LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 7 von insgesamt 7

Suchoptionen

  1. Artikel ; Online: Usefulness of the coagulation indicators in predicting short and long disease-free interval in breast cancer and development of a nomogram.

    Yao, Huibin / Liang, Ying / Sha, Yingjian / Jia, Yongsheng / Shi, Yehui

    Minerva medica

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-02-06
    Erscheinungsland Italy
    Dokumenttyp Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.24.09169-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ua VI Zs.132: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Optic Nerve Sheath Measurements by Computed Tomography to Predict Intracranial Pressure and Guide Surgery in Patients with Traumatic Brain Injury.

    Liu, Meng / Yang, Zhi-Kun / Yan, Yu-Feng / Shen, Xiao / Yao, Hui-Bin / Fei, Li / Wang, Er-Song

    World neurosurgery

    2019  Band 134, Seite(n) e317–e324

    Abstract: Background: Research has shown that the optic nerve sheath diameter (ONSD) is a good predictor of intracranial pressure (ICP) and may predict the need for surgery in patients with head injury. The objective was to test the value of ONSD in predicting ... ...

    Abstract Background: Research has shown that the optic nerve sheath diameter (ONSD) is a good predictor of intracranial pressure (ICP) and may predict the need for surgery in patients with head injury. The objective was to test the value of ONSD in predicting the requirement for surgery in patients with traumatic brain injury (TBI).
    Methods: In this retrospective cohort study, we first verified the correlation between ICP and ONSD using data from 62 patients with TBI who had undergone ICP monitoring. Second, we analyzed head computed tomography images from patients with TBI who were admitted to the emergency department where patients had been divided into surgery or conservative treatment groups, dependent on the assessment of a neurosurgeon. The correlation between ICP and ONSD was measured using linear regression analysis. Biologistic and receiver operating characteristic curve analyses were used to test the diagnostic value of ONSD to predict surgery.
    Results: ONSD was significantly correlated with ICP (r = 0.606; P < 0.01), and there was a significant linear regression equation (ŷ = 0.071 × ICP + 3.533; P < 0.01), with ONSD predicting the requirement for surgery in patients with TBI (area under the curve, 0.920; P < 0.01; 95% confidence interval, 0.877-0.962).
    Conclusions: ONSD measured via head computed tomography correlates with ICP and can predict the requirement for surgery in patients with TBI following admission to the emergency department.
    Mesh-Begriff(e) Aged ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/surgery ; Cohort Studies ; Female ; Humans ; Intracranial Pressure/physiology ; Intraoperative Neurophysiological Monitoring/methods ; Male ; Middle Aged ; Myelin Sheath/pathology ; Optic Nerve/diagnostic imaging ; Optic Nerve/surgery ; Predictive Value of Tests ; Retrospective Studies ; Tomography, X-Ray Computed/methods
    Sprache Englisch
    Erscheinungsdatum 2019-10-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2019.10.065
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1159: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: Investigating the frequency-dependent amplification of a tapered amplifier in atom interferometers.

    Zhan, Su / Duan, Xiao-Chun / Zhou, Min-Kang / Yao, Hui-Bin / Xu, Wen-Jie / Hu, Zhong-Kun

    Optics letters

    2015  Band 40, Heft 1, Seite(n) 29–32

    Abstract: We present the investigation on the frequency-dependent amplification (FDA) of a tapered amplifier (TA) and the corresponding influence on Raman-type atom interferometers. In our interferometer, the output of two phase-locked diode lasers is injected ... ...

    Abstract We present the investigation on the frequency-dependent amplification (FDA) of a tapered amplifier (TA) and the corresponding influence on Raman-type atom interferometers. In our interferometer, the output of two phase-locked diode lasers is injected into a TA to generate Raman beams. The frequency of one laser is chirped during the interfering process, which induces a variance of the Raman lasers power as a result of the FDA of the TA. The corresponding power ratio variation of the Raman lasers is measured by beat note method, which shows a linear dependence with a slope of -0.087(4)/GHz when the laser frequency changes over 2 GHz at 780 nm. The corresponding error related to AC Stark effect due to this frequency-dependent variation is estimated for our atom interferometer. The investigation presented here may provide hints for other experiments involving TAs.
    Sprache Englisch
    Erscheinungsdatum 2015-01-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.40.000029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: Tetranectin knockout mice develop features of Parkinson disease.

    Wang, Er-song / Zhang, Xiao-ping / Yao, Hui-bin / Wang, Gan / Chen, Shi-wen / Gao, Wen-wei / Yao, Hai-jun / Sun, Yi-rui / Xi, Cai-hua / Ji, Yao-dong

    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

    2014  Band 34, Heft 2, Seite(n) 277–287

    Abstract: Background/aims: Aggregation of insoluble α-synuclein to form Lewy bodies (LBs) may contribute to the selective loss of midbrain dopaminergic neurons in Parkinson disease (PD). Lack of robust animal models has impeded elucidation of the molecular ... ...

