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  1. Article ; Online: Exploring Novel Antidepressants Targeting G Protein-Coupled Receptors and Key Membrane Receptors Based on Molecular Structures.

    Yao, Hanbo / Wang, Xiaodong / Chi, Jiaxin / Chen, Haorong / Liu, Yilin / Yang, Jiayi / Yu, Jiaqi / Ruan, Yongdui / Xiang, Xufu / Pi, Jiang / Xu, Jun-Fa

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 5

    Abstract: Major Depressive Disorder (MDD) is a complex mental disorder that involves alterations in signal transmission across multiple scales and structural abnormalities. The development of effective antidepressants (ADs) has been hindered by the dominance of ... ...

    Abstract Major Depressive Disorder (MDD) is a complex mental disorder that involves alterations in signal transmission across multiple scales and structural abnormalities. The development of effective antidepressants (ADs) has been hindered by the dominance of monoamine hypothesis, resulting in slow progress. Traditional ADs have undesirable traits like delayed onset of action, limited efficacy, and severe side effects. Recently, two categories of fast-acting antidepressant compounds have surfaced, dissociative anesthetics S-ketamine and its metabolites, as well as psychedelics such as lysergic acid diethylamide (LSD). This has led to structural research and drug development of the receptors that they target. This review provides breakthroughs and achievements in the structure of depression-related receptors and novel ADs based on these. Cryo-electron microscopy (cryo-EM) has enabled researchers to identify the structures of membrane receptors, including the N-methyl-D-aspartate receptor (NMDAR) and the 5-hydroxytryptamine 2A (5-HT
    MeSH term(s) Humans ; Depressive Disorder, Major/drug therapy ; Serotonin ; Molecular Structure ; Cryoelectron Microscopy ; Antidepressive Agents/pharmacology ; Receptors, G-Protein-Coupled/metabolism ; Receptors, N-Methyl-D-Aspartate/metabolism
    Chemical Substances Serotonin (333DO1RDJY) ; Antidepressive Agents ; Receptors, G-Protein-Coupled ; Receptors, N-Methyl-D-Aspartate
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29050964
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article: Engineered exosomes as drug and RNA co-delivery system: new hope for enhanced therapeutics?

    Chen, Haorong / Yao, Hanbo / Chi, Jiaxin / Li, Chaowei / Liu, Yilin / Yang, Jiayi / Yu, Jiaqi / Wang, Jiajun / Ruan, Yongdui / Pi, Jiang / Xu, Jun-Fa

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1254356

    Abstract: Chemotherapy often faces some obstacles such as low targeting effects and drug resistance, which introduce the low therapeutic efficiency and strong side effects. Recent advances in nanotechnology allows the use of novel nanosystems for targeted drug ... ...

    Abstract Chemotherapy often faces some obstacles such as low targeting effects and drug resistance, which introduce the low therapeutic efficiency and strong side effects. Recent advances in nanotechnology allows the use of novel nanosystems for targeted drug delivery, although the chemically synthesized nanomaterials always show unexpected low biocompability. The emergence of exosome research has offered a better understanding of disease treatment and created novel opportunities for developing effective drug delivery systems with high biocompability. Moreover, RNA interference has emerged as a promising strategy for disease treatments by selectively knocking down or over-expressing specific genes, which allows new possibilities to directly control cell signaling events or drug resistance. Recently, more and more interests have been paid to develop optimal delivery nanosystems with high efficiency and high biocompability for drug and functional RNA co-delivery to achieve enhanced chemotherapy. In light of the challenges for developing drug and RNA co-delivery system, exosomes have been found to show very attractive prospects. This review aims to explore current technologies and challenges in the use of exosomes as drug and RNA co-delivery system with a focus on the emerging trends and issues associated with their further applications, which may contribute to the accelerated developments of exosome-based theraputics.
    Language English
    Publishing date 2023-09-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1254356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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