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Article ; Online: 1,2-Fluorosulfenylation of unactivated alkenes with thiols and a fluoride source promoted by bromodimethylsulfonium bromide.

Yang, Zihui / Liu, Jia / Xie, Lan-Gui

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 95, Page(s) 14153–14156

Abstract: A practical method that enables the fluorosulfenylation of unactivated alkenes processed directly with thiols and fluoride salts is presented. Good to excellent efficiencies and functional group tolerance are observed for both alkene substrates and ... ...

Abstract	A practical method that enables the fluorosulfenylation of unactivated alkenes processed directly with thiols and fluoride salts is presented. Good to excellent efficiencies and functional group tolerance are observed for both alkene substrates and thiols. The procedure also allows the use of gaseous ethylene as a two-carbon building block for β-fluoro thioether products.
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc05045a
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Book ; Online: Answer Retrieval in Legal Community Question Answering

Askari, Arian / Yang, Zihui / Ren, Zhaochun / Verberne, Suzan

2024

Abstract: The task of answer retrieval in the legal domain aims to help users to seek relevant legal advice from massive amounts of professional responses. Two main challenges hinder applying existing answer retrieval approaches in other domains to the legal ... ...

Abstract	The task of answer retrieval in the legal domain aims to help users to seek relevant legal advice from massive amounts of professional responses. Two main challenges hinder applying existing answer retrieval approaches in other domains to the legal domain: (1) a huge knowledge gap between lawyers and non-professionals; and (2) a mix of informal and formal content on legal QA websites. To tackle these challenges, we propose CE_FS, a novel cross-encoder (CE) re-ranker based on the fine-grained structured inputs. CE_FS uses additional structured information in the CQA data to improve the effectiveness of cross-encoder re-rankers. Furthermore, we propose LegalQA: a real-world benchmark dataset for evaluating answer retrieval in the legal domain. Experiments conducted on LegalQA show that our proposed method significantly outperforms strong cross-encoder re-rankers fine-tuned on MS MARCO. Our novel finding is that adding the question tags of each question besides the question description and title into the input of cross-encoder re-rankers structurally boosts the rankers' effectiveness. While we study our proposed method in the legal domain, we believe that our method can be applied in similar applications in other domains. Comment: accepted at ECIR 2024
Keywords	Computer Science - Information Retrieval
Subject code	006
Publishing date	2024-01-09
Publishing country	us
Document type	Book ; Online
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Article ; Online: Extracellular vesicle-derived non-coding RNAs in remodeling melanoma.

Zhan, Yuanyuan / Yang, Zihui / Zeng, Hong / Yu, Jing / Chen, Xue / Wu, Yiping

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 172, Page(s) 116213

Abstract: Melanoma is one of the most lethal cutaneous malignancies. Despite great advances in radiotherapy, chemotherapy, and immunotherapy, the survival rate and prognosis of patients with melanoma remain poor. The abundant and sophisticated reciprocal ... ...

Abstract	Melanoma is one of the most lethal cutaneous malignancies. Despite great advances in radiotherapy, chemotherapy, and immunotherapy, the survival rate and prognosis of patients with melanoma remain poor. The abundant and sophisticated reciprocal communication network between melanoma cells and non-tumor cells contributes to the high heterogeneity of the melanoma microenvironment and is intimately related to varying treatment responses and clinical courses. Extracellular vesicles (EVs) are membrane structures generated by nearly all cell types. EVs contain biologically active molecules, mainly comprising proteins, lipids, and RNAs, and undoubtedly play multifaceted roles in numerous diseases, represented by melanoma. Non-coding RNAs (ncRNAs) mainly encompass long non-coding RNAs, microRNAs, and circular RNAs and constitute the majority of the human transcriptome. Multiple ncRNAs encapsulated in EVs coordinate various pathophysiological processes in melanoma. This review summarizes the mechanisms by which EV-ncRNAs modulate biological behaviors and immunity, and their potential diagnostic and therapeutic applications in melanoma. Undoubtedly, further insight into EV-ncRNAs and their functions in melanoma will contribute to the clinical treatment of melanoma and the implementation of precision medicine.
MeSH term(s)	Humans ; Melanoma/genetics ; Melanoma/therapy ; RNA, Untranslated/genetics ; Extracellular Vesicles/genetics ; MicroRNAs/genetics ; Skin Neoplasms ; Tumor Microenvironment/genetics
Chemical Substances	RNA, Untranslated ; MicroRNAs
Language	English
Publishing date	2024-02-01
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116213
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Article ; Online: Synthesis and Antifungal Activity of Norbornene Carboxamide/sulfonamide Derivatives as Potential Fungicides Targeting Laccase.

