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  1. Article ; Online: Difficult-to-treat (DTR)

    Vega, Ana D / DeRonde, Kailynn / Jimenez, Adriana / Piazza, Michael / Vu, Christine / Martinez, Octavio / Rojas, Laura J / Marshall, Steven / Yasmin, Mohamad / Bonomo, Robert A / Abbo, Lilian M

    Antimicrobial agents and chemotherapy

    2024  Volume 68, Issue 5, Page(s) e0147423

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    MeSH term(s) Humans ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/genetics ; beta-Lactamases/genetics ; Male ; Female ; Middle Aged ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Retrospective Studies ; Microbial Sensitivity Tests ; Integrons/genetics ; Aged ; Drug Combinations ; Adult ; Azabicyclo Compounds/therapeutic use ; Ceftazidime/therapeutic use ; Ceftazidime/pharmacology ; Aztreonam/therapeutic use ; Aztreonam/pharmacology ; Carbapenems/therapeutic use ; Carbapenems/pharmacology ; Antimicrobial Stewardship ; Drug Resistance, Multiple, Bacterial/genetics
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; Anti-Bacterial Agents ; Drug Combinations ; Azabicyclo Compounds ; avibactam, ceftazidime drug combination ; Ceftazidime (9M416Z9QNR) ; Aztreonam (G2B4VE5GH8) ; Carbapenems
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01474-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 809: Show issues Location:
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  2. Article: Polymyxins: To Combine or Not to Combine?

    Perez, Federico / El Chakhtoura, Nadim G / Yasmin, Mohamad / Bonomo, Robert A

    Antibiotics (Basel, Switzerland)

    2019  Volume 8, Issue 2

    Abstract: Polymyxins have been a mainstay for the treatment of extensively drug resistant (XDR) Gram-negative bacteria for the past two decades. Many questions regarding the clinical use of polymyxins have been answered, but whether the administration of ... ...

    Abstract Polymyxins have been a mainstay for the treatment of extensively drug resistant (XDR) Gram-negative bacteria for the past two decades. Many questions regarding the clinical use of polymyxins have been answered, but whether the administration of polymyxins in combination with other antibiotics leads to better outcomes remains unknown. This review discusses the limitations of observational studies that suggest a benefit of combinations of colistin and carbapenems to treat infections caused by carbapenem-resistant Enterobacteriaceae (CRE), especially
    Language English
    Publishing date 2019-04-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics8020038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Utilizing Ceftazidime/Avibactam Therapeutic Drug Monitoring in the Treatment of Neurosurgical Meningitis Caused by Difficult-to-Treat Resistant

    Yasmin, Mohamad / Nutman, Amir / Wang, Lu / Marshall, Steven / Chen, Ke / Wang, Jiping / Yahav, Dafna / Lupinsky, Liad / Hujer, Andrea M / Bhimraj, Adarsh / van Duin, David / Li, Jian / Bonomo, Robert A

    Open forum infectious diseases

    2023  Volume 10, Issue 11, Page(s) ofad507

    Abstract: Background: Central nervous system (CNS) infections caused by : Methods: Therapeutic drug monitoring (TDM) was performed in 3 patients with health care-associated ventriculitis and meningitis (HAVM) using CAZ-AVI 2.5 g infused intravenously every 8 ... ...

    Abstract Background: Central nervous system (CNS) infections caused by
    Methods: Therapeutic drug monitoring (TDM) was performed in 3 patients with health care-associated ventriculitis and meningitis (HAVM) using CAZ-AVI 2.5 g infused intravenously every 8 hours as standard and extended infusion. Simultaneous CSF and plasma samples were obtained throughout the dosing interval in each patient. Concentrations of CAZ and AVI were determined by liquid chromatography/mass spectrometry.
    Results: Bacterial identification revealed KPC-producing
    Conclusions: Postinfusion concentrations of CAZ-AVI were measured in plasma and CSF samples obtained from 3 patients with complicated CNS infections caused by antimicrobial-resistant isolates. The measured concentrations revealed that standard CAZ and AVI exposures sufficiently attained values correlating to 50%
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Characterization of a Novel Pathogen in Immunocompromised Patients:

    Yasmin, Mohamad / Rojas, Laura J / Marshall, Steven H / Hujer, Andrea M / Cmolik, Anna / Marshall, Emma / Boucher, Helen W / Vila, Alejandro J / Soldevila, Maxime / Diene, Seydina M / Rolain, Jean-Marc / Bonomo, Robert A

    Open forum infectious diseases

    2023  Volume 10, Issue 2, Page(s) ofad014

    Abstract: Background: Elizabethkingia anophelis: Methods: Whole-genome sequencing (WGS) was conducted to accurately identify isolate species and elucidate the determinants of β-lactam resistance. Antimicrobial susceptibility testing was performed using broth ... ...

