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Article: Antibody and transcription landscape in peripheral blood mononuclear cells of elderly adults over 70 years of age with third dose of COVID-19 BBIBP-CorV and ZF2001 booster vaccine.

Zhang, Yuwei / Zhao, Lianxiang / Zhang, Jinzhong / Zhang, Xiaomei / Han, Shanshan / Sun, Qingshuai / Yao, Mingxiao / Pang, Bo / Duan, Qing / Jiang, Xiaolin

Immunity & ageing : I & A

2024 Volume 21, Issue 1, Page(s) 11

Abstract: Background: In the context of the COVID-19 pandemic and extensive vaccination, it is important to explore the immune response of elderly adults to homologous and heterologous booster vaccines of COVID-19. At this point, we detected serum IgG antibodies ... ...

Abstract	Background: In the context of the COVID-19 pandemic and extensive vaccination, it is important to explore the immune response of elderly adults to homologous and heterologous booster vaccines of COVID-19. At this point, we detected serum IgG antibodies and PBMC sample transcriptome profiles in 46 participants under 70 years old and 25 participants over 70 years old who received the third dose of the BBIBP-CorV and ZF2001 vaccines. Results: On day 7, the antibody levels of people over 70 years old after the third dose of booster vaccine were lower than those of young people, and the transcriptional responses of innate and adaptive immunity were also weak. The age of the participants showed a significant negative correlation with functions related to T-cell differentiation and costimulation. Nevertheless, 28 days after the third dose, the IgG antibodies of elderly adults reached equivalence to those of younger adults, and immune-related transcriptional regulation was significantly improved. The age showed a significant positive correlation with functions related to "chemokine receptor binding", "chemokine activity", and "chemokine-mediated signaling pathway". Conclusions: Our results document that the response of elderly adults to the third dose of the vaccine was delayed, but still able to achieve comparable immune effects compared to younger adults, in regard to antibody responses as well as at the transcript level.
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2168941-6
ISSN	1742-4933
ISSN	1742-4933
DOI	10.1186/s12979-023-00408-x
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Article ; Online: Correlation between the sulfamethoxazole-trimethoprim resistance of Shigella flexneri and the sul genes.

Ma, Quanping / Zhu, Chengbao / Yao, Mingxiao / Yuan, Guangying / Sun, Yuguo

Medicine

2021 Volume 100, Issue 10, Page(s) e24970

Abstract: Abstract: The aim of this study was to discuss the correlation between the sulfamethoxazole-trimethoprim resistance of Shigella flexneri (S. flexneri) and the antibiotic resistance genes sul1, sul2, and sul3 and SXT element.From May 2013 to October 2018, ...

