LIVIVO - Search results -

Search results

Result 1 - 10 of total 1127

Search options

Article: Effect of Patient Factors on Portal Vein and Hepatic Contrast Enhancement at Computed Tomography Scan With Protocol Combining Fixed Injection Duration and Patients' Body Weight Tailored Dose of Contrast Material.

Ye, Hui

2022 Volume 14, Issue 9, Page(s) e29283

Abstract: Introduction Fixed injection duration with patients' body weight tailored dose of contrast material was recommended as the practical scan protocol in multiphasic contrast-enhanced abdominal computed tomography (CT). This study evaluated the effect of the ...

Abstract	Introduction Fixed injection duration with patients' body weight tailored dose of contrast material was recommended as the practical scan protocol in multiphasic contrast-enhanced abdominal computed tomography (CT). This study evaluated the effect of the demographic variables on portal vein and hepatic contrast enhancement in hepatic arterial phase (HAP), aiming to reduce the patient-to-patient variability and optimize the HAP images. Methods This retrospective analysis included 87 patients who underwent abdominal enhancement multiphase CT from April to June 2022. All the patients were examined using protocol combining fixed injection duration and patients' body weight tailored dose of contrast material. Univariate and multivariate linear regression analyses were performed between all patient characteristics and the contrast-enhanced CT number of portal vein and hepatic parenchyma during HAP. Results Univariate linear regression analysis demonstrated statistically significant correlations between the CT number of hepatic parenchyma, and the body mass index (BMI), body surface area (BSA), and total body weight (TBW) (all P < 0.001) during HAP. However, multivariate linear regression analysis showed that the BMI or BMI and age were of independent predictive values (P < 0.001). Also, only the age was independently and negatively related to the CT number of portal vein enhancement during HAP (r = 0.240, P < 0.05) according to univariate linear regression analysis. Conclusions Univariate linear regression analysis revealed a significant inverse correlation between portal vein CT value and age. By multivariate linear regression analysis, only the BMI and age were significantly correlated with liver parenchymal enhancement, while gender, TBW, BSA, and HT were not.
Language	English
Publishing date	2022-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.29283
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Finding the Location of Axonal Activation by a Miniature Magnetic Coil.

Ye, Hui

Frontiers in computational neuroscience

2022 Volume 16, Page(s) 932615

Abstract: Magnetic stimulation for neural activation is widely used in clinical and lab research. In comparison to electric stimulation using an implanted electrode, stimulation with a large magnetic coil is associated with poor spatial specificity and ... ...

Abstract	Magnetic stimulation for neural activation is widely used in clinical and lab research. In comparison to electric stimulation using an implanted electrode, stimulation with a large magnetic coil is associated with poor spatial specificity and incapability to stimulate deep brain structures. Recent developments in micromagnetic stimulation (μMS) technology mitigates some of these shortcomings. The sub-millimeter coils can be covered with soft, biocompatible material, and chronically implanted. They can provide highly specific neural stimulation in the deep neural structure. Although the μMS technology is expected to provide a precise location of neural stimulation, the exact site of neural activation is difficult to determine. Furthermore, factors that could cause the shifting of the activation site during μMS have not been fully investigated. To estimate the location of axon activation in μMS, we first derived an analytical expression of the activating function, which predicts the location of membrane depolarization in an unmyelinated axon. Then, we developed a multi-compartment, Hodgkin-Huxley (H-H) type of NEURON model of an unmyelinated axon to test the impact of several important coil parameters on the location of axonal activation. The location of axonal activation was dependent on both the parameters of the stimulus and the biophysics properties of the targeted axon during μMS. The activating function analysis predicted that the location of membrane depolarization and activation could shift due to the reversal of the coil current and the change in the coil-axon distance. The NEURON modeling confirmed these predictions. Interestingly, the NEURON simulation further revealed that the intensity of stimulation played a significant role in the activation location. Moderate or strong coil currents activated the axon at different locations, mediated by two distinct ion channel mechanisms. This study reports several experimental factors that could cause a potential shift in the location of neural activation during μMS, which is essential for further development of this novel technology.
Language	English
Publishing date	2022-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452964-3
ISSN	1662-5188
ISSN	1662-5188
DOI	10.3389/fncom.2022.932615
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Predictive Indicators of Brain Metastasis-Free Survival in Patients With Lung Cancer at a Chinese Cancer Center.

Ye, Hui

Cureus

2021 Volume 13, Issue 11, Page(s) e19995

Abstract: Introduction Metastasis tumors of the brain derive mostly from lung cancer, breast cancer, melanoma, and more commonly among lung cancer patients. Once brain metastasis is diagnosed, the prognosis of untreated patients is shown to be very poor. In this ... ...

