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Article ; Online: Mitophagy in Astrocytes Is Required for the Health of Optic Nerve.

Yazdankhah, Meysam / Ghosh, Sayan / Liu, Haitao / Hose, Stacey / Zigler, J Samuel / Sinha, Debasish

2023 Volume 12, Issue 20

Abstract: Mitochondrial dysfunction in astrocytes has been implicated in the development of various neurological disorders. Mitophagy, mitochondrial autophagy, is required for proper mitochondrial function by preventing the accumulation of damaged mitochondria. ... ...

Abstract	Mitochondrial dysfunction in astrocytes has been implicated in the development of various neurological disorders. Mitophagy, mitochondrial autophagy, is required for proper mitochondrial function by preventing the accumulation of damaged mitochondria. The importance of mitophagy, specifically in the astrocytes of the optic nerve (ON), has been little studied. We introduce an animal model in which two separate mutations act synergistically to produce severe ON degeneration. The first mutation is in
MeSH term(s)	Animals ; Mitophagy ; Astrocytes/metabolism ; Lysosomes/metabolism ; Mitochondria/metabolism ; Optic Nerve/metabolism
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12202496
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Article ; Online: 3D bio-printing technology for body tissues and organs regeneration.

Biazar, Esmaeil / Najafi S, Masoumeh / Heidari K, Saeed / Yazdankhah, Meysam / Rafiei, Ataollah / Biazar, Dariush

Journal of medical engineering & technology

2018 Volume 42, Issue 3, Page(s) 187–202

Abstract: In the last decade, the use of new technologies in the reconstruction of body tissues has greatly developed. Utilising stem cell technology, nanotechnology and scaffolding design has created new opportunities in tissue regeneration. The use of accurate ... ...

Abstract	In the last decade, the use of new technologies in the reconstruction of body tissues has greatly developed. Utilising stem cell technology, nanotechnology and scaffolding design has created new opportunities in tissue regeneration. The use of accurate engineering design in the creation of scaffolds, including 3D printers, has been widely considered. Three-dimensional printers, especially high precision bio-printers, have opened up a new way in the design of 3D tissue engineering scaffolds. In this article, a review of the latest applications of this technology in this promising area has been addressed.
MeSH term(s)	Animals ; Humans ; Printing, Three-Dimensional ; Regeneration ; Tissue Engineering
Language	English
Publishing date	2018-04-19
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	243092-7
ISSN	1464-522X ; 0309-1902
ISSN (online)	1464-522X
ISSN	0309-1902
DOI	10.1080/03091902.2018.1457094
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Article ; Online: A cAMP analog attenuates beta-amyloid (1-42)-induced mitochondrial dysfunction and spatial learning and memory deficits.

Aghsami, Mehdi / Sharifzadeh, Mohammad / Sepand, Mohammad Reza / Yazdankhah, Meysam / Seyednejad, Seyed Afshin / Pourahmad, Jalal

Brain research bulletin

2018 Volume 140, Page(s) 34–42

Abstract: Alzheimer's disease (AD), a neurodegenerative disorder in elderly, is indicated with deposition of Amyloid β (Aβ) in the brain and accompanied with cognitive impairment. Bucladesine, a phosphodiesterase inhibitor, may ameliorate AD's cognitive ... ...

Abstract	Alzheimer's disease (AD), a neurodegenerative disorder in elderly, is indicated with deposition of Amyloid β (Aβ) in the brain and accompanied with cognitive impairment. Bucladesine, a phosphodiesterase inhibitor, may ameliorate AD's cognitive dysfunctions through mimicking the action of cAMP and raising its intracellular level. Here, we investigated the effects of bucladesine on Aβ-induced memory and learning impairment in a Morris water maze (MWM) model. Rats were injected with bucladesine (1 μl/side from a 100 μM stock solution) and Aβ (1 μl/side from a 100 μM stock solution) intra-hippocampally and after 19 days were trained for 4 successive days. The oxidative stress was evaluated through measurement of thiobarbituric acid (TBARS), thiol groups, and ferric reducing antioxidant power (FRAP). Effect of Aβ and its combination with bucladesine on the mitochondrial function was assessed according to changes in the ROS generation, mitochondrial membrane potential (MMP), mitochondrial swelling, ATP/ADP ratio, mitochondrial outer membrane damage and cytochrome C release. Our results showed a significant elevation in TBARS level after administration of Aβ causing mitochondrial ROS generation, swelling, outer membrane damage, cytochrome C release and also lower thiol, FRAP, and MMP levels. Aβ-induced spatial memory impairment was prevented by pre-treatment with bucladesine and the changed mitochondrial and biochemical indices upon treatment dose were improved. Taken together, we have obtained satisfactory results suggesting protecting effects of bucladesine against the Aβ-mediated memory deficit and implying its plausible beneficial capacity as a therapeutic agent in oxidative stress-associated neurodegenerative diseases.
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Animals ; Antioxidants/pharmacology ; Bucladesine/pharmacology ; Cyclic AMP/analogs & derivatives ; Disease Models, Animal ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; Male ; Maze Learning/drug effects ; Maze Learning/physiology ; Memory Disorders/drug therapy ; Memory Disorders/metabolism ; Memory Disorders/pathology ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Diseases/drug therapy ; Mitochondrial Diseases/metabolism ; Mitochondrial Diseases/pathology ; Neuroprotective Agents/pharmacology ; Nootropic Agents/pharmacology ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Peptide Fragments/metabolism ; Rats, Wistar ; Spatial Memory/drug effects ; Spatial Memory/physiology
Chemical Substances	Amyloid beta-Peptides ; Antioxidants ; Neuroprotective Agents ; Nootropic Agents ; Peptide Fragments ; amyloid beta-protein (1-42) ; Bucladesine (63X7MBT2LQ) ; Cyclic AMP (E0399OZS9N)
Language	English
Publishing date	2018-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	197620-5
ISSN	1873-2747 ; 0361-9230
ISSN (online)	1873-2747
ISSN	0361-9230
DOI	10.1016/j.brainresbull.2018.03.016
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Article: Melatonin as the Possible Link Between Age-Related Retinal Regeneration and the Disrupted Circadian Rhythm in Elderly.

Stepicheva, Nadezda A / Weiss, Joseph / Shang, Peng / Yazdankhah, Meysam / Ghosh, Sayan / Bhutto, Imran A / Hose, Stacey / Zigler, J Samuel / Sinha, Debasish

Advances in experimental medicine and biology

2019 Volume 1185, Page(s) 45–49

Abstract: The association between age-related macular degeneration (AMD) and biological rhythms has been insufficiently studied; however there are several reasons to believe that impairment in circadian rhythm may affect incidence and pathogenesis of AMD. The ... ...

Abstract	The association between age-related macular degeneration (AMD) and biological rhythms has been insufficiently studied; however there are several reasons to believe that impairment in circadian rhythm may affect incidence and pathogenesis of AMD. The current understanding of AMD pathology is based on age-related, cumulative oxidative damage to the retinal pigmented epithelium (RPE) partially due to impaired clearance of phagocytosed photoreceptor outer segments. In higher vertebrates, phagocytosis of the outer segments is synchronized by circadian rhythms and occurs shortly after dawn, followed by lysosomal-mediated clearance. Aging has been shown to be associated with the changes in circadian rhythmicity of melatonin production, which can be a major factor contributing to the impaired balance between phagocytosis and clearance and increased levels of reactive oxygen species resulting in degenerative changes in the retina. This minireview summarizes studies linking AMD with melatonin production and discusses challenges and perspectives of this area of research.
MeSH term(s)	Animals ; Circadian Rhythm ; Humans ; Macular Degeneration/pathology ; Melatonin/biosynthesis ; Phagocytosis ; Reactive Oxygen Species ; Retinal Pigment Epithelium/pathology
Chemical Substances	Reactive Oxygen Species ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2019-12-28
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-27378-1_8
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Article ; Online: Sepantronium Bromide (YM155), A Small Molecule Survivin Inhibitor, Promotes Apoptosis by Induction of Oxidative Stress, Worsens the Behavioral Deficits and Develops an Early Model of Toxic Demyelination: In Vivo and In-Silico Study.

Reiszadeh-Jahromi, Samaneh / Sepand, Mohammad-Reza / Ramezani-Sefidar, Samaneh / Shahlaei, Mohsen / Moradi, Sajad / Yazdankhah, Meysam / Sanadgol, Nima

Neurochemical research

2019 Volume 44, Issue 11, Page(s) 2482–2498

Abstract: Cuprizone (cup) model targets oligodendrocytes (OLGs) degeneration and is frequently used for the mechanistic understanding of de- and remyelination. Improperly, this classic model is time-consuming and the extent of brain lesions and behavioral deficits ...

Abstract	Cuprizone (cup) model targets oligodendrocytes (OLGs) degeneration and is frequently used for the mechanistic understanding of de- and remyelination. Improperly, this classic model is time-consuming and the extent of brain lesions and behavioral deficits are changeable (both temporally and spatially) within a mouse strain. We aimed to offer an alternative, less time-consuming, and more reproducible cup model. Mice (C57BL/6) were treated with cup (400 mg kg
MeSH term(s)	Animals ; Apoptosis/drug effects ; Base Sequence ; Caspase 3/metabolism ; Caspase 9/metabolism ; Corpus Callosum/metabolism ; Cuprizone/pharmacology ; Demyelinating Diseases/metabolism ; Disease Models, Animal ; Imidazoles/chemistry ; Imidazoles/pharmacology ; Inhibitor of Apoptosis Proteins/genetics ; Inhibitor of Apoptosis Proteins/metabolism ; Male ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Naphthoquinones/chemistry ; Naphthoquinones/pharmacology ; Oligodendroglia/drug effects ; Oligodendroglia/metabolism ; Oxidative Stress/drug effects ; Promoter Regions, Genetic
Chemical Substances	Imidazoles ; Inhibitor of Apoptosis Proteins ; Naphthoquinones ; Cuprizone (5N16U7E0AO) ; Casp3 protein, mouse (EC 3.4.22.-) ; Casp9 protein, mouse (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-) ; sepantronium (UZ77T1VFBM)
Language	English
Publishing date	2019-09-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	199335-5
ISSN	1573-6903 ; 0364-3190
ISSN (online)	1573-6903
ISSN	0364-3190
DOI	10.1007/s11064-019-02865-7
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Zs.A 1368: Show issues

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Article ; Online: A Novel Method of Mouse RPE Explant Culture and Effective Introduction of Transgenes Using Adenoviral Transduction for

Shang, Peng / Stepicheva, Nadezda A / Liu, Haitao / Chowdhury, Olivia / Franks, Jonathan / Sun, Ming / Hose, Stacey / Ghosh, Sayan / Yazdankhah, Meysam / Strizhakova, Anastasia / Stolz, Donna Beer / Zigler, J Samuel / Sinha, Debasish

International journal of molecular sciences

2021 Volume 22, Issue 21

Abstract: Degeneration of retinal pigment epithelium (RPE) is one of the most critical phenotypic changes of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly. While cultured polarized RPE cells with original properties are ... ...

Abstract	Degeneration of retinal pigment epithelium (RPE) is one of the most critical phenotypic changes of age-related macular degeneration (AMD), the leading cause of vision loss in the elderly. While cultured polarized RPE cells with original properties are valuable in
MeSH term(s)	Adenoviridae/genetics ; Animals ; Cells, Cultured ; Genetic Vectors/administration & dosage ; Macular Degeneration/genetics ; Macular Degeneration/metabolism ; Macular Degeneration/pathology ; Mice ; Mice, Inbred C57BL ; Models, Animal ; Organ Culture Techniques/methods ; Retinal Pigment Epithelium/cytology ; Retinal Pigment Epithelium/metabolism ; Transduction, Genetic ; Transgenes
Language	English
Publishing date	2021-11-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222111979
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Article ; Online: In vivo assessment of a nanofibrous silk tube as nerve guide for sciatic nerve regeneration.

Ebrahimi, Maryam / Ai, Jafar / Biazar, Esmaeil / Ebrahimi-Barough, Somayeh / Khojasteh, Arash / Yazdankhah, Meysam / Sharifi, Siavash / Ai, Arman / Heidari-Keshel, Saeed

Artificial cells, nanomedicine, and biotechnology

2018 Volume 46, Issue sup1, Page(s) 394–401

Abstract: A nanofibrous silk nerve conduit has been evaluated for its efficiency based on the promotion of peripheral nerve regeneration in rats. The designed tubes with or without Schwann cells were implanted into a 10 mm gap in the sciatic nerves of the rats. ... ...

Abstract	A nanofibrous silk nerve conduit has been evaluated for its efficiency based on the promotion of peripheral nerve regeneration in rats. The designed tubes with or without Schwann cells were implanted into a 10 mm gap in the sciatic nerves of the rats. Four months after the surgery, the regenerated nerves were monitored and evaluated by macroscopic assessments and histology. The results demonstrated that the nanofibrous grafts, especially in the presence of Schwann cells, enabled reconstruction of the rat sciatic nerve trunk with a restoration of nerve continuity and formation of nerve fibres with myelination. Histological data demonstrated the presence of Schwann and glial cells in regenerated nerves. This study strongly supports the feasibility of using artificial nerve grafts for peripheral nerve regeneration by bridging large defects in a rat model.
MeSH term(s)	Animals ; Guided Tissue Regeneration/methods ; Male ; Nanofibers/chemistry ; Nerve Regeneration/drug effects ; Rats ; Rats, Wistar ; Sciatic Nerve/drug effects ; Sciatic Nerve/physiology ; Silk/chemistry ; Silk/pharmacology
Chemical Substances	Silk
Language	English
Publishing date	2018-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2723095-8
ISSN	2169-141X ; 2169-1401
ISSN (online)	2169-141X
ISSN	2169-1401
DOI	10.1080/21691401.2018.1426593
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Article ; Online: PCL/gelatin nanofibrous scaffolds with human endometrial stem cells/Schwann cells facilitate axon regeneration in spinal cord injury.

Babaloo, Hamideh / Ebrahimi-Barough, Somayeh / Derakhshan, Mohammad Ali / Yazdankhah, Meysam / Lotfibakhshaiesh, Nasrin / Soleimani, Masoud / Joghataei, Mohammad-Taghi / Ai, Jafar

Journal of cellular physiology

2018 Volume 234, Issue 7, Page(s) 11060–11069

Abstract: The significant consequences of spinal cord injury (SCI) include sensory and motor disability resulting from the death of neuronal cells and axon degeneration. In this respect, overcoming the consequences of SCI including the recovery of sensory and ... ...

Abstract	The significant consequences of spinal cord injury (SCI) include sensory and motor disability resulting from the death of neuronal cells and axon degeneration. In this respect, overcoming the consequences of SCI including the recovery of sensory and motor functions is considered to be a difficult tasks that requires attention to multiple aspects of treatment. The breakthrough in tissue engineering through the integration of biomaterial scaffolds and stem cells has brought a new hope for the treatment of SCI. In the present study, human endometrial stem cells (hEnSCs) were cultured with human Schwann cells (hSC) in transwells, their differentiation into nerve-like cells was confirmed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) and immunocytochemistry techniques. The differentiated cells (co-hEnSC) were then seeded on the poly ε-caprolactone (PCL)/gelatin scaffolds. The SEM images displayed the favorable seeding and survival of the cells on the scaffolds. The seeded scaffolds were then transplanted into hemisected SCI rats. The growth of neuronal cells was confirmed with immunohistochemical study using NF-H as a neuronal marker. Finally, the Basso, Beattie, and Bresnahan (BBB) test confirmed the recovery of sensory and motor functions. The results suggested that combination therapy using the differentiated hEnSC seeded on PCL/gelatin scaffolds has the potential to heal the injured spinal cord and to limit the secondary damage.
MeSH term(s)	Animals ; Axons/physiology ; Blood Vessel Prosthesis ; Endometrium/cytology ; Female ; Gelatin/chemistry ; Humans ; Male ; Nanostructures ; Nerve Regeneration/physiology ; Polyesters/chemistry ; Rats ; Rats, Sprague-Dawley ; Schwann Cells/physiology ; Spinal Cord Injuries/therapy ; Stem Cells/physiology ; Tissue Scaffolds
Chemical Substances	Polyesters ; polycaprolactone (24980-41-4) ; Gelatin (9000-70-8)
Language	English
Publishing date	2018-12-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.27936
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Article ; Online: The role of lipocalin-2 in age-related macular degeneration (AMD).

