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  1. Article: Effects of sarcopenia, hypoalbuminemia, and laparoscopic surgery on postoperative complications in elderly patients with colorectal cancer: A prospective study.

    Chen, W S / Huang, Y S / Xu, L B / Shi, M M / Chen, X D / Ye, G Q / Wu, T T / Zhu, G B

    Neoplasma

    2020  Volume 67, Issue 4, Page(s) 922–932

    Abstract: With the increasing number of elderly patients, the risk of diseases such as colorectal cancer (CRC) has increased. The objective of this prospective study was to explore the effects of sarcopenia, hypoalbuminemia, and laparoscopic surgery on ... ...

    Abstract With the increasing number of elderly patients, the risk of diseases such as colorectal cancer (CRC) has increased. The objective of this prospective study was to explore the effects of sarcopenia, hypoalbuminemia, and laparoscopic surgery on postoperative complications among elderly patients who recently underwent colorectal surgery. Patients aged over 65 years who underwent surgery for CRC at the First Affiliated Hospital of Wenzhou Medical University were considered for this study. The demographical and clinical characteristics of these patients, as well as postoperative complications, were prospectively analyzed. The patients were divided into two groups depending on the diagnosis of sarcopenia, and the clinical variables corresponding to the two groups were compared. Further, the risk factors associated with postoperative complications were evaluated using univariate analysis and multivariate logistic regression analysis. A total of 360 patients fulfilled the inclusion criteria. Incidences of postoperative complications in the sarcopenia and non-sarcopenia groups were at 38.3% and 27.3%, respectively. In addition, sarcopenia (p=0.029) and hypoalbuminemia (p=0.010) were identified as independent risk factors, while laparoscopic surgery (p=0.023) was identified as a protective factor for postoperative complications. However, laparoscopic surgery was a protective factor for postoperative complications in the colon group only (p=0.001). Sarcopenia and hypoalbuminemia are independent risk factors that influence the probability of developing complications following CRC surgery. Laparoscopic surgery is a protective factor for postoperative complications of CRC patients, particularly colon cancer patients.
    MeSH term(s) Aged ; Colonic Neoplasms ; Colorectal Neoplasms/complications ; Colorectal Neoplasms/surgery ; Humans ; Hypoalbuminemia/complications ; Laparoscopy ; Postoperative Complications/epidemiology ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Sarcopenia/complications ; Treatment Outcome
    Language English
    Publishing date 2020-05-06
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 415445-9
    ISSN 0028-2685
    ISSN 0028-2685
    DOI 10.4149/neo_2020_190908N882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 28: Show issues Location:
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  2. Article: Flow cytometry analysis of the neutralization effect of anti-IL-8 McAbs on IL-8-activated human granulocytes.

    Ji, Y Y / Ye, G Q

    Shi yan sheng wu xue bao

    1995  Volume 28, Issue 3, Page(s) 257–261

    Abstract: Two hybridoma clones, I8-S2 and I 8-63, secreting anti- IL-8 antibodies were constructed from fusion of immunized spleen cells of BALB/c mice with either Sp 2/0 or 653 myeloma cells. They recognized different epitopes on IL-8 molecule. IL-8 could ... ...

    Abstract Two hybridoma clones, I8-S2 and I 8-63, secreting anti- IL-8 antibodies were constructed from fusion of immunized spleen cells of BALB/c mice with either Sp 2/0 or 653 myeloma cells. They recognized different epitopes on IL-8 molecule. IL-8 could activate human granulocytes and induce the elevation of [Ca2+]i. Through flow cytometry analysis the two clones displayed different neutralizing effects on the cell activation function of IL-8. The neutralizing effect of clone I8-S2 was apparently higher than that of clone I8-63. It is suggested that the cell activation function of IL-8 is restricted to a certain epitope of IL-8 molecule.
    MeSH term(s) Animals ; Antibodies, Monoclonal/biosynthesis ; Antibodies, Monoclonal/pharmacology ; Biological Transport, Active ; Calcium/metabolism ; Flow Cytometry ; Granulocytes/metabolism ; Humans ; Hybridomas/secretion ; Interleukin-8/immunology ; Mice ; Mice, Inbred BALB C
    Chemical Substances Antibodies, Monoclonal ; Interleukin-8 ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 1995-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 955679-5
    ISSN 0001-5334 ; 0371-4853
    ISSN 0001-5334 ; 0371-4853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2959: Show issues Location:
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  3. Article: [Research development in biological effects of microwave (author's transl)].

