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  1. Article: Palynology-based reconstruction of Holocene environmental history in the northern Yangtze Delta, China

    Ye, Liangtao / Gao, Lei / Li, Yongfei / Wang, Guoqiang

    Palaeogeography, palaeoclimatology, palaeoecology. 2022 Oct. 01, v. 603

    2022  

    Abstract: The Holocene vegetation in the Yangtze Delta is sensitive to global/regional climate change, sea-level oscillations, and human impacts, and it represents a valuable archive for deciphering environmental change. In this paper, the vegetation history of ... ...

    Abstract The Holocene vegetation in the Yangtze Delta is sensitive to global/regional climate change, sea-level oscillations, and human impacts, and it represents a valuable archive for deciphering environmental change. In this paper, the vegetation history of the northern Yangtze deltaic coast, and its response to climate/sea-level changes over the past 10.3 ka, have been investigated based on palynological assemblages from a well-dated sediment core (YZ07) in the northern Yangtze delta. Comparison of vegetation successions with regional climatic proxies, relative sea level change, and depositional environments suggests that this region was dominated by mixed subtropical and temperate forests in a warm /wet climate regime during the early Holocene (~10.3–8.7 ka), when it was characterized by tidally-influenced fluvial environments. From ~8.7 ka to 7.5 ka, subtropical and warm temperate pollen taxa decreased significantly while cool-tolerant conifers and grasses became more dominant, indicating a cooler and drier climate. During the mid-Holocene thermal optimum (~7.5–4.3 ka), mixed subtropical and temperate forests expanded markedly in coastal regions, caused by a return to a warm/wet climate during an episode of rising sea-level. At the start of late Holocene (~4.3 to 3.4 ka), subtropical and temperate trees were widely replaced by grasses around coastal environments, indicating a cooling climate. From ~3.4–1.7 ka, mixed subtropical and temperate forests flourished in the delta region, suggesting that climate returned to warm and wet conditions again. From ~1.7–1.3 ka, in delta environments, subtropical and temperate forests contracted under cool/dry climatic conditions. Since ~1.3 ka, subtropical and temperate pollen taxa increased around the marsh to intertidal flat environments, suggesting a warm/wet climate resurgence. The generally warm/wet Holoence climate of the Yangtze Delta region was interrupted by a series of short-term cold events at 8.2 ka, 7.3 ka, 4.2 ka, 3.5 ka and 1.4 ka. These fluctuations are broadly synchronous with regional climate variability and global sea-level oscillations. In addition, the influence of human cultivation on vegetation is recognized since the mid-Holocene (around 5.6 ka), with the appearance of Fagopyrum pollen in the northern Yangtze Delta.
    Keywords Fagopyrum ; Holocene epoch ; climate change ; coasts ; cold ; humans ; littoral zone ; marshes ; palaeogeography ; paleoclimatology ; paleoecology ; palynology ; pollen ; river deltas ; sea level ; sediments ; China
    Language English
    Dates of publication 2022-1001
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 417718-6
    ISSN 0031-0182
    ISSN 0031-0182
    DOI 10.1016/j.palaeo.2022.111186
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Response to Chen et al.

    Ye, Liangtao / Reiter, Florian P / Guba, Markus / De Toni, Enrico N

    Clinical and translational gastroenterology

    2020  Volume 11, Issue 8, Page(s) e00205

    MeSH term(s) Carcinoma, Hepatocellular ; Extracellular Matrix Proteins ; Glycoproteins ; Humans ; Liver Neoplasms ; Prognosis
    Chemical Substances Extracellular Matrix Proteins ; Glycoproteins ; olfactomedin
    Language English
    Publishing date 2020-11-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2581516-7
    ISSN 2155-384X ; 2155-384X
    ISSN (online) 2155-384X
    ISSN 2155-384X
    DOI 10.14309/ctg.0000000000000205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A hormesis-like effect of FeS on heterotrophic denitrification and its mechanisms.

