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  1. Article ; Online: Cutibacterium acnes

    Yaphe, Sean / Bahcheli, Kemal

    BMJ case reports

    2021  Volume 14, Issue 7

    Abstract: Sternoclavicular joint osteomyelitis is extremely rare, with only 225 reported cases in the last 45 years. We present an unusual case in an otherwise healthy 55-year-old man with a history of well-controlled type 2 diabetes mellitus and hypertension. He ... ...

    Abstract Sternoclavicular joint osteomyelitis is extremely rare, with only 225 reported cases in the last 45 years. We present an unusual case in an otherwise healthy 55-year-old man with a history of well-controlled type 2 diabetes mellitus and hypertension. He presented to the emergency department after a week of left knee pain that worsened to full-body joint pain with left sternoclavicular swelling. He was started on antibiotics with multiple washouts of the left knee and treated for septic arthritis. By MRI and CT, he was found to have left sternoclavicular joint osteomyelitis and abscess and underwent debridement and resection. We believe that the initial joint injection resulted in haematogenous spread to the left sternoclavicular joint, stressing the importance of a sterile field for joint procedures.
    MeSH term(s) Abscess ; Arthritis, Infectious/diagnosis ; Arthritis, Infectious/drug therapy ; Diabetes Mellitus, Type 2 ; Humans ; Male ; Middle Aged ; Osteomyelitis/diagnostic imaging ; Osteomyelitis/drug therapy ; Sternoclavicular Joint/diagnostic imaging
    Language English
    Publishing date 2021-07-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-241778
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  2. Article ; Online: The seroprevalence of COVID-19 in patients living with HIV in metropolitan Detroit.

    Gudipati, Smitha / Lee, Monica / Scott, Megan / Yaphe, Sean / Huisting, Joanne / Yared, Nicholas / Brar, Indira / Markowitz, Norman

    International journal of STD & AIDS

    2022  Volume 33, Issue 6, Page(s) 554–558

    Abstract: Background: COVID-19, a novel respiratory illness caused by SARS-CoV-2, has become a global pandemic. As of December 2020, 4.8% of the 941 people living with HIV in our Ryan White clinic have tested polymerase chain reaction positive for SARS-CoV-2. The ...

    Abstract Background: COVID-19, a novel respiratory illness caused by SARS-CoV-2, has become a global pandemic. As of December 2020, 4.8% of the 941 people living with HIV in our Ryan White clinic have tested polymerase chain reaction positive for SARS-CoV-2. The aim of our study was to estimate the seroprevalence of COVID-19 in our Ryan White people living with HIV, irrespective of known past infection.
    Methods: We conducted a cross-sectional study that recruited people living with HIV in the Ryan White program at Henry Ford Hospital in Detroit, Michigan, from September 2020 through May 2021. All Ryan White patients were offered participation during clinic visits. After informed consent, patients completed a survey, and had blood sampled for SARS-CoV-2 antibody testing.
    Results: Of the 529 individuals who completed the written survey, 504 participants were tested for SARS-CoV-2 antibody and 52 people living with HIV were COVID-19 immunoglobulin (Ig) G positive resulting in a seroprevalence of 10.3%. Among 36 persons with PCR-confirmed COVID-19, 52.8% were IgG negative. Inclusion of PCR positive but IgG-negative people living with HIV yields a COVID-19 infection prevalence of 14.1%.
    Conclusions: These findings suggest that passive public health-based antibody surveillance in people living with HIV significantly underestimates past infection.
    MeSH term(s) Antibodies, Viral ; COVID-19/epidemiology ; Cross-Sectional Studies ; HIV Infections/epidemiology ; Humans ; Immunoglobulin G ; SARS-CoV-2 ; Seroepidemiologic Studies
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2022-03-25
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624221076629
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    Zs.A 2829: Show issues Location:
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  3. Article ; Online: Outpatient Antibiotic Prescribing Patterns for Adult End-Stage Renal Disease Patients in New York State.

