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Article ; Online: Anatomic variations of the deltoid muscle insertion: a cadaveric study.

Vohra, Arjun / Paul, Benjamin / Saunders, Patrick / Galal, Youssef / Yao, Stephen / Hui, Clayton / Lederman, Evan / McKee, Michael / Shah, Anup

JSES international

2024 Volume 8, Issue 3, Page(s) 546–550

Abstract: Background: The deltoid is a trisegmented muscle with anterior, middle, and posterior components. While the clinical relevance of the presence of anatomic variations of the deltoid origin and insertion continues to be debated, the architecture of the ... ...

Abstract	Background: The deltoid is a trisegmented muscle with anterior, middle, and posterior components. While the clinical relevance of the presence of anatomic variations of the deltoid origin and insertion continues to be debated, the architecture of the deltoid muscle is more complex than initially believed. This study aimed to evaluate the gross anatomy of the deltoid muscle insertion by qualitatively and quantitatively characterizing the insertion and location of the deltoid muscle's anterior, middle, and posterior components. This information is valuable to surgeons as it raises awareness of potential variants that could be encountered during surgery, promotes mindfulness of neurovascular proximities, and reduces the likelihood of confusion between adjacent muscle fibers. Methods: Eight nonpaired, fresh-frozen clavicle-to-fingertip cadaveric shoulders were acquired for the study (6 left, 2 right). The average age of the cadavers was 79.5 years (range: 64-92). The standard deltopectoral approach was carried out on all specimens. The planes dividing the anterior, middle, and posterior deltoid were identified and marked. Once complete exposure had been achieved, digital calipers were used to record the size of the deltoid insertion. The specimens were qualitatively assessed to characterize the style of insertion they demonstrated. Results: The average length of the deltoid insertion was 39.45 ± 9.33 mm (n = 8). Six of the eight shoulders demonstrated an insertion style previously characterized in the literature. The remaining two shoulders highlighted an insertion pattern not previously described. Conclusion: The current study demonstrates a novel insertion pattern for the deltoid muscle that has not been previously characterized. This "step-off" insertion pattern shows that the anterior, middle, and posterior tendons are inserted superior-medial, directly on, and inferior-lateral to the deltoid tuberosity and was found in 2/8 of our cadaveric specimens.
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Journal Article
ISSN	2666-6383
ISSN (online)	2666-6383
DOI	10.1016/j.jseint.2024.01.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dynamic duo - FMRP and TDP-43: Regulating common targets, causing different diseases.

Ferro, Diana / Yao, Stephen / Zarnescu, Daniela C

Brain research

2018 Volume 1693, Issue Pt A, Page(s) 37–42

Abstract: RNA binding proteins play essential roles during development and aging, and are also involved in disease pathomechanisms. RNA sequencing and omics analyses have provided a window into systems level alterations in neurological disease, and have identified ...

Abstract	RNA binding proteins play essential roles during development and aging, and are also involved in disease pathomechanisms. RNA sequencing and omics analyses have provided a window into systems level alterations in neurological disease, and have identified RNA processing defects among notable disease mechanisms. This review focuses on two seemingly distinct neurological disorders, the RNA binding proteins they are linked to, and their newly discovered functional relationship. When deficient, Fragile X Mental Retardation Protein (FMRP) causes developmental deficits and autistic behaviors while TAR-DNA Binding Protein (TDP-43) dysregulation causes age dependent neuronal degeneration. Recent findings that FMRP and TDP-43 associate in ribonuclear protein particles and share mRNA targets in neurons highlight the critical importance of translation regulation in synaptic plasticity and provide new perspectives on neuronal vulnerability during lifespan.
MeSH term(s)	Animals ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/physiology ; Disease Models, Animal ; Fragile X Mental Retardation Protein/genetics ; Fragile X Mental Retardation Protein/physiology ; Fragile X Syndrome/genetics ; Fragile X Syndrome/physiopathology ; Humans ; Neuronal Plasticity/physiology ; Neurons/metabolism ; Protein Biosynthesis/genetics ; Protein Biosynthesis/physiology ; RNA, Messenger/metabolism ; Receptors, Metabotropic Glutamate/physiology ; Ribonucleoproteins/metabolism ; Signal Transduction
Chemical Substances	DNA-Binding Proteins ; FMR1 protein, human ; RNA, Messenger ; Receptors, Metabotropic Glutamate ; Ribonucleoproteins ; TARDBP protein, human ; metabotropic glutamate receptor type 1 ; Fragile X Mental Retardation Protein (139135-51-6)
Language	English
Publishing date	2018-04-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2018.04.034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differential Cytotoxicity Induced by Transition Metal Oxide Nanoparticles is a Function of Cell Killing and Suppression of Cell Proliferation

