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Article ; Online: The FGFR2 Variant rs13387042 is Associated With Breast Cancer Risk: A Meta-Analysis and Systematic Review.

Pan, Weining / Cheng, Hui / Zhang, Juan / Yang, Zijie / Lin, Mengbo

2024

Abstract: Objective: The association of FGFR2-rs13387042 polymorphism with breast cancer (BC) susceptibility in women remains inconclusive due to varying reports. In this study, we conducted a meta-analysis to explore the relationship between FGFR2-rs13387042 ... ...

Abstract	Objective: The association of FGFR2-rs13387042 polymorphism with breast cancer (BC) susceptibility in women remains inconclusive due to varying reports. In this study, we conducted a meta-analysis to explore the relationship between FGFR2-rs13387042 polymorphism and susceptibility to BC. Methods: Relevant literature were acquired through searches across multiple databases. Odds ratio (OR) values were pooled to assess the risk of BC for different alleles and genotypes. The heterogeneity among the included literature was evaluated. Sensitivity analysis was used to verify the stability of the results. Egger's linear regression test was used to assess the significance of publication bias of the included literature. Results: A total of 17 publications were included, encompassing 122,607 cases and 175,966 controls. There was significantly increased risk of BC for allele A compared with G (OR = 1.15, 95% CI = 1.14-1.67, P < .001), genotype AA compared with GG (OR = 1.34, 95% CI = 1.29-1.38, P < .001), and genotype GA compared with GG (OR = 1.19, 95% CI = 1.12-1.26, P < .001). Both Egger's test and funnel plot indicated the presence of publication bias. After adjusting potential publication bias by the trim-and-fill method, the comparison of allele A versus G (OR = 1.15, 95% CI = 1.13-1.17, P < .001), genotype AA versus GG (OR = 1.32, 95% CI = 1.28-1.37, P < .001), and genotype GA versus GG (OR = 1.15, 95% CI = 1.09-1.22, P < .001) remained statistically significant. In various subgroups, the allele A showed significantly higher risk of BC upon allele G in estrogen receptor (ER) positive BC, ER negative BC, progesterone receptor (PR) positive BC, PR negative BC, triple-negative BC, pathological grade I BC, grade II BC, and grade III breast cancer. The subsequent sensitivity analysis suggested the above findings stable and reliable. Conclusion: In this study, we found that the allele A of the FGFR2-rs13387042 polymorphism is associated with increased risk of developing breast cancer. This study underscores its potential as a genetic marker for personalized risk assessment and targeted interventions.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2106734-X
ISSN	1938-0666 ; 1526-8209
ISSN (online)	1938-0666
ISSN	1526-8209
DOI	10.1016/j.clbc.2024.03.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Exosomal circ_0000722 derived from periodontal ligament stem cells undergoing osteogenic differentiation promotes osteoclastogenesis.

Xie, Liangkun / Ren, Xuefeng / Yang, Zijie / Zhou, Ting / Zhang, Mingzhu / An, Wei / Guan, Zheng

International immunopharmacology

2024 Volume 128, Page(s) 111520

Abstract: Periodontal ligament stem cells (PDLSCs), which are considered promising stem cells for regeneration of periodontal bony tissue, can also manipulate alveolar bone remodeling by exosomes. In this study, we investigated interactions between PDLSCs under ... ...

Abstract	Periodontal ligament stem cells (PDLSCs), which are considered promising stem cells for regeneration of periodontal bony tissue, can also manipulate alveolar bone remodeling by exosomes. In this study, we investigated interactions between PDLSCs under osteogenic differentiation and osteoclast precursors. The results showed that conditioned medium from PDLSCs under 5d osteogenic induction promoted osteoclastogenesis of RAW264.7 cells. The exosomes extracted from those conditioned media showed similar effects on osteoclastogenesis. Furthermore, exosomes from PDLSCs under 5d of osteogenic induction showed significantly high expression of circ_0000722, compared with exosomes from PDLSCs before osteogenic induction. Downregulation of circ_0000722 significantly attenuated the effect of PDLSC-derived exosomes on the osteoclastogenesis of RAW264.7 cells. Our findings suggested that exosomal circ_0000722 derived from periodontal ligament stem cells undergoing osteogenic differentiation might promote osteoclastogenesis by upregulating TRAF6 expression and activating downstream NF-κB and AKT signaling pathways.
MeSH term(s)	Osteogenesis ; Periodontal Ligament ; Cells, Cultured ; Stem Cells ; Cell Differentiation
Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111520
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Article ; Online: Species Differentiation and Quality Evaluation for Atractylodes Medicinal Plants by GC/MS Coupled with Chemometric Analysis.

