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  1. AU="Yatoo, Ali Mohd"
  2. AU="Zhang, Zhiru"
  3. AU="Hadie Adams"
  4. AU="Gaskin, Thomas R"
  5. AU="Guo, Chong"
  6. AU="Guocan Wang"
  7. AU="Catherine Crenn-Hebert"
  8. AU="Alistar, Cristina F"
  9. AU="Makhani, Sarah S"
  10. AU="Tayyeb Pourfallah"
  11. AU="Mauad, Thais"

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  1. Artikel: Production of Nutrient-Enriched Vermicompost from Aquatic Macrophytes Supplemented with Kitchen Waste: Assessment of Nutrient Changes, Phytotoxicity, and Earthworm Biodynamics

    Yatoo, Ali Mohd / Bhat, Sartaj Ahmad / Ali, Md. Niamat / Baba, Zahoor Ahmad / Zaheen, Zarka

    Agronomy. 2022 May 29, v. 12, no. 6

    2022  

    Abstract: Vermicompost is an organic fertilizer rich in nutrients, beneficial microbes, and plant growth hormones that not only enhances the growth of crops but also contributes to the improvement in the physicochemical and biological properties of the soil. ... ...

    Abstract Vermicompost is an organic fertilizer rich in nutrients, beneficial microbes, and plant growth hormones that not only enhances the growth of crops but also contributes to the improvement in the physicochemical and biological properties of the soil. However, its lower nutrient content makes it less preferable among farmers and limits its applicability. Here, we investigate, for the first time, nutrient enrichment of vermicompost by supplementing the free-floating macrophyte biomass with cow manure and organic nutrient supplements (eggshell, bone meal, banana peel, and tea waste). Free-floating macrophytes are aquatic plants that are found suspended on the water surface, playing a significant role in the structural and functional aspects of aquatic ecosystems. However, uncontrolled proliferation of these macrophytes endangers these ecosystems, having both economic and ecological implications; therefore, they need to be managed. Results showed an enhanced total nitrogen (2.87%), total phosphorus (0.86%), total potassium (3.74%), and other nutrients in vermicompost amended with cow manure and nutrient supplements. Highest biomass gain (710–782 mg), growth rate (11.83–13.04 mg), and reproduction rate (3.34–3.75 cocoons per worm) was also observed, indicating that amending bulking agent and nutrient supplements not only enhance the nutrient content of the final product but also improve overall earthworm activity. The stability and maturity of vermicompost, as indicated by C/N (<20) and Germination Index (>80), indicates that vermicompost obtained is suitable for agricultural applications. The study concluded that amendment of cow manure and organic nutrient supplements results in producing mature and nutrient-enriched vermicompost suitable for sustainable agricultural production.
    Schlagwörter agronomy ; banana peels ; biomass ; biomechanics ; bone meal ; cow manure ; earthworms ; egg shell ; germination ; kitchen waste ; macrophytes ; nutrient content ; phytotoxicity ; plant growth ; potassium ; reproduction ; soil ; sustainable agriculture ; tea ; total nitrogen ; total phosphorus ; vermicomposts
    Sprache Englisch
    Erscheinungsverlauf 2022-0529
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy12061303
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: TGF-β signaling pathway: Therapeutic targeting and potential for anti-cancer immunity.

    Ali, Shafat / Rehman, Muneeb U / Yatoo, Ali Mohd / Arafah, Azher / Khan, Andleeb / Rashid, Summya / Majid, Sabhiya / Ali, Aarif / Ali, Md Niamat

    European journal of pharmacology

    2023  Band 947, Seite(n) 175678

    Abstract: Transforming growth factor-β (TGFβ) is a pleiotropic secretory cytokine exhibiting both cancer-inhibitory and promoting properties. It transmits its signals via Suppressor of Mother against Decapentaplegic (SMAD) and non-SMAD pathways and regulates cell ... ...

