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Article: Impact of Hydroxyurea on Clinical and Biological Parameters of Sickle Cell Anemia in Children in Abidjan.

Yayo-Aye, Mireille / Adjambri, Adia Eusèbe / Kouakou, Boidy / N'guessan-Blao, Rebecca / Adjé, Louis Missa / Kamagaté, Tairatou / Yapo, Vincent / Sawadogo, Duni

Mediterranean journal of hematology and infectious diseases

2024 Volume 16, Issue 1, Page(s) e2024026

Language	English
Publishing date	2024-03-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2674750-9
ISSN	2035-3006
ISSN	2035-3006
DOI	10.4084/MJHID.2024.026
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Article ; Online: HIV-2 inhibits HIV-1 gene expression via two independent mechanisms during cellular co-infection.

Yapo, Vincent / Majumder, Kinjal / Tedbury, Philip R / Wen, Xin / Ong, Yee T / Johnson, Marc C / Sarafianos, Stefan G

Journal of virology

2023 Volume 97, Issue 12, Page(s) e0187022

Abstract: Importance: Twenty-five years after the first report that HIV-2 infection can reduce HIV-1-associated pathogenesis in dual-infected patients, the mechanisms are still not well understood. We explored these mechanisms in cell culture and showed first ... ...

Abstract	Importance: Twenty-five years after the first report that HIV-2 infection can reduce HIV-1-associated pathogenesis in dual-infected patients, the mechanisms are still not well understood. We explored these mechanisms in cell culture and showed first that these viruses can co-infect individual cells. Under specific conditions, HIV-2 inhibits HIV-1 through two distinct mechanisms, a broad-spectrum interferon response and an HIV-1-specific inhibition conferred by the HIV-2 TAR. The former could play a prominent role in dually infected individuals, whereas the latter targets HIV-1 promoter activity through competition for HIV-1 Tat binding when the same target cell is dually infected. That mechanism suppresses HIV-1 transcription by stalling RNA polymerase II complexes at the promoter through a minimal inhibitory region within the HIV-2 TAR. This work delineates the sequence of appearance and the modus operandi of each mechanism.
MeSH term(s)	Humans ; Coinfection/immunology ; Coinfection/virology ; HIV Long Terminal Repeat/genetics ; HIV-1/genetics ; HIV-1/immunology ; HIV-2/genetics ; HIV-2/immunology ; HIV-2/metabolism ; RNA, Viral/genetics ; tat Gene Products, Human Immunodeficiency Virus/metabolism ; Gene Expression Regulation, Viral ; Interferons/immunology ; Promoter Regions, Genetic/genetics ; Binding, Competitive ; RNA Polymerase II/metabolism ; Transcription, Genetic
Chemical Substances	RNA, Viral ; tat Gene Products, Human Immunodeficiency Virus ; Interferons (9008-11-1) ; tat peptide (17-25), Human immunodeficiency virus 1 ; RNA Polymerase II (EC 2.7.7.-)
Language	English
Publishing date	2023-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01870-22
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Article: Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication

Puray-Chavez, Maritza N / Farghali, Mahmoud H / Yapo, Vincent / Huber, Andrew D / Liu, Dandan / Ndongwe, Tanyaradzwa P / Casey, Mary C / Laughlin, Thomas G / Hannink, Mark / Tedbury, Philip R / Sarafianos, Stefan G

Viruses. 2019 July 17, v. 11, no. 7

2019

Abstract: Moloney leukemia virus 10 (MOV10) is an RNA helicase that has been shown to affect the replication of several viruses. The effect of MOV10 on Hepatitis B virus (HBV) infection is not known and its role on the replication of this virus is poorly ... ...

Abstract	Moloney leukemia virus 10 (MOV10) is an RNA helicase that has been shown to affect the replication of several viruses. The effect of MOV10 on Hepatitis B virus (HBV) infection is not known and its role on the replication of this virus is poorly understood. We investigated the effect of MOV10 down-regulation and MOV10 over-expression on HBV in a variety of cell lines, as well as in an infection system using a replication competent virus. We report that MOV10 down-regulation, using siRNA, shRNA, and CRISPR/Cas9 gene editing technology, resulted in increased levels of HBV DNA, HBV pre-genomic RNA, and HBV core protein. In contrast, MOV10 over-expression reduced HBV DNA, HBV pre-genomic RNA, and HBV core protein. These effects were consistent in all tested cell lines, providing strong evidence for the involvement of MOV10 in the HBV life cycle. We demonstrated that MOV10 does not interact with HBV-core. However, MOV10 binds HBV pgRNA and this interaction does not affect HBV pgRNA decay rate. We conclude that the restriction of HBV by MOV10 is mediated through effects at the level of viral RNA.
Keywords	CRISPR-Cas systems ; DNA ; Hepatitis B virus ; RNA helicases ; cell lines ; gene editing ; gene overexpression ; hepatitis B ; leukemia ; small interfering RNA ; virus replication ; viruses
Language	English
Dates of publication	2019-0717
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v11070651
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Article ; Online: Effects of Moloney Leukemia Virus 10 Protein on Hepatitis B Virus Infection and Viral Replication.