    Abstract Background: Elizabethkingia anophelis
    Methods: Whole-genome sequencing (WGS) was conducted to accurately identify isolate species and elucidate the determinants of β-lactam resistance. Antimicrobial susceptibility testing was performed using broth microdilution and disk diffusion assays. To assess the functional contribution of the major metallo-β-lactamase (MBL) encoding genes to the resistance profile,
    Results: WGS identified the organism as
    Conclusions: Using WGS, we accurately identified and characterized an extensively drug-resistant
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad014
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  5. Article ; Online: Investigating and Treating a Corneal Ulcer Due to Extensively Drug-Resistant Pseudomonas aeruginosa.

    Morelli, Morgan K / Kloosterboer, Amy / Fulton, Scott A / Furin, Jennifer / Newman, Nicholas / Omar, Ahmed F / Rojas, Laura J / Marshall, Steven H / Yasmin, Mohamad / Bonomo, Robert A

    Antimicrobial agents and chemotherapy

    2023  Volume 67, Issue 7, Page(s) e0027723

    Abstract: Resistant Gram-negative bacteria are a growing concern in the United States, leading to significant morbidity and mortality. We identified a 72-year-old female patient who presented with unilateral vision loss. She was found to have a large corneal ulcer ...

    Abstract Resistant Gram-negative bacteria are a growing concern in the United States, leading to significant morbidity and mortality. We identified a 72-year-old female patient who presented with unilateral vision loss. She was found to have a large corneal ulcer with hypopyon. Culture of corneal scrapings grew extensively drug-resistant Pseudomonas aeruginosa. Treatment involved a combination of systemic and topical antibiotics. Whole genome sequencing revealed the presence of
    MeSH term(s) Female ; Humans ; Aged ; Corneal Ulcer/drug therapy ; Corneal Ulcer/microbiology ; Pseudomonas aeruginosa/genetics ; Anti-Bacterial Agents/therapeutic use ; Gram-Negative Bacteria ; Pseudomonas Infections/microbiology ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.00277-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Orthopedic Implant-Associated and Central Venous Catheter-Associated Infections Caused by

    Twardy, Brandon S / Yasmin, Mohamad / Bej, Taissa / Wera, Glenn D / Marshall, Steven H / Rojas, Laura J / Bonomo, Robert A / Jump, Robin L P

    Surgical infections

    2021  Volume 23, Issue 1, Page(s) 84–88

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Aged ; Catheter-Related Infections/epidemiology ; Central Venous Catheters ; Delivery of Health Care ; Humans ; Male ; Microbacterium ; Veterans
    Language English
    Publishing date 2021-10-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1440120-4
    ISSN 1557-8674 ; 1096-2964
    ISSN (online) 1557-8674
    ISSN 1096-2964
    DOI 10.1089/sur.2021.133
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    Zs.A 5617: Show issues Location:
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  7. Article: Idiopathic Hemophagocytic Lymphohistiocytosis During Pregnancy Treated with Steroids.

    Samra, Bachar / Yasmin, Mohamad / Arnaout, Sami / Azzi, Jacques

    Hematology reports

    2015  Volume 7, Issue 3, Page(s) 6100

    Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe clinical syndrome characterized by a dysregulated hyperinflammatory immune response. The diagnosis of HLH during pregnancy is especially challenging due to the rarity of this condition. The ... ...

    Abstract Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe clinical syndrome characterized by a dysregulated hyperinflammatory immune response. The diagnosis of HLH during pregnancy is especially challenging due to the rarity of this condition. The highly variable clinical presentation, laboratory findings, and associated diagnoses accompanying this syndrome further complicate the problem. A pronounced hyperferritinemia in the setting of systemic signs and symptoms along with a negative infectious and rheumatological workup should raise suspicions for HLH. While treatment ideally consists of immunosuppressive chemotherapy and hematopoietic stem cell transplant, the potential toxicity to both the pregnant woman and the fetus poses a challenging decision. We report the first case of idiopathic HLH presenting as fever of unknown origin in a pregnant woman successfully treated with steroids.
    Language English
    Publishing date 2015-09-23
    Publishing country Italy
    Document type Case Reports
    ZDB-ID 2586645-X
    ISSN 2038-8330 ; 2038-8322
    ISSN (online) 2038-8330
    ISSN 2038-8322
    DOI 10.4081/hr.2015.6100
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  8. Article: Using Therapeutic Drug Monitoring to Treat KPC-Producing

    Yasmin, Mohamad / Hanrahan, Jennifer / Marshall, Steven / Lodise, Thomas P / Chen, Liang / Perez, Federico / Kreiswirth, Barry / Bonomo, Robert A

    Open forum infectious diseases

    2020  Volume 7, Issue 9, Page(s) ofaa349

    Abstract: This report describes the treatment ... ...

