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Article ; Online: Mitochondrial Ca 2+ Homeostasis

Dejiu Zhang / Fei Wang / Peifeng Li / Yanyan Gao

International Journal of Molecular Sciences, Vol 23, Iss 3025, p

Emerging Roles and Clinical Significance in Cardiac Remodeling

2022 Volume 3025

Abstract: Mitochondria are the sites of oxidative metabolism in eukaryotes where the metabolites of sugars, fats, and amino acids are oxidized to harvest energy. Notably, mitochondria store Ca 2+ and work in synergy with organelles such as the endoplasmic ... ...

Abstract	Mitochondria are the sites of oxidative metabolism in eukaryotes where the metabolites of sugars, fats, and amino acids are oxidized to harvest energy. Notably, mitochondria store Ca 2+ and work in synergy with organelles such as the endoplasmic reticulum and extracellular matrix to control the dynamic balance of Ca 2+ concentration in cells. Mitochondria are the vital organelles in heart tissue. Mitochondrial Ca 2+ homeostasis is particularly important for maintaining the physiological and pathological mechanisms of the heart. Mitochondrial Ca 2+ homeostasis plays a key role in the regulation of cardiac energy metabolism, mechanisms of death, oxygen free radical production, and autophagy. The imbalance of mitochondrial Ca 2+ balance is closely associated with cardiac remodeling. The mitochondrial Ca 2+ uniporter (mtCU) protein complex is responsible for the uptake and release of mitochondrial Ca 2+ and regulation of Ca 2+ homeostasis in mitochondria and consequently, in cells. This review summarizes the mechanisms of mitochondrial Ca 2+ homeostasis in physiological and pathological cardiac remodeling and the regulatory effects of the mitochondrial calcium regulatory complex on cardiac energy metabolism, cell death, and autophagy, and also provides the theoretical basis for mitochondrial Ca 2+ as a novel target for the treatment of cardiovascular diseases.
Keywords	mitochondria ; Ca 2+ homeostasis ; cardiac remodeling ; mitochondrial Ca 2+ uniporter protein complex ; cardiovascular diseases ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Human flourishing and religious liberty

Christos Andreas Makridis / Yanyan Gao

PLoS ONE, Vol 15, Iss

Evidence from over 150 countries

2020 Volume 10

Abstract: This paper studies the spatial and time series patterns of religious liberty across countries and estimates its effect on measures of human flourishing. First, while there are significant cross-country differences in religious liberty, it has declined in ...

Abstract	This paper studies the spatial and time series patterns of religious liberty across countries and estimates its effect on measures of human flourishing. First, while there are significant cross-country differences in religious liberty, it has declined in the past decade across countries, particularly among countries that rank higher in economic freedom. Second, countries with greater religious liberty nonetheless exhibit greater levels of economic freedom, particularly property rights. Third, using micro-data across over 150 countries in the world between 2006 and 2018, increases in religious freedom are associated with robust increases in measures of human flourishing even after controlling for time-invariant characteristics across space and time and a wide array of time-varying country-specific factors, such as economic activity and institutional quality. Fourth, these improvements in well-being are primarily driven by improvements in civil liberties, such as women empowerment and freedom of expression.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A de novo heterozygous variant in ACOX1 gene cause Mitchell syndrome

Mengxiao Shen / Qian Chen / Yanyan Gao / Hongyu Yan / Shuo Feng / Xinna Ji / Xue Zhang

BMC Medical Genomics, Vol 16, Iss 1, Pp 1-

the first case in China and literature review

2023 Volume 6

Abstract: Abstract Background Mitchell syndrome (MITCH) is a rare autosomal dominant hereditary disorder, characterized by episodic demyelination, sensorimotor polyneuropathy and hearing loss. MITCH is caused by heterozygous mutation in the ACOX1 gene, which ... ...