Larry M. Tolliver / Natalie J. Holl / Fang Yao Stephen Hou / Han-Jung Lee / Melissa H. Cambre / Yue-Wern Huang

International Journal of Molecular Sciences, Vol 21, Iss 5, p

2020 Volume 1731

Abstract: The application of nanoparticles (NPs) in industry is on the rise, along with the potential for human exposure. While the toxicity of microscale equivalents has been studied, nanoscale materials exhibit different properties and bodily uptake, which ... ...

Abstract	The application of nanoparticles (NPs) in industry is on the rise, along with the potential for human exposure. While the toxicity of microscale equivalents has been studied, nanoscale materials exhibit different properties and bodily uptake, which limits the prediction ability of microscale models. Here, we examine the cytotoxicity of seven transition metal oxide NPs in the fourth period of the periodic table of the chemical elements. We hypothesized that NP-mediated cytotoxicity is a function of cell killing and suppression of cell proliferation. To test our hypothesis, transition metal oxide NPs were tested in a human lung cancer cell model (A549). Cells were exposed to a series of concentrations of TiO 2 , Cr 2 O 3 , Mn 2 O 3 , Fe 2 O 3 , NiO, CuO, or ZnO for either 24 or 48 h. All NPs aside from Cr 2 O 3 and Fe 2 O 3 showed a time- and dose-dependent decrease in viability. All NPs significantly inhibited cellular proliferation. The trend of cytotoxicity was in parallel with that of proliferative inhibition. Toxicity was ranked according to severity of cellular responses, revealing a strong correlation between viability, proliferation, and apoptosis. Cell cycle alteration was observed in the most toxic NPs, which may have contributed to promoting apoptosis and suppressing cell division rate. Collectively, our data support the hypothesis that cell killing and cell proliferative inhibition are essential independent variables in NP-mediated cytotoxicity.
Keywords	nanoparticle ; cell proliferation ; transition metal oxide ; cell cycle ; apoptosis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differential Cytotoxicity Induced by Transition Metal Oxide Nanoparticles is a Function of Cell Killing and Suppression of Cell Proliferation.

Tolliver, Larry M / Holl, Natalie J / Hou, Fang Yao Stephen / Lee, Han-Jung / Cambre, Melissa H / Huang, Yue-Wern

International journal of molecular sciences

2020 Volume 21, Issue 5

Abstract	The application of nanoparticles (NPs) in industry is on the rise, along with the potential for human exposure. While the toxicity of microscale equivalents has been studied, nanoscale materials exhibit different properties and bodily uptake, which limits the prediction ability of microscale models. Here, we examine the cytotoxicity of seven transition metal oxide NPs in the fourth period of the periodic table of the chemical elements. We hypothesized that NP-mediated cytotoxicity is a function of cell killing and suppression of cell proliferation. To test our hypothesis, transition metal oxide NPs were tested in a human lung cancer cell model (A549). Cells were exposed to a series of concentrations of TiO
MeSH term(s)	A549 Cells ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/toxicity ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Oxides/chemistry ; Zinc Oxide/chemistry
Chemical Substances	Oxides ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2020-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21051731
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cellulose-Chitosan-Keratin Composite Materials: Synthesis, Immunological and Antibacterial Properties.

