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  1. Article: Heat shock protein: a double-edged sword linking innate immunity and hepatitis B virus infection.

    Dai, Wen-Ying / Yao, Guo-Qing / Deng, Xi-Chuan / Zang, Guang-Chao / Liu, Jia / Zhang, Guang-Yuan / Chen, Yu-Meng / Lv, Ming-Qi / Chen, Ting-Ting

    Journal of virus eradication

    2023  Volume 9, Issue 1, Page(s) 100322

    Abstract: Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associated with, ... ...

    Abstract Heat shock proteins (HSPs), which have a variety of functions, are one of the stress protein families. In recent years, They have been reported to play a dual role in hepatitis B virus (HBV) which as persistent infection which is associated with, cirrhosis and liver cancer. In this article, we have summarized the regulatory mechanisms between HSPs and viruses, especially HBV and associated diseases based on HSP biological functions of in response to viral infections. In view of their potential as broad-spectrum antiviral targets, we have also discuss current progress and challenges in drug development based on HSPs, as well as the potential applications of agents that have been evaluated clinically in HBV treatment.
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2868549-0
    ISSN 2055-6659 ; 2055-6640
    ISSN (online) 2055-6659
    ISSN 2055-6640
    DOI 10.1016/j.jve.2023.100322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Peritumoral lymphatic microvessel density is related to poor prognosis in lung adenocarcinoma: A retrospective study of 65 cases.

    Zhang, Bi-Cheng / Guan, Sha / Zhang, Ya-Fei / Yao, Guo-Qing / Yang, Bo / Zhao, Yong / Rao, Zhi-Guo / Gao, Jian-Fei

    Experimental and therapeutic medicine

    2012  Volume 3, Issue 4, Page(s) 636–640

    Abstract: Although recent investigations have identified that lymphangiogenesis is associated with regional lymph node metastasis and tumor prognosis in non-small cell lung cancer (NSCLC), peritumoral lymphatic microvessel density (LMVD) and its prognostic ... ...

    Abstract Although recent investigations have identified that lymphangiogenesis is associated with regional lymph node metastasis and tumor prognosis in non-small cell lung cancer (NSCLC), peritumoral lymphatic microvessel density (LMVD) and its prognostic significance in lung adenocarcinoma remain unknown. In the present study, we assessed peritumoral LMVD in lung adenocarcinoma and investigated its correlation with patient prognosis. Using immunohistochemistry (SP method), the D2-40-positive peritumoral LMVD count in lung adenocarcinoma was found to be 11.56±10.73, which was higher than intratumoral LMVD (P<0.001), and was found to be associated with lymphatic metastasis (P=0.003) and pTNM staging (P=0.046). Furthermore, a significant difference in the patient overall survival time was demonstrated between tumors with a high peritumoral LMVD and those with a low peritumoral LMVD (P=0.005). Finally, using multivariate analysis, it was determined that peritumoral LMVD, lymphatic metastasis and pTNM staging were independent prognostic factors. In conclusion, the results suggest that D2-40-positive peritumoral LMVD may predict the prognosis of lung adenocarcinoma.
    Language English
    Publishing date 2012-02-03
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2012.470
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Intravenous flurbiprofen axetil enhances analgesic effect of opioids in patients with refractory cancer pain by increasing plasma β-endorphin.

    Wu, Ting-Ting / Wang, Zhi-Gang / Ou, Wu-Ling / Wang, Jun / Yao, Guo-Qing / Yang, Bo / Rao, Zhi-Guo / Gao, Jian-Fei / Zhang, Bi-Cheng

    Asian Pacific journal of cancer prevention : APJCP

    2015  Volume 15, Issue 24, Page(s) 10855–10860

    Abstract: Background: The study aimed to investigate the analgesic effect of a combination of intravenous flurbiprofen axetil and opioids, and evaluate the relationship between refractory pain relief and plasma β-endorphin levels in cancer patients.: Materials ... ...

    Abstract Background: The study aimed to investigate the analgesic effect of a combination of intravenous flurbiprofen axetil and opioids, and evaluate the relationship between refractory pain relief and plasma β-endorphin levels in cancer patients.
    Materials and methods: A total of 120 cancer patients was randomly divided into two groups, 60 patients took orally morphine sulfate sustained-release tablets in group A, and another 60 patients receiving the combination treatment of intravenous flurbiprofen axetil and opioid drugs in group B. After 7 days, pain relief, quality of life improvement and side effects were evaluated. Furthermore, plasma β-endorphin levels were measured by radioimmunoassay.
    Results: With the combination treatment of intravenous intravenous flurbiprofen axetil and opioids, the total effective rate of pain relief rose to 91.4%, as compared to 82.1% when morphine sulfate sustained-release tablet was used alone. Compared with that of group A, the analgesic effect increased in group B (p=0.031). Moreover, satisfactory pain relief was associated with a significant increase in plasma β-endorphin levels. After the treatment, plasma β-endorphin level in group B was 62.4±13.5 pg/ml, which was higher than that in group A (45.8±11.2 pg/ml) (p<0.05).
    Conclusions: Our results suggest the combination of intravenous flurbiprofen axetil and opioids can enhance the analgesic effect of opioid drugs by increasing plasma β-endorphin levels, which would offer a selected and reliable strategy for refractory cancer pain treatment.
    MeSH term(s) Analgesics, Opioid/administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage ; Drug Synergism ; Drug Therapy, Combination ; Female ; Flurbiprofen/administration & dosage ; Flurbiprofen/analogs & derivatives ; Follow-Up Studies ; Humans ; Injections, Intravenous ; Male ; Middle Aged ; Neoplasms/complications ; Pain, Intractable/drug therapy ; Pain, Intractable/etiology ; Prognosis ; Quality of Life ; Radioimmunoassay ; beta-Endorphin/blood
    Chemical Substances Analgesics, Opioid ; Anti-Inflammatory Agents, Non-Steroidal ; Flurbiprofen (5GRO578KLP) ; beta-Endorphin (60617-12-1) ; flurbiprofen axetil (I0OU31PUI5)
    Language English
    Publishing date 2015-01-21
    Publishing country Thailand
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2218955-5
    ISSN 2476-762X ; 1513-7368
    ISSN (online) 2476-762X
    ISSN 1513-7368
    DOI 10.7314/apjcp.2014.15.24.10855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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