Viruses

2019 Volume 11, Issue 7

Abstract	Moloney leukemia virus 10 (MOV10) is an RNA helicase that has been shown to affect the replication of several viruses. The effect of MOV10 on Hepatitis B virus (HBV) infection is not known and its role on the replication of this virus is poorly understood. We investigated the effect of MOV10 down-regulation and MOV10 over-expression on HBV in a variety of cell lines, as well as in an infection system using a replication competent virus. We report that MOV10 down-regulation, using siRNA, shRNA, and CRISPR/Cas9 gene editing technology, resulted in increased levels of HBV DNA, HBV pre-genomic RNA, and HBV core protein. In contrast, MOV10 over-expression reduced HBV DNA, HBV pre-genomic RNA, and HBV core protein. These effects were consistent in all tested cell lines, providing strong evidence for the involvement of MOV10 in the HBV life cycle. We demonstrated that MOV10 does not interact with HBV-core. However, MOV10 binds HBV pgRNA and this interaction does not affect HBV pgRNA decay rate. We conclude that the restriction of HBV by MOV10 is mediated through effects at the level of viral RNA.
MeSH term(s)	Animals ; Cell Line ; Cells, Cultured ; Gene Expression Regulation, Viral ; Hepatitis B/virology ; Hepatitis B virus/physiology ; Host-Pathogen Interactions ; Humans ; Mice ; Microbial Interactions ; Moloney murine leukemia virus/physiology ; Protein Binding ; RNA ; RNA Helicases/metabolism ; RNA, Viral ; Viral Proteins/metabolism ; Virus Replication
Chemical Substances	RNA, Viral ; Viral Proteins ; pgRNA ; RNA (63231-63-0) ; Mov10 protein, human (EC 2.7.7.-) ; RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2019-07-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v11070651
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Article: Asymmetries in risk and in risk attitude

Larue, Bruno / Yapo, Vincent

Journal of economics and business Vol. 52, No. 5 , p. 435-453

the duopoly case

2000 Volume 52, Issue 5, Page(s) 435–453

Author's details	Bruno Larue and Vincent Yapo
Keywords	Duopol ; Gewinn ; Risiko ; Risikoaversion ; Theorie
Language	English
Size	Graph. Darst
Publisher	Elsevier
Publishing place	Amsterdam [u.a.]
Document type	Article
ZDB-ID	716757x
Database	ECONomics Information System

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Article ; Online: Multiplex single-cell visualization of nucleic acids and protein during HIV infection.

Puray-Chavez, Maritza / Tedbury, Philip R / Huber, Andrew D / Ukah, Obiaara B / Yapo, Vincent / Liu, Dandan / Ji, Juan / Wolf, Jennifer J / Engelman, Alan N / Sarafianos, Stefan G

Nature communications

2017 Volume 8, Issue 1, Page(s) 1882

Abstract: Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we develop a microscopy approach, multiplex immunofluorescent cell-based detection of DNA, RNA ... ...

Abstract	Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we develop a microscopy approach, multiplex immunofluorescent cell-based detection of DNA, RNA and Protein (MICDDRP), which is based on branched DNA in situ hybridization technology. MICDDRP enables simultaneous single-cell visualization of HIV (a) spliced and unspliced RNA, (b) cytoplasmic and nuclear DNA, and (c) Gag. We use MICDDRP to visualize incoming capsid cores containing RNA and/or nascent DNA and follow reverse transcription kinetics. We also report transcriptional "bursts" of nascent RNA from integrated proviral DNA, and concomitant HIV-1, HIV-2 transcription in co-infected cells. MICDDRP can be used to simultaneously detect multiple viral nucleic acid intermediates, characterize the effects of host factors or drugs on steps of the HIV life cycle, or its reactivation from the latent state, thus facilitating the development of antivirals and latency reactivating agents.
MeSH term(s)	Cell Line ; Cell Nucleus/chemistry ; Cell Nucleus/virology ; DNA, Viral/chemistry ; DNA, Viral/genetics ; DNA, Viral/metabolism ; Fluoroimmunoassay/methods ; HIV Infections/virology ; HIV-1/chemistry ; HIV-1/genetics ; HIV-1/metabolism ; Humans ; RNA Splicing ; RNA, Viral/chemistry ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Viral Proteins/chemistry ; Viral Proteins/genetics ; Viral Proteins/metabolism
Chemical Substances	DNA, Viral ; RNA, Viral ; Viral Proteins
Language	English
Publishing date	2017-12-01
Publishing country	England
Document type	Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-017-01693-z
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Article ; Online: Acceptabilite´ du test VIH propose´ aux nourrissons dans les services pediatriques, en Cote d'Ivoire, significations pour la couverture du diagnostic pediatrique

Oga, Maxime / Brou, Hermann / Dago-Akribi, Hortense / Coffie, Patrick / Amani-Bossé, Clarisse / Ekouévi, Didier / Yapo, Vincent / Menan, Hervé / Ndondoki, Camille / Timité-Konan, M / Leroy, Valériane

SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliance

2014 Volume 11, Page(s) 148–157

Abstract: Problem: HIV testing in children had rarely been a central concern for researchers. When pediatric tracking retained the attention, it was more to inform on the diagnosis tools' performances rather than the fact the pediatric test can be accepted or ... ...

Title translation	Acceptability of HIV testing provided to infants in pediatric services in Cote d'Ivoire, meanings for pediatric diagnostic coverage.
Abstract	Problem: HIV testing in children had rarely been a central concern for researchers. When pediatric tracking retained the attention, it was more to inform on the diagnosis tools' performances rather than the fact the pediatric test can be accepted or refused. This article highlights the parents' reasons which explain why pediatric HIV test is accepted or refused. Objective: To study among parents, the explanatory factors of the acceptability of pediatric HIV testing among infant less than six months. Methods: Semi-structured interview with repeated passages in the parents of infants less than six months attending in health care facilities for the pediatric weighing/vaccination and consultations. Results: We highlight that the parents' acceptance of the pediatric HIV screening is based on three elements. Firstly, the health care workers by his speech (which indicates its own knowledge and perceptions on the infection) directed towards mothers' influences their acceptance or not of the HIV test. Secondly, the mother who by her knowledge and perceptions on HIV, whose particular status, give an impression of her own wellbeing for her and her child influences any acceptance of the pediatric HIV test. Thirdly, the marital environment of the mother, particularly characterized by the ease of communication within the couple, to speak about the HIV test and its realization for the parents or the mother only are many factors which influence the effective realization of the pediatric HIV testing. The preventive principle of HIV transmission and the desire to realize the test in the newborn are not enough alone to lead to its effective realization, according to certain mothers confronted with the father's refusal. On the other hand, the other mothers refusing the realization of the pediatric test told to be opposed to it; of course, even if their partner would accept it. Discussion: The mothers are the principal facing the pediatric HIV question and fear the reprimands and stigma. The father, the partner could be an obstacle, when he is opposed to the infant HIV testing, or also the facilitator with his realization if he is convinced. The father position thus remains essential face to the question of pediatric HIV testing acceptability. The mothers are aware of this and predict the difficulties of achieving their infant to be tested without the preliminary opinion of their partner at the same time father, and head of the family. Conclusion: The issue of pediatric HIV testing, at the end of our analysis, highlights three elements which require a comprehensive management to improve the coverage of pediatric HIV test. These three elements would not exist without being influenced; therefore they are constantly in interaction and prevent or support the realization or not pediatric test. Also, with the aim to improve the pediatric HIV test coverage, it is necessary to take into account the harmonious management of these elements. Firstly, the mother alone (with her knowledge, and perceptions), its marital environment (with the proposal of the HIV test integrating (1) the partner and/or father with his perceptions and knowledge on HIV infection and (2) facility of speaking about the test and its realization at both or one about the parents, the mother) and of the knowledge, attitudes and practices about the infection of health care workers of the sanitary institution. Recommendations: Our recommendations proposed taking into account a redefinition of the HIV/AIDS approach towards the families exposed to HIV and a more accentuated integration of the father facilitating their own HIV test acceptation and that of his child.
MeSH term(s)	AIDS Serodiagnosis/methods ; Cote d'Ivoire/epidemiology ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Infant ; Infant, Newborn ; Interviews as Topic ; Male ; Motivation ; Parents/psychology ; Patient Acceptance of Health Care ; Stereotyping
Language	French
Publishing date	2014-08-04
Publishing country	South Africa
Document type	English Abstract ; Journal Article
ZDB-ID	2166971-5
ISSN	1813-4424 ; 1729-0376
ISSN (online)	1813-4424
ISSN	1729-0376
DOI	10.1080/17290376.2014.938101
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Article ; Online: Increasing rate of TAMs and etravirine resistance in HIV-1-infected adults between 12 and 24 months of treatment: the VOLTART cohort study in Côte d'Ivoire, West Africa.

