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  1. Article ; Online: Control strategies in systemic metabolism.

    Ye, Jessica / Medzhitov, Ruslan

    Nature metabolism

    2019  Volume 1, Issue 10, Page(s) 947–957

    Abstract: Metabolic control systems coordinate myriad processes across the cellular, tissue and organismal levels to optimize the allocation of limited supplies across multiple, often competing, metabolic demands. As such, the regulation of metabolism can be ... ...

    Abstract Metabolic control systems coordinate myriad processes across the cellular, tissue and organismal levels to optimize the allocation of limited supplies across multiple, often competing, metabolic demands. As such, the regulation of metabolism can be analysed from the perspective of the economic theory of supply and demand. Here, we discuss how such analyses can provide new insights into the logic of metabolic control. In particular, we suggest that, in addition to being subject to well-appreciated homeostatic control, metabolism is subject to supply-driven and demand-driven controls, each operated by a dedicated set of signals throughout various physiological states, including inflammation. Furthermore, we argue that systemic homeostasis is a derived feature that evolved from the control systems that monitor metabolic supply and demand.
    MeSH term(s) Animals ; Homeostasis ; Humans ; Metabolic Networks and Pathways/physiology ; Metabolism/physiology ; Models, Biological
    Language English
    Publishing date 2019-10-07
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-019-0118-8
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  2. Article ; Online: Understanding the role of transition metal single-atom electronic structure in oxysulfur radical-mediated oxidative degradation.

    Zhao, Guanshu / Ding, Jing / Ren, Jiayi / Zhao, Qingliang / Mao, Chengliang / Wang, Kun / Ye, Jessica / Chen, Xueqi / Wang, Xianjie / Long, Mingce

    Environmental science and ecotechnology

    2024  Volume 20, Page(s) 100405

    Abstract: The ubiquity of refractory organic matter in aquatic environments necessitates innovative removal strategies. Sulfate radical-based advanced oxidation has emerged as an attractive solution, offering high selectivity, enduring efficacy, and anti- ... ...

    Abstract The ubiquity of refractory organic matter in aquatic environments necessitates innovative removal strategies. Sulfate radical-based advanced oxidation has emerged as an attractive solution, offering high selectivity, enduring efficacy, and anti-interference ability. Among many technologies, sulfite activation, leveraging its cost-effectiveness and lower toxicity compared to conventional persulfates, stands out. Yet, the activation process often relies on transition metals, suffering from low atom utilization. Here we introduce a series of single-atom catalysts (SACs) employing transition metals on g-C
    Language English
    Publishing date 2024-02-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-4984
    ISSN (online) 2666-4984
    DOI 10.1016/j.ese.2024.100405
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  3. Article ; Online: Sideways maneuvers enable narrow aperture negotiation by free-flying hummingbirds.

    Badger, Marc A / McClain, Kathryn / Smiley, Ashley / Ye, Jessica / Dudley, Robert

    The Journal of experimental biology

    2023  Volume 226, Issue 21

    Abstract: Many birds routinely fly fast through dense vegetation characterized by variably sized structures and voids. Successfully negotiating these cluttered environments requires maneuvering through narrow constrictions between obstacles. We show that Anna's ... ...

    Abstract Many birds routinely fly fast through dense vegetation characterized by variably sized structures and voids. Successfully negotiating these cluttered environments requires maneuvering through narrow constrictions between obstacles. We show that Anna's hummingbirds (Calypte anna) can negotiate apertures less than one wingspan in diameter using a novel sideways maneuver that incorporates continuous, bilaterally asymmetric wing motions. Crucially, this maneuver allows hummingbirds to continue flapping as they negotiate the constriction. Even smaller openings are negotiated via a faster ballistic trajectory characterized by tucked and thus non-flapping wings, which reduces force production and increases descent rate relative to the asymmetric technique. Hummingbirds progressively shift to the swept method as they perform hundreds of consecutive transits, suggesting increased locomotor performance with task familiarity. Initial use of the slower asymmetric transit technique may allow birds to better assess upcoming obstacles and voids, thereby reducing the likelihood of subsequent collisions. Repeated disruptions of normal wing kinematics as birds negotiate tight apertures may determine the limits of flight performance in structurally complex environments. These strategies for aperture transit and associated flight trajectories can inform designs and algorithms for small aerial vehicles flying within cluttered environments.
    MeSH term(s) Animals ; Negotiating ; Flight, Animal ; Birds ; Biomechanical Phenomena ; Wings, Animal
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.245643
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    Zs.A 2629: Show issues Location:
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  4. Article: Giant Cell Arteritis Presenting With Multiple Cranial Neuropathies - Case Report.

    Ye, Jessica J / Bouffard, Marc A / Brooks, Earllondra / Hung, Yin P / Kimchi, Eyal Y

    The Neurohospitalist

    2022  Volume 13, Issue 2, Page(s) 188–191

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2629083-2
    ISSN 1941-8752 ; 1941-8744
    ISSN (online) 1941-8752
    ISSN 1941-8744
    DOI 10.1177/19418744221139893
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  5. Article ; Online: Patient survey superior to EMR extraction for eliciting positive symptoms at COVID-19 illness onset.

    Mockler, Gretchen / Novotny, Samantha / Schoenfeld, Elinor / Liu, Yuhang / Ye, Jessica / Medrano, Christopher

    Annals of family medicine

    2022  , Issue 20 Suppl 1

    Abstract: Context: COVID-19 has ravaged nations around the world, with New York City (NYC) and the NYC suburbs being particular epicenters of COVID-19 infection. Suffolk County, NY, has reported over 200,000 cases and 3,000 deaths to date. Most initial COVID-19 ... ...

    Abstract Context: COVID-19 has ravaged nations around the world, with New York City (NYC) and the NYC suburbs being particular epicenters of COVID-19 infection. Suffolk County, NY, has reported over 200,000 cases and 3,000 deaths to date. Most initial COVID-19 research concerned hospitalized patients. Presenting symptomology in the outpatient setting was poorly characterized, as were the implications of specific presenting symptoms, beyond respiratory distress or hypoxia, for eventual disease severity. This made it difficult for primary care physicians to predict which patients would require hospitalization for COVID-19 disease or decompensate while being managed at home during a time when hospital and ICU beds were limited. Objective: To characterize presenting symptoms of COVID-19 infection in the outpatient setting and evaluate for correlation with severity, duration, and chronicity of disease. Study Design and Analysis: We collected survey data from both patient telephone interviews and electronic medical record (EMR) extraction. Patient characteristics were described using means and percentages when appropriate. Percentage of symptoms by severity level, symptom duration, COVID-19 testing and escalating medical care were calculated. To evaluate association of risk factors with positive testing, severity, duration and chronicity of symptoms, logistic regression was used. Patient characteristics, medications and repeat measures were evaluated as risk factors in logistic regression. Setting or Dataset: 107 patients with suspected and confirmed COVID-19 cases at the 3 primary care practices of Stony Brook University Hospital between March and December, 2020. Population Studied: adult, English speaking primary care patients with suspected or confirmed COVID-19 Intervention/Instrument: patient self report telephone survey, EMR data extraction survey Outcome Measures: symptom duration, symptom severity, persistence of symptoms at 3 month time point Significant Results: Patient self-report survey elicited nearly twice as many symptoms described at illness onset vs. those recorded in the EMR. Conclusions: Early in the setting of newly emerging infectious diseases, particularly those such as COVID-19 which involve multiple organ systems, patient self report of symptoms of illness rather than EMR extraction alone may be crucial both for identifying cases and in order to characterize pathophysiology of disease in real time.
    MeSH term(s) Adult ; Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; SARS-CoV-2 ; COVID-19 Testing ; Electronic Health Records ; Surveys and Questionnaires
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171425-3
    ISSN 1544-1717 ; 1544-1709
    ISSN (online) 1544-1717
    ISSN 1544-1709
    DOI 10.1370/afm.20.s1.3070
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    Zs.A 6065: Show issues Location:
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  6. Article ; Online: Adiponectin and related C1q/TNF-related proteins bind selectively to anionic phospholipids and sphingolipids.

    Ye, Jessica J / Bian, Xin / Lim, Jaechul / Medzhitov, Ruslan

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 29, Page(s) 17381–17388

    Abstract: Adiponectin (Acrp30) is an adipokine associated with protection from cardiovascular disease, insulin resistance, and inflammation. Although its effects are conventionally attributed to binding Adipor1/2 and T-cadherin, its abundance in circulation, role ... ...

    Abstract Adiponectin (Acrp30) is an adipokine associated with protection from cardiovascular disease, insulin resistance, and inflammation. Although its effects are conventionally attributed to binding Adipor1/2 and T-cadherin, its abundance in circulation, role in ceramide metabolism, and homology to C1q suggest an overlooked role as a lipid-binding protein, possibly generalizable to other C1q/TNF-related proteins (CTRPs) and C1q family members. To investigate this, adiponectin, representative family members, and variants were expressed in Expi293 cells and tested for binding to lipids in liposomes using density centrifugation. Binding to physiological lipids were also analyzed using gradient ultracentrifugation, liquid chromatography-mass spectrometry, and shotgun lipidomics. Interestingly, adiponectin selectively bound several anionic phospholipids and sphingolipids, including phosphatidylserine, ceramide-1-phosphate, glucosylceramide, and sulfatide, via the C1q domain in an oligomerization-dependent fashion. Binding to lipids was observed in liposomes, low-density lipoproteins, cell membranes, and plasma. Other CTRPs and C1q family members (Cbln1, CTRP1, CTRP5, and CTRP13) also bound similar lipids. These findings suggest that adiponectin and CTRPs function not only as hormones, but also as lipid opsonins, as may other C1q family proteins.
    MeSH term(s) Adipokines/metabolism ; Adiponectin/genetics ; Adiponectin/metabolism ; Animals ; Anions ; Cell Membrane ; Cholesterol, LDL ; Complement C1q/metabolism ; Humans ; Lipid Metabolism ; Lipidomics ; Lipoproteins/metabolism ; Liposomes ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Opsonin Proteins/metabolism ; Phospholipids/metabolism ; Plasma ; Sphingolipids/metabolism ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Adipokines ; Adiponectin ; Adipoq protein, mouse ; Anions ; Cholesterol, LDL ; Lipoproteins ; Liposomes ; Opsonin Proteins ; Phospholipids ; Sphingolipids ; TNF protein, human ; Tumor Necrosis Factor-alpha ; Complement C1q (80295-33-6)
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1922270117
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    Zs.A 1148: Show issues Location:
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  7. Article ; Online: Association of Presenting Symptoms With Abnormal Laboratory Values for Vector-Borne Illness - Experience in an Urban Gastroenterology Practice.

    Erdman, Michael D / Kossari, Niloofar / Ye, Jessica / Reynolds, Kristen H / Blodget, Emily / Mozayeni, B Robert / Rahbar, Farshid Sam

    Journal of patient-centered research and reviews

    2021  Volume 8, Issue 1, Page(s) 39–47

    Abstract: Purpose: In the clinical setting, it is not common practice to consider a vector bite, such as from a tick or flea, to be a contributing factor to chronic digestive symptoms. This article investigates associations we have observed among symptomatic ... ...

    Abstract Purpose: In the clinical setting, it is not common practice to consider a vector bite, such as from a tick or flea, to be a contributing factor to chronic digestive symptoms. This article investigates associations we have observed among symptomatic patients and positive blood tests for vector-borne illness (VBI).
    Methods: Patients who visited an urban gastroenterology clinic over a 3-year period were retrospectively reviewed. A total of 270 patients presenting with a constellation of digestive symptoms - and who had no apparent digestive pathology and reported no prior diagnosis or treatments for VBI - were analyzed. Before the initial visit, all patients completed a review of systems medical history form, which comprised 19 gastrointestinal (GI) symptoms and 73 non-GI-related symptoms and conditions. Patients were tested for small intestinal bacterial overgrowth (SIBO) by lactulose breath test. VBI (babesiosis, ehrlichiosis, anaplasmosis, bartonellosis, borreliosis) was established using 1 or more of several blood tests. Odds ratio (OR) analysis determined associations between exposure to VBI, SIBO, and presenting symptoms/conditions. Two age groups (≤35 years and ≥36 years) were studied using Cochran-Mantel-Haenszel stratum-based test.
    Results: A higher OR (2.03, 95% CI: 1.5-3.6) was found between patients with ≥3 digestive symptoms and positive blood tests for ≥1 VBI. Five of the 19 GI symptoms were independently associated with VBI-positive samples: food intolerance, indigestion, nausea/vomiting, constipation, and heartburn. A similar association in patients with ≥3 non-GI symptoms (OR: 2.83, 95% CI: 1.3-6.4) was observed. Five of the 73 non-GI symptoms/conditions were independently associated with VBI-positive samples: chest pain, shortness of breath, extremity or joint pain, anxiety, and night sweats. Having ≥3 of any digestive or nondigestive symptoms generated significant relative risk of being VBI-positive. Presence of SIBO alone did not identify significant relative risk for a VBI, and age was not a confounder.
    Conclusions: Findings revealed an association between positive blood tests for vector-borne illness and chronically symptomatic patients regardless of whether symptoms were digestive or nondigestive. The manifestation of 3 or more gastrointestinal and/or extraintestinal symptoms should raise suspicion for a VBI.
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3022292-8
    ISSN 2330-0698 ; 2330-068X
    ISSN (online) 2330-0698
    ISSN 2330-068X
    DOI 10.17294/2330-0698.1729
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  8. Article ; Online: Photochemical Acceleration of Ammonia Production by Pt

