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Article: [A convolutional neural network based model for assisting pathological diagnoses on thyroid liquid-based cytology].

Ye, M H / Chen, W Y / Cai, B J / Jin, C H / He, X L

Zhonghua bing li xue za zhi = Chinese journal of pathology

2021 Volume 50, Issue 4, Page(s) 358–362

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Algorithms ; Cytodiagnosis ; Humans ; Neural Networks, Computer ; Pathologists ; Thyroid Gland
Language	Chinese
Publishing date	2021-04-08
Publishing country	China
Document type	Journal Article
ZDB-ID	784533-9
ISSN	0529-5807
ISSN	0529-5807
DOI	10.3760/cma.j.cn112151-20200802-00613
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Article: [A longitudinal study on the progression and influencing factors of myopia in primary school students from grade one to grade three in Hubei Province].

Xiong, X W / Zhou, L H / Zeng, C Q / Wang, J / Ye, M H / Meng, Y F / Hu, X M / Yi, B Q

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2021 Volume 57, Issue 10, Page(s) 749–756

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Child ; Female ; Humans ; Longitudinal Studies ; Male ; Myopia/epidemiology ; Refraction, Ocular ; Schools ; Students
Language	Chinese
Publishing date	2021-10-07
Publishing country	China
Document type	Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.cn112142-20201106-00740
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Article: Comparative transcriptomic analysis of porcine peripheral blood reveals differentially expressed genes from the cytokineâcytokine receptor interaction pathway related to health status

Ye, M.H / G. Plastow / H. Bao / L.L. Guan / P. Stothard / Y. Meng

Genome. 2017 Aug. 1, v. 60, no. 12

2017

Abstract: While some research has looked into the host genetic response in pigs challenged with specific viruses or bacteria, few studies have explored the expression changes of transcripts in the peripheral blood of sick pigs that may be infected with multiple ... ...

Abstract	While some research has looked into the host genetic response in pigs challenged with specific viruses or bacteria, few studies have explored the expression changes of transcripts in the peripheral blood of sick pigs that may be infected with multiple pathogens on farms. In this study, the architecture of the peripheral blood transcriptome of 64 Duroc sired commercial pigs, including 18 healthy animals at entry to a growing facility (set as a control) and 23 pairs of samples from healthy and sick pen mates, was generated using RNA-Seq technology. In total, 246 differentially expressed genes were identified to be specific to the sick animals. Functional enrichment analysis for those genes revealed that the over-represented gene ontology terms for the biological processes category were exclusively immune activity related. The cytokineâcytokine receptor interaction pathway was significantly enriched. Nine functional genes from this pathway encoding members (as well as their receptors) of the interleukins, chemokines, tumor necrosis factors, colony stimulating factors, activins, and interferons exhibited significant transcriptional alteration in sick animals. Our results suggest a subset of novel marker genes that may be useful candidate genes in the evaluation and prediction of health status in pigs under commercial production conditions.
Keywords	activins ; bacteria ; blood ; chemokines ; Duroc ; farms ; gene ontology ; genes ; genetic markers ; health status ; interferons ; interleukins ; pathogens ; prediction ; receptors ; sequence analysis ; swine ; transcription (genetics) ; transcriptome ; transcriptomics ; tumor necrosis factors ; viruses
Language	English
Dates of publication	2017-0801
Size	p. 1021-1028.
Publishing place	NRC Research Press
Document type	Article
ZDB-ID	639031-6
ISSN	1480-3321 ; 0831-2796
ISSN (online)	1480-3321
ISSN	0831-2796
DOI	10.1139/gen-2017-0074
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Article ; Online: Comparative transcriptomic analysis of porcine peripheral blood reveals differentially expressed genes from the cytokine-cytokine receptor interaction pathway related to health status.

Ye, M H / Bao, H / Meng, Y / Guan, L L / Stothard, P / Plastow, G

Genome

2017 Volume 60, Issue 12, Page(s) 1021–1028

Abstract	While some research has looked into the host genetic response in pigs challenged with specific viruses or bacteria, few studies have explored the expression changes of transcripts in the peripheral blood of sick pigs that may be infected with multiple pathogens on farms. In this study, the architecture of the peripheral blood transcriptome of 64 Duroc sired commercial pigs, including 18 healthy animals at entry to a growing facility (set as a control) and 23 pairs of samples from healthy and sick pen mates, was generated using RNA-Seq technology. In total, 246 differentially expressed genes were identified to be specific to the sick animals. Functional enrichment analysis for those genes revealed that the over-represented gene ontology terms for the biological processes category were exclusively immune activity related. The cytokine-cytokine receptor interaction pathway was significantly enriched. Nine functional genes from this pathway encoding members (as well as their receptors) of the interleukins, chemokines, tumor necrosis factors, colony stimulating factors, activins, and interferons exhibited significant transcriptional alteration in sick animals. Our results suggest a subset of novel marker genes that may be useful candidate genes in the evaluation and prediction of health status in pigs under commercial production conditions.
MeSH term(s)	Animals ; Cytokines/genetics ; Cytokines/metabolism ; Receptors, Cytokine/genetics ; Receptors, Cytokine/metabolism ; Swine/blood ; Swine/genetics ; Swine/immunology ; Transcriptome
Chemical Substances	Cytokines ; Receptors, Cytokine
Language	English
Publishing date	2017-12
Publishing country	Canada
Document type	Journal Article
ZDB-ID	639031-6
ISSN	1480-3321 ; 0831-2796
ISSN (online)	1480-3321
ISSN	0831-2796
DOI	10.1139/gen-2017-0074
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Article: [The epidemiology of myopia in primary school students of grade 1 to 3 in Hubei province].

Zeng, C Q / Zhou, L H / Zhang, P / Wang, J / Ye, M H / Yi, B X / Xiong, X W / Liang, X C

Zhonghua yan ke za zhi] Chinese journal of ophthalmology

2018 Volume 54, Issue 10, Page(s) 756–761

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Child ; China/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Myopia/epidemiology ; Prevalence ; Schools ; Students ; Surveys and Questionnaires ; Visual Acuity
Language	Chinese
Publishing date	2018-10-22
Publishing country	China
Document type	Journal Article
ZDB-ID	604574-1
ISSN	0412-4081
ISSN	0412-4081
DOI	10.3760/cma.j.issn.0412-4081.2018.10.007
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Article: Correlation between polymorphisms in ADSL and GARS-AIRS-GART genes with inosine 5'-monophosphate (IMP) contents in Beijing-you chickens

Ye, M.H / Chen, J.L / Zhao, G.P / Zheng, M.Q / Wen, J

British poultry science. 2010 Oct., v. 51, no. 5

2010

Abstract: 1. The association of single nucleotide polymorphisms identified within the ADSL (adenylosuccinate lyase deficiency) gene and GARS-AIRS-GART (glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide ... ...

Abstract	1. The association of single nucleotide polymorphisms identified within the ADSL (adenylosuccinate lyase deficiency) gene and GARS-AIRS-GART (glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase) gene with the content of inosine 5'-monophosphate (IMP) was studied in a population of male Beijing-you (BJY) chickens slaughtered at 90 d of age. 2. A single nucleotide polymorphism in exon 2 of the ADSL gene had an effect on IMP content. Chickens inheriting the positive allele at ADSL, both homozygous and heterozygous genotypes, had a higher content of IMP in breast muscle than did individuals without it. 3. Similar results were obtained for the GARS-AIRS-GART gene. The marker at the 5' untranslated region (UTR) of the GARS-AIRS-GART gene was also significant for the IMP value. Chickens inheriting the genotypes with the positive allele at this locus had a much higher content of IMP than did those homozygous for the unfavourable one. 4. Interactions between ADSL and GARS-AIRS-GART were detected for such traits as body weight and muscle yields in the tested population. The two loci acted in an additive fashion. Because IMP is one of the most important flavour components in meat, markers developed at these two genes, as well as the combination genotypes, could be used as potential molecular markers for improving chicken quality.
Keywords	body weight ; breast muscle ; chickens ; flavor ; genes ; genetic markers ; genotype ; inosine monophosphate ; loci ; meat ; single nucleotide polymorphism
Language	English
Size	p. 609-613.
Publishing place	Longman
Document type	Article
ZDB-ID	956653-3
ISSN	1466-1799 ; 0007-1668
ISSN (online)	1466-1799
ISSN	0007-1668
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correlation between polymorphisms in ADSL and GARS-AIRS-GART genes with inosine 5'-monophosphate (IMP) contents in Beijing-you chickens.