Abstract	Abstract: The aim of this study was to discuss the correlation between the sulfamethoxazole-trimethoprim resistance of Shigella flexneri (S. flexneri) and the antibiotic resistance genes sul1, sul2, and sul3 and SXT element.From May 2013 to October 2018, 102 isolates of S. flexneri were collected from the clinical samples in Jinan. The Kirby-Bauer (K-B) test was employed to determine the antibiotic susceptibility of the S. flexneri isolates. The antibiotic resistance rate was analyzed with the WHONET5.4 software. The isolates were subject to the PCR amplification of the sul genes (sul1, sul2, and sul3) and the SXT element. On the basis of the sequencing results, the correlation between the sulfamethoxazole-trimethoprim resistance of the S. flexneri isolates and the sul genes was analyzed.The antibiotic resistance rates of the 102 S. flexneri isolates to ampicillin, streptomycin, chloramphenicol, tetracycline, and sulfamethoxazole-trimethoprim were 90.2%, 90.2%, 88.2%, 88.2%, and 62.7%, respectively. The antibiotic resistance rates of these isolates to cefotaxime, ceftazidime, and ciprofloxacin varied between 20% and 35%. However, these isolates were 100% susceptible to cefoxitin. Positive fragments were amplified from 59.8% (61/102) of the 102 S. flexneri isolates, the sizes of the sul1 and sul2 genes being 338 bp and 286 bp, respectively. The sequence alignment revealed the presence of the sul1 and sul2 genes encoding for dihydrofolate synthase. The carrying rate of the sul1 gene was 13.7% (14/102), and that of the sul2 gene was 48.0% (49/102). No target gene fragments were amplified from the 3 isolates resistant to sulfamethoxazole-trimethoprim. The sul3 gene and SXT element were not amplified from any of the isolates. The testing and statistical analysis showed that the resistance of the S. flexneri isolates to sulfamethoxazole-trimethoprim correlated to the sul1 and sul2 genes.The acquired antibiotic resistance genes sul1 and sul2 were closely associated with the resistance of the 102 S. flexneri isolates to sulfamethoxazole-trimethoprim.
MeSH term(s)	Bacterial Proteins/genetics ; Carrier Proteins/genetics ; DNA Transposable Elements/genetics ; DNA, Bacterial/genetics ; DNA, Bacterial/isolation & purification ; Dysentery, Bacillary/drug therapy ; Dysentery, Bacillary/microbiology ; Feces/microbiology ; Humans ; Microbial Sensitivity Tests ; Polymerase Chain Reaction ; Shigella flexneri/drug effects ; Shigella flexneri/genetics ; Shigella flexneri/isolation & purification ; Trimethoprim Resistance/genetics ; Trimethoprim, Sulfamethoxazole Drug Combination/pharmacology ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
Chemical Substances	Bacterial Proteins ; Carrier Proteins ; DNA Transposable Elements ; DNA, Bacterial ; Sul2 protein, bacteria ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
Language	English
Publishing date	2021-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024970
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Article ; Online: Factors Associated With Severe Fever With Thrombocytopenia Syndrome in Endemic Areas of China.

Jiang, Xiaolin / Wang, Yiguan / Zhang, Xiaomei / Pang, Bo / Yao, Mingxiao / Tian, Xueying / Sang, Shaowei

Frontiers in public health

2022 Volume 10, Page(s) 844220

Abstract: Objective: To explore the influence of climatic, environmental and socioeconomic factors on SFTS occurrence in Shandong Province, China.: Methods: We used generalized additive model to estimate the association between SFTS cases and climatic factors, ...

Abstract	Objective: To explore the influence of climatic, environmental and socioeconomic factors on SFTS occurrence in Shandong Province, China. Methods: We used generalized additive model to estimate the association between SFTS cases and climatic factors, environmental factors and socioeconomic factors, including annual average temperature, precipitation, land cover, normalized difference vegetation index, altitude, population density, meat production, milk production, and gross domestic product (GDP). Results: There were a total of 4,830 cases reported in 100 (70.9%) counties and districts in Shandong Province from 2010 to 2020. The results showed that the annual average temperature, precipitation, forest and grassland coverage rate, altitude and meat production (square root transform) had a reversed "V" relationship with SFTS occurrence, with the inflection points around 12.5-13.0°C in temperature, around 650 mm in precipitation, around 0.3 in forest and grassland coverage rate, around 300 m in altitude, and around 200-300 tons in meat production (square root transform), respectively. SFTS occurrence had a "V" relationship with milk production (square root transform) and GDP (square root transform), with the inflection points around 100-200 tons in milk production (square root transform), and around 150,000-200,000 yuan in GDP (square root transform), respectively. Conclusions: Climatic, environmental, and socioeconomic factors contributed to the heterogeneous distribution of SFTS in Shandong Province, and the influence of these factors on SFTS occurrence was nonlinear.
MeSH term(s)	China/epidemiology ; Humans ; Phlebovirus ; Severe Fever with Thrombocytopenia Syndrome ; Temperature ; Thrombocytopenia/epidemiology
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.844220
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Article ; Online: Spatiotemporal distribution and environmental influences of severe fever with thrombocytopenia syndrome in Shandong Province, China.