Abstract	Abstract Background Mitchell syndrome (MITCH) is a rare autosomal dominant hereditary disorder, characterized by episodic demyelination, sensorimotor polyneuropathy and hearing loss. MITCH is caused by heterozygous mutation in the ACOX1 gene, which encodes straight-chain acyl-CoA oxidase, on chromosome 17q25.1. Only 5 unrelated patients have been reported so far, and no reports from China. Here, we describe the first MITCH case in a Chinese individual. Case presentation A 7-year-old girl initially presented with diffuse desquamatory rash at age 3. Her clinical symptoms in order of presentation were diffuse desquamatory rash, gait instability, ptosis with photophobia, hearing loss, abdominal pain, diarrhea, nausea, and dysuria. Genetic analysis demonstrated that the patient carried a heterozygous variant c.710A>G(p.Asp237Ser) in the ACOX1 gene, which can cause MITCH symptoms. This is the first MITCH case with gastrointestinal and urinary tract symptoms. After administrating N acetylcysteine amide (NACA), some symptoms were relieved and the patient’s condition improved. Conclusion This is the first MITCH case in the Chinese population, and we expanded the genotype spectrum of it. The p.Asp237Ser may be a mutational hotspot in ACOX1 regardless of race. In terms of diagnosis, patients with recurrent rash, gait instability, and hearing loss with some autonomic symptoms should raise the suspicion of MITCH and proper and prompt treatment should be given.
Keywords	Mitchell syndrome (MITCH) ; ACOX1 gene ; Recurrent rash ; Gait instability ; Hearing loss ; Autonomic symptoms ; Internal medicine ; RC31-1245 ; Genetics ; QH426-470
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A machine learning method to monitor China's AIDS epidemics with data from Baidu trends.

Yongqing Nan / Yanyan Gao

PLoS ONE, Vol 13, Iss 7, p e

2018 Volume 0199697

Abstract: BACKGROUND:AIDS is a worrying public health issue in China and lacks timely and effective surveillance. With the diffusion and adoption of the Internet, the 'big data' aggregated from Internet search engines, which contain users' information on the ... ...

Abstract	BACKGROUND:AIDS is a worrying public health issue in China and lacks timely and effective surveillance. With the diffusion and adoption of the Internet, the 'big data' aggregated from Internet search engines, which contain users' information on the concern or reality of their health status, provide a new opportunity for AIDS surveillance. This paper uses search engine data to monitor and forecast AIDS in China. METHODS:A machine learning method, artificial neural networks (ANNs), is used to forecast AIDS incidences and deaths. Search trend data related to AIDS from the largest Chinese search engine, Baidu.com, are collected and selected as the input variables of ANNs, and officially reported actual AIDS incidences and deaths are used as the output variable. Three criteria, the mean absolute percentage error, the root mean squared percentage error, and the index of agreement, are used to test the forecasting performance of the ANN method. RESULTS:Based on the monthly time series data from January 2011 to June 2017, this article finds that, under the three criteria, the ANN method can lead to satisfactory forecasting of AIDS incidences and deaths, regardless of the change in the number of search queries. CONCLUSIONS:Despite the inability to self-detect HIV/AIDS through online searching, Internet-based data should be adopted as a timely, cost-effective complement to a traditional AIDS surveillance system.
Keywords	Medicine ; R ; Science ; Q
Subject code	303
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Initial Thermal Decomposition Mechanism of (NH2)2CC(NO2)(ONO) Revealed by Double-Hybrid Density Functional Calculations

Yulei Guan / Xingzhen Zhu / Yanyan Gao / Haixia Ma / Jirong Song

ACS Omega, Vol 6, Iss 23, Pp 15292-

2021 Volume 15299

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mitochondrial Protein Translation

Fei Wang / Deyu Zhang / Dejiu Zhang / Peifeng Li / Yanyan Gao

Frontiers in Cell and Developmental Biology, Vol

Emerging Roles and Clinical Significance in Disease

2021 Volume 9

Abstract: Mitochondria are one of the most important organelles in cells. Mitochondria are semi-autonomous organelles with their own genetic system, and can independently replicate, transcribe, and translate mitochondrial DNA. Translation initiation, elongation, ... ...

