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Article ; Online: Phosphatidic acid plays key roles regulating plant development and stress responses.

Yao, Hong-Yan / Xue, Hong-Wei

2018 Volume 60, Issue 9, Page(s) 851–863

Abstract: Phospholipids, including phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidylserine (PS) and phosphoinositides, have emerged as an important class of cellular messenger molecules in ... ...

Abstract	Phospholipids, including phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidylserine (PS) and phosphoinositides, have emerged as an important class of cellular messenger molecules in various cellular and physiological processes, of which PA attracts much attention of researchers. In addition to its effect on stimulating vesicle trafficking, many studies have demonstrated that PA plays a crucial role in various signaling pathways by binding target proteins and regulating their activity and subcellular localization. Here, we summarize the functional mechanisms and target proteins underlying PA-mediated regulation of cellular signaling, development, hormonal responses, and stress responses in plants.
MeSH term(s)	Phosphatidic Acids/metabolism ; Phosphatidylethanolamines/metabolism ; Phosphatidylglycerols/metabolism ; Phosphatidylinositols/metabolism ; Phosphatidylserines/metabolism ; Plant Development/physiology
Chemical Substances	Phosphatidic Acids ; Phosphatidylethanolamines ; Phosphatidylglycerols ; Phosphatidylinositols ; Phosphatidylserines ; phosphatidylethanolamine (39382-08-6)
Language	English
Publishing date	2018-07-09
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Review
ZDB-ID	2130095-1
ISSN	1744-7909 ; 1672-9072
ISSN (online)	1744-7909
ISSN	1672-9072
DOI	10.1111/jipb.12655
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Article ; Online: Developing a Subjective Evaluation Scale for Assessing the Built Environments of China's Hygienic City Initiative.

Zheng, Wen Jing / Yao, Hong Yan / Liu, Jian Jun / Yu, Shi Cheng

Biomedical and environmental sciences : BES

2021 Volume 34, Issue 5, Page(s) 372–378

Abstract: Objective: To develop a preliminary subjective evaluation scale for assessing the built environments of China's Hygienic City Initiative and to evaluate its reliability and validity.: Methods: The initial items of the scale were determined based on a ...

Abstract	Objective: To develop a preliminary subjective evaluation scale for assessing the built environments of China's Hygienic City Initiative and to evaluate its reliability and validity. Methods: The initial items of the scale were determined based on a review of policy documents and consultations with experts. The final items of the scale were confirmed through individual interviews with residents combined with the discretetrend method, critical ratio method, correlation coefficient method, and factor analysis method. Then, the dimensions of the scale were determined using exploratory factor analysis (EFA). The Cronbach's Results: A scale containing five dimensions with 22 items was established, including urban lifestyle, governance, basic functions, environmental sanitation, and amenities. The Cronbach's Conclusion: The preliminarily subjective evaluation scale for assessing the built environments of China's Hygienic City Initiative demonstrates a high level of reliability and validity. Additional empirical studies should be carried out to further verify the value of the scale in terms of practical application.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Built Environment/psychology ; China ; Factor Analysis, Statistical ; Female ; Health Policy ; Humans ; Hygiene ; Male ; Middle Aged ; Perception ; Personal Satisfaction ; Reproducibility of Results ; Surveys and Questionnaires ; Urban Health ; Young Adult
Language	English
Publishing date	2021-05-31
Publishing country	China
Document type	Journal Article
ZDB-ID	645083-0
ISSN	2214-0190 ; 0895-3988
ISSN (online)	2214-0190
ISSN	0895-3988
DOI	10.3967/bes2021.049
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Article ; Online: Cytidinediphosphate diacylglycerol synthase-Mediated phosphatidic acid metabolism is crucial for early embryonic development of Arabidopsis.

Du, Xin-Qiao / Yao, Hong-Yan / Luo, Pan / Tang, Xing-Chun / Xue, Hong-Wei

PLoS genetics

2022 Volume 18, Issue 7, Page(s) e1010320

Abstract: Embryonic development is a key developmental event in plant sexual reproduction; however, regulatory networks of plant early embryonic development, particularly the effects and functional mechanisms of phospholipid molecules are still unknown due to the ... ...

Abstract	Embryonic development is a key developmental event in plant sexual reproduction; however, regulatory networks of plant early embryonic development, particularly the effects and functional mechanisms of phospholipid molecules are still unknown due to the limitation of sample collection and analysis. We innovatively applied the microspore-derived in vitro embryogenesis of Brassica napus and revealed the dynamics of phospholipid molecules, especially phosphatidic acid (PA, an important second messenger that plays an important role in plant growth, development, and stress responses), at different embryonic developmental stages by using a lipidomics approach. Further analysis of Arabidopsis mutants deficiency of CDS1 and CDS2 (cytidinediphosphate diacylglycerol synthase, key protein in PA metabolism) revealed the delayed embryonic development from the proembryo stage, indicating the crucial effect of CDS and PA metabolism in early embryonic development. Decreased auxin level and disturbed polar localization of auxin efflux carrier PIN1 implicate that CDS-mediated PA metabolism may regulate early embryogenesis through modulating auxin transport and distribution. These results demonstrate the dynamics and importance of phospholipid molecules during embryo development, and provide informative clues to elucidate the regulatory network of embryogenesis.
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Diglycerides ; Embryonic Development ; Gene Expression Regulation, Plant ; Indoleacetic Acids/metabolism ; Phosphatidic Acids/metabolism
Chemical Substances	Arabidopsis Proteins ; Diglycerides ; Indoleacetic Acids ; Phosphatidic Acids
Language	English
Publishing date	2022-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2186725-2
ISSN	1553-7404 ; 1553-7390
ISSN (online)	1553-7404
ISSN	1553-7390
DOI	10.1371/journal.pgen.1010320
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Article ; Online: Arabidopsis Sec14 proteins (SFH5 and SFH7) mediate interorganelle transport of phosphatidic acid and regulate chloroplast development.

Yao, Hong-Yan / Lu, Yao-Qi / Yang, Xiao-Li / Wang, Xiao-Qing / Luo, Zhipu / Lin, De-Li / Wu, Jia-Wei / Xue, Hong-Wei

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 6, Page(s) e2221637120

Abstract: Lipids establish the specialized thylakoid membrane of chloroplast in eukaryotic photosynthetic organisms, while the molecular basis of lipid transfer from other organelles to chloroplast remains further elucidation. Here we revealed the structural basis ...

Abstract	Lipids establish the specialized thylakoid membrane of chloroplast in eukaryotic photosynthetic organisms, while the molecular basis of lipid transfer from other organelles to chloroplast remains further elucidation. Here we revealed the structural basis of
MeSH term(s)	Arabidopsis/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Chloroplasts/metabolism ; Phosphatidic Acids/metabolism ; Thylakoids/metabolism
Chemical Substances	Arabidopsis Proteins ; Phosphatidic Acids
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2221637120
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Article ; Online: Changes in Notified Incidence of Pulmonary Tuberculosis in China, 2005-2020.

Dong, Zhe / Yao, Hong Yan / Yu, Shi Cheng / Huang, Fei / Liu, Jian Jun / Zhao, Yan Lin / Wang, Qi Qi

Biomedical and environmental sciences : BES

2023 Volume 36, Issue 2, Page(s) 117–126

Abstract: Objective: To evaluate the trend of notified incidence of pulmonary tuberculosis (PTB) in China at different periods by population and region and to explore the effect of TB prevention and control in recent years.: Methods: Using pooled data on TB ... ...

Abstract	Objective: To evaluate the trend of notified incidence of pulmonary tuberculosis (PTB) in China at different periods by population and region and to explore the effect of TB prevention and control in recent years. Methods: Using pooled data on TB cases reported by the TB Information Management Reporting System (TBIMS) from 2005 to 2020, we calculated the annual percentage change (APC) using the Joinpoint regression model. Results: From 2005 to 2020, a total of 16.2 million cases of PTB were reported in China, with an average notified incidence of 75.5 per 100,000 population. The age standardization rate (ASR) continued to decline from 116.9 (/100,000) in 2005 to 47.6 (/100,000) in 2020, with an average annual decrease of 5.6% [APC = -5.6, 95% confidence interval ( Conclusions: From 2005 to 2020, the notified incidence of PTB in China continued to decline, falling by 55%. For high-risk groups such as males, older adults, high-burden areas in South, Southwest, and Northwest China, and rural regions, proactive screening should be strengthened to provide timely and effective anti-TB treatment and patient management services for confirmed cases. There is also a necessity to be vigilant about the upward trend of children in recent years, the specific reasons for which need to be further studied.
MeSH term(s)	Child ; Middle Aged ; Adolescent ; Humans ; Female ; Male ; Aged ; Incidence ; Tuberculosis, Pulmonary/epidemiology ; China/epidemiology ; Social Group
Language	English
Publishing date	2023-02-27
Publishing country	China
Document type	Journal Article
ZDB-ID	645083-0
ISSN	2214-0190 ; 0895-3988
ISSN (online)	2214-0190
ISSN	0895-3988
DOI	10.3967/bes2023.015
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Article ; Online: The mechanism of Bushen Huoxue decoction in treating intervertebral disc degeneration based on network pharmacology.