    Coritsidis, George N / Yaphe, Sean / Rahkman, Ilay / Lubowski, Teresa / Munro, Carly / Lee, Ti-Kuang / Stern, Aaron / Bhat, Premila

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 11, Page(s) e4493–e4498

    Abstract: Background: Infections are important complications of end-stage renal disease (ESRD) with few studies having investigated oral antibiotic use. Inappropriate antibiotic prescribing can contribute to multidrug-resistant organisms and Clostridioides ... ...

    Abstract Background: Infections are important complications of end-stage renal disease (ESRD) with few studies having investigated oral antibiotic use. Inappropriate antibiotic prescribing can contribute to multidrug-resistant organisms and Clostridioides difficile infections seen in ESRD. This study investigates antibiotic prescribing practices in ESRD across New York State (NYS).
    Methods: Retrospective case-control study from 2016 to 2017 of NYS ESRD and non-ESRD patients analyzing Medicare part B billing codes, 7 days before and 3 days after part D claims. Frequencies of each infection, each antibiotic, dosages, and the antibiotics associated with infections were assessed using χ 2 analysis. A NYS small dialysis organization comprising approximately 2200 patients was also analyzed. Outcomes measured were the frequencies of infections and of each antibiotic prescribed. Incidence measures included antibiotics per 1000 and individuals receiving antibiotics per 1000.
    Results: A total of 48 100 infections were treated in 35 369 ESRD patients and 2 544 443 infections treated in 3 777 314 non-ESRD patients. ESRD patients were younger, male, and African American. ESRD and non-ESRD patients receiving antibiotics was 520.29/1000 and 296.48/1000, respectively (P < .05). The prescription incidence was 1359.95/1000 ESRD vs 673.61/1000 non-ESRD patients. In 36%, trimethoprim-sulfamethoxazole dosage was elevated by current ESRD guidelines. Top infectious categories included nonspecific symptoms, skin, and respiratory for ESRD; and respiratory, nonspecific symptoms, and genitourinary in non-ESRD.
    Conclusions: This study identifies issues with appropriate antibiotic usage stressing the importance of antibiotic education to nephrologist and nonnephrologist providers. It provides support for outpatient antibiotic stewardship programs.
    MeSH term(s) Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Case-Control Studies ; Humans ; Inappropriate Prescribing ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Male ; Medicare ; New York ; Outpatients ; Practice Patterns, Physicians' ; Respiratory Tract Infections/epidemiology ; Retrospective Studies ; United States
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1801
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    Zs.A 1505: Show issues Location:
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  4. Article ; Online: Point-of-care ultrasound for assessing arteriovenous fistula maturity in outpatient hemodialysis.

    Coritsidis, George N / Machado, Orlando N / Levi-Haim, Farzin / Yaphe, Sean / Patel, Roshan A / Depa, Jayaramakrishna

    The journal of vascular access

    2020  Volume 21, Issue 6, Page(s) 923–930

    Abstract: Background: Point-of-care ultrasound in end-stage renal disease is on the rise. Presently the decision to cannulate an arteriovenous fistula is based on its duration since surgery and physical exam. This study examines the effects of point-of-care ... ...