Abstract	Introduction Metastasis tumors of the brain derive mostly from lung cancer, breast cancer, melanoma, and more commonly among lung cancer patients. Once brain metastasis is diagnosed, the prognosis of untreated patients is shown to be very poor. In this study, we describe the clinical and pathological features of patients with lung cancer at our institution from 2009 to 2021. We also examined factors like gender, type, size, and location of the primary tumor and leukoaraiosis level at the first visit are associated with patients' brain metastasis-free survival (the time free of brain metastases since the first diagnosis of lung cancer). Materials and methods We retrospectively reviewed patients with a final histologic diagnosis of lung cancer from September 2009 to January 2015. The evaluation included history, physical examination, and contrast-enhanced computerized tomography of the chest. Contrast-enhanced magnetic resonance imaging of the head was performed at the first visit and following treatment. The patients' age, gender, tumor size, histology type, location of the lung tumor, and leukoaraiosis level at the first visit were recorded and correlated to the patients' brain-metastasis-free survival time. Results The study included 68 patients - 39 males and 29 females -with a mean age of 55.15 years (range 35-69 years). Adenocarcinoma was diagnosed in 47 patients (22 males and 25 females), Squamous carcinoma was diagnosed in 12 patients (9 males and 3 females), non-small cell lung carcinoma was diagnosed in 3 patients (2 males and one female), one male patient had the diagnosis of adenosquamous tumor and 1 male patient had the diagnosis of neuroendocrine tumor. Tumor size was <3 cm in 19 patients, 3-5 cm in 29 patients, 5-10 cm in 17 patients, and three other patients' size was hard to measure. Of the 68 patients, 10 patients were detected as brain metastasis by magnetic resonance imaging at first diagnosis, 22 patients were diagnosed as brain metastasis during the follow-up visits, 36 patients were not found as brain metastasis until the last visit. According to the Cox regression univariate analysis, two factors were correlated to shorter brain metastasis-free survival: Not-squamous lung carcinoma (SCC) and higher location of the tumor. The multivariate statistical analysis correlated two factors to shorter brain metastasis-free survival: non-SCC histology type and age≥62. Conclusions In conclusion, we found that SCC had a lower incidence of brain metastasis in patients than other lung cancer types. According to the Cox regression multivariate analysis, age <62 and SCC were two protective factors of brain metastasis. According to the Cox regression univariate and analysis. The lower location of the tumor was the protective factor of brain metastasis. According to the Cox regression univariate analysis, other parameters, such as gender or tumor size, did not have a role in brain metastasis-free survival in these patients.
Language	English
Publishing date	2021-11-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.19995
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: 18

Jiang, Cheng-Zhi / Ye, Hui

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2023 Volume 137, Page(s) 71–72

MeSH term(s)	Humans ; Positron Emission Tomography Computed Tomography ; Patients ; Fluorodeoxyglucose F18 ; Quinolines
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Quinolines
Language	English
Publishing date	2023-10-30
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2023.10.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4516: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cross-talk between

Yang, Shanshan / Hao, Shaodong / Ye, Hui / Zhang, Xuezhi

Frontiers in cellular and infection microbiology

2024 Volume 14, Page(s) 1353094

Abstract: Background: Helicobacter pylori: Methods: A bibliographic search was conducted on October 24, 2023, to retrieve relevant studies on HP/GC research between 2003 and 2022. The search terms were attached to HP and GC. The main data were from the Web of ... ...

Abstract	Background: Helicobacter pylori Methods: A bibliographic search was conducted on October 24, 2023, to retrieve relevant studies on HP/GC research between 2003 and 2022. The search terms were attached to HP and GC. The main data were from the Web of Science Core Collection (WoSCC). Data visualization was performed using Biblioshiny, VOSviewer, and Microsoft Excel. Results: In HP/GC research, 1970 papers were retrieved. The total number of papers (Np) in HP/GC was growing from 2003 to 2022. China and Japan were in the leading position and made the most contributions to HP/GC. Conclusion: This study evaluated the global scientific output in HP/GC research and its quantitative characteristics, identified the essential works, and collected information on the current status, main focuses and emerging trends in HP/GC research to provide academics with guidance for future paths.
MeSH term(s)	Humans ; Stomach Neoplasms ; Helicobacter pylori ; Cell Physiological Phenomena ; Autophagy
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2024.1353094
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Cellular mechanisms underlying carry-over effects after magnetic stimulation.

Ye, Hui / Dima, Maria / Hall, Vincent / Hendee, Jenna

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5167

Abstract: Magnetic fields are widely used for neuromodulation in clinical settings. The intended effect of magnetic stimulation is that neural activity resumes its pre-stimulation state right after stimulation. Many theoretical and experimental works have focused ... ...

Abstract	Magnetic fields are widely used for neuromodulation in clinical settings. The intended effect of magnetic stimulation is that neural activity resumes its pre-stimulation state right after stimulation. Many theoretical and experimental works have focused on the cellular and molecular basis of the acute neural response to magnetic field. However, effects of magnetic stimulation can still last after the termination of the magnetic stimulation (named "carry-over effects"), which could generate profound effects to the outcome of the stimulation. However, the cellular and molecular mechanisms of carry-over effects are largely unknown, which renders the neural modulation practice using magnetic stimulation unpredictable. Here, we investigated carry-over effects at the cellular level, using the combination of micro-magnetic stimulation (µMS), electrophysiology, and computation modeling. We found that high frequency magnetic stimulation could lead to immediate neural inhibition in ganglion neurons from Aplysia californica, as well as persistent, carry-over inhibition after withdrawing the magnetic stimulus. Carry-over effects were found in the neurons that fired action potentials under a variety of conditions. The carry-over effects were also observed in the neurons when the magnetic field was applied across the ganglion sheath. The state of the neuron, specifically synaptic input and membrane potential fluctuation, plays a significant role in generating the carry-over effects after magnetic stimulation. To elucidate the cellular mechanisms of such carry-over effects under magnetic stimulation, we simulated a single neuron under magnetic stimulation with multi-compartment modeling. The model successfully replicated the carry-over effects in the neuron, and revealed that the carry-over effect was due to the dysfunction of the ion channel dynamics that were responsible for the initiation and sustaining of membrane excitability. A virtual voltage-clamp experiment revealed a compromised Na conductance and enhanced K conductance post magnetic stimulation, rendering the neurons incapable of generating action potentials and, therefore, leading to the carry over effects. Finally, both simulation and experimental results demonstrated that the carry-over effects could be controlled by disturbing the membrane potential during the post-stimulus inhibition period. Delineating the cellular and ion channel mechanisms underlying carry-over effects could provide insights to the clinical outcomes in brain stimulation using TMS and other modalities. This research incentivizes the development of novel neural engineering or pharmacological approaches to better control the carry-over effects for optimized clinical outcomes.
MeSH term(s)	Neurons/physiology ; Membrane Potentials/physiology ; Action Potentials ; Ion Channels/physiology ; Magnetic Phenomena ; Electric Stimulation
Chemical Substances	Ion Channels
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55915-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Melatonin improves stroke through MDM2-mediated ubiquitination of ACSL4.

Ji, Qing / Zhang, Le / Ye, Hui

Aging

2024 Volume 16, Issue 2, Page(s) 1925–1937

Abstract: The objective of this study is to investigate the impact of melatonin on ischemic brain injury and elucidate its underlying molecular mechanism. In this investigation, a mouse model of middle cerebral artery occlusion (MCAO) was established using the ... ...

Abstract	The objective of this study is to investigate the impact of melatonin on ischemic brain injury and elucidate its underlying molecular mechanism. In this investigation, a mouse model of middle cerebral artery occlusion (MCAO) was established using the thread occlusion method, followed by treatment with two different doses of melatonin: 5 mg/kg and 10 mg/kg. Additionally, HT-22 cells were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) and treated with varying concentrations of melatonin. The findings demonstrated that melatonin significantly reduced the extent of cerebral ischemia, nerve damage, brain edema, and neuronal apoptosis in MCAO mice.
MeSH term(s)	Animals ; Mice ; Apoptosis ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Glucose/pharmacology ; Infarction, Middle Cerebral Artery/metabolism ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Stroke/drug therapy ; Stroke/metabolism ; Proto-Oncogene Proteins c-mdm2/metabolism ; Coenzyme A Ligases/metabolism ; Ubiquitination
Chemical Substances	Glucose (IY9XDZ35W2) ; Melatonin (JL5DK93RCL) ; Mdm2 protein, mouse (EC 2.3.2.27) ; Acsl4 protein, mouse (EC 6.2.1.-) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Coenzyme A Ligases (EC 6.2.1.-)
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205469
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Mechanic stress generated by a time-varying electromagnetic field on bone surface.

Ye, Hui

Medical & biological engineering & computing

2018 Volume 56, Issue 10, Page(s) 1793–1805

Abstract: Bone cells sense mechanical load, which is essential for bone growth and remodeling. In a fracture, this mechanism is compromised. Electromagnetic stimulation has been widely used to assist in bone healing, but the underlying mechanisms are largely ... ...

Abstract	Bone cells sense mechanical load, which is essential for bone growth and remodeling. In a fracture, this mechanism is compromised. Electromagnetic stimulation has been widely used to assist in bone healing, but the underlying mechanisms are largely unknown. A recent hypothesis suggests that electromagnetic stimulation could influence tissue biomechanics; however, a detailed quantitative understanding of EM-induced biomechanical changes in the bone is unavailable. This paper used a muscle/bone model to study the biomechanics of the bone under EM exposure. Due to the dielectric properties of the muscle/bone interface, a time-varying magnetic field can generate both compressing and shear stresses on the bone surface, where many mechanical sensing cells are available for cellular mechanotransduction. I calculated these stresses and found that the shear stress is significantly greater than the compressing stress. Detailed parametric analysis suggests that both the compressing and shear stresses are dependent on the geometrical and electrical properties of the muscle and the bone. These stresses are also functions of the orientation of the coil and the frequency of the magnetic field. It is speculated that the EM field could apply biomechanical influence to fractured bone, through the fine-tuning of the controllable field parameters. Graphical abstract Mechanic stress on bone surface in a time-varying magnetic field.
MeSH term(s)	Bone and Bones/anatomy & histology ; Bone and Bones/physiology ; Compressive Strength ; Electromagnetic Fields ; Extremities/physiology ; Humans ; Models, Biological ; Stress, Mechanical ; Time Factors
Language	English
Publishing date	2018-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	282327-5
ISSN	1741-0444 ; 0025-696X ; 0140-0118
ISSN (online)	1741-0444
ISSN	0025-696X ; 0140-0118
DOI	10.1007/s11517-018-1814-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 294: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Molecular design of antimicrobial peptides based on hemagglutinin fusion domain to combat antibiotic resistance in bacterial infection.

Ye, Hui

Journal of peptide science : an official publication of the European Peptide Society

2018 Volume 24, Issue 3

Abstract: Antimicrobial peptides are derived from the viral fusion domain of influenza virus hemagglutinin based on rational analysis of the intermolecular interaction between peptides and bacterial outer membrane. It is revealed that the isolated viral fusion ... ...

Abstract	Antimicrobial peptides are derived from the viral fusion domain of influenza virus hemagglutinin based on rational analysis of the intermolecular interaction between peptides and bacterial outer membrane. It is revealed that the isolated viral fusion domain is a negatively charged peptide HAfp
MeSH term(s)	Animals ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/genetics ; Antimicrobial Cationic Peptides/pharmacology ; Cyclization ; Drug Resistance, Multiple, Bacterial/drug effects ; Entropy ; Hemagglutinins, Viral/chemistry ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Mice ; Microbial Sensitivity Tests ; Models, Molecular ; Mutation ; Orthomyxoviridae/chemistry ; Orthomyxoviridae/metabolism ; Protein Conformation ; Pseudomonas aeruginosa/drug effects
Chemical Substances	Antimicrobial Cationic Peptides ; Hemagglutinins, Viral
Language	English
Publishing date	2018-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1234416-3
ISSN	1099-1387 ; 1075-2617
ISSN (online)	1099-1387
ISSN	1075-2617
DOI	10.1002/psc.3068
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6200: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: An observer-based adaptive fault-tolerant control for hypersonic vehicle with unexpected centroid shift and input saturation.

Ye, Hui / Meng, Yizhen

ISA transactions

2022 Volume 130, Page(s) 51–62

Abstract: This paper makes an investigation on the fault-tolerant control (FTC) problem for a hypersonic reentry vehicle (HSV) in the coexistence of unknown movement of center-of-mass, system input constraint and failure of actuator. Firstly, the dynamics of HSV's ...

Abstract	This paper makes an investigation on the fault-tolerant control (FTC) problem for a hypersonic reentry vehicle (HSV) in the coexistence of unknown movement of center-of-mass, system input constraint and failure of actuator. Firstly, the dynamics of HSV's attitude system with the unknown factors mentioned above are developed to illustrate the particularity of the researched topic. The influences of unexpected centroid shift on an FTC design can be summarized into the following three parts: unknown system uncertainties, eccentric torque as well as changing system moment of inertia matrix, which are coupled and unknown. Secondly, due to the difficulty in decoupling and estimating these influences (embodied in the output states of the system) one by one, it is the attitude system states observer that is proposed to estimate those detrimental unknown effects. The designed observer is consisted of an adaptive fault observer and an adaptive sliding-mode observer, supporting an innovative adaptive FTC scheme free from the variation of inverse matrix that might be singular due to an unexpected centroid shift. This fault-tolerant controller established in the estimated system states is derived by utilizing the above mentioned observer and adaptive backstepping control in conjunction with adaptive auxiliary compensation systems to handle the system input saturation. Moreover, the convergence of attitude tracking error and the boundedness of all closed-loop signals are achieved in the light of Lyapunov stability theory and boundedness analysis. Ultimately, simulation results are delivered to demonstrate the effectiveness of the proposed FTC scheme.
Language	English
Publishing date	2022-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2012746-7
ISSN	1879-2022 ; 0019-0578
ISSN (online)	1879-2022
ISSN	0019-0578
DOI	10.1016/j.isatra.2022.04.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito