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  1. Article: Editorial: Drug discovery and nano delivery of natural products.

    Ye, Jun

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1402362

    Language English
    Publishing date 2024-04-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1402362
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  2. Article: Commentary: Inhibitors of mitochondrial respiratory chain in the treatment of type 2 diabetes.

    Ye, Jianping

    Acta pharmaceutica Sinica. B

    2023  Volume 13, Issue 6, Page(s) 2807–2808

    Language English
    Publishing date 2023-03-21
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2211-3835
    ISSN 2211-3835
    DOI 10.1016/j.apsb.2023.03.016
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  3. Article: Editorial: Insights in lipids, membranes and membranous organelles.

    Ye, Jin

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1210167

    Language English
    Publishing date 2023-05-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1210167
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  4. Article ; Online: Patient Safety of Perioperative Medication Through the Lens of Digital Health and Artificial Intelligence.

    Ye, Jiancheng

    JMIR perioperative medicine

    2023  Volume 6, Page(s) e34453

    Abstract: Perioperative medication has made significant contributions to enhancing patient safety. Nevertheless, administering medication during this period still poses considerable safety concerns, with many errors being detected only after causing significant ... ...

    Abstract Perioperative medication has made significant contributions to enhancing patient safety. Nevertheless, administering medication during this period still poses considerable safety concerns, with many errors being detected only after causing significant physiological disturbances. The intricacy of medication administration in the perioperative setting poses specific challenges to patient safety. To address these challenges, implementing potential strategies and interventions is critical. One such strategy is raising awareness and revising educational curricula regarding drug safety in the operating room. Another crucial strategy is recognizing the importance of redundancy and multiple checks in the operating room as a hallmark of medication safety, which is not a common practice. Digital health technologies and artificial intelligence (AI) also offer the potential to improve perioperative medication safety. Computerized physician order entry systems, electronic medication administration records, and barcode medication administration systems have been proven to reduce medication errors and improve patient safety. By implementing these strategies and interventions, health care professionals can enhance the safety of perioperative medication administration and improve patient outcomes.
    Language English
    Publishing date 2023-05-31
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-9128
    ISSN (online) 2561-9128
    DOI 10.2196/34453
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  5. Article: [Surgical timing for childhood blepharoptosis].

    Ye, J / Lou, L X

    Zhonghua yan ke za zhi] Chinese journal of ophthalmology

    2023  Volume 59, Issue 7, Page(s) 514–517

    Abstract: Blepharoptosis in children is one of the common pediatric eye diseases. It is not only a matter of aesthetics, but also affects visual and psychological development. How to choose the right time to operate has been controversial in clinical practice. ... ...

    Abstract Blepharoptosis in children is one of the common pediatric eye diseases. It is not only a matter of aesthetics, but also affects visual and psychological development. How to choose the right time to operate has been controversial in clinical practice. Based on the domestic and foreign research progress and clinical experience, we propose that factors, such as the etiology of blepharoptosis, visual and psychological development characteristics of children, developmental characteristics of eyelid-related muscles, and types of blepharoptosis, should be considered for selection of the timing of surgery in a personalized and standardized manner, so as to provide reference and guidance for the clinical diagnosis and treatment of blepharoptosis in children.
    MeSH term(s) Child ; Humans ; Blepharoptosis/surgery ; Oculomotor Muscles/surgery ; Retrospective Studies ; Treatment Outcome
    Language Chinese
    Publishing date 2023-07-05
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604574-1
    ISSN 0412-4081
    ISSN 0412-4081
    DOI 10.3760/cma.j.cn112142-20230317-00104
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  6. Article ; Online: Design and development of an informatics-driven implementation research framework for primary care studies.

    Ye, Jiancheng

    AMIA ... Annual Symposium proceedings. AMIA Symposium

    2022  Volume 2021, Page(s) 1208–1214

    Abstract: The digitalization of the healthcare systems has resulted in a deluge of big data and has prompted the rapid growth of data science in medicine. Many informatics tools, such as data science, which is the field of study dedicated to the principled ... ...