Feng, Shuai-Hua / Xie, Fang / Yao, Hong-Yan / Wu, Guan-Bao / Sun, Xiang-Yun / Yang, Jie

Annals of palliative medicine

2021 Volume 10, Issue 4, Page(s) 3783–3792

Abstract: Background: This study aimed to explore the mechanism of Bushen Huoxue decoction (BHD) in treating intervertebral disc degeneration using the network pharmacology method.: Methods: Using of oral bioavailability >30% and drug-likeness >0.18 as the ... ...

Abstract	Background: This study aimed to explore the mechanism of Bushen Huoxue decoction (BHD) in treating intervertebral disc degeneration using the network pharmacology method. Methods: Using of oral bioavailability >30% and drug-likeness >0.18 as the screening standards, the effective components and targets of BHD were retrieved from the TCMSP database and the BATMAN-TCM database. The disease targets of intervertebral disc degeneration were retrieved from the GeneCards database. The Wayne map of the interaction targets of the effective components of BHD and intervertebral disc degeneration were drawn using R software. The protein-protein interaction (PPI) network of common targets was constructed using STRING software. The network map of the interaction targets of the effective components of BHD-intervertebral disc degeneration was drawn using Cytoscape3.7.2 software. The GO and KEGG enrichment analysis of the common targets of BHD and intervertebral disc degeneration was performed using R software and the related plug-ins to screen the potential pathways and analyze its mechanism. Results: This study screened 164 effective components of BHD, 131 interaction targets, 626 targets for degenerative disc disease, and 31 common interaction targets. IL6, VEGFA, CASP3, EGFR, ESR1, and MAPK8 appeared more frequently. These were mainly enriched in the AGE-RAGE, TNF, PI3K Akt, and MAPK signaling pathways. Conclusions: BHD mainly intervenes in intervertebral disc degeneration through IL6, VEGFA, CASP3, EGFR, ESR1, and MAPK8. The mechanism of the intervention of BHD on intervertebral disc degeneration may be related to AGE-RAGE, TNF, PI3K Akt, MAPK, and other signal pathways.
MeSH term(s)	Drugs, Chinese Herbal/therapeutic use ; Humans ; Intervertebral Disc Degeneration/drug therapy ; Medicine, Chinese Traditional ; Phosphatidylinositol 3-Kinases
Chemical Substances	Drugs, Chinese Herbal ; bushen huoxue
Language	English
Publishing date	2021-03-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-20-2586
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Article: Phosphatidic acid plays key roles regulating plant development and stress responses

Yao, Hong‐Yan / Hong‐Wei Xue

Journal of integrative plant biology. 2018 Sept., v. 60, no. 9

2018

Abstract	Phospholipids, including phosphatidic acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidylserine (PS) and phosphoinositides, have emerged as an important class of cellular messenger molecules in various cellular and physiological processes, of which PA attracts much attention of researchers. In addition to its effect on stimulating vesicle trafficking, many studies have demonstrated that PA plays a crucial role in various signaling pathways by binding target proteins and regulating their activity and subcellular localization. Here, we summarize the functional mechanisms and target proteins underlying PA‐mediated regulation of cellular signaling, development, hormonal responses, and stress responses in plants.
Keywords	phosphatidylcholines ; phosphatidylethanolamines ; phosphatidylserines ; physiological transport ; plant development ; proteins ; signal transduction ; stress response
Language	English
Dates of publication	2018-09
Size	p. 851-863.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	REVIEW
ZDB-ID	2130095-1
ISSN	1744-7909 ; 1672-9072
ISSN (online)	1744-7909
ISSN	1672-9072
DOI	10.1111/jipb.12655
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006-2020.

Dong, Zhe / Wang, Qi-Qi / Yu, Shi-Cheng / Huang, Fei / Liu, Jian-Jun / Yao, Hong-Yan / Zhao, Yan-Lin

Infectious diseases of poverty

2022 Volume 11, Issue 1, Page(s) 85

Abstract: Background: Tuberculosis (TB) poses a severe public health challenge in China and worldwide. This study evaluated the effects of age, period, and birth cohort on reported incidence trends of TB based on population and refined the characteristics of high- ...

