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  1. Article: [Craving in Substance Addiction: A Concept Analysis].

    Ye, Jia-You / Shih, Chun-Ying

    Hu li za zhi The journal of nursing

    2023  Volume 70, Issue 6, Page(s) 74–81

    Abstract: Craving in the context of substance addiction is considered an important predictor of substance addictive disorders and relapse risk. Behavior therapy, mindfulness, and exercise may be employed clinically to alleviate cravings. However, many scholars ... ...

    Abstract Craving in the context of substance addiction is considered an important predictor of substance addictive disorders and relapse risk. Behavior therapy, mindfulness, and exercise may be employed clinically to alleviate cravings. However, many scholars have offered various interpretations of craving in substance addiction. Despite these definitions sharing some overlapping elements, a consensus has yet to be reached. Although many studies have presented the effects of and interventions for craving to alleviate substance addiction, this issue has rarely been explored in the clinical nursing context, resulting in a lack of understanding of the concept of craving in substance addiction among nursing professionals. Therefore, based on the conceptual analysis approach proposed by Walker and Avant (2019), a conceptual analysis of craving in substance addiction was conducted in this study by interpreting and defining the characteristics, pre-factors, consequences, and effects of craving in substance addiction using examples of typical, borderline, related, and contrary cases. The findings are intended to help nurses gain a more comprehensive understanding of craving in substance addiction and become more familiar with cases requiring clinical care.
    MeSH term(s) Humans ; Craving ; Behavior Therapy ; Consensus ; Exercise ; Substance-Related Disorders
    Language Chinese
    Publishing date 2023-12-20
    Publishing country China (Republic : 1949- )
    Document type English Abstract ; Journal Article
    ISSN 0047-262X
    ISSN 0047-262X
    DOI 10.6224/JN.202312_70(6).09
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An updated meta-analysis of effectiveness and safety of mTOR inhibitors in the management of tuberous sclerosis complex patients.

    Liu, Mengling / Ye, Jiayou / You, Xiaoling

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2023  Volume 40, Issue 3, Page(s) 823–829

    Abstract: Purpose: Tuberculous sclerosis complex (TSC) is an autosomal dominant multi-system disease. In TSC patients, the inhibition of mTOR pathway is weakened, which leads to the uncontrolled proliferation of normal resting cells. Therefore, mTOR inhibitors ... ...

    Abstract Purpose: Tuberculous sclerosis complex (TSC) is an autosomal dominant multi-system disease. In TSC patients, the inhibition of mTOR pathway is weakened, which leads to the uncontrolled proliferation of normal resting cells. Therefore, mTOR inhibitors have many therapeutic potentials in the treatment of TSC. However, there is no consensus on the safety and efficacy of mTOR inhibitors so far. This article aimed to present new evidence for the efficacy and safety of mTOR inhibitors in the treatment of TSC by evaluating published clinical trials.
    Methods: A systemic search of online databases, such as Cochrane Library, Embase, PubMed, and the US National Institutes of Health Clinical Trials Registry, was conducted. The researchers selected studies that met the following entry criteria: randomized, double-blinded or single-blinded, placebo-controlled, parallel-group studies with active and control arms receiving rapamycin or everolimus and matched placebo, respectively. The meta-analysis included seven studies. Tumor response or epilepsy seizure frequency response rates were considered efficacy outcomes.
    Results: In seven studies involving 877 patients, using of mTOR inhibitors therapy showed an improvement in both tumor response and seizure frequency outcomes in TSC. In combination of AML (angiomyolipomas), SEGA (subependymal giant cell astrocytoma), epilepsy, and facial angiofibroma subjects, the RR is 3.01 (95% CI 2.03 to 4.45, p = 0.000) with observed heterogeneity (I-squared = 55.4%). The main side effect of mTOR inhibitors was stomatitis.
    Conclusion: The updated meta-analysis suggests that the use of mTOR inhibitors is an effective therapy for patients with TSC.
    MeSH term(s) Humans ; MTOR Inhibitors ; Tuberous Sclerosis/drug therapy ; Sirolimus/adverse effects ; Epilepsy/drug therapy ; Seizures/drug therapy ; Astrocytoma/pathology
    Chemical Substances MTOR Inhibitors ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2023-10-31
    Publishing country Germany
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-023-06200-y
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  3. Article ; Online: Dual-task training in older adults with cognitive impairment: A meta-analysis and trial sequential analysis of randomized controlled trials.

    Ye, Jia-You / Chen, Ruey / Chu, Hsin / Lin, Hui-Chen / Liu, Doresses / Jen, Hsiu-Ju / Banda, Kondwani Joseph / Kustanti, Christina Yeni / Chou, Kuei-Ru

    International journal of nursing studies

    2024  Volume 155, Page(s) 104776

    Abstract: Objective: To determine the effects of simultaneous dual-task training on cognitive function, physical function, and depression in older adults with mild cognitive impairment or dementia.: Methods: Comprehensive database searches were conducted in ... ...

    Abstract Objective: To determine the effects of simultaneous dual-task training on cognitive function, physical function, and depression in older adults with mild cognitive impairment or dementia.
    Methods: Comprehensive database searches were conducted in PubMed, Embase, the Cochrane Library, CINAHL, Ovid-Medline, Web of Science, and Scopus up to December 2022. Randomized controlled trials were included to assess the efficacy of simultaneous dual-task training for older adults with mild cognitive impairment or dementia. The analysis utilized Comprehensive Meta-Analysis version 3.0, presenting Hedges' g and the corresponding 95 % confidence interval (CI) for the pooled effect size and, applying a random-effects model. The I
    Results: Of the 1676 studies identified, 20 studies involving 1477 older adults with cognitive impairment were included. Dual-task training significantly enhanced global cognition (0.477, 95 % CI: 0.282 to 0.671), executive function (-0.310, 95 % CI: -0.586 to -0.035), working memory (0.714, 95 % CI: 0.072 to 1.355), gait (0.418, 95 % CI: 0.252 to 0.583), physical activity (0.586, 95 % CI: 0.012 to 1.16), and depression (-0.703, 95 % CI: -1.253 to -0.153). Trial sequential analyses revealed the robustness of this meta-analysis, which was based on a sufficient sample size from the included studies. Moreover, dual-task training demonstrated beneficial effects on global cognition, executive function, working memory, and gait.
    Conclusions: Dual-task training improved cognition, physical function, and depression among older adults with cognitive impairment. Accordingly, dual-task training should be considered a clinical nonpharmacological intervention for older adults with mild cognitive impairment or dementia. Nevertheless, the trial sequential analysis results were consistent with those of the pairwise meta-analysis but only global cognition reached significance by crossing the trial sequential analysis boundary. Future studies with higher-quality designs and larger sample sizes are required to obtain more conclusive results regarding other outcomes.
    Registration: PROSPERO CRD42023418598.
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80148-3
    ISSN 1873-491X ; 0020-7489
    ISSN (online) 1873-491X
    ISSN 0020-7489
    DOI 10.1016/j.ijnurstu.2024.104776
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  4. Article ; Online: Smac is another pathway in the anti-tumour activity of Trichosanthin and reverses Trichosanthin resistance in CaSki cervical cancer cells.

    Cui, Lei / Song, Jian / Wu, Liting / Huang, Liming / Wang, Yanlin / Huang, Yingdi / Yu, Han / Huang, Yiling / You, C C / Ye, Jiayou

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2015  Volume 69, Page(s) 119–124

    Abstract: Trichosanthin (TCS), or Tin Hua Fen, is a renowned traditional Chinese medicine and is still used in Chinese clinics for midterm abortion and the treatment of choriocarcinoma. Many studies have demonstrated that TCS has anti-tumour action as a type I ... ...

    Abstract Trichosanthin (TCS), or Tin Hua Fen, is a renowned traditional Chinese medicine and is still used in Chinese clinics for midterm abortion and the treatment of choriocarcinoma. Many studies have demonstrated that TCS has anti-tumour action as a type I ribosome-inactivating protein. We hypothesized that there is another pathway of the anti-tumour activity of TCS. cDNA array analysis was applied to profile changes in gene expression of human CaSki in response to TCS stimulation. Smac, a mitochondrial protein, was identified as the highly upregulated protein in response to TCS treatment. The mRNA and protein levels of Smac were determined by real-time RT-PCR and Western blotting respectively. We analysed the methylation status of Smac using methylation-specific PCR (MSP) and indicates that TCS promotes Smac demethylation and increases its expression in cervical CaSki cells. Tumour cells develop resistance to TCS during prolonged treatment, as with other classic chemotherapeutic agents. Smac expression was downregulated and Twist was upregulated in TCS-resistant cells. These results indicate that TCS has demethylating activity and that Smac is involved in both TCS response and TCS resistance.
    MeSH term(s) Antineoplastic Agents, Phytogenic/pharmacology ; Base Sequence ; Cell Line, Tumor ; Cell Proliferation/drug effects ; CpG Islands/genetics ; DNA Methylation/drug effects ; DNA Methylation/genetics ; Down-Regulation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Mitochondrial Proteins/metabolism ; Molecular Sequence Data ; Signal Transduction/drug effects ; Trichosanthin/pharmacology ; Up-Regulation/drug effects ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/metabolism ; Uterine Cervical Neoplasms/pathology
    Chemical Substances Antineoplastic Agents, Phytogenic ; DIABLO protein, human ; Intracellular Signaling Peptides and Proteins ; Mitochondrial Proteins ; Trichosanthin (60318-52-7)
    Language English
    Publishing date 2015-02
    Publishing country France
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2014.10.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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