Abstract	Mitochondria are one of the most important organelles in cells. Mitochondria are semi-autonomous organelles with their own genetic system, and can independently replicate, transcribe, and translate mitochondrial DNA. Translation initiation, elongation, termination, and recycling of the ribosome are four stages in the process of mitochondrial protein translation. In this process, mitochondrial protein translation factors and translation activators, mitochondrial RNA, and other regulatory factors regulate mitochondrial protein translation. Mitochondrial protein translation abnormalities are associated with a variety of diseases, including cancer, cardiovascular diseases, and nervous system diseases. Mutation or deletion of various mitochondrial protein translation factors and translation activators leads to abnormal mitochondrial protein translation. Mitochondrial tRNAs and mitochondrial ribosomal proteins are essential players during translation and mutations in genes encoding them represent a large fraction of mitochondrial diseases. Moreover, there is crosstalk between mitochondrial protein translation and cytoplasmic translation, and the imbalance between mitochondrial protein translation and cytoplasmic translation can affect some physiological and pathological processes. This review summarizes the regulation of mitochondrial protein translation factors, mitochondrial ribosomal proteins, mitochondrial tRNAs, and mitochondrial aminoacyl-tRNA synthetases (mt-aaRSs) in the mitochondrial protein translation process and its relationship with diseases. The regulation of mitochondrial protein translation and cytoplasmic translation in multiple diseases is also summarized.
Keywords	mitochondria ; protein translation ; translation factors ; mitochondrial ribosome ; mitoribosome assembly factors ; mitochondrial aminoacyl-tRNA synthetase ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multi-Scale Coal Fire Detection Based on an Improved Active Contour Model from Landsat-8 Satellite and UAV Images

Yanyan Gao / Ming Hao / Yunjia Wang / Libo Dang / Yuecheng Guo

ISPRS International Journal of Geo-Information, Vol 10, Iss 449, p

2021 Volume 449

Abstract: Underground coal fires can increase surface temperature, cause surface cracks and collapse, and release poisonous and harmful gases, which significantly harm the ecological environment and humans. Traditional methods of extracting coal fires, such as ... ...

Abstract	Underground coal fires can increase surface temperature, cause surface cracks and collapse, and release poisonous and harmful gases, which significantly harm the ecological environment and humans. Traditional methods of extracting coal fires, such as global threshold, K-mean and active contour model, usually produce many false alarms. Therefore, this paper proposes an improved active contour model by introducing the distinguishing energies of coal fires and others into the traditional active contour model. Taking Urumqi, Xinjiang, China as the research area, coal fires are detected from Landsat-8 satellite and unmanned aerial vehicle (UAV) data. The results show that the proposed method can eliminate many false alarms compared with some traditional methods, and achieve detection of small-area coal fires by referring field survey data. More importantly, the results obtained from UAV data can help identify not only burning coal fires but also potential underground coal fires. This paper provides an efficient method for high-precision coal fire detection and strong technical support for reducing environmental pollution and coal energy use.
Keywords	coal fires ; Landsat-8 ; UAV ; multi-scale ; active contour model ; Geography (General) ; G1-922
Subject code	670
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Generation of a human induced pluripotent stem cell line (CIPi002-A) from an early infantile epileptic encephalopathy patient with a heterozygous mutation in SCN8A

Pingping Zhang / Ping Zheng / Xinna Ji / Yanyan Gao / Xue Zhang / Qian Chen

Stem Cell Research, Vol 63, Iss , Pp 102862- (2022)

2022

Abstract: SCN8A is linked to early infantile epileptic encephalopathy type 13 (EIEE13). We generate a human induced pluripotent stem cell (iPSC) line from a child diagnosed with EIEE, caused by SCN8A variation. The iPSC line expresses high pluripotency markers, ... ...

