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  1. AU="Yao-Zhong Zhao"
  2. AU="Chern, Chang-Ming"
  3. AU="Floeter, Jens"
  4. AU="Wijnen, Petal"
  5. AU="Saravanamuthu, Pira"
  6. AU="Kalpana Deepa Priya Dorayappan"
  7. AU="Xiao, Hongkui"
  8. AU="Lali, Arvind M"
  9. AU="Kim, Hyojeong"
  10. AU="Nasseri, Saeed"
  11. AU="Kluge"
  12. AU="Bierbaumer, Lisa"
  13. AU="Rashid, Muhammad"
  14. AU="Huang, Chiun-Sheng"
  15. AU="Shevchuk, O O"
  16. AU="Mulvihill, Emily"
  17. AU="Gandhi, Adarsh"
  18. AU="Zhao, Chuanrui"
  19. AU="Shelley Wiart"
  20. AU="Lydia E. Wroblewski" AU="Lydia E. Wroblewski"
  21. AU="Paterson, Ross"
  22. AU="Alexander Marx"
  23. AU="Robinson, Jill"
  24. AU="Mitchell, Adam W M"
  25. AU="Ingham, Jesse R"

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  1. Artikel ; Online: Research Progress on the Antiemetic Effect of Traditional Chinese Medicine Against Chemotherapy-Induced Nausea and Vomiting

    Yao-Zhong Zhao / Yong-Zhao Dai / Ke Nie

    Frontiers in Pharmacology, Vol

    A Review

    2022  Band 12

    Abstract: Chemotherapy-induced nausea and vomiting (CINV), a common side effect in antineoplastic treatment, dramatically decreases the quality of life as well as the compliance of cancer patients. Although numerous antiemetic agents have been used for CINV ... ...

    Abstract Chemotherapy-induced nausea and vomiting (CINV), a common side effect in antineoplastic treatment, dramatically decreases the quality of life as well as the compliance of cancer patients. Although numerous antiemetic agents have been used for CINV treatment, its adverse reactions as well as its inadequate control toward delayed emesis still limit its clinical usage. Traditional Chinese medicine (TCM), with more than 3,000 years of practical history in Asia, has been successfully applied to mitigate chemotherapy-induced side effects. Growing attention is drawn to the antiemetic effect of TCM against CINV due to its promising therapeutic property and higher safety recently. In this review, we summarize the classic antiemetic TCM-based treatment and its mechanisms, so as to provide a theoretical basis for further investigations of TCM against CINV in the future.
    Schlagwörter chemotherapy ; nausea ; vomiting ; traditional Chinese medicine ; review ; Therapeutics. Pharmacology ; RM1-950
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Treatment adherence and health outcomes in MSM with HIV/AIDS: patients enrolled in "one-stop" and standard care clinics in Wuhan China.

    Zhou, Wang / Zhao, Min / Wang, Xia / Schilling, Robert F / Zhou, Sheng / Qiu, Hong-Yan / Xie, Nian-Hua / Liu, Man-Qing / Dong, Han-Sheng / Yao, Zhong-Zhao / Cai, Thomas

    PloS one

    2014  Band 9, Heft 12, Seite(n) e113736

    Abstract: Background: Conducted in Wuhan China, this study examined follow-up and health markers in HIV patients receiving care in two treatment settings. Participants, all men who have sex with men, were followed for 18-24 months.: Method: Patients in a "one- ... ...

    Abstract Background: Conducted in Wuhan China, this study examined follow-up and health markers in HIV patients receiving care in two treatment settings. Participants, all men who have sex with men, were followed for 18-24 months.
    Method: Patients in a "one-stop" service (ACC; N = 89) vs those in standard care clinics (CDC; N = 243) were compared on HIV treatment and retention in care outcomes.
    Results: Among patients with CD4 cell count ≦350 cells/µL, the proportion receiving cART did not differ across clinic groups. The ACC was favored across five other indicators: proportion receiving tests for CD4 cell count at the six-month interval (98.2% vs. 79.4%, 95% CI 13.3-24.3, p = 0.000), proportion with HIV suppression for patients receiving cART for 6 months (86.5% vs. 57.1%, 95% CI 14.1-44.7, p = 0.000), proportion with CD4 cell recovery for patients receiving cART for 12 months (55.8% vs. 22.2%, 95% CI 18.5-48.6, p = 0.000), median time from HIV confirmation to first test for CD4 cell count (7 days, 95% CI 4-8 vs. 10 days, 95% CI 9-12, log-rank p = 0.000) and median time from first CD4 cell count ≦350 cells/µL to cART initiation (26 days, 95% CI 16-37 vs. 41.5 days, 95% CI 35-46, log-rank p = 0.031). Clinic groups did not differ on any biomedical indicator at baseline, and no baseline biomedical or demographic variables remained significant in the multivariate analysis. Nonetheless, post-hoc analyses suggest the possibility of self-selection bias.
    Conclusions: Study findings lend preliminary support to a one-stop patient-centered care model that may be useful across various HIV care settings.
    Mesh-Begriff(e) Acquired Immunodeficiency Syndrome/drug therapy ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-HIV Agents/therapeutic use ; China ; HIV Infections/drug therapy ; Homosexuality, Male ; Humans ; Male ; Middle Aged ; Patient Compliance ; Patient-Centered Care ; Treatment Outcome ; Young Adult
    Chemische Substanzen Anti-HIV Agents
    Sprache Englisch
    Erscheinungsdatum 2014
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0113736
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: CD4+ T cell count, HIV-1 viral loads and demographic variables of newly identified patients with HIV infection in Wuhan, China.

