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  1. AU="Yanqin Yang"
  2. AU="von Paris, Philip"
  3. AU=Tanaka K
  4. AU="Olesen, Jes"
  5. AU="Liao, Walter"
  6. AU="Lindfeldt, Isis"
  7. AU="A Bataineh, Ziad"

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  1. Artikel ; Online: Inhibitory Mechanisms of trans -2-Hexenal on the Growth of Geotrichum citri - aurantii

    Qiuli Ouyang / Shiwei Shi / Yangmei Liu / Yanqin Yang / Yonghua Zhang / Xingxing Yuan / Nengguo Tao / Lu Li

    Journal of Fungi, Vol 9, Iss 930, p

    2023  Band 930

    Abstract: Geotrichum citri - aurantii ( G. citri - aurantii ) is one of the most important postharvest pathogens leading to a postharvest loss of citrus by causing sour rot. In this study, the antifungal activity of trans -2-hexenal, a natural component of ... ...

    Abstract Geotrichum citri - aurantii ( G. citri - aurantii ) is one of the most important postharvest pathogens leading to a postharvest loss of citrus by causing sour rot. In this study, the antifungal activity of trans -2-hexenal, a natural component of essential oil, against G. citri - aurantii was evaluated. Trans -2-hexenal treatment inhibited the mycelia growth of G. citri - aurantii with a minimum inhibitory concentration and minimum fungicidal concentration of trans -2-hexenal at 0.50 and 1.00 μL/mL, respectively. Moreover, trans -2-hexenal efficiently reduced the incidence of sour rot of Satsuma fruit inoculated with G. citri - aurantii . Ultrastructural observations and Fourier transform infrared (FT−IR) results showed that trans -2-hexenal treatment affected the cell wall and cell membrane instructions of G. citri - aurantii . The content of β -1,3-glucan was significantly decreased after trans -2-hexenal treatment, but the cell wall permeability was not changed. The decrease in lipid and ergosterol contents might be responsible for this antifungal activity. Several important genes, FKS1 , ERG1 , ERG7 , and ERG11 , showed decreasing expression levels after trans -2-hexenal treatment. Molecule-docking results also indicated that trans -2-hexenal could join with the protein of FKS1, ERG1, ERG7, and ERG11 to impact enzyme activities. These results demonstrated that trans -2-hexenal is a promising fungicide for controlling sour rot of harvested citrus fruit by damaging the membrane integrity of G. citri - aurantii.
    Schlagwörter G. citri - aurantii ; trans -2-hexeanl ; antifungal mechanism ; cell wall ; cell membrane ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Rapid Sensing of Key Quality Components in Black Tea Fermentation Using Electrical Characteristics Coupled to Variables Selection Algorithms

    Chunwang Dong / Ting An / Hongkai Zhu / Jinjin Wang / Bin Hu / Yongwen Jiang / Yanqin Yang / Jia Li

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Band 10

    Abstract: Abstract Based on the electrical characteristic detection technology, the quantitative prediction models of sensory score and physical and chemical quality Index (theaflavins, thearubigins, and theabrownins) were established by using the fermented ... ...

    Abstract Abstract Based on the electrical characteristic detection technology, the quantitative prediction models of sensory score and physical and chemical quality Index (theaflavins, thearubigins, and theabrownins) were established by using the fermented products of Congou black tea as the research object. The variation law of electrical parameters during the process of fermentation and the effects of different standardized pretreatment methods and variable optimization methods on the models were discussed. The results showed that the electrical parameters vary regularly with the test frequency and fermentation time, and the substances that hinder the charge transfer increase gradually during the fermentation process. The Zero-mean normalization (Zscore) preprocessing method had the best noise reduction effect, and the prediction set correlation coefficient (Rp) value of the original data could be increased from 0.172 to 0.842. The mixed variable optimization method (MCUVE-CARS) of Monte Carlo uninformed variable elimination (MC UVE) and competitive adaptive reweighted sampling (CARS) was proved that the characteristic electrical parameters were the loss factor (D) and reactance (X) of the low range. Based on the characteristic variables screened by MCUVE-CARS, the quantitative prediction models for each fermentation quality indicator were established. The Rp values of the sensory score, theaflavin, thearubigin and theabrownins of the predicted models were 0.924, 0.811, 0.85 and 0.938 respectively. The relative percent deviation (RPD) values of the sensory score, theaflavins, thearubigins and theabrownins of the predicted models were 2.593, 1.517, 1,851 and 2.920 respectively, and it showed that these models have good performance and could realize quantitative characterization of key fermentation quality indexes.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 620
    Sprache Englisch
    Erscheinungsdatum 2020-01-01T00:00:00Z
    Verlag Nature Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Genome-wide transcriptome study using deep RNA sequencing for myocardial infarction and coronary artery calcification