    Abstract Transforming growth factor-β (TGFβ) is a pleiotropic secretory cytokine exhibiting both cancer-inhibitory and promoting properties. It transmits its signals via Suppressor of Mother against Decapentaplegic (SMAD) and non-SMAD pathways and regulates cell proliferation, differentiation, invasion, migration, and apoptosis. In non-cancer and early-stage cancer cells, TGFβ signaling suppresses cancer progression via inducing apoptosis, cell cycle arrest, or anti-proliferation, and promoting cell differentiation. On the other hand, TGFβ may also act as an oncogene in advanced stages of tumors, wherein it develops immune-suppressive tumor microenvironments and induces the proliferation of cancer cells, invasion, angiogenesis, tumorigenesis, and metastasis. Higher TGFβ expression leads to the instigation and development of cancer. Therefore, suppressing TGFβ signals may present a potential treatment option for inhibiting tumorigenesis and metastasis. Different inhibitory molecules, including ligand traps, anti-sense oligo-nucleotides, small molecule receptor-kinase inhibitors, small molecule inhibitors, and vaccines, have been developed and clinically trialed for blocking the TGFβ signaling pathway. These molecules are not pro-oncogenic response-specific but block all signaling effects induced by TGFβ. Nonetheless, targeting the activation of TGFβ signaling with maximized specificity and minimized toxicity can enhance the efficacy of therapeutic approaches against this signaling pathway. The molecules that are used to target TGFβ are non-cytotoxic to cancer cells but designed to curtail the over-activation of invasion and metastasis driving TGFβ signaling in stromal and cancer cells. Here, we discussed the critical role of TGFβ in tumorigenesis, and metastasis, as well as the outcome and the promising achievement of TGFβ inhibitory molecules in the treatment of cancer.
    Mesh-Begriff(e) Humans ; Neoplasms/drug therapy ; Transforming Growth Factor beta/metabolism ; Signal Transduction ; Cell Differentiation ; Carcinogenesis ; Tumor Microenvironment
    Chemische Substanzen Transforming Growth Factor beta
    Sprache Englisch
    Erscheinungsdatum 2023-03-27
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 80121-5
    ISSN 1879-0712 ; 0014-2999
    ISSN (online) 1879-0712
    ISSN 0014-2999
    DOI 10.1016/j.ejphar.2023.175678
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Sustainable management of diseases and pests in crops by vermicompost and vermicompost tea. A review

    Yatoo, Ali Mohd / Ali, Md. Niamat / Baba, Zahoor Ahmad / Hassan, Birjees

    Agronomy for sustainable development. 2021 Feb., v. 41, no. 1

    2021  

    Abstract: The intensive use of inorganic fertilizers and pesticides in the agricultural field has globally destroyed soil fertility, killed beneficial microorganisms, and also decreased natural resistance in crops, thereby making them more vulnerable to diseases ... ...

    Abstract The intensive use of inorganic fertilizers and pesticides in the agricultural field has globally destroyed soil fertility, killed beneficial microorganisms, and also decreased natural resistance in crops, thereby making them more vulnerable to diseases besides affecting human health and the environment. To overcome these problems, it is very important to shift our attention towards eco-friendly alternatives like vermicompost and vermicompost tea which not only can increase crop growth and yield, suppress diseases and pests sustainably but can also protect human health and the environment. Vermicompost with its rich nutrient content, plant growth promoters like auxins, gibberellins, cytokinins, and beneficial microbes not only improves the growth and yield of crops but also increases the diversity and activity of antagonistic microbes and nematodes, which helps to suppress pests and diseases caused by soil-borne phytopathogens. Vermicompost tea also has a tremendous potential to protect plants from diseases and its application to plants can coat leaf surfaces and reduce available sites for pathogen infection or increases microbial diversity that can kill harmful pathogens. Here, we review recent scientific achievements towards the management of crop diseases and pests by these organic amendments and the major points are the following: (1) production of vermicompost and vermicompost tea, (2) management of crop pests and diseases by vermicompost and vermicompost tea, and (3) the possible mechanisms and some important factors involved in the suppression of diseases and pests. Finally, we conclude that by using these eco-friendly organic amendments as a replacement to inorganic pesticides and fungicides, diseases and pests can be managed successfully without affecting human health and the environment and chemical-free food can be provided to humankind in the future.
    Schlagwörter Nematoda ; administrative management ; agricultural land ; agronomy ; auxins ; beneficial microorganisms ; compost extracts ; crop yield ; crops ; cytokinins ; disease control ; environment ; fungicides ; gibberellins ; human health ; infection ; leaves ; mineral fertilizers ; nutrient content ; plant pathogens ; plant pests ; soil fertility ; surfaces ; sustainable development ; vermicomposts
    Sprache Englisch
    Erscheinungsverlauf 2021-02
    Umfang p. 7.
    Erscheinungsort Springer Paris
    Dokumenttyp Artikel
    Anmerkung NAL-light ; Review
    ISSN 1774-0746
    DOI 10.1007/s13593-020-00657-w
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Global perspective of municipal solid waste and landfill leachate: generation, composition, eco-toxicity, and sustainable management strategies.

    Yatoo, Ali Mohd / Hamid, Basharat / Sheikh, Tahir Ahmad / Ali, Shafat / Bhat, Sartaj Ahmad / Ramola, Sudipta / Ali, Md Niamat / Baba, Zahoor Ahmad / Kumar, Sunil

    Environmental science and pollution research international

    2024  Band 31, Heft 16, Seite(n) 23363–23392

    Abstract: Globally, more than 2 billion tonnes of municipal solid waste (MSW) are generated each year, with that amount anticipated to reach around 3.5 billion tonnes by 2050. On a worldwide scale, food and green waste contribute the major proportion of MSW, which ...

    Abstract Globally, more than 2 billion tonnes of municipal solid waste (MSW) are generated each year, with that amount anticipated to reach around 3.5 billion tonnes by 2050. On a worldwide scale, food and green waste contribute the major proportion of MSW, which accounts for 44% of global waste, followed by recycling waste (38%), which includes plastic, glass, cardboard, and paper, and 18% of other materials. Population growth, urbanization, and industrial expansion are the principal drivers of the ever-increasing production of MSW across the world. Among the different practices employed for the management of waste, landfill disposal has been the most popular and easiest method across the world. Waste management practices differ significantly depending on the income level. In high-income nations, only 2% of waste is dumped, whereas in low-income nations, approximately 93% of waste is burned or dumped. However, the unscientific disposal of waste in landfills causes the generation of gases, heat, and leachate and results in a variety of ecotoxicological problems, including global warming, water pollution, fire hazards, and health effects that are hazardous to both the environment and public health. Therefore, sustainable management of MSW and landfill leachate is critical, necessitating the use of more advanced techniques to lessen waste production and maximize recycling to assure environmental sustainability. The present review provides an updated overview of the global perspective of municipal waste generation, composition, landfill heat and leachate formation, and ecotoxicological effects, and also discusses integrated-waste management approaches for the sustainable management of municipal waste and landfill leachate.
    Mesh-Begriff(e) Solid Waste/analysis ; Refuse Disposal/methods ; Water Pollutants, Chemical/analysis ; Waste Management/methods ; Waste Disposal Facilities
    Chemische Substanzen Solid Waste ; Water Pollutants, Chemical
    Sprache Englisch
    Erscheinungsdatum 2024-03-05
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32669-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Deciphering waste bound nitrogen by employing psychrophillic Aporrectodea caliginosa and priming of coprolites by associated heterotrophic nitrifiers under high altitude Himalayas.

    Sheikh, Tahir / Baba, Zahoor / Yatoo, Ali Mohd / Hamid, Basharat / Iqbal, Sadaf / Wani, Fehim / Fatima, Sabah / Alfarraj, Saleh / Javed Ansari, Mohammad

    Scientific reports

    2022  Band 12, Heft 1, Seite(n) 9556

    Abstract: Himalayan ecosystem is characterized by its fragile climate with rich repositories of biodiversity. Waste collection and disposal are becoming increasingly difficult due to topographical variations. Aporrectodea caligenosa, a versatile psychrophillic ... ...

    Abstract Himalayan ecosystem is characterized by its fragile climate with rich repositories of biodiversity. Waste collection and disposal are becoming increasingly difficult due to topographical variations. Aporrectodea caligenosa, a versatile psychrophillic soil dweller, is a useful biocatalyst with potent bio-augmented capability for waste treatment at low temperatures. Microcosm experiments were conducted to elucidate the comprehensive nature of biogenic nitrogen transformation to NH
    Mesh-Begriff(e) Aerobiosis ; Altitude ; Animals ; Denitrification ; Ecosystem ; Heterotrophic Processes ; Manure ; Nitrification ; Nitrogen/metabolism ; Oligochaeta/metabolism ; Soil ; Waste Water
    Chemische Substanzen Manure ; Soil ; Waste Water ; Nitrogen (N762921K75)
    Sprache Englisch
    Erscheinungsdatum 2022-06-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-12972-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19.