Rosewald, Meghann / Hou, Fang Yao Stephen / Mututuvari, Tamutsiwa / Harkins, April L / Tran, Chieu D

ECS transactions

2015 Volume 64, Issue 4, Page(s) 499–505

Abstract: Novel composites were synthesized from keratin (KER), cellulose (CEL) and chitosan (CS). The method is recyclable because majority (>88%) of [ ... ...

Abstract	Novel composites were synthesized from keratin (KER), cellulose (CEL) and chitosan (CS). The method is recyclable because majority (>88%) of [BMIm
Keywords	covid19
Language	English
Publishing date	2015-05-17
Publishing country	United States
Document type	Journal Article
ISSN	1938-5862
ISSN	1938-5862
DOI	10.1149/06404.0499ecst
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Article ; Online: Cytotoxicity in the age of nano: the role of fourth period transition metal oxide nanoparticle physicochemical properties.

Chusuei, Charles C / Wu, Chi-Heng / Mallavarapu, Shravan / Hou, Fang Yao Stephen / Hsu, Chen-Ming / Winiarz, Jeffrey G / Aronstam, Robert S / Huang, Yue-Wern

Chemico-biological interactions

2013 Volume 206, Issue 2, Page(s) 319–326

Abstract: A clear understanding of physicochemical factors governing nanoparticle toxicity is still in its infancy. We used a systematic approach to delineate physicochemical properties of nanoparticles that govern cytotoxicity. The cytotoxicity of fourth period ... ...

Abstract	A clear understanding of physicochemical factors governing nanoparticle toxicity is still in its infancy. We used a systematic approach to delineate physicochemical properties of nanoparticles that govern cytotoxicity. The cytotoxicity of fourth period metal oxide nanoparticles (NPs): TiO2, Cr2O3, Mn2O3, Fe2O3, NiO, CuO, and ZnO increases with the atomic number of the transition metal oxide. This trend was not cell-type specific, as observed in non-transformed human lung cells (BEAS-2B) and human bronchoalveolar carcinoma-derived cells (A549). Addition of NPs to the cell culture medium did not significantly alter pH. Physiochemical properties were assessed to discover the determinants of cytotoxicity: (1) point-of-zero charge (PZC) (i.e., isoelectric point) described the surface charge of NPs in cytosolic and lysosomal compartments; (2) relative number of available binding sites on the NP surface quantified by X-ray photoelectron spectroscopy was used to estimate the probability of biomolecular interactions on the particle surface; (3) band-gap energy measurements to predict electron abstraction from NPs which might lead to oxidative stress and subsequent cell death; and (4) ion dissolution. Our results indicate that cytotoxicity is a function of particle surface charge, the relative number of available surface binding sites, and metal ion dissolution from NPs. These findings provide a physicochemical basis for both risk assessment and the design of safer nanomaterials.
MeSH term(s)	Apoptosis/drug effects ; Binding Sites ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Hydrogen-Ion Concentration ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/toxicity ; Oxides/chemistry ; Surface Properties ; Transition Elements/chemistry
Chemical Substances	Oxides ; Transition Elements
Language	English
Publishing date	2013-11-25
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2013.09.020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 686: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Cytotoxicity in the age of nano: The role of fourth period transition metal oxide nanoparticle physicochemical properties

Chusuei, Charles C / Wu, Chi-Heng / Mallavarapu, Shravan / Hou, Fang Yao Stephen / Hsu, Chen-Ming / Winiarz, Jeffrey G / Aronstam, Robert S / Huang, Yue-Wern