    Mao, Chengliang / Wang, Jiaxian / Zou, Yunjie / Shi, Yanbiao / Viasus, Camilo J / Loh, Joel Y Y / Xia, Meikun / Ji, Shufang / Li, Meiqi / Shang, Huan / Ghoussoub, Mireille / Xu, Yang-Fan / Ye, Jessica / Li, Zhilin / Kherani, Nazir P / Zheng, Lirong / Liu, Yanjiang / Zhang, Lizhi / Ozin, Geoffrey A

    Journal of the American Chemical Society

    2023  Volume 145, Issue 24, Page(s) 13134–13146

    Abstract: Stable metal nitrides (MN) are promising materials to fit the future "green" ammonia-hydrogen nexus. Either through catalysis or chemical looping, the reductive hydrogenation of MN to ... ...

    Abstract Stable metal nitrides (MN) are promising materials to fit the future "green" ammonia-hydrogen nexus. Either through catalysis or chemical looping, the reductive hydrogenation of MN to MN
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c01947
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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
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  9. Article ; Online: Corrigendum to "Evaluation of antiviral effect and toxicity of total flavonoids extracted from Robinia pseudoacacia cv. idaho" [Biomed. Pharmacother. 118 (2019) 109335].

    Guo, Hao / Wan, Xinhuan / Niu, Fengju / Sun, Jujie / Shi, Chenxiao / Ye, Jessica Meng / Zhou, Changzheng

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2020  Volume 123, Page(s) 109809

    Language English
    Publishing date 2020-01-06
    Publishing country France
    Document type Journal Article ; Published Erratum
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2019.109809
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  10. Article ; Online: Evaluation of antiviral effect and toxicity of total flavonoids extracted from Robinia pseudoacacia cv. idaho.

    Guo, Hao / Wan, Xinhuan / Niu, Fengju / Sun, Jujie / Shi, Chenxiao / Ye, Jessica Meng / Zhou, Changzheng

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2019  Volume 118, Page(s) 109335

    Abstract: In this study, we aimed to evaluate the antiviral effect of total flavonoids extracted from Robinia pseudoacacia cv. idaho (RPTF) in vivo and its toxicity on rats with oral gavage. RPTF was prepared by percolation with 70% ethanol for 24 h and its ... ...

    Abstract In this study, we aimed to evaluate the antiviral effect of total flavonoids extracted from Robinia pseudoacacia cv. idaho (RPTF) in vivo and its toxicity on rats with oral gavage. RPTF was prepared by percolation with 70% ethanol for 24 h and its antiviral effect on different kinds of viruses was evaluated in vitro by MTT staining. The long-term toxicity of RPTF on rats was evaluated through the detection of general behavior, body weight, food intake and related organ tissue sections of experimental animals. We found that RPTF produced significantly inhibitory effects on HSV-1 and EV-71 viruses with the therapeutic index TI values 113.8 and 46.2, respectively. Moreover, toxicity evaluation in vivo showed no significantly adverse effects in rats, indicating that RPTF was safe in use. In conclusion, we demonstrated that RPTF, natural compounds in the Chinese traditional medicine, could act as promising and effective antiviral therapeutics with relative safety in use.
    MeSH term(s) Animals ; Antiviral Agents/isolation & purification ; Antiviral Agents/pharmacology ; Antiviral Agents/toxicity ; Body Weight/drug effects ; Feeding Behavior/drug effects ; Female ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Flavonoids/toxicity ; Liver/drug effects ; Liver/pathology ; Male ; Rats, Wistar ; Robinia/chemistry ; Toxicity Tests
    Chemical Substances Antiviral Agents ; Flavonoids
    Language English
    Publishing date 2019-08-12
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2019.109335
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