    Arafah, Azher / Ali, Shafat / Yatoo, Ali Mohd / Ali, Md Niamat / Rehman, Muneeb U

    Archives of medical research

    2020  Band 51, Heft 7, Seite(n) 718–720

    Abstract: The novel corona virus (SARS-CoV-2) that causes severe acute respiratory syndrome, now called COVID-19 initially originated in Wuhan city of China and later spread across borders and infected more than five million people and killed over 3.4 lakh people ... ...

    Abstract The novel corona virus (SARS-CoV-2) that causes severe acute respiratory syndrome, now called COVID-19 initially originated in Wuhan city of China and later spread across borders and infected more than five million people and killed over 3.4 lakh people all over the globe. This disease has been announced as pandemic by WHO. So far, there has been not much progress in terms of drug development for fighting against this deadliest virus, also no existing drugs has been reported completely effective for COVID-19 treatment owing to lack of effective therapeutic targets and a broad understanding of the viral behavior in target cell. Some reports have found and confirmed that SARS-CoV-2 like others SARS-CoVs utilizes angiotensin converting enzyme-2 receptor for making entry into target cell by binding to the receptor with its S1 subunit and employing host cell proteases for cleaving S2 subunit at S2' in order to fuse with cell membrane. Thus, simultaneous blocking of S1 subunit and inactivation of proteases seem to be promising therapeutic targets for the development of effective novel drugs. In current write up we hypothesize that S1 subunit and host proteases as potential therapeutic avenues for the treatment of COVID-19.
    Mesh-Begriff(e) Angiotensin-Converting Enzyme 2 ; Antiviral Agents ; COVID-19/drug therapy ; COVID-19/virology ; Drug Development ; Humans ; Protease Inhibitors ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemische Substanzen Antiviral Agents ; Protease Inhibitors ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2020.05.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Assessment of pesticide toxicity on earthworms using multiple biomarkers: a review

    Yatoo, Ali Mohd / Ali, Md. Niamat / Zaheen, Zarka / Baba, Zahoor Ahmad / Ali, Shafat / Rasool, Saiema / Sheikh, Tahir Ahmad / Sillanpää, Mika / Gupta, Pankaj Kumar / Hamid, Burhan / Hamid, Basharat

    Environ Chem Lett. 2022 Aug., v. 20, no. 4 p.2573-2596

    2022  

    Abstract: Two million tonnes of pesticides are currently used globally to improve crop production, yet these pesticides induce adverse effects on soil quality and biodiversity. Moreover, less than 1% of pesticides reach the target pests, while the rest contaminate ...

    Abstract Two million tonnes of pesticides are currently used globally to improve crop production, yet these pesticides induce adverse effects on soil quality and biodiversity. Moreover, less than 1% of pesticides reach the target pests, while the rest contaminate the surrounding environment. In particular, earthworms are exposed to pesticides and are thus an ideal biological model for ecotoxicological research. Here, we review acute and sub-lethal effects of pesticides on earthworms. We found that pesticides alter growth, reproduction, behaviour, essential enzymes, and DNA of earthworms, even at low pesticide concentrations. These sub-lethal biomarkers allow to evaluate the overall response of an earthworm to pesticides, and to identify the risk for other non-target organisms.
    Schlagwörter DNA ; biodiversity ; biological models ; biomarkers ; crop production ; earthworms ; ecotoxicology ; pesticides ; reproduction ; risk ; soil quality ; toxicity
    Sprache Englisch
    Erscheinungsverlauf 2022-08
    Umfang p. 2573-2596.
    Erscheinungsort Springer International Publishing
    Dokumenttyp Artikel ; Online
    Anmerkung Review
    ZDB-ID 2107984-5
    ISSN 1610-3661 ; 1610-3653
    ISSN (online) 1610-3661
    ISSN 1610-3653
    DOI 10.1007/s10311-022-01386-0
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Cold-Active Enzymes and Their Potential Industrial Applications-A Review.

