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  1. Article ; Online: Immune-related genetic prognostic index to predict prognosis and immune checkpoint inhibitor therapy efficiency in acute myeloid leukemia

    Xunhong Cao / Xiaojun Huang / Xiangyu Zhao / Yanjie Yin

    Chinese Medical Journal, Vol 136, Iss 10, Pp 1253-

    2023  Volume 1255

    Keywords Medicine ; R
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Concomitant transverse myelitis and Guillain-Barré syndrome following varicella-zoster virus infection

    Danmei Lan / Lingyu Liu / Yanjie Yin

    Chinese Medical Journal, Vol 136, Iss 10, Pp 1256-

    2023  Volume 1257

    Keywords Medicine ; R
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Epidural hydroxyethyl starch ameliorating postdural puncture headache after accidental dural puncture

    Yin Zhou / Zhiyu Geng / Linlin Song / Dongxin Wang / Yanjie Yin

    Chinese Medical Journal, Vol 136, Iss 1, Pp 88-

    2023  Volume 95

    Abstract: Background:. No convincing modalities have been shown to completely prevent postdural puncture headache (PDPH) after accidental dural puncture (ADP) during obstetric epidural procedures. We aimed to evaluate the role of epidural administration of ... ...

    Abstract Background:. No convincing modalities have been shown to completely prevent postdural puncture headache (PDPH) after accidental dural puncture (ADP) during obstetric epidural procedures. We aimed to evaluate the role of epidural administration of hydroxyethyl starch (HES) in preventing PDPH following ADP, regarding the prophylactic efficacy and side effects. Methods:. Between January 2019 and February 2021, patients with a recognized ADP during epidural procedures for labor or cesarean delivery were retrospectively reviewed to evaluate the prophylactic strategies for the development of PDPH at a single tertiary hospital. The development of PDPH, severity and duration of headache, adverse events associated with prophylactic strategies, and hospital length of stay postpartum were reported. Results:. A total of 105 patients experiencing ADP received a re-sited epidural catheter. For PDPH prophylaxis, 46 patients solely received epidural analgesia, 25 patients were administered epidural HES on epidural analgesia, and 34 patients received two doses of epidural HES on and after epidural analgesia, respectively. A significant difference was observed in the incidence of PDPH across the groups (epidural analgesia alone, 31 [67.4%]; HES-Epidural analgesia, ten [40.0%]; HES-Epidural analgesia-HES, five [14.7%]; P <0.001). No neurologic deficits, including paresthesias and motor deficits related to prophylactic strategies, were reported from at least 2 months to up to more than 2 years after delivery. An overall backache rate related to HES administration was 10%. The multivariable regression analysis revealed that the HES-Epidural analgesia-HES strategy was significantly associated with reduced risk of PDPH following ADP (OR = 0.030, 95% confidence interval: 0.006–0.143; P < 0.001). Conclusions:. The incorporated prophylactic strategy was associated with a great decrease in the risk of PDPH following obstetric ADP. This strategy consisted of re-siting an epidural catheter with continuous epidural analgesia and two ...
    Keywords Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Factors influencing folic acid, multivitamin, and calcium supplementation among pregnant women in China based on a national cross-sectional survey

    Guolin He / Hongmei Yang / Meng Chen / Xinghui Liu / Yanjie Yin

    Chinese Medical Journal, Vol 136, Iss 4, Pp 473-

    2023  Volume 475

    Keywords Medicine ; R
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Telomerase-mediated immortalization of human vaginal wall fibroblasts derived from patients with pelvic organ prolapse

    Tao Guo / Ting Xie / Jinghe Lang / Zhijing Sun / Yanjie Yin

    Chinese Medical Journal, Vol 136, Iss 5, Pp 578-

    2023  Volume 587

    Abstract: Abstract. Background:. Extracellular matrix (ECM) remodeling is the most important pathomechanism of pelvic organ prolapse (POP). Fibroblasts are the key to ECM regulation. The passaging capacity of human vaginal wall fibroblasts (hVWFs) is limited in ... ...

    Abstract Abstract. Background:. Extracellular matrix (ECM) remodeling is the most important pathomechanism of pelvic organ prolapse (POP). Fibroblasts are the key to ECM regulation. The passaging capacity of human vaginal wall fibroblasts (hVWFs) is limited in vitro. Here, we aimed to immortalize hVWFs through the introduction of human telomerase reverse transcriptase (hTERT). Methods:. Primary cells were derived from the vaginal wall tissue of patients with POP. Cellular senescence was detected via senescence-associated β-galactosidase staining. We employed a lentiviral transfection vector to stably express hTERT in hVWFs at passage 3, generating immortalized hVWFs (i-hVWFs). We then assessed cellular proliferation via the CCK-8 and EdU assays as well as cellular migration via wound healing assays. G-banded chromosome karyotypic analysis was performed to evaluate chromosomal karyotype stability. Finally, cellular tumorigenesis capacity was assessed in nude mice. A two-tailed Student's t test was used to compare differences between the two groups. Results:. Our results showed that senescence of primary hVWFs significantly increased from passage seven. From passage 11, hVWFs showed a significantly higher senescence percentage than i-hVWFs. During the continuous passage, i-hVWFs presented stability in proliferation, migration capacity, expression of ECM regulation-related genes, and chromosome karyotype. In vivo tumorigenesis was absent in i-hVWFs. Conclusions:. The senescence of hVWFs significantly increased from the seventh passage, and we successfully used hTERT to immortalize hVWFs derived from patients with POP. Studies on POP that require a long-lived hVWF line will benefit from our technique.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Predicting the risk of Turner syndrome based on ultrasonographic markers in the first trimester of pregnancy

    Xiaohua Gao / Yongqing Sun / Jingjing Wang / Qingqing Wu / Yanjie Yin

    Chinese Medical Journal, Vol 136, Iss 15, Pp 1879-

    2023  Volume 1881

    Keywords Medicine ; R
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Exercise intervention during pregnancy induces DNA methylation alterations in maternal blood and cord blood

    Jie Yan / Chen Wang / Yumei Wei / Huixia Yang / Yanjie Yin

    Chinese Medical Journal, Vol 136, Iss 13, Pp 1624-

    2023  Volume 1626

    Keywords Medicine ; R
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Cold snare polypectomy for colorectal polyps

    Tengjiao Gao / Xiaoyun Ding / Yanjie Yin

    Chinese Medical Journal, Vol 135, Iss 1, Pp 20-

    current uses and development

    2022  Volume 22

    Keywords Medicine ; R
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Early life 1000 days

    Juan Juan / Huixia Yang / Yanjie Yin

    Chinese Medical Journal, Vol 135, Iss 5, Pp 516-

    opportunities for preventing adult diseases

    2022  Volume 518

    Keywords Medicine ; R
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Beyond interleukin-17-targeted therapy

    Xin Wu / Huji Xu / Chen Dong / Yanjie Yin

    Chinese Medical Journal, Vol 135, Iss 5, Pp 511-

    Complexity of environment-genetics-immunology needs to be addressed

    2022  Volume 512

    Keywords Medicine ; R
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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