    Zha, Yunyi / Wan, Rui / Wu, Mengqi / Ye, Ping / Ye, Liangtao / Li, Xiaoxiao / Yang, Haifeng / Luo, Jingyang

    Chemosphere

    2022  Volume 311, Issue Pt 1, Page(s) 136855

    Abstract: To alleviate the insufficiency of carbon source in sewage, many sulfur-containing inorganic electron donors were added into traditional heterotrophic denitrification process. However, the effects of extraneous inorganic electron donors on heterotrophic ... ...

    Abstract To alleviate the insufficiency of carbon source in sewage, many sulfur-containing inorganic electron donors were added into traditional heterotrophic denitrification process. However, the effects of extraneous inorganic electron donors on heterotrophic denitrification were still largely unknown. In this study, a hormesis-like effect of ferrous sulfide (FeS, a representative inorganic electron donors) on Paracoccus denitrificans was observed. Total nitrogen (TN) removal efficiency of P. denitrificans rose by 15% with the increase of FeS dosage from 0 to 0.3 g L
    MeSH term(s) Denitrification ; Bioreactors/microbiology ; Hormesis ; Nitrates/metabolism ; Autotrophic Processes ; Nitrogen/metabolism ; Glucose/pharmacology
    Chemical Substances Nitrates ; Nitrogen (N762921K75) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2022.136855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4

    Ye, Liangtao / Ziesch, Andreas / Schneider, Julia S / Ofner, Andrea / Nieß, Hanno / Denk, Gerald / Hohenester, Simon / Mayr, Doris / Mahajan, Ujjwal M / Munker, Stefan / Khaled, Najib Ben / Wimmer, Ralf / Gerbes, Alexander L / Mayerle, Julia / He, Yulong / Geier, Andreas / Toni, Enrico N De / Zhang, Changhua / Reiter, Florian P

    Aging and disease

    2024  Volume 15, Issue 1, Page(s) 338–356

    Abstract: Primary sclerosing cholangitis (PSC) represents a chronic liver disease characterized by poor prognosis and lacking causal treatment options. Yes-associated protein (YAP) functions as a critical mediator of fibrogenesis; however, its therapeutic ... ...

    Abstract Primary sclerosing cholangitis (PSC) represents a chronic liver disease characterized by poor prognosis and lacking causal treatment options. Yes-associated protein (YAP) functions as a critical mediator of fibrogenesis; however, its therapeutic potential in chronic biliary diseases such as PSC remains unestablished. The objective of this study is to elucidate the possible significance of YAP inhibition in biliary fibrosis by examining the pathophysiology of hepatic stellate cells (HSC) and biliary epithelial cells (BEC). Human liver tissue samples from PSC patients were analyzed to assess the expression of YAP/connective tissue growth factor (CTGF) relative to non-fibrotic control samples. The pathophysiological relevance of YAP/CTGF in HSC and BEC was investigated in primary human HSC (phHSC), LX-2, H69, and TFK-1 cell lines through siRNA or pharmacological inhibition utilizing verteporfin (VP) and metformin (MF). The Abcb4
    MeSH term(s) Mice ; Animals ; Humans ; Hepatic Stellate Cells ; Liver Cirrhosis/drug therapy ; Fibrosis ; Cholestasis/metabolism ; Bile Ducts ; Epithelium/metabolism
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625789-0
    ISSN 2152-5250 ; 2152-5250
    ISSN (online) 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2023.0602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Durable Complete Response of Brain Metastasis From Hepatocellular Carcinoma On Treatment With Nivolumab and Radiation Treatment.

    Ye, Liangtao / Zhang, Changhua / Seidensticker, Max / Mayerle, Julia / Reiter, Florian P / De Toni, Enrico N

    The American journal of gastroenterology

    2020  Volume 115, Issue 12, Page(s) 2114–2116

    MeSH term(s) Antineoplastic Agents, Immunological/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/therapy ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Nivolumab/therapeutic use ; Remission Induction
    Chemical Substances Antineoplastic Agents, Immunological ; Nivolumab (31YO63LBSN)
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nano-fumed silica as a novel pollutant that inhibits the algicidal effect of p-hydroxybenzoic acid on Microcystis aeruginosa.

