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  1. AU="Ye, Jessica Meng"
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  1. Artikel ; Online: Corrigendum to "Evaluation of antiviral effect and toxicity of total flavonoids extracted from Robinia pseudoacacia cv. idaho" [Biomed. Pharmacother. 118 (2019) 109335].

    Guo, Hao / Wan, Xinhuan / Niu, Fengju / Sun, Jujie / Shi, Chenxiao / Ye, Jessica Meng / Zhou, Changzheng

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2020  Band 123, Seite(n) 109809

    Sprache Englisch
    Erscheinungsdatum 2020-01-06
    Erscheinungsland France
    Dokumenttyp Journal Article ; Published Erratum
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2019.109809
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Evaluation of antiviral effect and toxicity of total flavonoids extracted from Robinia pseudoacacia cv. idaho.

    Guo, Hao / Wan, Xinhuan / Niu, Fengju / Sun, Jujie / Shi, Chenxiao / Ye, Jessica Meng / Zhou, Changzheng

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2019  Band 118, Seite(n) 109335

    Abstract: In this study, we aimed to evaluate the antiviral effect of total flavonoids extracted from Robinia pseudoacacia cv. idaho (RPTF) in vivo and its toxicity on rats with oral gavage. RPTF was prepared by percolation with 70% ethanol for 24 h and its ... ...

    Abstract In this study, we aimed to evaluate the antiviral effect of total flavonoids extracted from Robinia pseudoacacia cv. idaho (RPTF) in vivo and its toxicity on rats with oral gavage. RPTF was prepared by percolation with 70% ethanol for 24 h and its antiviral effect on different kinds of viruses was evaluated in vitro by MTT staining. The long-term toxicity of RPTF on rats was evaluated through the detection of general behavior, body weight, food intake and related organ tissue sections of experimental animals. We found that RPTF produced significantly inhibitory effects on HSV-1 and EV-71 viruses with the therapeutic index TI values 113.8 and 46.2, respectively. Moreover, toxicity evaluation in vivo showed no significantly adverse effects in rats, indicating that RPTF was safe in use. In conclusion, we demonstrated that RPTF, natural compounds in the Chinese traditional medicine, could act as promising and effective antiviral therapeutics with relative safety in use.
    Mesh-Begriff(e) Animals ; Antiviral Agents/isolation & purification ; Antiviral Agents/pharmacology ; Antiviral Agents/toxicity ; Body Weight/drug effects ; Feeding Behavior/drug effects ; Female ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Flavonoids/toxicity ; Liver/drug effects ; Liver/pathology ; Male ; Rats, Wistar ; Robinia/chemistry ; Toxicity Tests
    Chemische Substanzen Antiviral Agents ; Flavonoids
    Sprache Englisch
    Erscheinungsdatum 2019-08-12
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2019.109335
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

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