Abstract	Background: Tuberculosis (TB) poses a severe public health challenge in China and worldwide. This study evaluated the effects of age, period, and birth cohort on reported incidence trends of TB based on population and refined the characteristics of high-risk groups. Methods: Aggregate data that reported pulmonary tuberculosis (PTB) cases from China Tuberculosis Management Information System (TBIMS) from 2006 to 2020 were used to analyze effect coefficients through the age-period-cohort (APC) model based on intrinsic estimator (IE) method, and converted them into relative risk (RR) to estimate trends. Results: A total of 14.82 million cases of PTB were reported in China from 2006 to 2020, showing a continuous downward trend. The reporting rate increased with age by age group, with 70-74 years old being 2-3 times higher than that in 20-24 years old. APC analysis model showed that age effects were bimodal in 20-24 years old [RR = 2.29, 95% confidence interval (CI): 1.73-3.03] and 70-74 years old (RR = 1.95, 95% CI: 1.67-2.27), and lower than the overall average in the groups under 15 years old. Stratified results showed that the risk was higher for women under age 40 than men and higher for men over 40. The risk was higher in urban than in rural areas under 30 years old and slightly higher in rural than in urban between 30 and 64 years old. The risk for 15-34 years old was significantly higher in the east than in other regions. The period effects showed a decreasing trend, and the risk was higher in rural in recent years. Except for cohorts born in 1961-1965 and 2001-2005, where the RR increased, the later the cohort was born, the lower the risk. The cohort 1926-1930 in eastern had the highest risk (RR = 3.49, 95% CI: 2.44-4.98). Conclusions: The reported incidence of PTB continued to decline in China from 2006 to 2020. The young (20-24 years old) and the elderly (70-74 years old) were equally at high risk. There were differences in the age, period and cohort effects on PTB incidence among gender, urban-rural and regions. Our findings better reflected the characteristics of high-risk populations, thus contributing to the development of timely and effective intervention strategies, and providing clues for etiological research.
MeSH term(s)	Adolescent ; Adult ; Aged ; China/epidemiology ; Cohort Studies ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Tuberculosis ; Tuberculosis, Pulmonary/epidemiology ; Young Adult
Language	English
Publishing date	2022-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2689396-4
ISSN	2049-9957 ; 2049-9957
ISSN (online)	2049-9957
ISSN	2049-9957
DOI	10.1186/s40249-022-01009-4
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Article ; Online: Joint Association of Metabolic Health and Obesity with Ten-Year Risk of Cardiovascular Disease among Chinese Adults.

Liu, Jun Ting / Yao, Hong Yan / Yu, Shi Cheng / Liu, Jian Jun / Zhu, Guang Jin / Han, Shao Mei / Xu, Tao

Biomedical and environmental sciences : BES

2022 Volume 35, Issue 1, Page(s) 13–21

Abstract: Objective: This study aims to investigate the association of metabolic phenotypes that are jointly determined by body mass index (BMI) or fat mass percentage and metabolic health status with the ten-year risk of cardiovascular disease (CVD) among ... ...

Abstract	Objective: This study aims to investigate the association of metabolic phenotypes that are jointly determined by body mass index (BMI) or fat mass percentage and metabolic health status with the ten-year risk of cardiovascular disease (CVD) among Chinese adults. Methods: Data were obtained from a cross-sectional study. BMI and body fat mass percentage (FMP) combined with the metabolic status were used to define metabolic phenotypes. Multiple linear regression and logistic regression were used to examine the effects of metabolic phenotypes on CVD risk. Results: A total of 13,239 adults aged 34-75 years were included in this study. Compared with the metabolically healthy non-obese (MHNO) phenotype, the metabolically unhealthy non-obese (MUNO) and metabolically unhealthy obese (MUO) phenotypes defined by BMI showed a higher CVD risk [odds ratio, Conclusion: General obesity without central obesity does not increase CVD risk in metabolically healthy individuals. FMP might be a more meaningful factor for the evaluation of the association of obesity with CVD risk. Obesity and metabolic status have a synergistic effect on CVD risk.
MeSH term(s)	Adipose Tissue/anatomy & histology ; Adult ; Aged ; Body Mass Index ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Metabolic Diseases/epidemiology ; Metabolic Diseases/etiology ; Middle Aged ; Obesity/complications ; Phenotype ; Regression Analysis ; Risk Factors
Language	English
Publishing date	2022-01-25
Publishing country	China
Document type	Journal Article
ZDB-ID	645083-0
ISSN	2214-0190 ; 0895-3988
ISSN (online)	2214-0190
ISSN	0895-3988
DOI	10.3967/bes2022.003
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Article: [Insight about the agricultural injury research].

Yao, Hong-yan / Liu, Jian-jun

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

2013 Volume 47, Issue 12, Page(s) 1080–1082

MeSH term(s)	Agricultural Workers' Diseases ; Agriculture ; Humans
Language	Chinese
Publishing date	2013-12
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604575-3
ISSN	0253-9624
ISSN	0253-9624
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