    Abstract Background/aims: Aggregation of insoluble α-synuclein to form Lewy bodies (LBs) may contribute to the selective loss of midbrain dopaminergic neurons in Parkinson disease (PD). Lack of robust animal models has impeded elucidation of the molecular mechanisms of LB formation and other critical aspects of PD pathogenesis.
    Methods: We established a mouse model with targeted deletion of the plasminogen-binding protein tetranectin (TN) gene (TN(-/-)) and measured the behavioral and histopathological features of PD.
    Results: Aged (15-to 20-month-old) TN(-/-) mice displayed motor deficits resembling PD symptoms, including limb rigidity and both slower ambulation (bradykinesia) and reduced rearing activity in the open field. In addition, these mice exhibited more numerous α-synuclein-positive LB-like inclusions within the substantia nigra pars compacta (SNc) and reduced numbers of SNc dopaminergic neurons than age-matched wild type (WT) mice. These pathological changes were also accompanied by loss of dopamine terminals in the dorsal striatum.
    Conclusion: The TN(-/-) mouse exhibits several key features of PD and so may be a valuable model for studying LB formation and testing candidate neuroprotective therapies for PD and other synucleinopathies.
    Mesh-Begriff(e) Animals ; Base Sequence ; DNA Primers ; Disease Models, Animal ; Lectins, C-Type/genetics ; Lectins, C-Type/physiology ; Mice ; Mice, Knockout ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Polymerase Chain Reaction ; alpha-Synuclein/metabolism
    Chemische Substanzen DNA Primers ; Lectins, C-Type ; alpha-Synuclein ; tetranectin (109489-77-2)
    Sprache Englisch
    Erscheinungsdatum 2014-07-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067572-3
    ISSN 1421-9778 ; 1015-8987
    ISSN (online) 1421-9778
    ISSN 1015-8987
    DOI 10.1159/000362998
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3160: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: Proteomic analysis of the cerebrospinal fluid of Parkinson's disease patients pre- and post-deep brain stimulation.

    Wang, Er-Song / Yao, Hui-Bin / Chen, Ying-Hui / Wang, Gan / Gao, Wen-Wei / Sun, Yi-Rui / Guo, Ji-Guang / Hu, Jian-Wen / Jiang, Cheng-Chuan / Hu, Jin

    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

    2013  Band 31, Heft 4-5, Seite(n) 625–637

    Abstract: Aims: To investigate alterations in protein expression associated with deep brain stimulation (DBS) in an attempt to elucidate possible mechanisms of action .: Methods: Cerebrospinal fluid (CSF), obtained from six Parkinson's disease (PD) patients ( ... ...

    Abstract Aims: To investigate alterations in protein expression associated with deep brain stimulation (DBS) in an attempt to elucidate possible mechanisms of action .
    Methods: Cerebrospinal fluid (CSF), obtained from six Parkinson's disease (PD) patients (pre- and post-DBS) and from six normal healthy controls, was studied for differentially expressed proteins. 2-D DIGE, in combination with MALDI-TOF and TOF-TOF Mass Spectrometry (MS) or ESI-MS, was used to identify the changed proteins (3 PD patients and 3 controls). Selected proteins were further studied using western blotting (6 PD patients and 6 controls).
    Results: Twenty-one proteins were identified after MS and protein database interrogation. Apart from apolipoprotein A-I (apoA-I), the expression levels of complement C4 (C4), IgA, tetranectin, and extracellular superoxide dismutase (EC-SOD), detected by western blotting, correlated well with the 2-D DIGE results. In the follow-up period, the expression levels of C4, apoA-I and IgA were stable whereas EC-SOD and tetranectin were significantly elevated. In addition, when DBS was ceased in one patient due to a suicide attempt, the levels of EC-SOD and tetranectin significantly decreased.
    Conclusion: Our preliminary results suggest that variations in the expression levels of EC-SOD and tetranectin in CSF is related to DBS.
    Mesh-Begriff(e) Aged ; Databases, Protein ; Deep Brain Stimulation ; Electrophoresis, Gel, Two-Dimensional ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/cerebrospinal fluid ; Parkinson Disease/therapy ; Proteome/analysis ; Proteomics ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
    Chemische Substanzen Proteome
    Sprache Englisch
    Erscheinungsdatum 2013-05-06
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1067572-3
    ISSN 1421-9778 ; 1015-8987
    ISSN (online) 1421-9778
    ISSN 1015-8987
    DOI 10.1159/000350082
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3160: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel: Tetranectin Knockout Mice Develop Features of Parkinson Disease

    Wang, Er-song / Zhang, Xiao-ping / Yao, Hui-bin / Wang, Gan / Chen, Shi-wen / Gao, Wen-wei / Yao, Hai-jun / Sun, Yi-rui / Xi, Cai-hua / Ji, Yao-dong

    Cellular Physiology and Biochemistry

    2014  Band 34, Heft 2, Seite(n) 277–287

    Abstract: Background/Aims: Aggregation of insoluble α-synuclein to form Lewy bodies (LBs) may contribute to the selective loss of midbrain dopaminergic neurons in Parkinson disease (PD). Lack of robust animal models has impeded elucidation of the molecular ... ...

