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  1. Article ; Online: Determination of amoxicillin trihydrate impurities 4-hydroxyphenylglycine (4-HPG) and 6-Aminopenicylanic acid (6-APA) by means of ultraviolet spectroscopy.

    Ergin, M F / Yasa, Hasniye

    Methods and applications in fluorescence

    2022  Volume 10, Issue 3

    Abstract: Amoxicillin is one of the broad- ... ...

    Abstract Amoxicillin is one of the broad-spectrum
    MeSH term(s) Amoxicillin ; Glycine/analogs & derivatives ; Humans ; Sodium Hydroxide ; Solvents ; Spectrum Analysis
    Chemical Substances Solvents ; Sodium Hydroxide (55X04QC32I) ; 4-hydroxyphenylglycine (7UYG7X0F53) ; Amoxicillin (804826J2HU) ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2022-05-25
    Publishing country England
    Document type Journal Article
    ISSN 2050-6120
    ISSN (online) 2050-6120
    DOI 10.1088/2050-6120/ac7037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: New Strategy for the Synthesis of Some Valuable Chiral 1,3-Diols with High Enantiomeric Purity: New Organocatalyst, Asymmetric Aldol Reaction, and Reduction.

    Yıldız, Tülay / Hasdemir, Belma / Yaşa, Hasniye / Başpınar Küçük, Hatice

    ACS omega

    2024  Volume 9, Issue 11, Page(s) 12657–12664

    Abstract: Chiral 1,3-diols are highly valuable molecules used in industries such as pharmaceuticals, cosmetics, and agriculture. Therefore, in this study, a new strategy was developed to synthesize enantiomerically pure (>99% ...

    Abstract Chiral 1,3-diols are highly valuable molecules used in industries such as pharmaceuticals, cosmetics, and agriculture. Therefore, in this study, a new strategy was developed to synthesize enantiomerically pure (>99%
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c07948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Investigating the Role of Citric Acid as a Natural Acid on the Crystallization of Amoxicillin Trihydrate.

    Celik Onar, Hulya / Ergin, Mustafa Fatih / Yasa, Hasniye

    ACS omega

    2023  Volume 8, Issue 39, Page(s) 36344–36354

    Abstract: This study investigates the use of environmentally friendly citric acid as the main player in the process, rather than as an additive, to remove impurities from amoxicillin trihydrate (AMCT) crystals, aiming to optimize their purity and yield. By ... ...

    Abstract This study investigates the use of environmentally friendly citric acid as the main player in the process, rather than as an additive, to remove impurities from amoxicillin trihydrate (AMCT) crystals, aiming to optimize their purity and yield. By manipulating the concentration of citric acid, mixing speed, crystallization time, and pH, the researchers conducted experiments using a full factorial design. The dissolution stage was analyzed in both batch and continuous crystallization processes, emphasizing the significance of citric acid in enhancing crystallization. HPLC analyses were performed on the resulting crystals, and the data were analyzed using the Multi-Vari Chart program. The findings demonstrated that higher citric acid concentrations positively affected the yield, while factors such as crystallization time, mixing speed, and pH also contributed to the increased yield. The crystals obtained exhibited desirable dimensions sought after in the pharmaceutical industry, eliminating the need for additional purification steps. This study showcased the potential of citric acid in AMCT crystallization, offering advantages in product design, purification, and synthesis. The optimized conditions included a citric acid concentration of 2.0 M, mixing speed of 1000 rpm, crystallization time of 120 min, and pH of 5.5. Notably, the developed process proved to be environmentally friendly by avoiding the use of harmful chemicals, serving as a green alternative for crystallization processes, and producing purer AMCT products. Overall, this research contributes to the existing literature by highlighting the efficacy of citric acid in impurity removal and the optimization of AMCT crystal purity and yield.
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c04965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Synthesis and elastase inhibition activities of novel aryl, substituted aryl, and heteroaryl oxime ester derivatives.

    Hasdemir, Belma / Sacan, Ozlem / Yasa, Hasniye / Kucuk, Hatice B / Yusufoglu, Ayse S / Yanardag, Refiye

    Archiv der Pharmazie

    2017  Volume 351, Issue 2

    Abstract: Fifteen novel aryl, substituted aryl and heteroaryl γ-hydroxy- (2a-e), γ-methoxyimino- (3a-e), and γ-benzyloxyimino- (4a-e) butyric acid methyl esters were investigated for their enzyme inhibition, and the synthesis of 10 compounds (3a-e, 4a-e) is given ... ...