    Xiaoling Zhang / Jeroen G. J. van Rooij / Yoshiyuki Wakabayashi / Shih-Jen Hwang / Yanqin Yang / Mohsen Ghanbari / Daniel Bos / BIOS Consortium / Daniel Levy / Andrew D. Johnson / Joyce B. J. van Meurs / Maryam Kavousi / Jun Zhu / Christopher J. O’Donnell

    BMC Medical Genomics, Vol 14, Iss 1, Pp 1-

    2021  Band 17

    Abstract: Abstract Background Coronary artery calcification (CAC) is a noninvasive measure of coronary atherosclerosis, the proximal pathophysiology underlying most cases of myocardial infarction (MI). We sought to identify expression signatures of early MI and ... ...

    Abstract Abstract Background Coronary artery calcification (CAC) is a noninvasive measure of coronary atherosclerosis, the proximal pathophysiology underlying most cases of myocardial infarction (MI). We sought to identify expression signatures of early MI and subclinical atherosclerosis in the Framingham Heart Study (FHS). In this study, we conducted paired-end RNA sequencing on whole blood collected from 198 FHS participants (55 with a history of early MI, 72 with high CAC without prior MI, and 71 controls free of elevated CAC levels or history of MI). We applied DESeq2 to identify coding-genes and long intergenic noncoding RNAs (lincRNAs) differentially expressed in MI and high CAC, respectively, compared with the control. Results On average, 150 million paired-end reads were obtained for each sample. At the false discovery rate (FDR) < 0.1, we found 68 coding genes and 2 lincRNAs that were differentially expressed in early MI versus controls. Among them, 60 coding genes were detectable and thus tested in an independent RNA-Seq data of 807 individuals from the Rotterdam Study, and 8 genes were supported by p value and direction of the effect. Immune response, lipid metabolic process, and interferon regulatory factor were enriched in these 68 genes. By contrast, only 3 coding genes and 1 lincRNA were differentially expressed in high CAC versus controls. APOD, encoding a component of high-density lipoprotein, was significantly downregulated in both early MI (FDR = 0.007) and high CAC (FDR = 0.01) compared with controls. Conclusions We identified transcriptomic signatures of early MI that include differentially expressed protein-coding genes and lincRNAs, suggesting important roles for protein-coding genes and lincRNAs in the pathogenesis of MI.
    Schlagwörter Gene expression signatures ; Protein-coding gene ; Long intergenic non-coding RNA ; Myocardial infarction ; Coronary artery calcification ; Whole blood ; Internal medicine ; RC31-1245 ; Genetics ; QH426-470
    Thema/Rubrik (Code) 572 ; 610
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis.

    Brian W Busser / Yongshun Lin / Yanqin Yang / Jun Zhu / Guokai Chen / Alan M Michelson

    PLoS ONE, Vol 10, Iss 10, p e

    2015  Band 0141066

    Abstract: Here we used predictive gene expression signatures within a multi-species framework to identify the genes that underlie cardiac cell fate decisions in differentiating embryonic stem cells. We show that the overlapping orthologous mouse and human genes ... ...