    Hamid, Burhan / Bashir, Zaffar / Yatoo, Ali Mohd / Mohiddin, Fayaz / Majeed, Neesa / Bansal, Monika / Poczai, Peter / Almalki, Waleed Hassan / Sayyed, R Z / Shati, Ali A / Alfaifi, Mohammad Y

    Molecules (Basel, Switzerland)

    2022  Band 27, Heft 18

    Abstract: More than 70% of our planet is covered by extremely cold environments, nourishing a broad diversity of microbial life. Temperature is the most significant parameter that plays a key role in the distribution of microorganisms on our planet. Psychrophilic ... ...

    Abstract More than 70% of our planet is covered by extremely cold environments, nourishing a broad diversity of microbial life. Temperature is the most significant parameter that plays a key role in the distribution of microorganisms on our planet. Psychrophilic microorganisms are the most prominent inhabitants of the cold ecosystems, and they possess potential cold-active enzymes with diverse uses in the research and commercial sectors. Psychrophiles are modified to nurture, replicate, and retain their active metabolic activities in low temperatures. Their enzymes possess characteristics of maximal activity at low to adequate temperatures; this feature makes them more appealing and attractive in biotechnology. The high enzymatic activity of psychrozymes at low temperatures implies an important feature for energy saving. These enzymes have proven more advantageous than their mesophilic and thermophilic counterparts. Therefore, it is very important to explore the efficiency and utility of different psychrozymes in food processing, pharmaceuticals, brewing, bioremediation, and molecular biology. In this review, we focused on the properties of cold-active enzymes and their diverse uses in different industries and research areas. This review will provide insight into the areas and characteristics to be improved in cold-active enzymes so that potential and desired enzymes can be made available for commercial purposes.
    Mesh-Begriff(e) Biotechnology ; Cold Temperature ; Ecosystem ; Enzymes/metabolism ; Pharmaceutical Preparations
    Chemische Substanzen Enzymes ; Pharmaceutical Preparations
    Sprache Englisch
    Erscheinungsdatum 2022-09-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27185885
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Isolation and Characterization of Flavonoid Naringenin and Evaluation of Cytotoxic and Biological Efficacy of Water Lilly (

    Din, Shajrath / Hamid, Saima / Yaseen, Aadil / Yatoo, Ali Mohd / Ali, Shafat / Shamim, Kashif / Mahdi, Wael A / Alshehri, Sultan / Rehman, Muneeb U / Shah, Wajaht A

    Plants (Basel, Switzerland)

    2022  Band 11, Heft 24

    Abstract: Despite its limited exploration, ...

    Abstract Despite its limited exploration,
    Sprache Englisch
    Erscheinungsdatum 2022-12-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11243588
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19

    Arafah, Azher / Ali, Shafat / Yatoo, Ali Mohd / Ali, Md Niamat / Rehman, Muneeb U

    Arch Med Res

    Abstract: The novel corona virus (SARS-CoV-2) that causes severe acute respiratory syndrome, now called COVID-19 initially originated in Wuhan city of China and later spread across borders and infected more than five million people and killed over 3.4 lakh people ... ...

    Abstract The novel corona virus (SARS-CoV-2) that causes severe acute respiratory syndrome, now called COVID-19 initially originated in Wuhan city of China and later spread across borders and infected more than five million people and killed over 3.4 lakh people all over the globe. This disease has been announced as pandemic by WHO. So far, there has been not much progress in terms of drug development for fighting against this deadliest virus, also no existing drugs has been reported completely effective for COVID-19 treatment owing to lack of effective therapeutic targets and a broad understanding of the viral behavior in target cell. Some reports have found and confirmed that SARS-CoV-2 like others SARS-CoVs utilizes angiotensin converting enzyme-2 receptor for making entry into target cell by binding to the receptor with its S1 subunit and employing host cell proteases for cleaving S2 subunit at S2' in order to fuse with cell membrane. Thus, simultaneous blocking of S1 subunit and inactivation of proteases seem to be promising therapeutic targets for the development of effective novel drugs. In current write up we hypothesize that S1 subunit and host proteases as potential therapeutic avenues for the treatment of COVID-19.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #526103
    Datenquelle COVID19

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