Chemico-biological interactions. 2013 Nov. 25, v. 206, no. 2

2013

Abstract	A clear understanding of physicochemical factors governing nanoparticle toxicity is still in its infancy. We used a systematic approach to delineate physicochemical properties of nanoparticles that govern cytotoxicity. The cytotoxicity of fourth period metal oxide nanoparticles (NPs): TiO₂, Cr₂O₃, Mn₂O₃, Fe₂O₃, NiO, CuO, and ZnO increases with the atomic number of the transition metal oxide. This trend was not cell-type specific, as observed in non-transformed human lung cells (BEAS-2B) and human bronchoalveolar carcinoma-derived cells (A549). Addition of NPs to the cell culture medium did not significantly alter pH. Physiochemical properties were assessed to discover the determinants of cytotoxicity: (1) point-of-zero charge (PZC) (i.e., isoelectric point) described the surface charge of NPs in cytosolic and lysosomal compartments; (2) relative number of available binding sites on the NP surface quantified by X-ray photoelectron spectroscopy was used to estimate the probability of biomolecular interactions on the particle surface; (3) band-gap energy measurements to predict electron abstraction from NPs which might lead to oxidative stress and subsequent cell death; and (4) ion dissolution. Our results indicate that cytotoxicity is a function of particle surface charge, the relative number of available surface binding sites, and metal ion dissolution from NPs. These findings provide a physicochemical basis for both risk assessment and the design of safer nanomaterials.
Keywords	X-ray photoelectron spectroscopy ; binding sites ; cell culture ; cell death ; culture media ; cytotoxicity ; energy ; ferric oxide ; humans ; isoelectric point ; nanoparticles ; oxidative stress ; pH ; probability ; risk assessment ; titanium dioxide
Language	English
Dates of publication	2013-1125
Size	p. 319-326.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2013.09.020
Database	NAL-Catalogue (AGRICOLA)

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Article: Cytotoxicity in the age of nano: The role of fourth period transition metal oxide nanoparticle physicochemical properties

Chusuei, Charles C. / Wu, Chi-Heng / Mallavarapu, Shravan / Hou, Fang Yao Stephen / Hsu, Chen-Ming / Winiarz, Jeffrey G. / Aronstam, Robert S. / Huang, Yue-Wern

Chemico-biological interactions

Volume v. 206,, Issue no. 2

Abstract	A clear understanding of physicochemical factors governing nanoparticle toxicity is still in its infancy. We used a systematic approach to delineate physicochemical properties of nanoparticles that govern cytotoxicity. The cytotoxicity of fourth period metal oxide nanoparticles (NPs): TiO₂, Cr₂O₃, Mn₂O₃, Fe₂O₃, NiO, CuO, and ZnO increases with the atomic number of the transition metal oxide. This trend was not cell-type specific, as observed in non-transformed human lung cells (BEAS-2B) and human bronchoalveolar carcinoma-derived cells (A549). Addition of NPs to the cell culture medium did not significantly alter pH. Physiochemical properties were assessed to discover the determinants of cytotoxicity: (1) point-of-zero charge (PZC) (i.e., isoelectric point) described the surface charge of NPs in cytosolic and lysosomal compartments; (2) relative number of available binding sites on the NP surface quantified by X-ray photoelectron spectroscopy was used to estimate the probability of biomolecular interactions on the particle surface; (3) band-gap energy measurements to predict electron abstraction from NPs which might lead to oxidative stress and subsequent cell death; and (4) ion dissolution. Our results indicate that cytotoxicity is a function of particle surface charge, the relative number of available surface binding sites, and metal ion dissolution from NPs. These findings provide a physicochemical basis for both risk assessment and the design of safer nanomaterials.
Keywords	cell culture ; cell death ; X-ray photoelectron spectroscopy ; titanium dioxide ; binding sites ; ferric oxide ; cytotoxicity ; humans ; isoelectric point ; oxidative stress ; culture media ; risk assessment ; probability ; nanoparticles ; energy ; pH
Language	English
Document type	Article
ISSN	0009-2797
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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