Yang, Zi-Hui / Qiu, Yi-Gui / Jin, Dao-Jun / Zheng, Yi-Ming / Li, Jia / Gu, Wen

Chemistry & biodiversity

2024 , Page(s) e202302033

Abstract: To explore more potential fungicides with new scaffolds, thirty-seven norbornene carboxamide/sulfonamide derivatives were designed, synthesized, and assayed for inhibitory activity against six plant pathogenic fungi and oomycetes. The preliminary ... ...

Abstract	To explore more potential fungicides with new scaffolds, thirty-seven norbornene carboxamide/sulfonamide derivatives were designed, synthesized, and assayed for inhibitory activity against six plant pathogenic fungi and oomycetes. The preliminary antifungal assay suggested that the title derivatives showed moderate to good antifungal activity against six plant pathogens. Especially, compound 6e presented excellent in vitro antifungal activity against Sclerotinia sclerotiorum (EC50 = 0.71 mg/L), which was substantially stronger than pydiflumetofen. In vivo antifungal assay indicated 6e displayed prominent protective and curative effects on rape leaves infected by S. sclerotiorum. The preliminary mechanism research displayed that 6e could damage the surface morphology and inhibit the sclerotia formation of S. sclerotiorum. In addition, the in vitro enzyme inhibition bioassay indicated that 6e displayed pronounced laccase inhibition activity (IC50 = 0.63 μM), much stronger than positive control cysteine. Molecular docking elucidated the binding modes between 6e and laccase. The bioassay results and mechanism investigation demonstrated that this class of norbornene carboxamide/sulfonamide derivatives could be promising laccase inhibitors for novel fungicide development.
Language	English
Publishing date	2024-04-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202302033
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Article ; Online: Design and application of training simulation system for nuclear accident emergency drill

WU Qiang / TIAN Shujian / YANG Zihui / SUN Guomin / TAO Guihua / CHEN Weihu / WANG Shipeng

Fushe yanjiu yu fushe gongyi xuebao, Vol 41, Iss 2, Pp 020601-

2023 Volume 020601

Abstract: In order to solve the problems of the nuclear accident emergency drill, such as invisible radiation field, potential radiation risk, and high labor costs, therefore, an adaptive ray-casting 3D nuclear radiation field visualization method based on feature ...

Abstract	In order to solve the problems of the nuclear accident emergency drill, such as invisible radiation field, potential radiation risk, and high labor costs, therefore, an adaptive ray-casting 3D nuclear radiation field visualization method based on feature importance was developed in this study. The nuclear accident emergency disposal drill training simulation system was developed based on the Unity3D simulation engine. The 3D visualization of a nuclear radiation field with millions of grids was realized using ShaderLab programming. Multi-job personnel collaborative operation exercise simulation was realized based on the finite state machine. The system frame rate was approximately 60 frames, which meets real-time interaction requirements. Considering an out-of-control radioactive source accident as a case, the operation modes and emergency disposal processes of the nuclear accident emergency drill could be rebuilt by the system. The proposed solution of the simulation system could be applied to ensure personnel radiation safety, enrich training methods, and reduce training costs.
Keywords	radiation field visualization ; nuclear emergency drill ; ray casting ; finite state machine ; Nuclear and particle physics. Atomic energy. Radioactivity ; QC770-798 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	600
Language	Chinese
Publishing date	2023-04-01T00:00:00Z
Publisher	Science Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design, synthesis and antifungal evaluation of novel nopol derivatives as potent laccase inhibitors