Abstract	SCN8A is linked to early infantile epileptic encephalopathy type 13 (EIEE13). We generate a human induced pluripotent stem cell (iPSC) line from a child diagnosed with EIEE, caused by SCN8A variation. The iPSC line expresses high pluripotency markers, retains SCN8A variation and is able to differentiate into three germ layers in vitro. The iPSC lines will provide useful resources for studying the pathogenesis and drug screening of SCN8A-related epilepsy.
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Robust and Highly Efficient Approach for Isolation of Mesenchymal Stem Cells From Wharton’s Jelly for Tissue Repair

Shengxia Zheng / Yanyan Gao / Kai Chen / Yusheng Liu / Ninuo Xia / Fang Fang

Cell Transplantation, Vol

2022 Volume 31

Abstract: Mesenchymal stem cells derived from umbilical cord Wharton’s Jelly (WJ-MSCs) are emerging as promising therapeutics for a variety of diseases due to their ability of regeneration and immunomodulation, and their non-tumorigenic and non-immunogenic ... ...

Abstract	Mesenchymal stem cells derived from umbilical cord Wharton’s Jelly (WJ-MSCs) are emerging as promising therapeutics for a variety of diseases due to their ability of regeneration and immunomodulation, and their non-tumorigenic and non-immunogenic properties. Although multiple protocols have been developed for WJ-MSC isolation, insufficient cell numbers, heterogeneous cell population, and variations in procedures between different laboratories impede further clinical applications. Here, we compared six widely used WJ-MSC isolation methods regarding cell morphology, yield, purity, proliferation rate, and differentiation potential. Based on these analyses, we identified that the inefficiency of the extracellular matrix digestion results in low cell yield. Thus, we developed a new method called “Mince-Soak-Digest (MSD)” to isolate MSCs from WJ by incorporating a soaking step to facilitate the digestion of the extracellular matrix and release of the cells. Our newly developed method generates significantly higher cell yield (4- to 10-fold higher) than six widely used methods that we tested with high purity and consistency. Importantly, by transplantation of WJ-MSCs to the rat uterus, we repair the endometrial injury and restore the fertility of the rats. In conclusion, our results provide a robust and highly efficient approach for the isolation of WJ-MSCs to restore injured tissue. The higher efficiency of MSD assures the abundance of WJ-MSCs for clinical applications. Furthermore, the reliability of MSD contributes to the standardization of WJ-MSC isolation, which eliminates the discrepancies due to isolation procedures, thus facilitating the evaluation of the efficacy of WJ-MSCs across various human clinical applications.
Keywords	Medicine ; R
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Analysis of the Elderly’s Preferences for Choosing Medical Service Facilities from the Perspective of Accessibility

Zao Li / Yanyan Gao / Li Yu / Charles L. Choguill / Weiyi Cui

International Journal of Environmental Research and Public Health, Vol 19, Iss 9432, p

A Case Study of Tertiary General Hospitals in Hefei, China

2022 Volume 9432

Abstract: The accessibility of medical service facilities is a vital influence on elderly people choosing medical treatment. Encouraging residents to seek nearby medical treatment can facilitate the rational layout and diversion of urban medical facilities and ... ...

Abstract	The accessibility of medical service facilities is a vital influence on elderly people choosing medical treatment. Encouraging residents to seek nearby medical treatment can facilitate the rational layout and diversion of urban medical facilities and reduce health resource waste. However, due to accessibility factors, elderly people may not choose the nearest hospital. In order to investigate such factors, we conducted a questionnaire survey among the elderly from 10 tertiary general hospitals in Hefei, China. On the basis of the origin-destination (OD) cost matrix analysis and statistical analysis of 830 valid questionnaires, this paper analyzed the elders’ selection rules when choosing medical facilities and the factors considered when making a choice. The study found that although 85% of elderly participants valued a short distance to tertiary hospitals, only 31% of them attended the closest hospitals in reality, which correlated with regularity according to their education level, travel activity status, and place of residence. The elderly highlighted road congestion, convenience of public transport stations, and number of transfers as critical in determining whether they sought nearby medical treatment. According to the results, effective ways to encourage the elderly to attend their nearest hospital, from the perspective of accessibility, include easing road congestion, improving the layout of public transport stations, and optimizing urban public transport routes. In particular, when planning future medical facilities, attention should be paid to the elderly with primary school education or below, who cannot travel independently, and those who live far from the city center.
Keywords	the elderly ; distance ; accessibility ; preference ; public health service ; medical-seeking behavior ; Medicine ; R
Subject code	380
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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