    Ye, G Q

    Sheng li ke xue jin zhan [Progress in physiology

    1980  Volume 11, Issue 4, Page(s) 309–314

    MeSH term(s) Animals ; Blood Cells/radiation effects ; Cardiovascular System/radiation effects ; Central Nervous System/radiation effects ; Endocrine Glands/radiation effects ; Eye/radiation effects ; Humans ; Microwaves/adverse effects
    Language Chinese
    Publishing date 1980-04
    Publishing country China
    Document type Journal Article
    ZDB-ID 259864-4
    ISSN 0559-7765
    ISSN 0559-7765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3363: Show issues Location:
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  4. Article: [Administration of ultrasonic aerosol inhalation of beclomethasone dipropionate compound in the treatment of chronic bronchial asthma: a report of 54 cases (author's transl)].

    Ye, G Q

    Zhonghua jie he he hu xi xi ji bing za zhi = Chinese journal of tuberculosis and respiratory diseases

    1980  Volume 3, Issue 3, Page(s) 163–166

    MeSH term(s) Adolescent ; Adult ; Aerosols ; Aged ; Asthma/drug therapy ; Beclomethasone/administration & dosage ; Child ; Chronic Disease ; Female ; Humans ; Male ; Middle Aged ; Ultrasonics
    Chemical Substances Aerosols ; Beclomethasone (KGZ1SLC28Z)
    Language Chinese
    Publishing date 1980-09
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 604670-8
    ISSN 0253-2689
    ISSN 0253-2689
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    Zs.B 2465: Show issues Location:
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  5. Article: [Studies on liposoluble constituents from the aerial parts of Siegesbeckia orientalis L].

    Guo, D A / Zhang, Z G / Ye, G Q / Lou, Z C

    Yao xue xue bao = Acta pharmaceutica Sinica

    1997  Volume 32, Issue 4, Page(s) 282–285

    Abstract: Eight compounds were isolated from the aerial parts of Siegesbeckia orientalis L. and their structures were elucidated by spectroscopic methods(IR, EI-MS, 13C-NMR, 1H-NMR, 1H-1H COSY, 1H-1H NOESY and 1H-13C COSY). Compounds I and II are new natural ... ...

    Abstract Eight compounds were isolated from the aerial parts of Siegesbeckia orientalis L. and their structures were elucidated by spectroscopic methods(IR, EI-MS, 13C-NMR, 1H-NMR, 1H-1H COSY, 1H-1H NOESY and 1H-13C COSY). Compounds I and II are new natural products and named siegesesteric acid(I) and siegesetheric acid(II), their structures were confirmed as ent-17-acetoxy-18-isobutyryloxy-16(alpha)-kauran-19-oic acid(I) and ent-17-ethoxy-16(alpha)-(-)-kauran-19-oic acid(II). The others were identified as known compounds: ent-16 beta, 17-dihydroxy-kauran-19-oic acid (III), kirenol(IV), beta-sitosteryl glucoside(V), heneicosanol(VI), methyl arachidate(VII) and beta-sitosterol(VIII). These compounds, except kirenol and beta-sitosterol, were isolated for the first time from the title plant.
    MeSH term(s) Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Diterpenes/chemistry ; Diterpenes/isolation & purification ; Furans/chemistry ; Furans/isolation & purification ; Lactones/chemistry ; Lactones/isolation & purification ; Magnoliopsida/chemistry ; Molecular Conformation ; Plants, Medicinal/chemistry
    Chemical Substances Antineoplastic Agents, Phytogenic ; Diterpenes ; Furans ; Lactones ; kirenol ; siegesesteric acid ; siegesetheric acid ; uvarigrin
    Language Chinese
    Publishing date 1997-04
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 788758-9
    ISSN 0513-4870
    ISSN 0513-4870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3194: Show issues Location:
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  6. Article: PSMA mimotope isolated from phage displayed peptide library can induce PSMA specific immune response.

    Zhu, Z Y / Zhong, C P / Xu, W F / Lin, G M / Ye, G Q / Ji, Y Y / Sun, B / Yeh, M

    Cell research

    1999  Volume 9, Issue 4, Page(s) 271–280

    Abstract: Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein expressed predominantly in prostate secretory acinar epithelium and prostate cancer cells as well as in several extraprostatic tissues. Mouse monoclonal antibody 4G5 specific to the ...