    Abstract Background: Point-of-care ultrasound in end-stage renal disease is on the rise. Presently the decision to cannulate an arteriovenous fistula is based on its duration since surgery and physical exam. This study examines the effects of point-of-care ultrasound on decreasing the time to arteriovenous fistula cannulation, time spent with a central venous catheter, and the complications and infections that arise.
    Methods: Prospective point-of-care ultrasound patients were recruited between January 2015 and January 2018, while retrospective data (non-point-of-care ultrasound) were collected via chart review from patients who had fistula creation between November 2011 and May 2014. Patients had point-of-care ultrasound within 3 weeks after arteriovenous fistula creation and were followed for 1 year. Arteriovenous fistula cannulation was initiated when the following parameters were met: diameter > 6 mm (with no depreciable narrowing of more than 20% throughout), depth < 6 mm, and length > 6 cm. Demographic data, as well as time to cannulation and central venous catheter removal, number of infections, complications, and interventions were compared between point-of-care ultrasound and non-point-of-care ultrasound groups using unpaired t-test, chi-square, and Fisher exact test statistical analysis.
    Results: A total of 37 patients with new arteriovenous fistulas were followed by point-of-care ultrasound compared to 29 non-point-of-care ultrasound patients. Point-of-care ultrasound patients had earlier cannulations (35.5 vs 63.3 days, p < 0.05), shorter central venous catheter duration (68.2 vs 98.3 days, p < 0.05), and less infections (12 vs 19) without differences in complication compared to the non-point-of-care ultrasound.
    Conclusion: Point-of-care ultrasound facilitates early and safe arteriovenous fistula cannulation leading to a reduction in central venous catheter time and risk of infection. Point-of-care ultrasound may also aid in earlier identification of complications and difficult cannulations.
    MeSH term(s) Adult ; Aged ; Ambulatory Care ; Arteriovenous Shunt, Surgical/adverse effects ; Catheter-Related Infections/microbiology ; Catheter-Related Infections/prevention & control ; Catheterization ; Catheterization, Central Venous/instrumentation ; Catheters, Indwelling ; Central Venous Catheters ; Device Removal ; Female ; Humans ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Point-of-Care Testing ; Predictive Value of Tests ; Prospective Studies ; Renal Dialysis ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome ; Ultrasonography ; Vascular Patency
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252820-9
    ISSN 1724-6032 ; 1129-7298
    ISSN (online) 1724-6032
    ISSN 1129-7298
    DOI 10.1177/1129729820913437
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    Zs.A 6414: Show issues Location:
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  5. Article: A pilot randomized controlled trial of a fruit and vegetable prescription program at a federally qualified health center in low income uncontrolled diabetics.

    Bryce, Richard / WolfsonBryce, Julia A / CohenBryce, Alicia / Milgrom, Nicki / Garcia, Danny / Steele, Alicia / Yaphe, Sean / Pike, Denise / Valbuena, Felix / Miller-Matero, Lisa R

    Preventive medicine reports

    2021  Volume 23, Page(s) 101410

    Abstract: Eating a healthy diet is important for managing diabetes. Although there are high rates of diabetes in low-income urban areas, these patients often have limited access to fruits and vegetables. The 15-week Fresh Prescription (Fresh Rx) program was ... ...

    Abstract Eating a healthy diet is important for managing diabetes. Although there are high rates of diabetes in low-income urban areas, these patients often have limited access to fruits and vegetables. The 15-week Fresh Prescription (Fresh Rx) program was designed to improve access and consumption of fruits and vegetables among low-income patients with diabetes in Detroit, MI. The purpose of this study was to evaluate the effects of a fruit and vegetable prescription program on changes in hemoglobin A1C (HbA
    Language English
    Publishing date 2021-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2021.101410
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  6. Article ; Online: Incidence of acute hepatitis C virus infection among men who have sex with men with and without HIV infection: a systematic review.

    Yaphe, Sean / Bozinoff, Nikki / Kyle, Rachel / Shivkumar, Sushmita / Pai, Nitika Pant / Klein, Marina

    Sexually transmitted infections

    2012  Volume 88, Issue 7, Page(s) 558–564

    Abstract: Background: A recent increase in reports of acute hepatitis C virus infection (HCV) in HIV-infected and HIV-uninfected men who have sex with men (MSM), with the sole risk factor being sexual exposure, has led to routine screening and targeted prevention ...

    Abstract Background: A recent increase in reports of acute hepatitis C virus infection (HCV) in HIV-infected and HIV-uninfected men who have sex with men (MSM), with the sole risk factor being sexual exposure, has led to routine screening and targeted prevention requests for this population; current evidence for this necessity is unclear.
    Objective: A systematic review was conducted to assess the incidence of HCV infection among studies conducted in HIV-positive and/or HIV-negative MSM to explore the implications for routine HCV screening.
    Data sources: The MEDLINE, EMBASE and BIOSYS databases were searched for the period January 2000 to May 2012, yielding 21 studies. Six conferences were hand-searched for the same period yielding four abstracts.
    Study selection: Only studies in English presenting incidence rates of HCV and specifying HIV status were included.
    Data abstraction: Data were abstracted by two authors using predefined data fields. The STROBE checklist was used to assess study quality.
    Data synthesis: Data were divided into HIV-negative MSM and HIV-positive MSM subgroups, and HCV incidence density measurements were pooled. Using a DerSimonian-Laird random effects model, pooled incidence was 1.48/1000 person-years (95% CI 0.75 to 2.21) for the HIV-negative MSM subgroup. The HIV-positive MSM subgroup was at 4.1 times higher risk of acquiring HCV at 6.08/1000 person-years (95% CI 5.18 to 6.99). Studies directly comparing subgroups estimated a pooled risk difference of 3.45/1000 person-years (95% CI 1.63 to 5.27).
    Conclusion: HIV-positive MSM were at higher risk for acute HCV infection than HIV-negative MSM, substantiating the need for routine screening initiatives. Insufficient evidence exists to warrant routine screening of HIV-negative MSM, except on a case-by-case basis, such as high-risk sexual behaviour.
    MeSH term(s) Coinfection/epidemiology ; HIV Infections/complications ; Hepatitis C/epidemiology ; Homosexuality, Male ; Humans ; Incidence ; Male ; Risk Assessment
    Language English
    Publishing date 2012-11
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2012-050566
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  7. Article ; Online: Mortality in HIV-hepatitis C co-infected patients in Canada compared to the general Canadian population (2003-2013).

    Klein, Marina B / Rollet-Kurhajec, Kathleen C / Moodie, Erica E M / Yaphe, Sean / Tyndall, Mark / Walmsley, Sharon / Gill, John / Martel-Laferriere, Valerie / Cooper, Curtis

    AIDS (London, England)

    2014  Volume 28, Issue 13, Page(s) 1957–1965

    Abstract: Objective: Recent studies suggest all-cause mortality in HIV mono-infected patients approaches that of the general population. We aimed to compare participants in the Canadian Co-infection Cohort to the general population to determine if co-infected ... ...

    Abstract Objective: Recent studies suggest all-cause mortality in HIV mono-infected patients approaches that of the general population. We aimed to compare participants in the Canadian Co-infection Cohort to the general population to determine if co-infected patients have had similar improvements in mortality.
    Design: Prospective multicentre cohort study.
    Methods: Between 2003 and 2013, deaths were captured using specific case reports and through linkage to provincial vital statistics for participants lost to follow-up. Standardized mortality ratios (SMRs) were calculated using age, sex and province-specific mortality rates from the Canadian Human Mortality Database, 2009, and compared across behavioural and clinical characteristics of participants at their most recent visit.
    Results: Among the 1150 patients, we observed 133 deaths over 3351 person-years (4.0 per 100 person-years, 95% confidence interval 3.3, 4.6). SMRs (95% confidence interval) were: 12.1(10.1, 14.2) overall; 9.3 (7.5, 11.1) for men and 19.4 (12.7, 26.2) for women. CD4 cell counts below 200 cells/μl [25.5 (17.7, 33.3)], active injection drug use [19.9 (13.9, 25.9)] and smoking [14.9 (12.1, 17.7)] were strongly associated with excess mortality. Lowest SMRs were seen for those who had spontaneous [4.5 (-0.6, 9.5)] or treatment-induced clearance of hepatitis C virus (HCV) infection [5.1 (1.3, 8.8)]. Conversely, high SMRs were seen with advanced liver disease [17.0 (11.7, 22.3)]. In no category did SMRs approach mortality seen in the general Canadian population.
    Conclusions: HIV-HCV co-infected persons remain at markedly increased risk for death despite antiretroviral therapy. Interventions targeting modifiable risk factors such as substance use, smoking, adherence to antiretrovirals and timely provision of HCV therapy could substantially reduce death rates.
    MeSH term(s) Adolescent ; Adult ; Canada/epidemiology ; Cohort Studies ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/mortality ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/mortality ; Humans ; Male ; Middle Aged ; Prospective Studies ; Survival Analysis
    Language English
    Publishing date 2014-08-24
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000000377
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