Ma, Zicheng / Liu, Guoqiang / Yang, Zijie / Zhang, Guoqin / Sun, Lili / Wang, Meng / Ren, Xiaoliang

Chemistry & biodiversity

2023 Volume 20, Issue 8, Page(s) e202300793

Abstract: The utilization of rhizomes from the genus Atractylodes has been challenging due to their closely related origins. In this study, we developed an analytical strategy to differentiate Atractylodes lancea (A. lancea), Atractylodes chinensis (A. chinensis), ...

Abstract	The utilization of rhizomes from the genus Atractylodes has been challenging due to their closely related origins. In this study, we developed an analytical strategy to differentiate Atractylodes lancea (A. lancea), Atractylodes chinensis (A. chinensis), Atractylodes japonica (A. japonica), and Atractylodes macrocephala (A. macrocephala), and compared their volatile compositions. Gas chromatography-mass spectrometry (GC/MS) was used to analyze the volatile profiles of essential oils extracted from 59 batches of samples. Chemometric methods enabled a better understanding of the differences in volatile oils between the four species and identified significant components affecting their classification and quality. A total of 50 volatile components were identified from the essential oils by GC/MS. Unsupervised and supervised chemometric analyses accurately distinguished A. lancea, A. chinensis, A. japonica, and A. macrocephala. Furthermore, five characteristic chemical markers, namely hinesol, β-eudesmol, atractylon, atractylodin and atractylenolide I, were obtained, and their respective percentage contents in individual species and samples were determined. This study provides a valuable reference for the quality evaluation of medicinal plants with essential oils and holds significance for species differentiation and the rational clinical application of Atractylodes herbs.
MeSH term(s)	Gas Chromatography-Mass Spectrometry ; Plants, Medicinal/chemistry ; Atractylodes/chemistry ; Chemometrics ; Oils, Volatile/chemistry
Chemical Substances	Oils, Volatile
Language	English
Publishing date	2023-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202300793
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prognostic relevance of rib invasion and modification of T description for resected NSCLC patients: A propensity score matching analysis of the SEER database.

Chen, Yiyong / Zhang, Juan / Chen, Jing / Yang, Zijie / Ding, Yun / Chen, Wenshu / Guo, Tianxing / Zhao, Lilan / Pan, Xiaojie

Frontiers in oncology

2023 Volume 12, Page(s) 1082850

Abstract: Introduction: The impact of rib invasion on the non-small cell lung cancer (NSCLC) T classifications remains unclear. Our study aims to verify the impact of rib invasion on survival in patients with NSCLC through multicenter data from the Surveillance, ... ...

Abstract	Introduction: The impact of rib invasion on the non-small cell lung cancer (NSCLC) T classifications remains unclear. Our study aims to verify the impact of rib invasion on survival in patients with NSCLC through multicenter data from the Surveillance, Epidemiology, and End Results (SEER) database, and proposed a more appropriate pT for the forthcoming 9 Method: The SEER database was used to collect T Result: Survival outcomes of the rib invasion group were worse than the other pT3 group (OS: 40.5% Conclusion: The rib invasion group had a worse prognosis than the other pT3 groups, but was similar to the pT4 group. Our recommendation is to change the classification of rib invasion to pT4 disease and further validate this in the forthcoming 9
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.1082850
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Water Environment Characteristics and Water Quality Assessment of Typical Lakes in Inner Mongolia].

Wang, Xin-Yuan / Pan, Bao-Zhu / Wang, Li-Xin / Liu, Tie-Jun / Liao, Zi-Long / Han, Xu / Yang, Zi-Jie

Huan jing ke xue= Huanjing kexue

2023 Volume 44, Issue 12, Page(s) 6744–6753

Abstract: Lakes on the Inner Mongolia Plateau, located in the ecologically fragile area of the northern border of China, play a very important role in regulating the regional climate and ecological environment and maintaining biodiversity. Owing to the dual ... ...

Abstract	Lakes on the Inner Mongolia Plateau, located in the ecologically fragile area of the northern border of China, play a very important role in regulating the regional climate and ecological environment and maintaining biodiversity. Owing to the dual influence of natural factors and human factors, the lake water environment in Inner Mongolia is facing challenges. To clarify the overall water quality of lakes in Inner Mongolia, based on the water quality data of typical lakes in Inner Mongolia in autumn 2019(October-November) and summer 2021(July-August), the temporal and spatial variation in water quality was discussed, and the influence of different indexes on lake water quality was analyzed, and the key factors affecting lake water quality were identified. The results showed as follows:① the spatiotemporal distribution of multiple physicochemical indices of typical lakes in Inner Mongolia were different in the two seasons. On the time scale, the concentration of ammonia nitrogen(NH
Language	Chinese
Publishing date	2023-12-14
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0250-3301
ISSN	0250-3301
DOI	10.13227/j.hjkx.202212207
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Panax japonicus C.A. Meyer: a comprehensive review on botany, phytochemistry, pharmacology, pharmacokinetics and authentication.

Chen, Yuan / Liu, Meiqi / Wen, Jinli / Yang, Zijie / Li, Guohui / Cao, Ying / Sun, Lili / Ren, Xiaoliang

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 148

Abstract: Background: Panax japonicus C.A. Meyer (Zhujieshen) is widely used in traditional medicine as a tonic hemostatic and anti-inflammatory agent in China, Japan, and Korea. Furthermore, it is used as an important substitute for ginseng roots by minority ... ...

Abstract	Background: Panax japonicus C.A. Meyer (Zhujieshen) is widely used in traditional medicine as a tonic hemostatic and anti-inflammatory agent in China, Japan, and Korea. Furthermore, it is used as an important substitute for ginseng roots by minority ethnic groups in China. The purpose of this review is to summarize the latest research on Zhujieshen in recent years, aiming at providing a systematic overview of the current knowledge, and perspectives for future research and exploitation. Main body: This review examines the research advances in botanical profile, phytochemicals, pharmacology, pharmacokinetics, and authentication of Zhujieshen. Various compounds have been reported as active components, mainly including saponins, volatile oils, and polysaccharides. Pharmacological investigations have demonstrated that Zhujieshen is an important herb with significant bioactivities, such as anti-inflammatory, hepato-protective, cardio-protective, neuro-protective, anti-tumor, anti-oxidant, anti-thrombotic and immunomodulatory activities. Conclusion: Currently, research on Zhujieshen is in the preliminary stages, and further research is required to understand the active compounds present and mechanisms of action. We hope that this comprehensive review of Zhujieshen will serve as a background for future research and exploitation.
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00857-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Variations in airborne pollen and spores in urban Guangzhou and their relationships with meteorological variables

Rahman, Ananna / Khan, Md Hafijur Rahaman / Luo, Chuanxiu / Yang, Zijie / Ke, Jinzhao / Jiang, Weiming

Heliyon. 2021 Nov., v. 7, no. 11

2021

Abstract: Airborne pollen causes various types of allergies in humans, and the extent of allergic infection is related to the presence of different types of sporo–pollen and existing meteorological conditions in a certain area. Therefore, an aeropalynological ... ...

Abstract	Airborne pollen causes various types of allergies in humans, and the extent of allergic infection is related to the presence of different types of sporo–pollen and existing meteorological conditions in a certain area. Therefore, an aeropalynological study of 72 airborne samples with a hydrofluoric acid (HF) treatment was conducted in the Haizhu district of Guangzhou, China, in 2016, to identify the temporal variations in airborne sporo–pollen and the relationship between airborne sporo–pollen concentrations and different meteorological variables in Guangzhou, China. Forty-five types of airborne pollen, seven types of airborne spores, and some undetermined sporo–pollen taxa were identified with two separate plant habitats occurring during this period (from January to December 2016): arboreal pollen (tree-based) and non-arboreal pollen (herb, shrub, aquatic, liane, etc.). Furthermore, the daily records of four key meteorological variables (temperature, precipitation, relative humidity, and wind speed) were acquired to distinguish the pollen seasons and correlated with Spearman's rho test to establish a pollen-weather data book with the seasonal variations. The two leading seasons were identified based on pollen abundance: spring and autumn. Among them, the primary dominant sporo–pollen families during the spring season were Poaceae, Pinaceae, Euphorbiaceae, Moraceae, Microlepia sp., and Polypodiaceae. Conversely, Artemisia sp., Asteraceae, Cyperaceae, Poaceae, Alnus sp., Corylus sp., Myrtaceae, and Rosaceae were the dominant pollen species during autumn. However, few pollen grains were identified in January, May–July, and December. The statistical analysis revealed that temperature had both positive and negative correlations with sporo–pollen concentrations. However, precipitation and relative humidity had a strong impact on the sporo–pollen dispersion and exhibited a negative correlation with the sporo–pollen concentrations. The wind speed had a positive but strong correlation with the sporo–pollen concentration during the study period. Some inconsistent results were found due to environmental variations, vegetation type, and climate change around the study area. This study will facilitate the identification of pollen seasons to prevent the occurrence of pollen-related allergies in the Guangzhou city area.
Keywords	Alnus ; Artemisia ; Corylus ; Cyperaceae ; Euphorbiaceae ; Microlepia ; Moraceae ; Myrtaceae ; Pinaceae ; Poaceae ; Polypodiaceae ; Rosaceae ; autumn ; climate change ; hydrofluoric acid ; pollen ; relative humidity ; shrubs ; spring ; statistical analysis ; temperature ; vegetation types ; wind speed ; China
Language	English
Dates of publication	2021-11
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e08379
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: AI-driven platform for systematic nomenclature and intelligent knowledge acquisition of natural medicinal materials

Yang, Zijie / Yin, Yongjing / Kong, Chaojun / Chi, Tiange / Tao, Wufan / Zhang, Yue / Xu, Tian

2023

Abstract: Natural Medicinal Materials (NMMs) have a long history of global clinical applications, accompanied by extensive informational records. Despite their significant impact on healthcare, the field faces a major challenge: the non-standardization of NMM ... ...

Abstract	Natural Medicinal Materials (NMMs) have a long history of global clinical applications, accompanied by extensive informational records. Despite their significant impact on healthcare, the field faces a major challenge: the non-standardization of NMM knowledge, stemming from historical complexities and causing limitations in broader applications. To address this, we introduce a Systematic Nomenclature for NMMs, underpinned by ShennongAlpha, an AI-driven platform designed for intelligent knowledge acquisition. This nomenclature system enables precise identification and differentiation of NMMs. ShennongAlpha, cataloging over ten thousand NMMs with standardized bilingual information, enhances knowledge management and application capabilities, thereby overcoming traditional barriers. Furthermore, it pioneers AI-empowered conversational knowledge acquisition and standardized machine translation. These synergistic innovations mark the first major advance in integrating domain-specific NMM knowledge with AI, propelling research and applications across both NMM and AI fields while establishing a groundbreaking precedent in this crucial area. Comment: 55 pages, 7 figures, 10 supplementary figures, 1 table, 1 supplementary table
Keywords	Computer Science - Artificial Intelligence ; Computer Science - Databases ; Computer Science - Information Retrieval
Subject code	004
Publishing date	2023-12-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Variations in airborne pollen and spores in urban Guangzhou and their relationships with meteorological variables.