    Abstract This report describes the treatment of
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofaa349
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  9. Article ; Online: A 27-year experience with infective endocarditis in Lebanon.

    El-Chakhtoura, Nadim / Yasmin, Mohamad / Kanj, Souha S / Baban, Tania / Sfeir, Jad / Kanafani, Zeina A

    Journal of infection and public health

    2017  Volume 10, Issue 6, Page(s) 734–739

    Abstract: Although rare, infective endocarditis (IE) continues to cause significant morbidity and mortality. Previous data from the American University of Beirut Medical Center (AUBMC) had shown predominance of streptococcal infection. As worldwide studies in ... ...

    Abstract Although rare, infective endocarditis (IE) continues to cause significant morbidity and mortality. Previous data from the American University of Beirut Medical Center (AUBMC) had shown predominance of streptococcal infection. As worldwide studies in developed countries show increasing trends in Staphylococcus aureus endocarditis, it becomes vital to continually inspect local data for epidemiological variations. We reviewed all IE cases between 2001 and 2014, and we performed a comparison to a historical cohort of 86 IE cases from 1987 to 2001. A total of 80 patients were diagnosed with IE between 2001 and 2014. The mean age was 61 years. The most commonly isolated organisms were streptococci (37%), compared to 51% in the previous cohort. S. aureus accounted for 11%. Only one S. aureus isolate was methicillin-resistant. In the historical cohort, 26% of cases were caused by S. aureus. Enterococci ranked behind staphylococci with 22% of total cases, while in the previous cohort, enterococcal IE was only 4%. Compared to previous data from AUBMC, the rates of streptococcal and staphylococcal endocarditis have decreased while enterococcal endocarditis has increased. This study reconfirms that in Lebanon, a developing country, we continue to have a low predominance of staphylococci as etiologic agents in IE.
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Journal Article
    ISSN 1876-035X
    ISSN (online) 1876-035X
    DOI 10.1016/j.jiph.2016.11.017
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  10. Article ; Online: Epidemiology of bloodstream infections caused by methicillin-resistant Staphylococcus aureus at a tertiary care hospital in New York.

    Yasmin, Mohamad / El Hage, Halim / Obeid, Rita / El Haddad, Hanine / Zaarour, Mazen / Khalil, Ambreen

    American journal of infection control

    2016  Volume 44, Issue 1, Page(s) 41–46

    Abstract: Background: In the United States, bloodstream infections (BSIs) are predominated by Staphylococcus aureus. The proportion of community-acquired methicillin-resistant S aureus (MRSA) BSI is on the rise. The goal of this study is to explore the ... ...

    Abstract Background: In the United States, bloodstream infections (BSIs) are predominated by Staphylococcus aureus. The proportion of community-acquired methicillin-resistant S aureus (MRSA) BSI is on the rise. The goal of this study is to explore the epidemiology of BSI caused by S aureus within Staten Island, New York.
    Methods: This is a case-case-control study from April 2012-October 2014. Cases were comprised of patients with BSI secondary to MRSA and methicillin-sensitive S aureus (MSSA). The control group contained patients who were hospitalized during the same time period as cases but did not develop infections during their stay. Two multivariable models compared each group of cases with the uninfected controls.
    Results: A total of 354 patients were analyzed. Infections were community acquired in 76% of cases. The major source of BSI was skin-related infections (n = 76). The first multivariable model showed that recent central venous catheter placement was an independent infection risk factor (odds ratio [OR] = 80.7; 95% confidence interval [CI], 2.2-3,014.1). In the second model, prior hospital stay >3 days (OR = 4.1; 95% CI, 1.5-5.7) and chronic kidney disease (OR = 3.0; 95% CI, 1.01-9.2) were uniquely associated with MSSA. Persistent bacteremia, recurrence, and other hospital-acquired infections were more likely with MRSA BSI than MSSA BSI.
    Conclusion: Most infections were community acquired. The presence of a central venous catheter constituted a robust independent risk factor for MRSA BSI. Patients with MRSA BSI suffered worse outcomes than those with MSSA BSI.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacteremia/epidemiology ; Bacteremia/etiology ; Case-Control Studies ; Catheterization, Central Venous/adverse effects ; Community-Acquired Infections/epidemiology ; Cross Infection/epidemiology ; Female ; Humans ; Length of Stay ; Male ; Methicillin Resistance ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Middle Aged ; New York/epidemiology ; Renal Insufficiency, Chronic/complications ; Risk Factors ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/etiology ; Staphylococcal Infections/microbiology ; Tertiary Healthcare ; Young Adult
    Language English
    Publishing date 2016-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2015.08.005
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