    Jiang, Xiaofeng / Zuo, Shengpeng / Ye, Liangtao / Hong, Wenxiu

    Environmental technology

    2017  Volume 40, Issue 6, Page(s) 693–700

    Abstract: Nanomaterials and/or contaminants are becoming more common in the developing world, but their effects on interspecific interactions are rarely reported, particularly in aquatic ecosystems. Thus, the present study determined the effects of the novel ... ...

    Abstract Nanomaterials and/or contaminants are becoming more common in the developing world, but their effects on interspecific interactions are rarely reported, particularly in aquatic ecosystems. Thus, the present study determined the effects of the novel pollutant nano-fumed silica (NFS) on algal control by a macrophyte via the allelochemical p-hydroxybenzoic acid in a microcosm test. The allelochemical p-hydroxybenzoic acid caused significant decreases in chlorophyll a, but increased the amount of superoxide anion radicals (
    MeSH term(s) Chlorophyll A ; Ecosystem ; Environmental Pollutants ; Microcystis ; Silicon Dioxide
    Chemical Substances Environmental Pollutants ; Silicon Dioxide (7631-86-9) ; Chlorophyll A (YF5Q9EJC8Y)
    Language English
    Publishing date 2017-11-21
    Publishing country England
    Document type Journal Article
    ISSN 1479-487X
    ISSN (online) 1479-487X
    DOI 10.1080/09593330.2017.1404135
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Combined Hepatocellular-Cholangiocarcinoma: Biology, Diagnosis, and Management.

    Ye, Liangtao / Schneider, Julia S / Ben Khaled, Najib / Schirmacher, Peter / Seifert, Carolin / Frey, Lea / He, Yulong / Geier, Andreas / De Toni, Enrico N / Zhang, Changhua / Reiter, Florian P

    Liver cancer

    2023  Volume 13, Issue 1, Page(s) 6–28

    Abstract: Background: Combined hepatocellular-cholangiocarcinoma (cHCC-iCCA) is a rare type of primary liver cancer displaying characteristics of both hepatocytic and cholangiocytic differentiation.: Summary: Because of its aggressive nature, patients with ... ...

    Abstract Background: Combined hepatocellular-cholangiocarcinoma (cHCC-iCCA) is a rare type of primary liver cancer displaying characteristics of both hepatocytic and cholangiocytic differentiation.
    Summary: Because of its aggressive nature, patients with cHCC-iCCA exhibit a poorer prognosis than those with HCC. Surgical resection and liver transplantation may be considered curative treatment approaches; however, only a minority of patients are eligible at the time of diagnosis, and postoperative recurrence rates are high. For cases that are not eligible for surgery, locoregional and systemic therapy are often administered based on treatment protocols applied for HCC or iCCA. Owing to the rarity of this cancer, there are still no established standard treatment protocols; therefore, the choice of therapy is often personalized and guided by the suspected predominant component. Further, the genomic and molecular heterogeneity of cHCC-iCCA can severely compromise the efficacy of the available therapies.
    Key messages: In the present review, we summarize the latest advances in cHCC-iCCA and attempt to clarify its terminology and molecular biology. We provide an overview of the etiology of cHCC-iCCA and present new insights into the molecular pathology of this disease that could contribute to further studies aiming to improve the patient outcomes through new systemic therapies.
    Language English
    Publishing date 2023-04-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2666925-0
    ISSN 1664-5553 ; 2235-1795
    ISSN (online) 1664-5553
    ISSN 2235-1795
    DOI 10.1159/000530700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online ; Thesis: Novel targets and therapeutic strategies for the treatment of hepatocellular carcinoma (HCC)