    Abstract Fifteen novel aryl, substituted aryl and heteroaryl γ-hydroxy- (2a-e), γ-methoxyimino- (3a-e), and γ-benzyloxyimino- (4a-e) butyric acid methyl esters were investigated for their enzyme inhibition, and the synthesis of 10 compounds (3a-e, 4a-e) is given in this study. The other five compounds (2a-e) were synthesized before in another study. Compounds 3a-e and 4a-e were synthesized in this work as original compounds and characterized by
    MeSH term(s) Dose-Response Relationship, Drug ; Humans ; Leukocyte Elastase/antagonists & inhibitors ; Leukocyte Elastase/metabolism ; Molecular Structure ; Serine Proteinase Inhibitors/chemical synthesis ; Serine Proteinase Inhibitors/chemistry ; Serine Proteinase Inhibitors/pharmacology ; Structure-Activity Relationship
    Chemical Substances Serine Proteinase Inhibitors ; Leukocyte Elastase (EC 3.4.21.37)
    Language English
    Publishing date 2017-12-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6381-2
    ISSN 1521-4184 ; 0365-6233 ; 1437-1014
    ISSN (online) 1521-4184
    ISSN 0365-6233 ; 1437-1014
    DOI 10.1002/ardp.201700269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Chemical Composition of the Essential Oil of Mentha pulegium L. from Bodrum, Turkey

    Yasa, Hasniye / Onar, Hülya Çelik / Yusufoglu, Ayse Sergüzel

    Journal of essential oil-bearing plants. 2012 Jan. 1, v. 15, no. 6

    2012  

    Abstract: The aim of this study was to investigate the chemical composition of Mentha pulegium L.’s essential oils from Bodrum, Turkey and to compare it with the literature values. The essential oils in this study were prepared by two different methods, by ... ...

    Abstract The aim of this study was to investigate the chemical composition of Mentha pulegium L.’s essential oils from Bodrum, Turkey and to compare it with the literature values. The essential oils in this study were prepared by two different methods, by Clevenger and Steam Distillation. The yields of the essential oils, obtained by Clevenger and steam distillation were 1.6 % and 1.1 %, respectively. The composition of the essential oils were analysed by GC and GC-MS using Carbowax-20M as polar and DB-5 as apolar columns. The headspace analysis of this plant was examined, too. The basic components of steam distillation method on apolar DB-5 column, were isomenthone (42.1 %), pulegone (28.9 %), piperitenone (11.8 %) and piperitone (11.6 %). Analysis of Clevenger type method on the same column gave pulegone (34.6 %), piperitenone (31.4 %), isomenthone (17.9 %) and piperitone (9.7 %) as main components. The major components of headspace analysis of Mentha pulegium L. on DB5 column were isomenthone (52.6 %), pulegone (29.5 %) and menthol (3.6 %).
    Keywords Mentha pulegium ; chemical composition ; distillation ; essential oils ; gas chromatography ; headspace analysis ; mass spectrometry ; menthol ; steam ; Turkey (country)
    Language English
    Dates of publication 2012-0101
    Size p. 1040-1043.
    Publishing place Taylor & Francis Group
    Document type Article
    ISSN 0976-5026
    DOI 10.1080/0972060X.2012.10662609
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Chemical Composition of the Essential Oil of Mentha pulegium L. from Bodrum, Turkey

    Yasa, Hasniye / Onar, Hülya Çelik / Yusufoglu, Ayse Sergüzel

    Journal of essential oil-bearing plants

    Volume v. 15,, Issue no. 6

    Abstract: The aim of this study was to investigate the chemical composition of Mentha pulegium L.’s essential oils from Bodrum, Turkey and to compare it with the literature values. The essential oils in this study were prepared by two different methods, by ... ...

    Abstract The aim of this study was to investigate the chemical composition of Mentha pulegium L.’s essential oils from Bodrum, Turkey and to compare it with the literature values. The essential oils in this study were prepared by two different methods, by Clevenger and Steam Distillation. The yields of the essential oils, obtained by Clevenger and steam distillation were 1.6 % and 1.1 %, respectively. The composition of the essential oils were analysed by GC and GC-MS using Carbowax-20M as polar and DB-5 as apolar columns. The headspace analysis of this plant was examined, too. The basic components of steam distillation method on apolar DB-5 column, were isomenthone (42.1 %), pulegone (28.9 %), piperitenone (11.8 %) and piperitone (11.6 %). Analysis of Clevenger type method on the same column gave pulegone (34.6 %), piperitenone (31.4 %), isomenthone (17.9 %) and piperitone (9.7 %) as main components. The major components of headspace analysis of Mentha pulegium L. on DB5 column were isomenthone (52.6 %), pulegone (29.5 %) and menthol (3.6 %).
    Keywords gas chromatography ; distillation ; menthol ; headspace analysis ; mass spectrometry ; essential oils ; chemical composition ; Mentha pulegium ; steam
    Language English
    Document type Article
    ISSN 0976-5026
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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