    Abstract The digitalization of the healthcare systems has resulted in a deluge of big data and has prompted the rapid growth of data science in medicine. Many informatics tools, such as data science, which is the field of study dedicated to the principled extraction of knowledge from complex data, can also introduce benefits into implementation science, quality improvement (QI), and primary care research. The increased amount of primary care QI initiatives, availability of practice facilitation-related data, the need for better evidence-based care, and the complexity of challenges make the use of data science techniques and data-driven research particularly appealing to primary care. Recent advances in the usability, applicability, and interpretability of data science models offer promising applications to implementation science. Despite the increasing number of studies and publications in the field, thus far there have been few examples of combining informatics and implementation framework to facilitate primary care studies. We designed and developed an informatics-driven implementation research framework to provide a coherent rationale and justification of the complex interrelationships among features, strategies, and outcomes. The proposed framework is a principle-guided tool designed to improve the specification, reproducibility, and testable causal pathways involved in implementation research projects in primary care settings.
    MeSH term(s) Big Data ; Delivery of Health Care ; Humans ; Primary Health Care ; Quality Improvement ; Reproducibility of Results
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article
    ISSN 1942-597X
    ISSN (online) 1942-597X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKⅡγ and CaMKⅡδ against ischemic reperfusion injury in mice].

    Liu, H / Lin, Z / Ye, J

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2024  Volume 44, Issue 3, Page(s) 563–570

    Abstract: Objective: To observe neuroprotective effects of Ca: Methods: Primary cultures of brain neurons isolated from fetal mice (gestational age of 18 days) were transfected with two specific siRNAs (si-CAMK2G and si-CAMK2D) or a control sequence (si-NT). ... ...

    Abstract Objective: To observe neuroprotective effects of Ca
    Methods: Primary cultures of brain neurons isolated from fetal mice (gestational age of 18 days) were transfected with two specific siRNAs (si-CAMK2G and si-CAMK2D) or a control sequence (si-NT). After the transfection, the cells were exposed to oxygen-glucose deprivation/reperfusion (OGD/R) conditions for 1 h followed by routine culture. The expressions of phosphatidylinositol-3-kinase/extracellular signal-regulated kinase (PI3K/Akt/Erk) signaling pathway components in the neurons were detected using immunoblotting. The expressions of the PI3K/Akt/Erk signaling pathway proteins were also detected in the brain tissues of mice receiving middle cerebral artery occlusion (MCAO) or sham operation.
    Results: The neuronal cells transfected with siCAMK2G showed significantly lower survival rates than those with si-NT transfection at 12, 24, 48, and 72 h after OGD/R (
    Conclusion: The neuroprotective effects of CaMKⅡδ and CaMKⅡγ against acute neuronal ischemic reperfusion injury are mediated probably by the PI3K/Akt/Erk pathway.
    MeSH term(s) Animals ; Mice ; Rats ; Brain Ischemia/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Infarction, Middle Cerebral Artery ; Neuroprotection ; Neuroprotective Agents/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism ; Signal Transduction
    Chemical Substances Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Neuroprotective Agents ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Camk2d protein, mouse (EC 2.7.11.17) ; Camk2g protein, mouse (EC 2.7.11.17)
    Language Chinese
    Publishing date 2024-04-10
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2024.03.18
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  8. Article ; Online: Advancing Mental Health and Psychological Support for Health Care Workers Using Digital Technologies and Platforms.

    Ye, Jiancheng

    JMIR formative research

    2021  Volume 5, Issue 6, Page(s) e22075

    Abstract: Background: The COVID-19 pandemic is a global public health crisis that has not only endangered the lives of patients but also resulted in increased psychological issues among medical professionals, especially frontline health care workers. As the ... ...

    Abstract Background: The COVID-19 pandemic is a global public health crisis that has not only endangered the lives of patients but also resulted in increased psychological issues among medical professionals, especially frontline health care workers. As the crisis caused by the pandemic shifts from acute to protracted, attention should be paid to the devastating impacts on health care workers' mental health and social well-being. Digital technologies are being harnessed to support the responses to the pandemic, which provide opportunities to advance mental health and psychological support for health care workers.
    Objective: The aim of this study is to develop a framework to describe and organize the psychological and mental health issues that health care workers are facing during the COVID-19 pandemic. Based on the framework, this study also proposes interventions from digital health perspectives that health care workers can leverage during and after the pandemic.
    Methods: The psychological problems and mental health issues that health care workers have encountered during the COVID-19 pandemic were reviewed and analyzed based on the proposed MEET (Mental Health, Environment, Event, and Technology) framework, which also demonstrated the interactions among mental health, digital interventions, and social support.
    Results: Health care workers are facing increased risk of experiencing mental health issues due to the COVID-19 pandemic, including burnout, fear, worry, distress, pressure, anxiety, and depression. These negative emotional stressors may cause psychological problems for health care workers and affect their physical and mental health. Digital technologies and platforms are playing pivotal roles in mitigating psychological issues and providing effective support. The proposed framework enabled a better understanding of how to mitigate the psychological effects during the pandemic, recover from associated experiences, and provide comprehensive institutional and societal infrastructures for the well-being of health care workers.
    Conclusions: The COVID-19 pandemic presents unprecedented challenges due to its prolonged uncertainty, immediate threat to patient safety, and evolving professional demands. It is urgent to protect the mental health and strengthen the psychological resilience of health care workers. Given that the pandemic is expected to exist for a long time, caring for mental health has become a "new normal" that needs a strengthened multisector collaboration to facilitate support and reduce health disparities. The proposed MEET framework could provide structured guidelines for further studies on how technology interacts with mental and psychological health for different populations.
    Language English
    Publishing date 2021-06-30
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-326X
    ISSN (online) 2561-326X
    DOI 10.2196/22075
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  9. Article ; Online: Health Information System's Responses to COVID-19 Pandemic in China: A National Cross-sectional Study.