Sun, Xue‐Bao / Yang, Zi‐Hui / Jin, Dao‐Jun / Qiu, Yi‐Gui / Gu, Wen

Pest Management Science. 2023 July, v. 79, no. 7 p.2469-2481

2023

Abstract: BACKGROUND: To explore further potential natural product‐based antifungal agents, a series of novel nopol‐based carboxamide and hydrazide derivatives containing a natural pinene structure were designed, synthesized, and evaluated for their inhibitory ... ...

Abstract	BACKGROUND: To explore further potential natural product‐based antifungal agents, a series of novel nopol‐based carboxamide and hydrazide derivatives containing a natural pinene structure were designed, synthesized, and evaluated for their inhibitory activities against seven phytopathogenic fungi and oomycetes. RESULTS: The bioassay results indicated that some compounds exhibited good inhibitory activities against Gibberella zeae, Sclerotinia sclerotiorum, and Phytophthora capsici. Among them, compound 3h displayed excellent in vitro activities against G. zeae, with EC₅₀ values of 1.09 mg L⁻¹, which was comparable with the commercial fungicides bixafen and carbendazim (median effective concentration [EC₅₀] = 1.21 and 0.89 mg L⁻¹, respectively). Notably, in vivo bioassay results suggested that compound 3h also showed prominent protective and curative effects (95.6% and 94.2%) at 200 mg L⁻¹ against G. zeae. The scanning electron microscopy study indicated that compound 3h could destroy the morphological integrity of G. zeae hyphae. The in vitro enzyme inhibitory bioassay revealed that compound 3h exhibited potent inhibitory activity against laccase with median inhibitory concentration (IC₅₀) values of 4.93 μm, superior to positive control cysteine (IC₅₀ = 35.50 μm), and its binding modes with laccase were elucidated by molecular docking study. In addition, the fluorescent imaging of the dansylamide‐labeled derivatives 8 on wheat leaf epidermal cells and the hyphae of G. zeae revealed that this class of hydrazide derivatives could readily permeate into wheat leaves and reached the laccase target in fungal cells. CONCLUSION: Some nopol‐based hydrazide derivatives exhibited excellent anti‐G. zeae activity and laccase inhibitory activity, which merits further development as a new fungicide candidate for controlling Fusarium head blight. © 2023 Society of Chemical Industry.
Keywords	Fusarium graminearum ; Fusarium head blight ; Phytophthora capsici ; Sclerotinia sclerotiorum ; antifungal properties ; bioassays ; carbendazim ; carboxamides ; cysteine ; electron microscopy ; fluorescence ; fungi ; fungicides ; hydrazides ; hyphae ; laccase ; leaf epidermis ; median effective concentration ; wheat
Language	English
Dates of publication	2023-07
Size	p. 2469-2481.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2001705-4
ISSN	1526-4998 ; 1526-498X
ISSN (online)	1526-4998
ISSN	1526-498X
DOI	10.1002/ps.7426
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A novel ratiometric dehydroabietic acid-based fluorescent probe for detecting HPO42- and its application in food samples

Sun, Lu / Chen, Linlin / Yang, Zihui / Sun, Xuebao / Jin, Daojun / Qiu, Yigui / Gu, Wen

Journal of Food Composition and Analysis. 2023 July, v. 120 p.105316-

2023

Abstract: Monohydrogen phosphate (HPO₄²⁻) is one of the most ubiquitous additives applied in a wide range of food products and played an important role in many biological processes. Therefore, the selective and sensitive detection techniques of HPO₄²⁻ are of great ...

Abstract	Monohydrogen phosphate (HPO₄²⁻) is one of the most ubiquitous additives applied in a wide range of food products and played an important role in many biological processes. Therefore, the selective and sensitive detection techniques of HPO₄²⁻ are of great significance. A novel ratiometric dehydroabietic acid-based fluorescent probe named methyl (6 R,9aS)− 11-bromo-2-(5-bromo-2-hydroxyphenyl)− 6,9a-dimethyl- 4,5,5a,6,7,8,9,9a-octahydro-1H-phenanthro[1,2-d]imidazole-6-carboxylate (CPL) was designed and synthesized for monitoring HPO₄²⁻. The probe CPL had a significant fluorescent response to HPO₄²⁻ changing from cyan to violet fluorescence. CPL demonstrated many fascinating advantages including low limit of detection (28 nM), high selectivity, short response time (20 s) and wide appropriate pH range (5−12). The detection mechanism was verified by FTIR, ¹H NMR, DFT calculation and Job's plot experiment. Subsequently, the probe CPL was applied to quantitatively detect HPO₄²⁻ contents in food samples (shrimp meat, Mozzarella cheese, Basa fish fillet and bread). In addition, CPL was successfully utilized for the bioimaging of HPO₄²⁻ in onion epidermal cells and zebrafishes.
Keywords	Danio rerio ; bioimaging ; breads ; detection limit ; fish fillets ; fluorescence ; fluorescent dyes ; food composition ; mozzarella cheese ; onions ; pH ; phosphates ; shrimp meat ; Fluorescent probe ; HPO42- ; Dehydroabietic acid ; Food analysis
Language	English
Dates of publication	2023-07
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	743572-1
ISSN	0889-1575 ; 1096-0481
ISSN	0889-1575 ; 1096-0481
DOI	10.1016/j.jfca.2023.105316
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Second primary malignancies after ovarian cancer: A SEER-based analysis (1975-2016).

Yang, Zihui / Liu, Xinyu / Yang, Xi / Liao, Qin-Ping

Taiwanese journal of obstetrics & gynecology

2022 Volume 61, Issue 1, Page(s) 80–85

Abstract: Objective: To investigate the risk of occurrence of second primary malignancies (SPMs) in survivors of ovarian cancer (OC) using large data from the Surveillance, Epidemiology, and End Results (SEER) database.: Materials and methods: Multiple ... ...

Abstract	Objective: To investigate the risk of occurrence of second primary malignancies (SPMs) in survivors of ovarian cancer (OC) using large data from the Surveillance, Epidemiology, and End Results (SEER) database. Materials and methods: Multiple primaries standardized incidence ratios (MP-SIRs) to calculate the risk of developing second primary malignancies after a diagnosis of ovarian cancer. Results: Of our included 59,880 women with OC, 3972 cases (6.6%) developed 4495 s primary malignancies over an average follow-up period of 114.39 (±102.66) months. Overall, the risk of occurrence of second primary malignancies after a diagnosis of OC was greater than what would be expected for a reference US population (SIR = 1.05, 95%CI = 1.02-1.08, p-value < 0.05). The occurrence of second myeloid malignancies and second thyroid cancer were most notable across our latency periods. Among the most significant second primary malignancies by latency were malignancies of the appendix (SIR = 14.04, 95%CI = 5.65-28.93, p-value <0.05) at 2-11 months, the small intestine (SIR = 3.15, 95%CI = 1.76-5.2, p-value <0.05) at 12-59 months, and the urinary bladder (SIR = 1.63, 95%CI = 1.3-2.02, p-value <0.05) after 10 years of an OC diagnosis. Conclusion: Women with OC are at significant risk for the development of second primary malignancies across all sites, as compared to a reference US population, and may benefit from second primary malignancies site-specific screening post-diagnosis.
MeSH term(s)	Appendiceal Neoplasms/epidemiology ; Appendiceal Neoplasms/pathology ; Carcinoma, Ovarian Epithelial/diagnosis ; Carcinoma, Ovarian Epithelial/epidemiology ; Female ; Humans ; Incidence ; Intestinal Neoplasms/epidemiology ; Intestinal Neoplasms/pathology ; Neoplasms, Second Primary/epidemiology ; Neoplasms, Second Primary/pathology ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/epidemiology ; Risk Assessment ; Risk Factors ; SEER Program ; Taiwan/epidemiology ; Urologic Neoplasms/epidemiology ; Urologic Neoplasms/pathology
Language	English
Publishing date	2022-02-18
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2202946-1
ISSN	1875-6263 ; 1028-4559
ISSN (online)	1875-6263
ISSN	1028-4559
DOI	10.1016/j.tjog.2021.11.015
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Article ; Online: Screening and identification of Lynch syndrome: a systematic review of the frequency of Lynch syndrome-associated clinicopathologic and molecular characteristics in Lynch syndrome gynecologic cancers.

Yang, Zihui / Liu, Xinyu / Yang, Xi / Liao, Qin-Ping

Translational cancer research

2022 Volume 10, Issue 10, Page(s) 4523–4531

Abstract: Background: This study aimed to investigate the frequency of Lynch syndrome-associated clinicopathologic and molecular characteristics in Lynch syndrome gynecologic cancers.: Methods: A systematic literature search was conducted in the literature ... ...

Abstract	Background: This study aimed to investigate the frequency of Lynch syndrome-associated clinicopathologic and molecular characteristics in Lynch syndrome gynecologic cancers. Methods: A systematic literature search was conducted in the literature databases (Medline, CINAHL, EMBASE, Google Scholar, Cochrane Library, and Clinicaltrials.gov) to identify the studies describing clinicopathologic characteristics, MMR protein immunohistochemistry and/or MSI, MLH1 methylation, and genetic testing in Lynch syndrome gynecologic cancer patients. Results: A total of 24 of the evaluated studies that met the inclusion criteria were identified. A clinicopathological examination confirmed 242 endometrial cancer, 17 clear cells endometrial cancer, 35 serous endometrial cancer, 30 mixed and 21 other endometrial cancer. Thus, a total of 345 endometrial cancer was confirmed from the screening of 1,317 gynaecological cancer. However, the morphological analysis demonstrated 236 patients with endometrial cancer associated with Lynch syndrome. The frequency of confirmed LS with endometrial cancer was 68.40%. At diagnosis, the median age was 49.94±4.34 years, and the average BMI was 26.07±3.77 kg/m Discussion: Lynch syndrome-associated clinicopathologic and molecular characteristics occur significantly in Lynch syndrome gynecologic cancers and may improve risk stratification and triaging of gynecologic cancers for genetic testing.
Language	English
Publishing date	2022-01-15
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr-21-677
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Article ; Online: Direct measurement of the sound velocity in water based on the acousto-optic signal.

Li, Chenxi / Xue, Bin / Yang, Zihui

Applied optics

2021 Volume 60, Issue 8, Page(s) 2455–2464

Abstract: Based on the acousto-optic effect, we propose a new method to directly measure water sound velocity that avoids the error-like phase ambiguity brought by the piezoelectric effect that is broadly adopted in current methods. In the experimental setup we ... ...

Abstract	Based on the acousto-optic effect, we propose a new method to directly measure water sound velocity that avoids the error-like phase ambiguity brought by the piezoelectric effect that is broadly adopted in current methods. In the experimental setup we designed, the laser signal modulated by the propagating acoustic wave changes its phase suddenly when the wave crosses the two or more intercepting laser lines simultaneously. This new design creatively realizes the possibility to capture time information at the phase level in sound velocity measurement, which is hardly realized in the piezoelectric-effect-based methods. Utilizing the above principle and the derived mathematical calculation, the accuracy of sound velocity with good traceability can be obtained. The experimental results show that the repeatability of the measurement results is less than 0.0159 m/s, and the accuracy compared with the commercial sound velocity profiler is better than 0.02 m/s.
Language	English
Publishing date	2021-03-09
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.417946
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