Messou, Eugène / Chaix, Marie-Laure / Gabillard, Delphine / Yapo, Vincent / Toni, Thomas-d'Aquin / Minga, Albert / Kouakou, Martial Guillaume / Ouattara, Eric / Rouzioux, Christine / Danel, Christine / Eholie, Serge P / Anglaret, Xavier

Journal of acquired immune deficiency syndromes (1999)

2013 Volume 64, Issue 2, Page(s) 211–219

Abstract: Background: In sub-Saharan Africa, most HIV-infected patients receive antiretroviral therapy (ART) without virological monitoring. Longitudinal data on secondary resistance are rare.: Methods: We conducted a prospective cohort study of HIV-1-infected ...

Abstract	Background: In sub-Saharan Africa, most HIV-infected patients receive antiretroviral therapy (ART) without virological monitoring. Longitudinal data on secondary resistance are rare. Methods: We conducted a prospective cohort study of HIV-1-infected adults initiating ART in 3 clinics using computerized monitoring systems. Patients had plasma HIV-1 RNA viral load (VL) tests at months 12 (M12) and 24 (M24) after ART initiation and HIV-1 resistance genotype tests if VL was detectable (≥300 copies/mL). Results: Overall, 1573 patients initiated ART with stavudine/zidovudine plus lamivudine plus nevirapine/efavirenz. At M12 and M24, 944 and 844 patients, respectively, remained in active follow-up. Among them, 25% (M12) and 27% (M24) had detectable VLs and 12% (M12) and 19% (M24) had virus resistant to at least 1 antiretroviral drug, accounting for 54% (M12) and 75% (M24) of patients with detectable VLs. Among the resistant strains, 95% (M12) and 97% (M24) were resistant to lamivudine/emtricitabine, efavirenz, and/or nevirapine, the frequency of thymidine analog mutations increased from 8.1% (M12) to 14.7% (M24) and etravirine resistance increased from 13.5% (M12) to 24.5% (M24). Conclusions: Of the patients with detectable VLs at M24, 25% still did not harbor resistant virus. Preventing mutations from emerging with adherence reinforcement in patients with detectable VLs remains important beyond M24. Switching therapy early in patients with resistance to 3 TC/FTC and/or to nonnucleoside reverse transcriptase inhibitors to prevent extended resistance to nucleoside reverse transcriptase inhibitors and etravirine resistance from occurring is also a major challenge.
MeSH term(s)	Adult ; Anti-HIV Agents/administration & dosage ; Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; Cohort Studies ; Cote d'Ivoire ; Drug Monitoring/methods ; Drug Resistance, Viral/genetics ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/virology ; HIV-1/drug effects ; HIV-1/genetics ; Humans ; Male ; Mutation ; Nitriles ; Prospective Studies ; Pyridazines/administration & dosage ; Pyridazines/pharmacology ; Pyridazines/therapeutic use ; Pyrimidines ; RNA, Viral/blood ; Reverse Transcriptase Inhibitors/administration & dosage ; Reverse Transcriptase Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/therapeutic use ; Thymidine/analogs & derivatives ; Thymidine/pharmacology ; Time Factors ; Viral Load
Chemical Substances	Anti-HIV Agents ; Nitriles ; Pyridazines ; Pyrimidines ; RNA, Viral ; Reverse Transcriptase Inhibitors ; etravirine (0C50HW4FO1) ; Thymidine (VC2W18DGKR)
Language	English
Publishing date	2013-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0b013e3182a009e4
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Article ; Online: Evaluation of dried blood spot diagnosis using HIV1-DNA and HIV1-RNA Biocentric assays in infants in Abidjan, Côte d'Ivoire. The Pedi-Test DBS ANRS 12183 Study.

Yapo, Vincent / d'Aquin Toni, Thomas d'Aquin / Desmonde, Sophie / Amani-Bosse, Clarisse / Oga, Maxime / Lenaud, Severin / Menan, Hervé / Timité-Konan, Marguerite / Leroy, Valériane / Rouzioux, Christine

Journal of virological methods

2013 Volume 193, Issue 2, Page(s) 439–445

Abstract: This study evaluates HIV infant diagnosis on DBS using Biocentric HIV1-DNA and HIV1-RNA assays, in field conditions in Côte d'Ivoire. Paediatric screening was offered to children≤3 years in clinical sites in Côte d'Ivoire in 2008. For each HIV-infected ... ...