Duan, Qing / Tian, Xueying / Pang, Bo / Zhang, Yuwei / Xiao, Chuanhao / Yao, Mingxiao / Ding, Shujun / Zhang, Xiaomei / Jiang, Xiaolin / Kou, Zengqiang

BMC infectious diseases

2023 Volume 23, Issue 1, Page(s) 891

Abstract: Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in China in 2009. The purpose of this study was to describe the spatiotemporal distribution of SFTS and to identify its environmental influencing ...

Abstract	Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease discovered in China in 2009. The purpose of this study was to describe the spatiotemporal distribution of SFTS and to identify its environmental influencing factors and potential high-risk areas in Shandong Province, China. Methods: Data on the SFTS incidence from 2010 to 2021 were collected. Spatiotemporal scan statistics were used to identify the time and area of SFTS clustering. The maximum entropy (MaxEnt) model was used to analyse environmental influences and predict high-risk areas. Results: From 2010 to 2021, a total of 5705 cases of SFTS were reported in Shandong. The number of SFTS cases increased yearly, with a peak incidence from April to October each year. Spatiotemporal scan statistics showed the existence of one most likely cluster and two secondary likely clusters in Shandong. The most likely cluster was in the eastern region, from May to October 2021. The first secondary cluster was in the central region, from May to October 2021. The second secondary cluster was in the southeastern region, from May to September 2020. The MaxEnt model showed that the mean annual wind speed, NDVI, cattle density and annual cumulative precipitation were the key factors influencing the occurrence of SFTS. The predicted risk map showed that the area of high prevalence was 28,120 km Conclusions: The spatiotemporal distribution of SFTS was heterogeneous and influenced by multidimensional environmental factors. This should be considered as a basis for delineating SFTS risk areas and developing SFTS prevention and control measures.
MeSH term(s)	Animals ; Cattle ; Severe Fever with Thrombocytopenia Syndrome ; Phlebovirus ; Thrombocytopenia/epidemiology ; Incidence ; China/epidemiology
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-023-08899-1
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Article ; Online: Spatial-temporal drivers and incidence heterogeneity of hemorrhagic fever with renal syndrome transmission in Shandong Province, China, 2016-2022.

Duan, Qing / Wang, Yao / Jiang, Xiaolin / Ding, Shujun / Zhang, Yuwei / Yao, Mingxiao / Pang, Bo / Tian, Xueying / Ma, Wei / Kou, Zengqiang / Wen, Hongling

BMC public health

2024 Volume 24, Issue 1, Page(s) 1032

Abstract: Background: Hemorrhagic fever with renal syndrome (HFRS) signals a recurring risk in Eurasia in recent years owing to its continued rise in case notifications and the extension of geographical distribution. This study was undertaken to investigate the ... ...

Abstract	Background: Hemorrhagic fever with renal syndrome (HFRS) signals a recurring risk in Eurasia in recent years owing to its continued rise in case notifications and the extension of geographical distribution. This study was undertaken to investigate the spatiotemporal drivers and incidence heterogeneity of HFRS transmission in Shandong Province. Methods: The epidemiological data for HFRS, meteorological data and socioeconomic data were obtained from China Information System for Disease Control and Prevention, China Meteorological Data Sharing Service System, and Shandong Statistical Yearbook, respectively. The spatial-temporal multicomponent model was employed to analyze the values of spatial-temporal components and the heterogeneity of HFRS transmission across distinct regions. Results: The total effect values of the autoregressive, epidemic, and endemic components were 0.451, 0.187, and 0.033, respectively, exhibiting significant heterogeneity across various cities. This suggested a pivotal role of the autoregressive component in propelling HFRS transmission in Shandong Province. The epidemic component of Qingdao, Weifang, Yantai, Weihai, and Jining declined sharply at the onset of 2020. The random effect identified distinct incidence levels associated with Qingdao and Weifang, signifying regional variations in HFRS occurrence. Conclusions: The autoregressive component emerged as a significant driver in the transmission of HFRS in Shandong Province. Targeted preventive measures should be strategically implemented across various regions, taking into account the predominant component influencing the epidemic.
MeSH term(s)	Humans ; Hemorrhagic Fever with Renal Syndrome/epidemiology ; Incidence ; China/epidemiology ; Cities ; Epidemics
Language	English
Publishing date	2024-04-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-18440-x
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Article ; Online: Analysis of the laboratory indexes and risk factors in 189 cases of severe fever with thrombocytopenia syndrome.

