELISA method for detecting ASFV antibodies was established based on recombinant p54 and matching mAb. Moreover, testing the protein sequence alignment verified that the method can theoretically detect antibodies produced by pigs affected by nearly all ASFVs worldwide.
MeSH term(s)	African Swine Fever/diagnosis ; African Swine Fever/epidemiology ; African Swine Fever Virus/genetics ; Animals ; Antibodies, Viral ; Enzyme-Linked Immunosorbent Assay/methods ; Enzyme-Linked Immunosorbent Assay/veterinary ; Epitopes ; Sequence Alignment/veterinary ; Swine ; Swine Diseases
Chemical Substances	Antibodies, Viral ; Epitopes
Language	English
Publishing date	2022-05-16
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2125308-0
ISSN	1976-555X ; 1976-555X
ISSN (online)	1976-555X
ISSN	1976-555X
DOI	10.4142/jvs.21134
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reactive Matrices for MALDI-MS of Cholesterol

Yang, Zhiyi / Chang, Zong / Deng, Ka / Gu, Junjie / Wu, Yihao / Sun, Qinchao / Luo, Qian

Analytical Chemistry. 2023 Nov. 10, v. 95, no. 46 p.16786-16790

2023

Abstract: Cholesterol is a critical molecule whose dysregulation in certain brain regions is related to multiple neurological disorders. It is of pathological importance to map the distribution of cholesterol in brain. Matrix-assisted laser desorption/ionization ... ...

Abstract	Cholesterol is a critical molecule whose dysregulation in certain brain regions is related to multiple neurological disorders. It is of pathological importance to map the distribution of cholesterol in brain. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been widely used in the molecular imaging of metabolites at a high spatial resolution. However, it is challenging to analyze cholesterol by MALDI-MS due to its difficulty in ionization. Herein, we present for the first time a type of reactive matrix for MALDI-MS of cholesterol. Methylpyridinium carboxaldehydes react with cholesterol and other hydroxyl-containing sterols, which greatly enhanced both desorption and ionization and improved the limits of detection to the low μg/mL range. Compared with previous methods, our reactive matrix requires only one step of chemical derivatization and avoids time-consuming enzymatic reaction, which simplified the sample pretreatment. The reactive matrix was successfully used in mapping the distribution of cholesterol in brain tissue sections using MALDI-MS imaging. In summary, this work has provided a sensitive and simple method for the MALDI-MS analysis of cholesterol, has proposed a novel solution to visualize the distribution of sterol metabolites, and has great potential for applications in neurological and pathological studies.
Keywords	analytical chemistry ; brain ; cholesterol ; derivatization ; desorption ; enzymatic reactions ; ionization ; mass spectrometry ; metabolites
Language	English
Dates of publication	2023-1110
Size	p. 16786-16790.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c04127
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Determination of oxylipins and their precursors in breast milk by solid phase extraction-ultra high performance liquid chromatography-triple quadrupole tandem mass spectrometry

Zhong, Huifang / Xie, Qinggang / Li, Fang / Yang, Zhiyi / Li, Kaifeng / Luo, Qian

Journal of Chromatography A. 2023 Sept. 19, p.464400-

2023 , Page(s) 464400–

Abstract: Oxylipins and their precursors (long-chain polyunsaturated fatty acids, LCPUFAs) are key intercellular signaling molecules influencing the inflammatory response. Each oxylipin has pro- and/or anti-inflammatory effects, and the relative abundance of ... ...

Abstract	Oxylipins and their precursors (long-chain polyunsaturated fatty acids, LCPUFAs) are key intercellular signaling molecules influencing the inflammatory response. Each oxylipin has pro- and/or anti-inflammatory effects, and the relative abundance of different oxylipins can alter the inflammatory balance, making it important to clarify the oxylipin profile of breast milk for optimal infant health. The extraction, identification, and simultaneous quantification of oxylipins in breast milk are challenging due to the structural similarity, limited stability, and the low endogenous concentration of oxylipins and the complex matrix of breast milk. This study aimed to develop a solid phase extraction-ultra high performance liquid chromatography-triple quadrupole tandem mass spectrometry (SPE-UPLC-MS/MS) method for the comprehensive and specific quantification of oxylipins and their precursors in breast milk. The LC conditions (including column, mobile phase, and gradient conditions) and SPE procedure (including SPE cartridges, elution solvent, and elution volume) were optimized to achieve accurate quantification and better analyte recovery. A single 18-minute chromatographic run allows for the quantification of 20 oxylipins and 5 PUFAs. The results showed good linearity (R² > 0.99) over the concentration range of 2 to 100 ng/mL, with the instrument detection limits ranging from 0.01 to 0.90 ng/mL for oxylipins and 0.02 to 0.59 ng/mL for PUFAs. The method is rapid, sensitive, and reproducible (RSD ≤ 10%) and is suitable for the quantitative analysis of oxylipins and their precursors in infant formula samples.
Keywords	breast milk ; chromatography ; infant formulas ; inflammation ; oxylipins ; quantitative analysis ; solvents ; tandem mass spectrometry ; PUFAs ; SPE-UPLC-MS/MS
Language	English
Dates of publication	2023-0919
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	218139-3
ISSN	0021-9673 ; 0378-4355 ; 0376-737X
ISSN	0021-9673 ; 0378-4355 ; 0376-737X
DOI	10.1016/j.chroma.2023.464400
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Reactive Matrices for MALDI-MS of Cholesterol.