    Körperschaft Department of Neurosurgery, Jinshan Hospital, Fudan University Institute of Medical Intervention Engineering, Tongji University; & Department of Interventional Radiology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China Department of Neurosurgery, Shanghai 6th People's Hospital, Shanghai Jiaotong University, Shanghai, Shanghai Traumatic Emergency Center Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai Neurosurgical Center, Shanghai, China
    Abstract Background/Aims: Aggregation of insoluble α-synuclein to form Lewy bodies (LBs) may contribute to the selective loss of midbrain dopaminergic neurons in Parkinson disease (PD). Lack of robust animal models has impeded elucidation of the molecular mechanisms of LB formation and other critical aspects of PD pathogenesis. Methods: We established a mouse model with targeted deletion of the plasminogen-binding protein tetranectin (TN) gene (TN) and measured the behavioral and histopathological features of PD. Results: Aged (15-to 20-month-old) TN mice displayed motor deficits resembling PD symptoms, including limb rigidity and both slower ambulation (bradykinesia) and reduced rearing activity in the open field. In addition, these mice exhibited more numerous α-synuclein-positive LB-like inclusions within the substantia nigra pars compacta (SNc) and reduced numbers of SNc dopaminergic neurons than age-matched wild type (WT) mice. These pathological changes were also accompanied by loss of dopamine terminals in the dorsal striatum. Conclusion: The TN mouse exhibits several key features of PD and so may be a valuable model for studying LB formation and testing candidate neuroprotective therapies for PD and other synucleinopathies.
    Schlagwörter Tetranectin ; Parkinson disease ; Motor deficits ; α-synuclein; ; Lewy bodies
    Sprache Englisch
    Erscheinungsdatum 2014-07-08
    Verlag S. Karger AG
    Erscheinungsort Basel, Switzerland
    Dokumenttyp Artikel
    ZDB-ID 1067572-3
    ISSN 1421-9778 ; 1015-8987
    ISSN (online) 1421-9778
    ISSN 1015-8987
    DOI 10.1159/000362998
    Datenquelle Karger Verlag

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3160: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel: Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation

    Wang, Er-Song / Yao, Hui-Bin / Chen, Ying-Hui / Wang, Gan / Gao, Wen-Wei / Sun, Yi-Rui / Guo, Ji-Guang / Hu, Jian-Wen / Jiang, Cheng-Chuan / Hu, Jin

    Cellular Physiology and Biochemistry

    2013  Band 31, Heft 4-5, Seite(n) 625–637

    Abstract: Aims: To investigate alterations in protein expression associated with deep brain stimulation (DBS) in an attempt to elucidate possible mechanisms of actionMethods: Cerebrospinal fluid (CSF), obtained from six Parkinson's disease (PD) patients (pre- and ... ...

    Körperschaft Department of Neurosurgery, Jinshan Hospital, Fudan University, Shanghai Department of Neurosurgery, Shanghai 6th People's Hospital, Shanghai Jiaotong University, Shanghai Department of Neurology, Jinshan Hospital, Fudan University, Shanghai Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, Shanghai Neurosurgical Center, Shanghai Shanghai Institute of Neuroscience, Chinese Academy of Sciences, Shanghai Research Center for Proteome Analysis, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai These authors contributed equally to the study
    Abstract Aims: To investigate alterations in protein expression associated with deep brain stimulation (DBS) in an attempt to elucidate possible mechanisms of actionMethods: Cerebrospinal fluid (CSF), obtained from six Parkinson's disease (PD) patients (pre- and post-DBS) and from six normal healthy controls, was studied for differentially expressed proteins. 2-D DIGE, in combination with MALDI-TOF and TOF-TOF Mass Spectrometry (MS) or ESI-MS, was used to identify the changed proteins (3 PD patients and 3 controls). Selected proteins were further studied using western blotting (6 PD patients and 6 controls). Results: Twenty-one proteins were identified after MS and protein database interrogation. Apart from apolipoprotein A-I (apoA-I), the expression levels of complement C4 (C4), IgA, tetranectin, and extracellular superoxide dismutase (EC-SOD), detected by western blotting, correlated well with the 2-D DIGE results. In the follow-up period, the expression levels of C4, apoA-I and IgA were stable whereas EC-SOD and tetranectin were significantly elevated. In addition, when DBS was ceased in one patient due to a suicide attempt, the levels of EC-SOD and tetranectin significantly decreased. Conclusion: Our preliminary results suggest that variations in the expression levels of EC-SOD and tetranectin in CSF is related to DBS.
    Schlagwörter Parkinson’s disease ; Proteomics ; Cerebrospinal fluid ; Deep brain stimulation
    Sprache Englisch
    Erscheinungsdatum 2013-05-06
    Verlag S. Karger AG
    Erscheinungsort Basel, Switzerland
    Dokumenttyp Artikel
    ZDB-ID 1067572-3
    ISSN 1421-9778 ; 1015-8987
    ISSN (online) 1421-9778
    ISSN 1015-8987
    DOI 10.1159/000350082
    Datenquelle Karger Verlag

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3160: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang