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  1. AU="Ye, Chaofu"
  2. AU="Tekin, Nur"
  3. AU="Martens, Dirk E"
  4. AU=Teos Leyla Y.
  5. AU="Sánchez-Garcia, Joaquín"
  6. AU="Schaller, Benoit"
  7. AU="Hernandez, A"
  8. AU="Nguyen, Thien H"
  9. AU="Park, Jung Wan"
  10. AU="Mahajan, Aman"
  11. AU="Hao, Yanling"
  12. AU="Eing, Lorenz"
  13. AU="Geoffroy, Pierre A"
  14. AU="Chapuis, J"
  15. AU="Berta, László"
  16. AU="Barzilay, Regina"
  17. AU="Schmidt, Michael Rahbek"
  18. AU=Tack J
  19. AU="Oh, Hye Min"
  20. AU=Gaffen Sarah L AU=Gaffen Sarah L
  21. AU="Schmitt, Christine"
  22. AU="McKay, Jackie"
  23. AU="Bellissimo, Catherine A"
  24. AU="Desai, Urja"
  25. AU="Chini, Maria Giovanna"
  26. AU="Xiao, Difei"
  27. AU="Ryan, Chris"
  28. AU="Omar Bazighifan"
  29. AU="Corominas Galbany, Jordi"
  30. AU=Fox Norma E
  31. AU="Hamilton, Shelia M"
  32. AU="Nichols, J Wylie"
  33. AU="Pesce R."
  34. AU="Gambitta, P"
  35. AU="Imran, Aqeel"
  36. AU="Sharma, Yashoda"
  37. AU="Kosai, Jordyn"
  38. AU="Aroca Ferri, María"
  39. AU="Laba, Stephanie"
  40. AU="Kim, Ye-Sel"

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  1. Artikel: [Study on Clinical Application and Supervision of LC-MS in

    Ye, Chaofu / Zhang, Lan / Kou, Yanqin / Wang, Yuhang / Yang, Xiaohe

    Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

    2023  Band 47, Heft 6, Seite(n) 690–694

    Abstract: From the perspective of technical evaluation, this study reviewed the current situation of application and clinical application of medical device products were detected by liquid chromatography-tandem mass spectrometry in the market in recent years. The ... ...

    Abstract From the perspective of technical evaluation, this study reviewed the current situation of application and clinical application of medical device products were detected by liquid chromatography-tandem mass spectrometry in the market in recent years. The regulatory requirements of these products in China, USA, EU and Japan were compared and analyzed, and the monitoring situation of adverse events after listing, the standards for reference and the domestic and foreign regulatory documents were combined, the clinical application and regulatory risks of the product were analyzed. The problems such as pre-treatment, system matching, adequacy of performance index requirements, inter-room consistency, reference interval and registration unit were discussed and suggestions for supervision were given, with a view to the field of product R&D and production, review and approval of supervision to provide technical reference.
    Mesh-Begriff(e) Chromatography, Liquid/methods ; Tandem Mass Spectrometry/methods ; Reference Standards ; Japan
    Sprache Chinesisch
    Erscheinungsdatum 2023-12-12
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article
    ISSN 1671-7104
    ISSN 1671-7104
    DOI 10.3969/j.issn.1671-7104.2023.06.019
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A prognostic biomarker for gastric cancer with lymph node metastases.

    Zhang, Mei-Hua / Xu, Xiao-Hong / Wang, Yue / Linq, Qi-Xin / Bi, Yun-Tao / Miao, Xiao-Jie / Ye, Chao-Fu / Gao, Shang-Xian / Gong, Cheng-Yu / Xiang, Hang / Dong, Mao-Sheng

    Anatomical record (Hoboken, N.J. : 2007)

    2013  Band 296, Heft 4, Seite(n) 590–594

    Abstract: Gastric cancer is one of the leading causes of tumor-related deaths in China. The tumor, node, metastasis (TNM) classification system is useful for predicting clinical prognosis of patients with gastric cancer. However, determining the presence of lymph ... ...

    Abstract Gastric cancer is one of the leading causes of tumor-related deaths in China. The tumor, node, metastasis (TNM) classification system is useful for predicting clinical prognosis of patients with gastric cancer. However, determining the presence of lymph node involvement in the early stages of gastric cancer is difficult without biopsy. Therefore, it is necessary to identify novel serum biomarkers for TNM cancer staging and prognostic follow-up. In this study, we have reported fibrinopeptide-A (FPA) with alanine truncation at the N-terminal as a novel biomarker to differentiate gastric cancer with and without lymph node metastases. We analyzed 369 individual serum samples including gastric cancer patients without lymph node metastases (n = 33), gastric cancer patients with lymph node metastases (n = 157; confirmed by pathology), and age- and sex-matched healthy individuals (n = 179). The data showed that 85.4% of patients with lymph node metastases were positive for FPA with alanine truncation at the N-terminal (degAla-FPA, 1,465.63 Da), as determined by tandem mass spectrometry (MS). Using degAla-FPA as the biomarker, the sensitivity was 85.4% for gastric cancer patients with lymph node metastases, and the specificity was 100% for gastric cancer patients without lymph node metastases. The high sensitivity and specificity achieved with serum degAla-FPA levels indicated that MS technology could facilitate the discovery of a novel and quantitative prognostic biomarker for gastric cancer with lymph node involvement.
    Mesh-Begriff(e) Biomarkers, Tumor/blood ; Case-Control Studies ; Fibrinopeptide A/analysis ; Humans ; Lymphatic Metastasis ; Neoplasm Invasiveness ; Neoplasm Staging ; Peptide Fragments/blood ; Predictive Value of Tests ; Prognosis ; Proteomics/methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Stomach Neoplasms/blood ; Stomach Neoplasms/pathology ; Tandem Mass Spectrometry
    Chemische Substanzen Biomarkers, Tumor ; Peptide Fragments ; Fibrinopeptide A (25422-31-5)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2013-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.22642
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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