Abstract	This study evaluates HIV infant diagnosis on DBS using Biocentric HIV1-DNA and HIV1-RNA assays, in field conditions in Côte d'Ivoire. Paediatric screening was offered to children≤3 years in clinical sites in Côte d'Ivoire in 2008. For each HIV-infected child, two non-infected children were included and blood samples were collected. HIV-DNA results obtained on EDTA blood samples with Biocentric assay were the reference for HIV infant diagnosis. Plasma and DBS viral loads were measured using HIV-RNA Biocentric assay. DBS samples were also tested for HIV-DNA detection using both Biocentric and Amplicor Roche assays. Sensitivity, specificity and concordance between tests were calculated. Overall samples from 138 HIV-exposed children, 46 infected, 92 non-infected were included. All tests were 100% sensitive and specific including 100% concordance with the two HIV-DNA assays. The median level of HIV-DNA on EDTA samples was 3.15 log10 copies/10(6) PBMCs; the median level of HIV RNA in plasma and DBS were respectively 5.82 and 5.17 log10 copies/ml (Pearson's correlation R2=0.92, p<0.0001). The threshold for detectable HIV-RNA on DBS was 3.3 log10. Although there are differences between viral load measured on DBS and plasma, the two Biocentric assays present very good performances for HIV infant diagnosis on DBS while cheap and feasible.
MeSH term(s)	Blood/virology ; Child, Preschool ; Cote d'Ivoire ; DNA, Viral/genetics ; DNA, Viral/isolation & purification ; Desiccation ; HIV Infections/diagnosis ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/isolation & purification ; Humans ; Infant ; Molecular Diagnostic Techniques/methods ; Plasma/virology ; RNA, Viral/genetics ; RNA, Viral/isolation & purification ; Sensitivity and Specificity ; Specimen Handling/methods ; Viral Load/methods
Chemical Substances	DNA, Viral ; RNA, Viral
Language	English
Publishing date	2013-11
Publishing country	Netherlands
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	8013-5
ISSN	1879-0984 ; 0166-0934
ISSN (online)	1879-0984
ISSN	0166-0934
DOI	10.1016/j.jviromet.2013.07.011
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Article ; Online: CD4 cell eligibility thresholds: an analysis of the time to antiretroviral treatment in HIV-1 seroconverters.

Minga, Albert K / Lewden, Charlotte / Gabillard, Delphine / Bomisso, Germain I / Toni, Thomas-d'aquin / Emième, Arlette A / Yapo, Vincent / Inwoley, André / Salamon, Roger / Anglaret, Xavier

AIDS (London, England)

2011 Volume 25, Issue 6, Page(s) 819–823

Abstract: Background: WHO recommends initiating combination antiretroviral treatment at the minimal CD4 cell threshold of 350 cells/μl. In sub-Saharan Africa, the time for a recently infected patient to reach this threshold is unclear.: Method: We estimated ... ...

Abstract	Background: WHO recommends initiating combination antiretroviral treatment at the minimal CD4 cell threshold of 350 cells/μl. In sub-Saharan Africa, the time for a recently infected patient to reach this threshold is unclear. Method: We estimated the probability of reaching different CD4 cell thresholds over time in the ANRS 1220 cohort of HIV-1 seroconverters in Côte d'Ivoire. CD4 cell slopes were estimated using a mixed linear model. Probabilities of crossing the 350 and 500 cells/μl CD4 cell thresholds were estimated by the Kaplan-Meier method. Results: Between 1997 and 2009, 304 recent seroconverters have been enrolled in the Primo-CI cohort (62% men, median baseline age 29 years and median time since the estimated date of seroconversion 9 months). The probability of having a first CD4 cell count below 500 cells/μl was 0.57, 0.72, 0.79 and 0.84 at study entry, 2, 4 and 6 years, respectively. For a first CD4 cell count below 350 cells/μl, these figures were 0.29, 0.40, 0.55 and 0.67. The time for 75% of patients to reach the threshold was 3.0 years for 500 cells/μl and 7.0 years for 350 cells/μl.
MeSH term(s)	Adult ; Anti-Retroviral Agents/administration & dosage ; CD4 Lymphocyte Count ; Drug Therapy, Combination ; HIV Infections/drug therapy ; HIV Seropositivity/diagnosis ; HIV Seropositivity/drug therapy ; HIV-1 ; Humans ; Male
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2011-04-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0b013e32834625d3
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