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  1. Article ; Online: Influencing Mechanism and Difference of Poultry Farmers’ Willingness and Behavior in Breeding Scale—Evidence from Jianghan Plain, China

    Yanqi Han / Hui Lyu / Shixiong Cheng / Yuhang He

    International Journal of Environmental Research and Public Health, Vol 19, Iss 1631, p

    2022  Volume 1631

    Abstract: This paper uses the Heckprobit two-stage econometric model to explore the influence mechanism of poultry farmers’ willingness and behavior regarding scale based on 269 household survey data in the hinterland of Jianghan Plain, China. The results show ... ...

    Abstract This paper uses the Heckprobit two-stage econometric model to explore the influence mechanism of poultry farmers’ willingness and behavior regarding scale based on 269 household survey data in the hinterland of Jianghan Plain, China. The results show that (1) family endowments, social capital, economic capital, product market prediction, and major public emergencies are the main influencing factors for farmers to engage in poultry farming; (2) economic capital, policy guarantees, product market prediction, and major public emergencies are the main factors that influence the changes in farmers’ poultry breeding scale; and (3) sampled poultry farmers are inconsistent between their breeding willingness and breeding behavior in poultry decision-making and the factors that affect the willingness and behavior are varied. Based on these findings, this paper suggests that the government should pay attention to inducing corresponding assistance and subsidy policies, formulating financial support countermeasures, organizing training and exchange meetings of the breeding industry, and promoting poultry market informatization to help the poultry industry prosper.
    Keywords poultry industry ; breeding willingness ; breeding behavior ; impact mechanism ; major public emergencies ; Jianghan Plain ; Medicine ; R
    Subject code 330
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Dynamic Transition and Convergence Trend of the Innovation Efficiency among Companies Listed on the Growth Enterprise Market in the Yangtze River Economic Belt—Empirical Analysis Based on DEA—Malmquist Model

    Yanqi Han / Minghui Hua / Malan Huang / Jin Li / Shirui Wang

    Sustainability, Vol 14, Iss 5269, p

    2022  Volume 5269

    Abstract: Background: The Yangtze River Economic Belt (YREB) occupies an important economic position in China and has great research value. Methods: Based on the panel data of 142 GEM-listed companies in the YREB from 2015 to 2019, using the DEA Malmquist index, σ ...

    Abstract Background: The Yangtze River Economic Belt (YREB) occupies an important economic position in China and has great research value. Methods: Based on the panel data of 142 GEM-listed companies in the YREB from 2015 to 2019, using the DEA Malmquist index, σ -convergence and β -convergence models, this study empirically analyzes the dynamic change and convergence trend of the innovation efficiency of these companies. Results: The number of these companies increased significantly but the innovation efficiency of them has not reached the optimal level. From a static point of view, companies in the middle reaches of the Yangtze River have the highest innovation efficiency, while from the dynamic point of view, the Yangtze River Delta region has the highest innovation efficiency. Moreover, most companies have an agglomeration effect, and there is a big gap in innovation efficiency. There is no σ -convergence trend in the YREB and its sub-regions, but there is an obvious β -convergence trend. Conclusions: The innovation efficiency of these companies has a lot of room for improvement. There is industry heterogeneity, and exogenous factors have different effects on the improvement of innovation efficiency in different regions owing to the differences in geographical location, economic development level, and other factors.
    Keywords Yangtze River ; economic belt ; GEM-listed companies ; innovation efficiency ; dynamic transition ; convergence trend ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 338
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Study on basic and clinical application of Shufeng Jiedu Capsule in treating respiratory tract infection

    Yanqi Han / Jun Xu / Qiang Zhu / Li Yang / Yitao Wang / Hua Luo / Tiejun Zhang

    Chinese Medicine, Vol 18, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Abstract Shufeng Jiedu Capsule (SFJDC), composed of eight herbs, is a big brand traditional Chinese medicine (TCM) for the treatment of different respiratory tract infectious diseases with good clinical efficacy and few side effects. It is clinically ... ...

    Abstract Abstract Shufeng Jiedu Capsule (SFJDC), composed of eight herbs, is a big brand traditional Chinese medicine (TCM) for the treatment of different respiratory tract infectious diseases with good clinical efficacy and few side effects. It is clinically applied to acute upper respiratory tract infection(URI), influenza, acute exacerbation of chronic obstructive pulmonary disease (AECOPD), community-acquired pneumonia(CAP) and other diseases, due to its antibacterial, antiviral, anti-inflammatory, immunoregulatory and antipyretic activities. In particular, it has shown good clinical effects for COVID-19, and was included in the fourth to tenth editions of the ‘Diagnosis and Treatment Protocol for COVID-19 (Trial)’ by the National Health Commission. In recent years, studies on the secondary development which focus on the basic and clinical application of SFJDC have been widely reported. In this paper, chemical components, pharmacodynamic material basis, mechanisms, compatibility rule and clinical application were systematically summarized, in order to provide theoretical and experimental basis for further research and clinical application of SFJDC.
    Keywords Big brand traditional Chinese medicine ; Shufeng Jiedu Capsule ; Secondary development of TCM ; Respiratory tract infections ; Systematical research ; Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Taste-Masking Mechanism of Chitosan at the Molecular Level on Bitter Drugs of Alkaloids and Flavonoid Glycosides from Traditional Chinese Medicine

    Yaqi Xu / Qianwen Sun / Wei Chen / Yanqi Han / Yue Gao / Jun Ye / Hongliang Wang / Lili Gao / Yuling Liu / Yanfang Yang

    Molecules, Vol 27, Iss 7455, p

    2022  Volume 7455

    Abstract: Taste masking of traditional Chinese medicines (TCMs) containing multiple bitter components remains an important challenge. In this study, berberine (BER) in alkaloids and phillyrin (PHI) in flavonoid glycosides, which are common bitter components in ... ...

    Abstract Taste masking of traditional Chinese medicines (TCMs) containing multiple bitter components remains an important challenge. In this study, berberine (BER) in alkaloids and phillyrin (PHI) in flavonoid glycosides, which are common bitter components in traditional Chinese medicines, were selected as model drugs. Chitosan (CS) was used to mask their unfriendly taste. Firstly, from the molecular level, we explained the taste-masking mechanism of CS on those two bitter components in detail. Based on those taste-masking mechanisms, the bitter taste of a mixture of BER and PHI was easily masked by CS in this work. The physicochemical characterization results showed the taste-masking compounds formed by CS with BER (named as BER/CS) and PHI (named as PHI/CS) were uneven in appearance. The drug binding efficiency of BER/CS and PHI/CS was 50.15 ± 2.63% and 67.10 ± 2.52%, respectively. The results of DSC, XRD, FTIR and molecular simulation further indicated that CS mainly masks the bitter taste by disturbing the binding site of bitter drugs and bitter receptors in the oral cavity via forming hydrogen bonds between its hydroxyl or amine groups and the nucleophilic groups of BER and PHI. The taste-masking evaluation results by the electronic tongue test confirmed the excellent taste-masking effects on alkaloids, flavonoid glycosides or a mixture of the two kinds of bitter components. The in vitro release as well as in vivo pharmacokinetic results suggested that the taste-masked compounds in this work could achieve rapid drug release in the gastric acid environment and did not influence the in vivo pharmacokinetic results of the drug. The taste-masking method in this work may have potential for the taste masking of traditional Chinese medicine compounds containing multiple bitter components.
    Keywords berberine ; phillyrin ; taste masking ; chitosan ; hydrogen bond ; molecular simulation ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: The comparative pharmacokinetic study of Yuanhu Zhitong prescription based on five quality-markers

    Zhang, Hongbing / Changxiao Liu / Jun Xu / Suxiao Gong / Tiejun Zhang / Xin Wu / Yanqi Han

    Phytomedicine. 2018 May 15, v. 44

    2018  

    Abstract: According to the compatibility theory, therapeutic effects of Chinese medicine prescription are generally attributed to the synergism of multi-herbs. Quality-markers, as the crucial effective components, play a key role in the interaction of ... ...

    Abstract According to the compatibility theory, therapeutic effects of Chinese medicine prescription are generally attributed to the synergism of multi-herbs. Quality-markers, as the crucial effective components, play a key role in the interaction of compatibility. Pharmacokinetic studies could illustrate the interaction between multiple components in dynamics perspective.This study aims to establish a rapid, reliable and sensitive ultra performance liquid chromatography coupled with tandem mass spectrometry method for simultaneous determination of corydaline, tetrahydropalmatine, protopine, imperatorin and isoimperatorin (quality-markers of Yuanhu Zhitong prescription) in rat plasma, and then applied to the comparative pharmacokinetic study for clearing the interaction of compatibility in Yuanhu Zhitong prescription.Five quality-markers were separated on a Waters Acquity UPLC BEH C18 column (2.1 mm × 50 mm, 1.7 μm) by gradient elution with 0.1% formic acid-water and 0.1% formic acid-acetonitrile. Detection was performed in the positive ionization and multiple reaction monitoring mode. The analytical method was validated and successfully applied to the comparative pharmacokinetic study after oral administration of Yuanhu Zhitong prescription and single-herb extracts.Calibration curves showed good linearity over the concentration ranges of 0.25–500 ng/ml for corydaline, tetrahydropalmatine and isoimperatorin, 0.1–200 ng/ml for protopine, and 0.5–500 ng/ml for imperatorin, respectively. Compared with Rhizoma corydalis group, AUC0-t and AUC0-∞ significantly increased (p < 0.01 for corydaline and tetrahydropalmatine, and p < 0.05 for protopine) after oral administration of Yuanhu Zhitong prescription extract. Meanwhile, Cmax of corydaline and tetrahydropalmatine increased remarkably, from 93.00 μg/l to 196.35 μg/l for corydaline (p < 0.05) and 181.62 μg/l to 311.22 μg/l for tetrahydropalmatine (p < 0.01). In addition, MRT0-t and MRT0-∞ of corydaline, as well as Tmax of protopine in Yuanhu Zhitong prescription group were obviously delayed compared to Rhizoma corydalis group (p < 0.01).These achieved results indicated that the compatibility of Rhizoma corydalis and Radix Angelicae dahuricae lead to greater absorption of corydaline, tetrahydropalmatine and protopine, which would be help to better understand the compatibility mechanism of Yuanhu Zhitong prescription.
    Keywords absorption ; Corydalis ; ionization ; monitoring ; oral administration ; Oriental traditional medicine ; pharmacokinetics ; rats ; synergism ; tandem mass spectrometry ; therapeutics ; ultra-performance liquid chromatography
    Language English
    Dates of publication 2018-0515
    Size p. 148-154.
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2018.02.005
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: The method of quality marker research and quality evaluation of traditional Chinese medicine based on drug properties and effect characteristics