Liu, Jingwen / Fu, Hongmei / Sun, Dapeng / Wu, Shuzhi / Wang, Li / Yao, Mingxiao / Yuan, Guangying

Medicine

2020 Volume 99, Issue 2, Page(s) e18727

Abstract: The current study aimed to analyze the clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) and to explore the risk factors of critical patients. From 2016 to 2018, we collected the hospitalized diagnosed cases with SFTS in ... ...

Abstract	The current study aimed to analyze the clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) and to explore the risk factors of critical patients. From 2016 to 2018, we collected the hospitalized diagnosed cases with SFTS in Jinan infectious disease hospital of Shandong University and analyzed by the descriptive epidemiological method. According to the prognosis, they were divided into general group and severe group. The epidemiological characteristics, clinical features, and laboratory indexes of these 2 groups of patients were compared and analyzed at the first visit. The risk factors related to the severity of the disease were analyzed by univariate Logistic regression. In total, 189 cases of SFTS were treated during the period and 33 deaths occurred in the severe group, with the fatality rate of 17.46%. The patients' age (χ = 8.864, P < .01), ALT (Z = -2.304, P = .03), AST (Z = -3.361, P < .01), GLU (t = -4.115, P < .01), CK (Z = -3.964, P < .01), CK-MB (Z = -2.225, P = .03), LDH (Z = -3.655, P < .01), α-HBDH (Z = -2.040, P = .04), APTT (t = -3.355, P < .01), BUN (Z = -2.040, P = .04), Cr (Z = -3.071, P = .01), and D-dimer (Z = -2.026, P = .04) in the severe group were higher than that in the normal group, but the blood platelet (PLT) counts were significantly lower (Z = -2.778, P < .01) than that in the normal group. With the neuropsychiatric symptoms (OR = 24.083, 95% CI = 6.064-95.642), skin bleeding point (OR = 30.000, 95% CI = 6.936-129.764), multiple organ dysfunction (OR = 34.048, 95% CI = 7.740-149.782), past medical history (OR = 3.792, 95% CI = 1.284-11.200), and fasting glucose elevation (OR = 1.359, 95% CI = 1.106-1.668) could predict the severity of the SFTS. In summary, the abnormality of the laboratory index, the special clinical manifestations, and the past medical history of SFTS patients were the important basis for judging the patient's serious condition.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Blood Glucose ; Comorbidity ; Female ; Fever/epidemiology ; Fever/physiopathology ; Humans ; Logistic Models ; Male ; Middle Aged ; Multiple Organ Failure/epidemiology ; Platelet Count ; Prognosis ; Risk Factors ; Seasons ; Severity of Illness Index ; Thrombocytopenia/epidemiology ; Thrombocytopenia/mortality ; Thrombocytopenia/physiopathology ; Young Adult
Chemical Substances	Blood Glucose
Language	English
Publishing date	2020-01-08
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000018727
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Article ; Online: Characterization of whole genomes from recently emerging Mpox cases in several regions of China, 2023.

Wu, Changcheng / Cui, Lunbiao / Pan, Yang / Lv, Ziquan / Yao, Mingxiao / Wang, Wenling / Ye, Fei / Huo, Weibang / Zhao, Li / Huang, Baoying / Zhu, Fengcai / Lu, Roujian / Deng, Yao / Wang, Quanyi / Tan, Wenjie

Science China. Life sciences

2023

Language	English
Publishing date	2023-11-24
Publishing country	China
Document type	Letter
ZDB-ID	2546732-3
ISSN	1869-1889 ; 1674-7305
ISSN (online)	1869-1889
ISSN	1674-7305
DOI	10.1007/s11427-023-2485-8
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Article ; Online: SARS-CoV-2 Variant of Concern 202 012/01 (B.1.1.7) in a traveller from the UK to China.

