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  1. Article: Hand-assisted laparoscopic donor nephrectomy in kidneys with multiple renal arteries versus a single renal artery: An analysis of vascular complications from 1,350 cases.

    Arpalı, Emre / Karataş, Cihan / Akyollu, Başak / Yaprak, Doğukan / Günaydın, Bilal / Koçak, Burak

    Turkish journal of urology

    2020  

    Abstract: Objective: Laparoscopic donor nephrectomy (LDN) has been shown to be a safe approach with better morbidity results. Impact of multiple renal arteries (MRAs) and anatomical variations has been reviewed by many authors. In our study, the relationship ... ...

    Abstract Objective: Laparoscopic donor nephrectomy (LDN) has been shown to be a safe approach with better morbidity results. Impact of multiple renal arteries (MRAs) and anatomical variations has been reviewed by many authors. In our study, the relationship between the donors with MRAs and risk of perioperative vascular complications related to donor nephrectomy was investigated.
    Material and methods: Patients who underwent hand-assisted LDNs between January 2007 and February 2018 were reviewed retrospectively. Patient age, sex, body mass index (BMI), waist circumference, side of donor nephrectomies, donors with MRAs, intraoperative vascular complications, conversion rates, hospitalization durations, and operative times were extracted. Risk factors for perioperative vascular complications were defined.
    Results: There were MRAs in 288 kidney donors (21.3%). The number of patients who underwent a right donor nephrectomy was 113 (8.4%). BMI, waist circumference, and postoperative hospital stay were not significantly different between donors with one artery and those with MRAs (p>0.05). The renovascular complication rate and overall conversion rate to open surgery were significantly higher in donors with MRAs (p<0.05).
    Conclusion: Perioperative safety of the kidney donors is of crucial importance. Surgeons performing LDNs must be aware of the potential risks. Our analysis suggests that procurement of kidneys from donors with MRAs is a risk factor for renovascular complications.
    Language English
    Publishing date 2020-03-27
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-3235
    ISSN 2149-3235
    DOI 10.5152/tud.2020.19280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Effectiveness of favipiravir in COVID-19: a live systematic review.

    Özlüşen, Batu / Kozan, Şima / Akcan, Rüştü Emre / Kalender, Mekselina / Yaprak, Doğukan / Peltek, İbrahim Batuhan / Keske, Şiran / Gönen, Mehmet / Ergönül, Önder

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2021  Volume 40, Issue 12, Page(s) 2575–2583

    Abstract: We performed a systematic review and meta-analysis for the effectiveness of Favipiravir on the fatality and the requirement of mechanical ventilation for the treatment of moderate to severe COVID-19 patients. We searched available literature and reported  ...

    Abstract We performed a systematic review and meta-analysis for the effectiveness of Favipiravir on the fatality and the requirement of mechanical ventilation for the treatment of moderate to severe COVID-19 patients. We searched available literature and reported it by using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Until June 1, 2021, we searched PubMed, bioRxiv, medRxiv, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar by using the keywords "Favipiravir" and terms synonymous with COVID-19. Studies for Favipiravir treatment compared to standard of care among moderate and severe COVID-19 patients were included. Risk of bias assessment was performed using Revised Cochrane risk of bias tool for randomized trials (RoB 2) and ROBINS-I assessment tool for non-randomized studies. We defined the outcome measures as fatality and requirement for mechanical ventilation. A total of 2702 studies were identified and 12 clinical trials with 1636 patients were analyzed. Nine out of 12 studies were randomized controlled trials. Among the randomized studies, one study has low risk of bias, six studies have moderate risk of bias, and 2 studies have high risk of bias. Observational studies were identified as having moderate risk of bias and non-randomized study was found to have serious risk of bias. Our meta-analysis did not reveal any significant difference between the intervention and the comparator on fatality rate (OR 1.11, 95% CI 0.64-1.94) and mechanical ventilation requirement (OR 0.50, 95% CI 0.13-1.95). There is no significant difference in fatality rate and mechanical ventilation requirement between Favipiravir treatment and the standard of care in moderate and severe COVID-19 patients.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amides/administration & dosage ; Amides/adverse effects ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; COVID-19/drug therapy ; COVID-19/mortality ; COVID-19/therapy ; COVID-19/virology ; Female ; Humans ; Male ; Middle Aged ; Observational Studies as Topic ; Pyrazines/administration & dosage ; Pyrazines/adverse effects ; Randomized Controlled Trials as Topic ; Respiration, Artificial ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Young Adult
    Chemical Substances Amides ; Antiviral Agents ; Pyrazines ; favipiravir (EW5GL2X7E0)
    Language English
    Publishing date 2021-08-04
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-021-04307-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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