Yang, Zhiyi / Chang, Zong / Deng, Ka / Gu, Junjie / Wu, Yihao / Sun, Qinchao / Luo, Qian

Analytical chemistry

2023 Volume 95, Issue 46, Page(s) 16786–16790

Abstract	Cholesterol is a critical molecule whose dysregulation in certain brain regions is related to multiple neurological disorders. It is of pathological importance to map the distribution of cholesterol in brain. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been widely used in the molecular imaging of metabolites at a high spatial resolution. However, it is challenging to analyze cholesterol by MALDI-MS due to its difficulty in ionization. Herein, we present for the first time a type of reactive matrix for MALDI-MS of cholesterol. Methylpyridinium carboxaldehydes react with cholesterol and other hydroxyl-containing sterols, which greatly enhanced both desorption and ionization and improved the limits of detection to the low μg/mL range. Compared with previous methods, our reactive matrix requires only one step of chemical derivatization and avoids time-consuming enzymatic reaction, which simplified the sample pretreatment. The reactive matrix was successfully used in mapping the distribution of cholesterol in brain tissue sections using MALDI-MS imaging. In summary, this work has provided a sensitive and simple method for the MALDI-MS analysis of cholesterol, has proposed a novel solution to visualize the distribution of sterol metabolites, and has great potential for applications in neurological and pathological studies.
MeSH term(s)	Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Sterols ; Cholesterol ; Phytosterols ; Brain
Chemical Substances	Sterols ; Cholesterol (97C5T2UQ7J) ; Phytosterols
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c04127
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Novel Domain Adversarial Networks Based on 3D-LSTM and Local Domain Discriminator for Hearing-Impaired Emotion Recognition.

Tian, Zekun / Li, Dahua / Yang, Yi / Hou, Fazheng / Yang, Zhiyi / Song, Yu / Gao, Qiang

IEEE journal of biomedical and health informatics

2023 Volume 27, Issue 1, Page(s) 363–373

Abstract: Recent research on emotion recognition suggests that deep network-based adversarial learning has an ability to solve the cross-subject problem of emotion recognition. This study constructed a hearing-impaired electroencephalography (EEG) emotion dataset ... ...

Abstract	Recent research on emotion recognition suggests that deep network-based adversarial learning has an ability to solve the cross-subject problem of emotion recognition. This study constructed a hearing-impaired electroencephalography (EEG) emotion dataset containing three emotions (positive, neutral, and negative) in 15 subjects. The emotional domain adversarial neural network (EDANN) was carried out to identify hearing-impaired subjects' emotions by learning hidden emotion information between the labeled data and the data with no-label. For the input data, we propose a spatial filter matrix to reduce the overfitting of the training data. A feature extraction network 3DLSTM-ConvNET was used to extract comprehensive emotional information from the time, frequency, and spatial dimensions. Moreover, emotion local domain discriminator and emotion film group local domain discriminator were added to reduce the distribution distance between the same kinds of emotions and different film groups, respectively. According to the experimental results, the average accuracy of subject-dependent is 0.984 (STD: 0.011), and that of subject-independent is 0.679 (STD: 0.140). In addition, by analyzing the discrimination characteristics, we found that the brain regions with emotional recognition in the hearing-impaired are distributed in the wider areas of the parietal and occipital lobes, which may be caused by visual processing.
MeSH term(s)	Humans ; Brain ; Electroencephalography/methods ; Emotions ; Hearing ; Persons With Hearing Impairments/psychology ; Nerve Net
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2022.3212475
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Article ; Online: Subjective cognitive complaints in White and African American older adults: associations with demographic, mood, cognitive, and neuroimaging features.

Goldstein, Felicia C / Okafor, Maureen / Yang, Zhiyi / Thomas, Tiffany / Saleh, Sabria / Hajjar, Ihab

Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition

2023 Volume 30, Issue 6, Page(s) 957–970

Abstract: Subjective cognitive complaints (SCC) in cognitively intact older adults have been investigated as a clinically important symptom that may portend the onset of a neurodegenerative disorder such as Alzheimer's disease. Few studies have concurrently ... ...

Abstract	Subjective cognitive complaints (SCC) in cognitively intact older adults have been investigated as a clinically important symptom that may portend the onset of a neurodegenerative disorder such as Alzheimer's disease. Few studies have concurrently incorporated demographic features, depressive symptoms, neuropsychological status, and neuroimaging correlates of SCC and evaluated whether these differ in White and African American older adults. In the current study, 131 (77 White, 54 African American) healthy participants ≥50 years old completed the Cognitive Function Instrument (CFI) to assess SCC, and they underwent objective cognitive testing, assessment of mood, and brain magnetic resonance imaging. Pearson Product Moment correlations were performed to evaluate associations of the CFI self-ratings with the above measures for the combined group and separately for White and African American participants. SCC were associated with greater depressive symptoms in both White and African American participants in adjusted models controlling for overall cognitive status, education, and hypertension. Greater white matter hyperintensities, lower cortical thickness, older age, and slower set shifting speed were associated with increased SCC in White participants. Although the correlations were not significant for African Americans, the strength of the associations were comparable to White participants. Hippocampal volume was not associated with either total SCC or items specific to memory functioning in the entire group. Longitudinal studies are needed to further evaluate the clinical significance of these associations with risk of conversion to mild cognitive impairment and dementia.
MeSH term(s)	Aged ; Humans ; Black or African American ; Cognition ; Cognitive Dysfunction/diagnosis ; Demography ; Neuroimaging ; Neuropsychological Tests ; White ; Middle Aged
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1482447-4
ISSN	1744-4128 ; 1382-5585
ISSN (online)	1744-4128
ISSN	1382-5585
DOI	10.1080/13825585.2023.2249181
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