    Abstract Here we used predictive gene expression signatures within a multi-species framework to identify the genes that underlie cardiac cell fate decisions in differentiating embryonic stem cells. We show that the overlapping orthologous mouse and human genes are the most accurate candidate cardiogenic genes as these genes identified the most conserved developmental pathways that characterize the cardiac lineage. An RNAi-based screen of the candidate genes in Drosophila uncovered numerous novel cardiogenic genes. shRNA knockdown combined with transcriptome profiling of the newly-identified transcription factors zinc finger protein 503 and zinc finger E-box binding homeobox 2 and the well-known cardiac regulatory factor NK2 homeobox 5 revealed that zinc finger E-box binding homeobox 2 activates terminal differentiation genes required for cardiomyocyte structure and function whereas zinc finger protein 503 and NK2 homeobox 5 are required for specification of the cardiac lineage. We further demonstrated that an essential role of NK2 homeobox 5 and zinc finger protein 503 in specification of the cardiac lineage is the repression of gene expression programs characteristic of alternative cell fates. Collectively, these results show that orthologous gene expression signatures can be used to identify conserved cardiogenic pathways.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  5. Artikel: Rapid volatiles fingerprinting by dopant-assisted positive photoionization ion mobility spectrometry for discrimination and characterization of Green Tea aromas

    Li, Jia / Chunwang Dong / Haibo Yuan / Haiyang Li / Jinjie Hua / Jinjin Wang / Qinghua Zhou / Yanqin Yang / Yongwen Jiang / Yuefeng Yao / Yuliang Deng

    Talanta. 2019 Jan. 01, v. 191

    2019  

    Abstract: Aroma is one major concern of tea flavor and represents an essential criterion for quality evaluation. Herein, we presented a novel approach for rapid, non-destructive and real-time fingerprinting of green tea aromas using ion mobility spectrometry (IMS) ...

    Abstract Aroma is one major concern of tea flavor and represents an essential criterion for quality evaluation. Herein, we presented a novel approach for rapid, non-destructive and real-time fingerprinting of green tea aromas using ion mobility spectrometry (IMS) without prior sample treatment. Positive photoionization with acetone as dopant was selected as suitable source for tea volatiles analysis in comparison to other sources. To demonstrate the effectiveness of presented method, chestnut-like aroma, an indicator of high-quality green teas, was distinguished from others using IMS fingerprinting. In particular, three sub-types with subtle difference in sensory evaluation, i.e., tender, pure and roasted chestnut-like aroma, were classified by IMS fingerprinting in combination with chemometrics with an overall predictive accuracy of 95.6%. Furthermore, we demonstrated a strategy of two-dimensional IMS profiling for capturing the “dynamics” of tea volatiles. To our knowledge this is the first report of tea aroma analysis using IMS-based tool, which may serve as a complement to the conventional tea sensory evaluation and is promising for process monitoring during tea manufacture.
    Schlagwörter acetone ; chemometrics ; flavor ; green tea ; manufacturing ; odors ; process monitoring ; sensory evaluation ; spectroscopy
    Sprache Englisch
    Erscheinungsverlauf 2019-0101
    Umfang p. 39-45.
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2018.08.039
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  6. Artikel ; Online: Insights into the molecular basis of L-form formation and survival in Escherichia coli.

    William A Glover / Yanqin Yang / Ying Zhang

    PLoS ONE, Vol 4, Iss 10, p e

    2009  Band 7316

    Abstract: L-forms have been shown to occur among many species of bacteria and are suspected to be involved in persistent infections. Since their discovery in 1935, numerous studies characterizing L-form morphology, growth, and pathogenic potential have been ... ...

    Abstract L-forms have been shown to occur among many species of bacteria and are suspected to be involved in persistent infections. Since their discovery in 1935, numerous studies characterizing L-form morphology, growth, and pathogenic potential have been conducted. However, the molecular mechanisms underlying the formation and survival of L-forms remain unknown. Using unstable L-form colonies of Escherichia coli as a model, we performed genome-wide transcriptome analysis and screened a deletion mutant library to study the molecular mechanisms involved in formation and survival of L-forms. Microarray analysis of L-form versus classical colonies revealed many up-regulated genes of unknown function as well as multiple over-expressed stress pathways shared in common with persister cells and biofilms. Mutant screens identified three groups of mutants which displayed varying degrees of defects in L-form colony formation. Group 1 mutants, which showed the strongest defect in L-form colony formation, belonged to pathways involved in cell envelope stress, DNA repair, iron homeostasis, outer membrane biogenesis, and drug efflux/ABC transporters. Four (Group 1) mutants, rcsB, a positive response regulator of colanic acid capsule synthesis, ruvA, a recombinational junction binding protein, fur, a ferric uptake regulator and smpA a small membrane lipoprotein were selected for complementation. Complementation of the mutants using a high-copy overexpression vector failed, while utilization of a low-copy inducible vector successfully restored L-form formation. This work represents the first systematic genetic evaluation of genes and pathways involved in the formation and survival of unstable L-form bacteria. Our findings provide new insights into the molecular mechanisms underlying L-form formation and survival and have implications for understanding the emergence of antibiotic resistance, bacterial persistence and latent infections and designing novel drugs and vaccines.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2009-10-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  7. Artikel ; Online: Rutin, γ-Aminobutyric Acid, Gallic Acid, and Caffeine Negatively Affect the Sweet-Mellow Taste of Congou Black Tea Infusions