    Ye, Jiancheng

    Applied clinical informatics

    2021  Volume 12, Issue 2, Page(s) 399–406

    Abstract: Objective: After the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, Chinese hospitals and health information technology (HIT) vendors collaborated to provide comprehensive information technology support for pandemic prevention and control. ...

    Abstract Objective: After the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, Chinese hospitals and health information technology (HIT) vendors collaborated to provide comprehensive information technology support for pandemic prevention and control. This study aims to describe the responses from the health information systems (HIS) to the COVID-19 pandemic and provide empirical evidence in the application of emerging health technologies in China.
    Methods: This observational descriptive study utilized a nationally representative, cross-sectional survey of hospitals in China (
    Results: Among all the responses, the most popular interventions and applications include expert question-and-answer sessions and science popularization (61.74%) in online medical consultation, online appointment registration (58.97%) in online medical service, and remote consultation (75.15%) in telehealth service. A total of 63.71% of the participating hospitals expanded their fever clinics during the pandemic, 15.38% hospitals used new or upgraded mobile ward rounds systems, and 44.68% hospitals applied online self-service systems. Challenges and barriers include protecting network information security (57.00%) since some hospitals experienced cybersecurity incidents. 71.79% participants hope to shorten wait time and optimize the treatment process. Health care workers experienced increased amount of work during the pandemic, while hospital information departments did not experience significant changes in their workload.
    Conclusion: In the process of fighting against the COVID-19, hospitals have widely used traditional and emerging novel HITs. These technologies have strengthened the capacity of prevention and control of the pandemic and provided comprehensive information technology support while also improving accessibility and efficiency of health care delivery.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; China/epidemiology ; Computer Security ; Cross-Sectional Studies ; Delivery of Health Care ; Health Information Systems/trends ; Hospital Information Systems/trends ; Hospitals/classification ; Humans ; Pandemics/prevention & control ; Remote Consultation ; SARS-CoV-2 ; Surveys and Questionnaires ; Telemedicine
    Language English
    Publishing date 2021-05-19
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/s-0041-1728770
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  10. Article ; Online: The impact of electronic health record-integrated patient-generated health data on clinician burnout.

    Ye, Jiancheng

    Journal of the American Medical Informatics Association : JAMIA

    2021  Volume 28, Issue 5, Page(s) 1051–1056

    Abstract: Patient-generated health data (PGHD), such as patient-reported outcomes and mobile health data, have been increasingly used to improve health care delivery and outcomes. Integrating PGHD into electronic health records (EHRs) further expands the ... ...

    Abstract Patient-generated health data (PGHD), such as patient-reported outcomes and mobile health data, have been increasingly used to improve health care delivery and outcomes. Integrating PGHD into electronic health records (EHRs) further expands the capacities to monitor patients' health status without requiring office visits or hospitalizations. By reviewing and discussing PGHD with patients remotely, clinicians could address the clinical issues efficiently outside of clinical settings. However, EHR-integrated PGHD may create a burden for clinicians, leading to burnout. This study aims to investigate how interactions with EHR-integrated PGHD may result in clinician burnout. We identify the potential contributing factors to clinician burnout using a modified FITT (Fit between Individuals, Task and Technology) framework. We found that technostress, time pressure, and workflow-related issues need to be addressed to accelerate the integration of PGHD into clinical care. The roles of artificial intelligence, algorithm-based clinical decision support, visualization format, human-computer interaction mechanism, workflow optimization, and financial reimbursement in reducing burnout are highlighted.
    MeSH term(s) Artificial Intelligence ; Burnout, Professional/etiology ; Electronic Health Records ; Humans ; Patient Generated Health Data ; Systems Integration ; Telemedicine ; User-Computer Interface ; Workflow ; Workload
    Language English
    Publishing date 2021-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1205156-1
    ISSN 1527-974X ; 1067-5027
    ISSN (online) 1527-974X
    ISSN 1067-5027
    DOI 10.1093/jamia/ocab017
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