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  1. Article ; Online: The Impact of the Molecular Weight of Degradation Products with Silicon from Porous Chitosan-Siloxane Hybrids on Neuronal Cell Behavior.

    Shirosaki, Yuki / Fregnan, Federica / Muratori, Luisa / Yasutomi, Saki / Geuna, Stefano / Raimondo, Stefania

    Polymers

    2023  Volume 15, Issue 15

    Abstract: Silicon (Si) is an essential trace element in the human body and it exists in connective tissue as aqueous orthosilicic acid. Porous chitosan-3-glycidoxypropyltrimethoxysilane (GPTMS) hybrids can regenerate nerve tissue and recover sensor and motor ... ...

    Abstract Silicon (Si) is an essential trace element in the human body and it exists in connective tissue as aqueous orthosilicic acid. Porous chitosan-3-glycidoxypropyltrimethoxysilane (GPTMS) hybrids can regenerate nerve tissue and recover sensor and motor functions. However, the structures and roles of the degradation products with Si extracted from the hybrids in nerve regeneration are not clear. In this study, we prepared porous chitosan-GPTMS hybrids with different amounts of GPTMS to amino groups of chitosan (chitosan:GPTMS = 1:0.5 and 1:1 molar ratios). The structures of the degradation products with Si from the hybrids were examined using time-of-flight mass spectrometry, and biological assessments were conducted in order to evaluate their potential use in the preparation of devices for nerve repair. Glial and motor cell lines and ex vivo explants of dorsal root ganglia were used in this study for evaluating their behavior in the presence of the different degradation products with Si. The structure of the degradation products with Si depended on the starting composition. The results showed that glial cell proliferation was lower in the medium with the higher-molecular-weight degradation products with Si. Moreover, motor cell line differentiation and the neurite outgrowth of dorsal root ganglion explants were improved with the lower-molecular-weight degradation products with Si. The results obtained could be useful for designing a new nerve regeneration scaffold including silicon components.
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15153272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Silane Coupling Agent Modifies the Mechanical Properties of a Chitosan Microfiber.

    Shirosaki, Yuki / Okabayashi, Toshinobu / Yasutomi, Saki

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 22

    Abstract: Chitosan microfibers are widely used in medical applications because they have favorable inherent properties. However, their mechanical properties require further improvement. In the present study, a trimethoxysilane aldehyde (TMSA) crosslinking agent ... ...

    Abstract Chitosan microfibers are widely used in medical applications because they have favorable inherent properties. However, their mechanical properties require further improvement. In the present study, a trimethoxysilane aldehyde (TMSA) crosslinking agent was added to chitosan microfibers to improve their tensile strength. The chitosan microfibers were prepared using a coagulation method. The tensile strength of the chitosan microfibers was improved by crosslinking them with TMSA, even when only a small amount was used (less than 1%). TMSA did not change the orientation of the chitosan molecules. Furthermore, aldehyde derived from TMSA did not remain, and siloxane units were formed in the microfibers.
    MeSH term(s) Aldehydes/chemistry ; Chitosan/chemistry ; Cross-Linking Reagents/chemistry ; Materials Testing ; Ninhydrin/chemistry ; Pressure ; Silanes/chemistry ; Silicon/chemistry ; Spectroscopy, Fourier Transform Infrared ; Stress, Mechanical ; Tensile Strength ; Tissue Scaffolds ; X-Ray Diffraction
    Chemical Substances Aldehydes ; Cross-Linking Reagents ; Silanes ; Chitosan (9012-76-4) ; Ninhydrin (HCL6S9K23A) ; trimethoxysilane (V1J39XPF91) ; Silicon (Z4152N8IUI)
    Language English
    Publishing date 2020-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25225292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Cytocompatible and Antibacterial Properties of Chitosan-Siloxane Hybrid Spheres.

    Shirosaki, Yuki / Nakatsukasa, Manato / Yasutomi, Saki / Cruz-Neves, Susana / Hayakawa, Satoshi / Osaka, Akiyoshi / Maeda, Toshinari / Miyazaki, Toshiki

    Polymers

    2019  Volume 11, Issue 10

    Abstract: Microporous spheres in a hybrid system consisting of chitosan and γ-glycidoxypropyltrimethoxysilane (GPTMS) have advantages in a range of applications, e.g., as vehicles for cell transplantation and soft tissue defect filling materials, because of their ... ...

    Abstract Microporous spheres in a hybrid system consisting of chitosan and γ-glycidoxypropyltrimethoxysilane (GPTMS) have advantages in a range of applications, e.g., as vehicles for cell transplantation and soft tissue defect filling materials, because of their excellent cytocompatibility with various cells. In this study, microporous chitosan-GPTMS spheres were prepared by dropping chitosan-GPTMS precursor sols, with or without a cerium chloride, into liquid nitrogen using a syringe pump. The droplets were then freeze dried to give the pores of size 10 to 50 μm. The cell culture tests showed that L929 fibroblast-like cells migrated into the micropores larger than 50 μm in diameter, whereas MG63 osteoblast-like cells proliferated well and covered the granule surfaces. The spheres with cerium chloride showed antibacterial properties against both gram-negative and gram-positive bacteria.
    Language English
    Publishing date 2019-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym11101676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enhanced biosafety of silica coated gadolinium based nanoparticles.

    Laranjeira, Marta / Shirosaki, Yuki / Yoshimatsu Yasutomi, Saki / Miyazaki, Toshiki / Monteiro, Fernando Jorge

    Journal of materials science. Materials in medicine

    2017  Volume 28, Issue 3, Page(s) 46

    Abstract: One of the most important and novel approaches of biomedical engineering is the development of new, effective and non-invasive medical diagnosis abilities, and treatments that have such requirements as advanced technologies for tumor imaging. Gadolinium ( ...

    Abstract One of the most important and novel approaches of biomedical engineering is the development of new, effective and non-invasive medical diagnosis abilities, and treatments that have such requirements as advanced technologies for tumor imaging. Gadolinium (Gd) compounds can be used as MRI contrast agents, however the release of Gd
    MeSH term(s) Biomedical Engineering ; Cell Proliferation ; Cell Survival ; Contrast Media/chemistry ; Fibroblasts/metabolism ; Gadolinium/chemistry ; Humans ; Hydrogen-Ion Concentration ; L-Lactate Dehydrogenase/metabolism ; Magnetic Resonance Imaging ; Magnetite Nanoparticles/chemistry ; Metal Nanoparticles/chemistry ; Microscopy, Electron, Transmission ; Nanotechnology/methods ; Necrosis/drug therapy ; Pancreatitis/drug therapy ; Propylamines/chemistry ; Renal Insufficiency/drug therapy ; Silanes/chemistry ; Silicon Dioxide/chemistry ; Spectroscopy, Fourier Transform Infrared ; Temperature ; X-Ray Diffraction
    Chemical Substances Contrast Media ; Magnetite Nanoparticles ; Propylamines ; Silanes ; Silicon Dioxide (7631-86-9) ; Gadolinium (AU0V1LM3JT) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; amino-propyl-triethoxysilane (L8S6UBW552)
    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1031752-1
    ISSN 1573-4838 ; 0957-4530
    ISSN (online) 1573-4838
    ISSN 0957-4530
    DOI 10.1007/s10856-017-5855-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3040: Show issues Location:
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