    Liu, Man-Qing / Tang, Li / Kong, Wen-Hua / Zhu, Ze-Rong / Peng, Jin-Song / Wang, Xia / Yao, Zhong-Zhao / Schilling, Robert / Zhou, Wang

    Journal of medical virology

    2013  Band 85, Heft 10, Seite(n) 1687–1691

    Abstract: In China, the rate of human immunodeficiency virus (HIV) testing is increasing among men who have sex with men. The purpose of the present study was to describe HIV-related biomarkers and selected demographic variables of persons with newly diagnosed HIV/ ...

    Abstract In China, the rate of human immunodeficiency virus (HIV) testing is increasing among men who have sex with men. The purpose of the present study was to describe HIV-related biomarkers and selected demographic variables of persons with newly diagnosed HIV/AIDS, among men who have sex with men in particular, in Wuhan China. Demographic indicators, and CD4+ T cell counts and HIV-1 viral load were collected from individuals newly identified as HIV-1 antibody positive during 2011. Of 176 enrolled patients, 132 (75.0%) were men who have sex with men. This group was significantly younger and had higher CD4+ T cell counts than patients who were likely infected through heterosexual contact. Most men who have sex with men (56.6%) were discovered by initiative investigation. Among heterosexual patients CD4+ T cell counts and HIV-1 viral load were significantly correlated; among the group of men who have sex with men, no such association was found.
    Mesh-Begriff(e) Adolescent ; Adult ; Age Factors ; Aged ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; China/epidemiology ; Demography ; Female ; HIV Antibodies/blood ; HIV Infections/epidemiology ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/isolation & purification ; Humans ; Male ; Middle Aged ; Sexual Behavior ; Viral Load ; Young Adult
    Chemische Substanzen HIV Antibodies
    Sprache Englisch
    Erscheinungsdatum 2013-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.23627
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: A survival study and prognostic factors analysis on acute promyelocytic leukemia at a single center.

    Xin, Li / Wan-jun, Sun / Zeng-jun, Li / Yao-zhong, Zhao / Yun-tao, Li / Yan, Li / Chang-chun, Wan / Qiao-chuan, Li / Ren-chi, Yang / Ming-zhe, Han / Jian-xiang, Wang / Lu-gui, Qiu

    Leukemia research

    2007  Band 31, Heft 6, Seite(n) 765–771

    Abstract: This study was aimed to investigate the factors influencing long-term survival on patients with acute promyelocytic leukemia. Here, we present a single center retrospective study with long-term follow-up to explore the prognostic factors and a rationale ... ...

    Abstract This study was aimed to investigate the factors influencing long-term survival on patients with acute promyelocytic leukemia. Here, we present a single center retrospective study with long-term follow-up to explore the prognostic factors and a rationale of the using of ATRA, chemotherapy and As(2)O(3) in the treatment of newly diagnosed APL patients. In total, 222 patients, 184 achieved complete remission (CR) with the CR rate of 82.88% and 22 patients died during early induction therapy with the early-death-rate of 10%. Total 171 newly diagnosed APL patients entering CR were retrospectively analyzed from November 1989 to December 2004,with a median follow-up of 36 months (6-185 months). Univariate and multivariate analysis of eight factors potentially influencing survival and prognosis were carried out with Log-Rank and Cox regression method, including sex, age, initial WBC count, the level of lactic dehydrogenase (LDH), first induction regimen, days from induction therapy to CR, post-remission therapy and the status of PML-RAR alpha fusion gene by reverse transcription-polymerase chain reaction (RT-PCR). The results showed that the estimated 5-year overall survival (OS) and relapse-free survival (RFS) were 80.9+/-4.0 and 71.0+/-4.0%, respectively. Univariate analyses showed that initial WBC count, first induction regimen, days from induction therapy to CR, post-remission therapy regimen and the status of PML-RAR alpha in remission were important prognostic factors for long-term survival. Multivariate study showed that only post-remission therapy regimen was associated with RFS and OS. It is concluded that the post-remission treatment combining ATRA, As(2)O(3) and chemotherapy would significantly improve the long-term survival of APL patients achieving CR(1).
    Mesh-Begriff(e) Adolescent ; Adult ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Arsenicals/administration & dosage ; Child ; Child, Preschool ; Disease-Free Survival ; Follow-Up Studies ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/genetics ; Leukemia, Promyelocytic, Acute/mortality ; Male ; Middle Aged ; Oncogene Proteins, Fusion/genetics ; Oxides/administration & dosage ; Recurrence ; Remission Induction ; Retrospective Studies ; Risk Factors ; Survival Rate ; Tretinoin/administration & dosage
    Chemische Substanzen Arsenicals ; Oncogene Proteins, Fusion ; Oxides ; promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein ; Tretinoin (5688UTC01R) ; arsenic trioxide (S7V92P67HO)
    Sprache Englisch
    Erscheinungsdatum 2007-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2006.07.028
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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