    Abstract Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein expressed predominantly in prostate secretory acinar epithelium and prostate cancer cells as well as in several extraprostatic tissues. Mouse monoclonal antibody 4G5 specific to the extracellular domain of PSMA was used to screen two phage displayed peptide libraries (9aa linear and 9aa cys library). Three 4G5-reactive phagotopes were identified. Sequence analysis of isolated clones demonstrated that the interaction motif "VDPA/SK" has high homology to 719-725aa on PSMA. Immunohistochemical staining of the prostate cancer sample with the PSMA-mimic phagotope (mimotope) immunized serum antibodies demonstrate that the mimotope isolated from the phage displayed peptide libraries can induce PSMA specific immune response in vivo.
    MeSH term(s) Animals ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/isolation & purification ; Antigens, Surface ; Carboxypeptidases/immunology ; Carboxypeptidases/isolation & purification ; Chromatography, Affinity ; Epitopes, B-Lymphocyte/immunology ; Glutamate Carboxypeptidase II ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Mimicry ; Peptide Library ; Prostate-Specific Antigen/analysis ; Prostate-Specific Antigen/immunology ; Prostatic Neoplasms/chemistry ; Prostatic Neoplasms/immunology ; Sequence Analysis
    Chemical Substances Antigens, Neoplasm ; Antigens, Surface ; Epitopes, B-Lymphocyte ; Peptide Library ; Carboxypeptidases (EC 3.4.-) ; FOLH1 protein, human (EC 3.4.17.21) ; Glutamate Carboxypeptidase II (EC 3.4.17.21) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 1999-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/sj.cr.7290026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5283: Show issues Location:
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  7. Article: Modulation of IL-8 receptor expression on purified human T lymphocytes is associated with changed chemotactic responses to IL-8.

    Xu, L / Kelvin, D J / Ye, G Q / Taub, D D / Ben-Baruch, A / Oppenheim, J J / Wang, J M

    Journal of leukocyte biology

    1995  Volume 57, Issue 2, Page(s) 335–342

    Abstract: Interleukin-8 is a member of the chemokine superfamily and is a major mediator of acute inflammation. Although IL-8 has been reported by some laboratories also to be a chemoattractant for T lymphocytes, this has been difficult to confirm and remains a ... ...

    Abstract Interleukin-8 is a member of the chemokine superfamily and is a major mediator of acute inflammation. Although IL-8 has been reported by some laboratories also to be a chemoattractant for T lymphocytes, this has been difficult to confirm and remains a controversial issue. By using freshly purified human T cells (90-95% CD3+), we could demonstrate consistent directional migration of T cells to recombinant human IL-8. IL-8 was as potent as RANTES, MIP1 alpha, and MIP1 beta in inducing T cell chemotaxis. Highly purified T cells, however, incubated at 37 degrees C for more than 12 h or cultured overnight with anti-CD3 antibody cross-linked to plastic dishes, showed a markedly reduced capacity to migrate in response to IL-8. This was associated with a decrease in binding of radioiodinated IL-8 to T cells. Northern blot and polymerase chain reaction analyses showed that freshly purified T cells expressed mRNA for both IL-8 receptor type A and type B. Steady-state levels of mRNA for the IL-8RA and IL-8RB genes were also reduced by incubation of the cells with or without anti-CD3 for 12 h at 37 degrees C. These results indicate that T cells are indeed one of the target cell populations for IL-8. The regulation of IL-8 receptor expression on T lymphocytes may contribute to the pathophysiological role of IL-8 in inducing the homing and infiltration of T cells.
    MeSH term(s) Antibodies, Monoclonal/pharmacology ; Base Sequence ; Blotting, Northern ; Chemotactic Factors/pharmacology ; Chemotaxis, Leukocyte/drug effects ; Chromatography, Affinity ; Humans ; Interleukin-8/pharmacology ; Molecular Sequence Data ; RNA, Messenger/analysis ; RNA, Messenger/metabolism ; Receptors, Interleukin/physiology ; Receptors, Interleukin-8A ; T-Lymphocytes/drug effects ; T-Lymphocytes/physiology ; T-Lymphocytes/ultrastructure
    Chemical Substances Antibodies, Monoclonal ; Chemotactic Factors ; Interleukin-8 ; RNA, Messenger ; Receptors, Interleukin ; Receptors, Interleukin-8A
    Language English
    Publishing date 1995-02
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/jlb.57.2.335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 603: Show issues Location:
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