Ye, M H / Chen, J L / Zhao, G P / Zheng, M Q / Wen, J

British poultry science

2010 Volume 51, Issue 5, Page(s) 609–613

Abstract	1. The association of single nucleotide polymorphisms identified within the ADSL (adenylosuccinate lyase deficiency) gene and GARS-AIRS-GART (glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase) gene with the content of inosine 5'-monophosphate (IMP) was studied in a population of male Beijing-you (BJY) chickens slaughtered at 90 d of age. 2. A single nucleotide polymorphism in exon 2 of the ADSL gene had an effect on IMP content. Chickens inheriting the positive allele at ADSL, both homozygous and heterozygous genotypes, had a higher content of IMP in breast muscle than did individuals without it. 3. Similar results were obtained for the GARS-AIRS-GART gene. The marker at the 5' untranslated region (UTR) of the GARS-AIRS-GART gene was also significant for the IMP value. Chickens inheriting the genotypes with the positive allele at this locus had a much higher content of IMP than did those homozygous for the unfavourable one. 4. Interactions between ADSL and GARS-AIRS-GART were detected for such traits as body weight and muscle yields in the tested population. The two loci acted in an additive fashion. Because IMP is one of the most important flavour components in meat, markers developed at these two genes, as well as the combination genotypes, could be used as potential molecular markers for improving chicken quality.
MeSH term(s)	Adenylosuccinate Lyase/genetics ; Alleles ; Animals ; Avian Proteins/genetics ; Body Weight/genetics ; Carbon-Nitrogen Ligases/genetics ; Chickens/genetics ; Chickens/metabolism ; Chromatography, High Pressure Liquid ; Genetic Markers ; Genotype ; Inosine Monophosphate/chemistry ; Inosine Monophosphate/metabolism ; Male ; Phosphoribosylglycinamide Formyltransferase/genetics ; Polymorphism, Single Nucleotide
Chemical Substances	Avian Proteins ; Genetic Markers ; Inosine Monophosphate (131-99-7) ; Phosphoribosylglycinamide Formyltransferase (EC 2.1.2.2) ; Adenylosuccinate Lyase (EC 4.3.2.2) ; Carbon-Nitrogen Ligases (EC 6.3.-) ; phosphoribosylamine-glycine ligase (EC 6.3.4.13)
Language	English
Publishing date	2010-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	956653-3
ISSN	1466-1799 ; 0007-1668
ISSN (online)	1466-1799
ISSN	0007-1668
DOI	10.1080/00071668.2010.508486
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Article ; Online: Associations of A-FABP and H-FABP markers with the content of intramuscular fat in Beijing-You chicken.

Ye, M H / Chen, J L / Zhao, G P / Zheng, M Q / Wen, J

Animal biotechnology

2010 Volume 21, Issue 1, Page(s) 14–24

Abstract: This study has assessed the association of single nucleotide polymorphisms (SNP) identified in the adipocyte fatty acid binding protein (A-FABP) and heart-type fatty acid binding protein (H-FABP) genes with the content of intramuscular fat (IMF) in a ... ...

Abstract	This study has assessed the association of single nucleotide polymorphisms (SNP) identified in the adipocyte fatty acid binding protein (A-FABP) and heart-type fatty acid binding protein (H-FABP) genes with the content of intramuscular fat (IMF) in a population of male Beijing-You chickens. A previously described SNP in the chicken A-FABP gene had a significant (P < 0.05) effect on IMF content. Chickens inheriting the homozygous BB genotype at A-FABP had a significantly higher content of IMF in thigh muscles and breast muscles than did those inheriting the AA and AB genotypes. A novel SNP, identified here, in the H-FABP gene was also significantly (P < 0.05) associated with IMF content in thigh and breast muscle. Chickens inheriting the genotypes of DD and CD had much higher content of IMF than those inheriting the homozygous genotype of CC. Markers at the A-FABP and H-FABP genes were associated with IMF content in the studied population. Chickens inheriting the BB genotype at A-FABP, along with the CD genotype at H-FABP, produced muscles with a much higher content of IMF when compared with all other genotypes. A weak interaction between A-FABP and H-FABP was detected (P < 0.09) for IMF content in the tested population. The statistical significance of interaction is tentative because of the limited number of observations for some genotypic combinations. Markers identified within the A-FABP and H-FABP genes are suitable for future use in identifying chickens with the genetic potential to produce more desirable muscle with higher IMF content, at least in the population of Beijing-You male chickens.
MeSH term(s)	Adipose Tissue/metabolism ; Animals ; Chickens/genetics ; Gene Frequency/genetics ; Genes/genetics ; Genetic Markers/genetics ; Genotype ; Male ; Meat/standards ; Molecular Sequence Data ; Muscle, Skeletal/metabolism ; Polymerase Chain Reaction ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	Genetic Markers
Language	English
Publishing date	2010
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2043243-4
ISSN	1532-2378 ; 1049-5398
ISSN (online)	1532-2378
ISSN	1049-5398
DOI	10.1080/10495390903328116
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Article: Feasibility study of vertical subcutaneous injection of insulin with an insulin pen injector in diabetic patients with normal body mass index.