    Zhang, Tiejun / Changxiao Liu / Gang Bai / Hongbing Zhang / Jun Xu / Suxiao Gong / Yanqi Han / Yazhuo Li

    Phytomedicine. 2018 May 15, v. 44

    2018  

    Abstract: Quality of traditional Chinese medicine (TCM) plays a critical role in industry of TCM. Rapid development of TCM pharmaceutical areas is, however, greatly limited, since there are many issues not been resolved, concerning the quality study of TCM.Core ... ...

    Abstract Quality of traditional Chinese medicine (TCM) plays a critical role in industry of TCM. Rapid development of TCM pharmaceutical areas is, however, greatly limited, since there are many issues not been resolved, concerning the quality study of TCM.Core concept of TCM quality as well as the characteristics of TCM was discussed, in order to guide the quality research and evaluation of TCM, further improve the level of TCM quality control.In this review, on the basis of systematic analysis of fundamental property and features of TCM in clinical application, the approaches and methods of quality marker (Q-marker) study were proposed through combination of transitivity and traceability of essentials of quality, correlation between chemical ingredients and drug property/efficacy, as well as analysis of endemicity of ingredients sharing similar pharmacophylogenetic and biosynthetic approaches.The approaches and methods of Q-marker study were proposed and the novel integrated pattern for quality assessment and control of TCM was established.The core concept of Q-marker has helped to break through the bottleneck of the current fragmented quality research of TCM and improved the scientificity, integrity and systematicness of quality control.
    Keywords biosynthesis ; drugs ; indigenous species ; industry ; ingredients ; Oriental traditional medicine ; research and development ; traceability
    Language English
    Dates of publication 2018-0515
    Size p. 204-211.
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2018.02.009
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Identification and comparison of anti-inflammatory ingredients from different organs of Lotus nelumbo by UPLC/Q-TOF and PCA coupled with a NF-κB reporter gene assay.

    Mengge Zhou / Min Jiang / Xuhui Ying / Qingxin Cui / Yanqi Han / Yuanyuan Hou / Jie Gao / Gang Bai / Guoan Luo

    PLoS ONE, Vol 8, Iss 11, p e

    2013  Volume 81971

    Abstract: Lotus nelumbo (LN) (Nelumbo nucifera Gaertn.) is an aquatic crop that is widely distributed throughout Asia and India, and various parts of this plant are edible and medicinal. It is noteworthy that different organs of this plant are used in traditional ... ...

    Abstract Lotus nelumbo (LN) (Nelumbo nucifera Gaertn.) is an aquatic crop that is widely distributed throughout Asia and India, and various parts of this plant are edible and medicinal. It is noteworthy that different organs of this plant are used in traditional herbal medicine or folk recipes to cure different diseases and to relieve their corresponding symptoms. The compounds that are contained in each organ, which are named based on their chemical compositions, have led to their respective usages. In this work, a strategy was used to identify the difference ingredients and screen for Nuclear-factor-kappaB (NF-κB) inhibitors with anti-inflammatory ability in LN. Seventeen main difference ingredients were compared and identified from 64 samples of 4 different organs by ultra-performance liquid chromatography that was coupled with quadrupole/time of flight mass spectrometry (UPLC/Q-TOF-MS) with principal component analysis (PCA). A luciferase reporter assay system combined with the UPLC/Q-TOF-MS information was applied to screen biologically active substances. Ten NF-κB inhibitors from Lotus plumule (LP) extracts, most of which were isoquinoline alkaloids or flavone C-glycosides, were screened. Heat map results showed that eight of these compounds were abundant in the LP. In conclusion, the LP extracts were considered to have the best anti-inflammatory ability of the four LN organs, and the chemical material basis (CMB) of this biological activity was successfully validated by multivariate statistical analysis and biological research methods.
    Keywords Medicine ; R ; Science ; Q
    Subject code 540
    Language English
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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