Ghosh, Sayan / Stepicheva, Nadezda / Yazdankhah, Meysam / Shang, Peng / Watson, Alan M / Hose, Stacey / Liu, Haitao / Weiss, Joseph / Zigler, J Samuel / Valapala, Mallika / Watkins, Simon C / Sinha, Debasish

Cellular and molecular life sciences : CMLS

2020 Volume 77, Issue 5, Page(s) 835–851

Abstract: Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of ... ...

Abstract	Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of several diseases including cancer, diabetes, obesity, and multiple sclerosis. Herein, we discuss the general molecular basis for the involvement of LCN-2 in acute infections and chronic disease progression and also ascertain the probable role of LCN-2 in ocular diseases, particularly in age-related macular degeneration (AMD). We elaborate on the signaling cascades which trigger LCN-2 upregulation in AMD and suggest therapeutic strategies for targeting such pathways.
MeSH term(s)	Animals ; Disease Models, Animal ; Humans ; Inflammation/pathology ; Lipocalin-2/genetics ; Lipocalin-2/metabolism ; Macular Degeneration/genetics ; Macular Degeneration/pathology ; Mice ; Retina/pathology ; Retinal Pigment Epithelium/pathology ; Signal Transduction ; Vision Disorders/genetics ; Vision Disorders/pathology
Chemical Substances	LCN2 protein, human ; Lipocalin-2
Keywords	covid19
Language	English
Publishing date	2020-01-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-019-03423-8
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Article ; Online: Role of glia in optic nerve.

Yazdankhah, Meysam / Shang, Peng / Ghosh, Sayan / Hose, Stacey / Liu, Haitao / Weiss, Joseph / Fitting, Christopher S / Bhutto, Imran A / Zigler, J Samuel / Qian, Jiang / Sahel, José-Alain / Sinha, Debasish / Stepicheva, Nadezda A

Progress in retinal and eye research

2020 Volume 81, Page(s) 100886

Abstract: Glial cells are critically important for maintenance of neuronal activity in the central nervous system (CNS), including the optic nerve (ON). However, the ON has several unique characteristics, such as an extremely high myelination level of retinal ... ...

Abstract	Glial cells are critically important for maintenance of neuronal activity in the central nervous system (CNS), including the optic nerve (ON). However, the ON has several unique characteristics, such as an extremely high myelination level of retinal ganglion cell (RGC) axons throughout the length of the nerve (with virtually all fibers myelinated by 7 months of age in humans), lack of synapses and very narrow geometry. Moreover, the optic nerve head (ONH) - a region where the RGC axons exit the eye - represents an interesting area that is morphologically distinct in different species. In many cases of multiple sclerosis (demyelinating disease of the CNS) vision problems are the first manifestation of the disease, suggesting that RGCs and/or glia in the ON are more sensitive to pathological conditions than cells in other parts of the CNS. Here, we summarize current knowledge on glial organization and function in the ON, focusing on glial support of RGCs. We cover both well-established concepts on the important role of glial cells in ON health and new findings, including novel insights into mechanisms of remyelination, microglia/NG2 cell-cell interaction, astrocyte reactivity and the regulation of reactive astrogliosis by mitochondrial fragmentation in microglia.
MeSH term(s)	Animals ; Axons/physiology ; Humans ; Neuroglia/physiology ; Optic Nerve/cytology ; Retinal Ganglion Cells/physiology
Language	English
Publishing date	2020-08-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1182683-6
ISSN	1873-1635 ; 1350-9462
ISSN (online)	1873-1635
ISSN	1350-9462
DOI	10.1016/j.preteyeres.2020.100886
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