Zhou, L / Fan, Y-F / Lu, X-Q / Ye, J-P / Ye, M-H

The Journal of international medical research

2010 Volume 38, Issue 2, Page(s) 669–673

Abstract: This study explored the feasibility of vertical insulin injection with an insulin pen injector in 40 Chinese diabetic outpatients with a normal body mass index. The patients, who received insulin in the hospital clinic, were assessed for abdominal ... ...

Abstract	This study explored the feasibility of vertical insulin injection with an insulin pen injector in 40 Chinese diabetic outpatients with a normal body mass index. The patients, who received insulin in the hospital clinic, were assessed for abdominal subcutaneous fat thickness and distribution at four abdominal points using ultrasonography. Abdominal subcutaneous fat thickness and distribution were found to be heterogeneous and to differ significantly at these four points. Abdominal subcutaneous fat thickness was < 5 mm in nine of the 40 patients. In patients with abdominal subcutaneous fat thickness of < 5 mm, vertical insulin injection risks injecting into the muscle layer and is, therefore, not desirable. Vertical injection into pinched skin with a rotary syringe is safe and effective in such patients.
MeSH term(s)	Adult ; Body Mass Index ; Diabetes Mellitus/drug therapy ; Feasibility Studies ; Female ; Humans ; Hypoglycemic Agents/administration & dosage ; Injections/instrumentation ; Injections, Intramuscular ; Injections, Subcutaneous ; Insulin/administration & dosage ; Male ; Subcutaneous Fat, Abdominal/diagnostic imaging ; Treatment Outcome ; Ultrasonography
Chemical Substances	Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2010-03
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/147323001003800230
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Article ; Online: Overexpression of miR-98 inhibits cell invasion in glioma cell lines via downregulation of IKKε.

Fan, Y-H / Ye, M-H / Wu, L / Lv, S-G / Wu, M-J / Xiao, B / Liao, C-C / Ji, Q-K / Chai, Y / Zhu, X-G

European review for medical and pharmacological sciences

2015 Volume 19, Issue 19, Page(s) 3593–3604

Abstract: Objective: MicroRNAs (miRNAs) function as negative regulators for the expression of genes involved in cancer metastasis. The aim of this study was to investigate the potential role of miR-98 in gliomas and validate its regulatory mechanism.: Patients ... ...

Abstract	Objective: MicroRNAs (miRNAs) function as negative regulators for the expression of genes involved in cancer metastasis. The aim of this study was to investigate the potential role of miR-98 in gliomas and validate its regulatory mechanism. Patients and methods: Cell viability assays are used to measure proliferation of cell. mRNA expression is measured by qRT-PCR. Western blot analysis is used to measure protein expression. Results: Functional studies showed that miR-98 overexpression inhibited glioma migration and invasion, but had no effect on the cell viability. An enhanced green fluorescent protein reporter assay, quantitative RT-PCR, and a western blot analysis confirmed that miR-98 suppressed the expression of IκB kinase (IKKε) by directly targeting its 3'-untranslated region, also, the NF-κB p65 nuclear translocation and matrix metalloproteinase (MMP)-9 expression were significantly arrested in glioma cells treated with miR-98 mimics. Accordingly, the overexpression of IKKε or NF-κB p65 can restore cell migration and invasion after being inhibited by miR-98, and can restore NF-κB p65 nuclear translocation as well as increase MMP-9 expression. Conclusions: These findings demonstrated that miR-98 functions as a tumor suppressor in gliomas. Furthermore, miR-98 may act as a potential therapeutic biomarker for glioma patients.
MeSH term(s)	Adult ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Survival/genetics ; Down-Regulation/physiology ; Female ; Gene Expression Regulation, Neoplastic ; Glioma/genetics ; Glioma/metabolism ; Glioma/pathology ; Humans ; I-kappa B Kinase/genetics ; I-kappa B Kinase/metabolism ; Male ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Invasiveness/genetics
Chemical Substances	MIRN98 microRNA, human ; MicroRNAs ; I-kappa B Kinase (EC 2.7.11.10)
Language	English
Publishing date	2015-10
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
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