    Jia Li / Yuefeng Yao / Jiaqin Wang / Jinjie Hua / Jinjin Wang / Yanqin Yang / Chunwang Dong / Qinghua Zhou / Yongwen Jiang / Yuliang Deng / Haibo Yuan

    Molecules, Vol 24, Iss 23, p

    2019  Band 4221

    Abstract: The sweet-mellow taste sensation is a unique and typical feature of premium congou black tea infusions. To explore the key taste-active compounds that influence the sweet-mellow taste, a sensory and molecular characterization was performed on thirty- ... ...

    Abstract The sweet-mellow taste sensation is a unique and typical feature of premium congou black tea infusions. To explore the key taste-active compounds that influence the sweet-mellow taste, a sensory and molecular characterization was performed on thirty-three congou black tea infusions presenting different taste qualities, including the sweet-mellow, mellow-pure, or less-mellow taste. An integrated application of quantitative analysis of 48 taste-active compounds, taste contribution analysis, and further validation by taste supplementation experiments, combined with human sensory evaluation revealed that caffeine, γ-aminobutyric acid, rutin, succinic acid, citric acid, and gallic acid negatively affect the sweet-mellow taste, whereas glucose, sucrose, and ornithine positively contribute to the sweet-mellow taste of congou black tea infusions. Particularly, rutin, γ-aminobutyric acid, gallic acid, and caffeine, which impart the major inhibitory effect to the manifestation of the sweet-mellow taste, were identified as the key influencing components through stepwise screening and validation experiments. A modest level of these compounds was found to be favorable for the development and manifestation of the sweet-mellow taste. These compounds might potentially serve as the regulatory targets for oriented-manufacturing of high-quality sweet-mellow congou black tea.
    Schlagwörter congou black tea ; sweet ; mellow ; taste flavor ; infusion ; quantitative analysis ; sensory evaluation ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2019-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel: Harnessing Filler Materials for Enhancing Biogas Separation Membranes

    Chuah, Chong Yang / Kunli Goh / Yanqin Yang / Heqing Gong / Wen Li / H. Enis Karahan / Michael D. Guiver / Rong Wang / Tae-Hyun Bae

    Chemical reviews. 2018 Aug. 23, v. 118, no. 18

    2018  

    Abstract: Biogas is an increasingly attractive renewable resource, envisioned to secure future energy demands and help curb global climate change. To capitalize on this resource, membrane processes and state-of-the-art membranes must efficiently recover methane ( ... ...

    Abstract Biogas is an increasingly attractive renewable resource, envisioned to secure future energy demands and help curb global climate change. To capitalize on this resource, membrane processes and state-of-the-art membranes must efficiently recover methane (CH₄) from biogas by separating carbon dioxide (CO₂). Composite (a.k.a. mixed-matrix) membranes, prepared from common polymers and rationally selected/engineered fillers, are highly promising for this application. This review comprehensively examines filler materials that are capable of enhancing the CO₂/CH₄ separation performance of polymeric membranes. Specifically, we highlight novel synthetic strategies for engineering filler materials to develop high-performance composite membranes. Besides, as the matrix components (polymers) of composite membranes largely dictate the overall gas separation performances, we introduce a new empirical metric, the “Filler Enhancement Index” (Fᵢₙdₑₓ), to aid researchers in assessing the effectiveness of the fillers from a big data perspective. The Fᵢₙdₑₓ systematically decouples the effect of polymer matrices and critically evaluates both conventional and emerging fillers to map out a future direction for next-generation (bio)gas separation membranes. Beyond biogas separation, this review is of relevance to a broader community with interests in composite membranes for other gas separation processes, as well as water treatment applications.
    Schlagwörter asymmetric membranes ; biogas ; carbon dioxide ; climate change ; energy ; engineering ; methane ; polymers ; water treatment
    Sprache Englisch
    Erscheinungsverlauf 2018-0823
    Umfang p. 8655-8769.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.8b00091
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  9. Artikel ; Online: Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology

    Wanxia Gai / Ze Zhou / Sean Agbor-Enoh / Xiaodan Fan / Sheng Lian / Peiyong Jiang / Suk Hang Cheng / John Wong / Stephen L Chan / Moon Kyoo Jang / Yanqin Yang / Raymond HS Liang / Wai Kong Chan / Edmond SK Ma / Tak Y Leung / Rossa WK Chiu / Hannah Valantine / KC Allen Chan / YM Dennis Lo

    eLife, Vol

    2021  Band 10

    Abstract: We developed genetic-epigenetic tissue mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated ... ...

    Abstract We developed genetic-epigenetic tissue mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated this approach by showing that, in pregnant women, circulating DNA carrying fetal-specific alleles was entirely placenta-derived. In lung transplant recipients, we showed that, at 72 hr after transplantation, the lung contributed only a median of 17% to the plasma DNA carrying donor-specific alleles, and hematopoietic cells contributed a median of 78%. In hepatocellular cancer patients, the liver was identified as the predominant source of plasma DNA carrying tumor-specific mutations. In a pregnant woman with lymphoma, plasma DNA molecules carrying cancer mutations and fetal-specific alleles were accurately shown to be derived from the lymphocytes and placenta, respectively. Analysis of tissue origin for plasma DNA carrying genetic variants is potentially useful for noninvasive prenatal testing, transplantation monitoring, and cancer screening.
    Schlagwörter cfdna ; ctdna ; plasma DNA deconvolution ; liquid biopsy ; nipt ; GETMap ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag eLife Sciences Publications Ltd
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: A Systems Biology Approach to Investigating Sex Differences in Cardiac Hypertrophy

    Josephine Harrington / Natasha Fillmore / Shouguo Gao / Yanqin Yang / Xue Zhang / Poching Liu / Andrea Stoehr / Ye Chen / Danielle Springer / Jun Zhu / Xujing Wang / Elizabeth Murphy

    Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss

    2017  Band 8

    Abstract: BackgroundHeart failure preceded by hypertrophy is a leading cause of death, and sex differences in hypertrophy are well known, although the basis for these sex differences is poorly understood. Methods and ResultsThis study used a systems biology ... ...

    Abstract BackgroundHeart failure preceded by hypertrophy is a leading cause of death, and sex differences in hypertrophy are well known, although the basis for these sex differences is poorly understood. Methods and ResultsThis study used a systems biology approach to investigate mechanisms underlying sex differences in cardiac hypertrophy. Male and female mice were treated for 2 and 3 weeks with angiotensin II to induce hypertrophy. Sex differences in cardiac hypertrophy were apparent after 3 weeks of treatment. RNA sequencing was performed on hearts, and sex differences in mRNA expression at baseline and following hypertrophy were observed, as well as within‐sex differences between baseline and hypertrophy. Sex differences in mRNA were substantial at baseline and reduced somewhat with hypertrophy, as the mRNA differences induced by hypertrophy tended to overwhelm the sex differences. We performed an integrative analysis to identify mRNA networks that were differentially regulated in the 2 sexes by hypertrophy and obtained a network centered on PPARα (peroxisome proliferator‐activated receptor α). Mouse experiments further showed that acute inhibition of PPARα blocked sex differences in the development of hypertrophy. ConclusionsThe data in this study suggest that PPARα is involved in the sex‐dimorphic regulation of cardiac hypertrophy.
    Schlagwörter hypertrophy ; sex ; systems biology ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2017-08-01T00:00:00Z
    Verlag Wiley
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