Yao, Mingxiao / Jiang, Fachun / Zhang, Yuwei / Li, Yan / Pang, Bo / Liang, Hao / Kou, Zengqiang / Jiang, Xiaolin / Wen, Hongling / Xu, Yifei

Journal of travel medicine

2021 Volume 28, Issue 4

MeSH term(s)	COVID-19/virology ; China ; Humans ; SARS-CoV-2/isolation & purification ; Travel ; United Kingdom
Language	English
Publishing date	2021-03-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212504-0
ISSN	1708-8305 ; 1195-1982
ISSN (online)	1708-8305
ISSN	1195-1982
DOI	10.1093/jtm/taab032
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Article ; Online: Resistance characteristics of CTX-M type

Bian, Fengzhi / Yao, Mingxiao / Fu, Hongmei / Yuan, Guangying / Wu, Shuzhi / Sun, Yuguo

Bioscience reports

2019 Volume 39, Issue 9

Abstract: The present study was to identify the drug resistance, resistance mechanism and the extended-spectrum β-lactamase (ESBLs) genotypes ... ...

Abstract	The present study was to identify the drug resistance, resistance mechanism and the extended-spectrum β-lactamase (ESBLs) genotypes of
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Drug Resistance, Multiple, Bacterial/genetics ; Dysentery, Bacillary/drug therapy ; Dysentery, Bacillary/enzymology ; Dysentery, Bacillary/microbiology ; Genotype ; Humans ; Microbial Sensitivity Tests ; Shigella flexneri/classification ; Shigella flexneri/genetics ; Shigella flexneri/pathogenicity ; beta-Lactamases/classification ; beta-Lactamases/genetics
Chemical Substances	Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2019-09-24
Publishing country	England
Document type	Journal Article
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20191741
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Article ; Online: Transmission of SARS-CoV-2 Omicron Variant under a Dynamic Clearance Strategy in Shandong, China.

Xu, Yifei / Liu, Ti / Li, Yan / Wei, Xuemin / Wang, Zhaoguo / Fang, Ming / Zhang, Yuwei / Zhang, Huaning / Zhang, Lifang / Zhang, Jinbo / Xu, Jin / Tian, Yunlong / He, Nianzheng / Zhang, Yuhan / Wang, Yao / Yao, Mingxiao / Pang, Bo / Wang, Shuang / Wen, Hongling /

Kou, Zengqiang

Microbiology spectrum

2023 , Page(s) e0463222

Abstract: SARS-CoV-2 Omicron caused a large wave of COVID-19 cases in China in spring 2022. Shandong was one of the most affected regions during this epidemic yet was also among those areas that were able to quickly contain the transmission. We aimed to ... ...

Abstract	SARS-CoV-2 Omicron caused a large wave of COVID-19 cases in China in spring 2022. Shandong was one of the most affected regions during this epidemic yet was also among those areas that were able to quickly contain the transmission. We aimed to investigate the origin, genetic diversity, and transmission patterns of the Omicron epidemic in Shandong under a dynamic clearance strategy. We generated 1,149 Omicron sequences, performed phylogenetic analysis, and interpreted results in the context of available epidemiological information. We observed that there were multiple introductions of distinct Omicron sublineages into Shandong from foreign countries and other regions in China, while a small number of introductions led to majority of local cases. We found evidence suggesting that some local clusters were potentially associated with foreign imported cases. Superspreading events and cryptic transmissions contributed to the rapid spread of this epidemic. We identified a BA.1.1 genome with the R493Q reversion mutation in the spike receptor binding domain, potentially associated with an escape from vaccine and Omicron infection elicited neutralizing immunity. Our findings illustrated how the dynamic clearance strategy constrained this epidemic's size, duration, and geographical distribution.
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.04632-22
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