    Ye, Liangtao [Verfasser] / Toni, Enrico de [Akademischer Betreuer]

    2019  

    Author's details Liangtao Ye ; Betreuer: Enrico de Toni
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article ; Conference proceedings: Prognostic significance of platelet count in HCC patients adjusted for surrogate parameters of portal hypertension

    Rodriguez, Isaac / Philipp, Alexander / Katrin, Lisa Katrin / Ye, Liangtao / Ben-Khaled, Najib / Reiter, Florian / Mayerle, Julia / de Toni, Enrico N / Munker, Stefan

    Zeitschrift für Gastroenterologie

    2024  Volume 62, Issue 01

    Event/congress 40. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber, Haus der Technik e.V., Essen, 2024-01-26
    Language German
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0043-1777625
    Database Thieme publisher's database

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  10. Article ; Online: Concomitant Irradiation to Checkpoint Inhibitor Therapy of Hepatocellular Carcinoma Patients: A Systematic Retrospective, Single-Center Analysis.

    Munker, Stefan / Roessler, Daniel / Öcal, Osman / Ben-Khaled, Najib / Bernhart, Kathrin / Ye, Liangtao / Piseddu, Ignazio / Vielhauer, Jakob / Reiter, Florian P / Rodriguez, Isaac / Ricke, Jens / Teufel, Andreas / De Toni, Enrico / Seidensticker, Max / Niyazi, Maximilian / Corradini, Stefanie

    Oncology research and treatment

    2023  Volume 46, Issue 11, Page(s) 466–475

    Abstract: Introduction: Immunotherapy has been established as the standard treatment option for patients with advanced hepatocellular carcinoma (aHCC). Despite the increased efficacy, disease progression occurs in a relevant proportion of patients even after an ... ...

    Abstract Introduction: Immunotherapy has been established as the standard treatment option for patients with advanced hepatocellular carcinoma (aHCC). Despite the increased efficacy, disease progression occurs in a relevant proportion of patients even after an objective response. Combination concepts with locoregional therapy are currently under investigation for hepatic disease but are also in discussion for the control of distant metastasis. Radiotherapy is a highly effective treatment modality for local tumor control. It is also thought to increase the efficacy of checkpoint inhibition and sensitize distant lesions to the effects of immunotherapy, but may potentially increase adverse effects. In our center, few patients with aHCC treated with immune checkpoint inhibitors (ICIs) received concomitant radiotherapy for symptom or disease control. The aim of this study was to retrospectively analyze adverse effects and efficacy of concomitant radiotherapy in patients with aHCC treated with checkpoint inhibition.
    Methods: To this aim, patients who received a combination of ICI and radiotherapy in our institution were retrospectively considered for analysis. The predefined inclusion criterion was radiotherapy after initiated checkpoint inhibition and continuation of ICI therapy for at least 8 weeks. Adverse effects and efficacy measurements were performed according to local standards.
    Results: The database search of 2016-2021 revealed six consecutive patients fulfilling the predefined criteria for concomitant ICI and radiotherapy. Three patients received high-dose-rate brachytherapy (15 Gy) to treat progredient hepatic lesions. Two patients received stereotactic body radiotherapy (SBRT) (25-30 Gy) for symptom control, and 1 patient received brachytherapy and SBRT to treat metastases. No severe adverse events were reported in the period (<6 months) after concomitant radiotherapy. In 5 out of 6 cases, long-term tumor control could be achieved by this therapeutic combination.
    Conclusion: A good efficacy of concomitant radiotherapy and checkpoint inhibition has been achieved with no safety concerns. Further investigations should evaluate the safety, appropriate clinical context, and efficacy of this promising approach.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/radiotherapy ; Retrospective Studies ; Liver Neoplasms/radiotherapy ; Treatment Outcome ; Radiosurgery
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2760274-6
    ISSN 2296-5262 ; 2296-5270
    ISSN (online) 2296-5262
    ISSN 2296-5270
    DOI 10.1159/000533983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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