Rahman, Ananna / Khan, Md Hafijur Rahaman / Luo, Chuanxiu / Yang, Zijie / Ke, Jinzhao / Jiang, Weiming

Heliyon

2021 Volume 7, Issue 11, Page(s) e08379

Abstract: Airborne pollen causes various types of allergies in humans, and the extent of allergic infection is related to the presence of different types of sporo-pollen and existing meteorological conditions in a certain area. Therefore, an aeropalynological ... ...

Abstract	Airborne pollen causes various types of allergies in humans, and the extent of allergic infection is related to the presence of different types of sporo-pollen and existing meteorological conditions in a certain area. Therefore, an aeropalynological study of 72 airborne samples with a hydrofluoric acid (HF) treatment was conducted in the Haizhu district of Guangzhou, China, in 2016, to identify the temporal variations in airborne sporo-pollen and the relationship between airborne sporo-pollen concentrations and different meteorological variables in Guangzhou, China. Forty-five types of airborne pollen, seven types of airborne spores, and some undetermined sporo-pollen taxa were identified with two separate plant habitats occurring during this period (from January to December 2016): arboreal pollen (tree-based) and non-arboreal pollen (herb, shrub, aquatic, liane, etc.). Furthermore, the daily records of four key meteorological variables (temperature, precipitation, relative humidity, and wind speed) were acquired to distinguish the pollen seasons and correlated with Spearman's rho test to establish a pollen-weather data book with the seasonal variations. The two leading seasons were identified based on pollen abundance: spring and autumn. Among them, the primary dominant sporo-pollen families during the spring season were Poaceae, Pinaceae, Euphorbiaceae, Moraceae,
Language	English
Publishing date	2021-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e08379
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Engineering of an enhanced synthetic Notch receptor by reducing ligand-independent activation.

Yang, Zi-Jie / Yu, Zi-Yan / Cai, Yi-Ming / Du, Rong-Rong / Cai, Liang

Communications biology

2020 Volume 3, Issue 1, Page(s) 116

Abstract: Notch signaling is highly conserved in most animals and plays critical roles during neurogenesis as well as embryonic development. Synthetic Notch-based systems, modeled from Notch receptors, have been developed to sense and respond to a specific ... ...

Abstract	Notch signaling is highly conserved in most animals and plays critical roles during neurogenesis as well as embryonic development. Synthetic Notch-based systems, modeled from Notch receptors, have been developed to sense and respond to a specific extracellular signal. Recent advancement of synNotch has shown promise for future use in cellular engineering to treat cancers. However, synNotch from Morsut et al. (2016) has a high level of ligand-independent activation, which limits its application. Here we show that adding an intracellular hydrophobic sequence (QHGQLWF, named as RAM7) present in native Notch, significantly reduced ligand-independent activation. Our enhanced synthetic Notch receptor (esNotch) demonstrates up to a 14.6-fold reduction in ligand-independent activation, without affecting its antigen-induced activation efficiency. Our work improves a previously reported transmembrane receptor and provides a powerful tool to develop better transmembrane signaling transduction modules for further advancement of eukaryotic synthetic biology.
MeSH term(s)	Amino Acid Sequence ; Antigens/metabolism ; Cell Engineering/methods ; Cell Membrane/metabolism ; Cloning, Molecular/methods ; HEK293 Cells ; Humans ; Ligands ; Plasmids/genetics ; Protein Domains ; Proteolysis ; Receptors, Artificial/chemistry ; Receptors, Artificial/metabolism ; Receptors, Notch/chemistry ; Receptors, Notch/genetics ; Receptors, Notch/metabolism ; Signal Transduction/genetics ; Single-Chain Antibodies ; Synthetic Biology/methods ; Transfection
Chemical Substances	Antigens ; Ligands ; Receptors, Artificial ; Receptors, Notch ; Single-Chain Antibodies
Language	English
Publishing date	2020-03-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-020-0848-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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