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  1. Article ; Online: The roles of FLOT1 in human diseases (Review).

    Zhan, Ziqing / Ye, Meng / Jin, Xiaofeng

    Molecular medicine reports

    2023  Volume 28, Issue 5

    Abstract: FLOT1, a scaffold protein of lipid rafts, is involved in several biological processes, including lipid raft protein‑-dependent or clathrin‑independent endocytosis, and the formation of hippocampal synapses, amongst others. Increasing evidence has shown ... ...

    Abstract FLOT1, a scaffold protein of lipid rafts, is involved in several biological processes, including lipid raft protein‑-dependent or clathrin‑independent endocytosis, and the formation of hippocampal synapses, amongst others. Increasing evidence has shown that FLOT1 can function as both a cancer promoter and cancer suppressor dependent on the type of cancer. FLOT1 can affect the occurrence and development of several types of cancer by affecting epithelial‑mesenchymal transition, proliferation of cancer cells, and relevant signaling pathways, and is regulated by long intergenic non‑coding RNAs or microRNAs. In the nervous system, overexpression or abnormally low expression of FLOT1 may lead to the occurrence of neurological diseases, such as Alzheimer's disease, Parkinson's disease, major depressive disorder and other diseases. Additionally, it is also associated with dilated cardiomyopathy, pathogenic microbial infection, diabetes‑related diseases, and gynecological diseases, amongst other diseases. In the present review, the structure and localization of FLOT1, as well as the physiological processes it is involved in are reviewed, and then the upstream and downstream regulation of FLOT1 in human disease, particularly in different types of cancer and neurological diseases are discussed, with a focus on potentially targeting FLOT1 for the clinical treatment of several diseases.
    MeSH term(s) Humans ; Cell Line, Tumor ; Depressive Disorder, Major ; MicroRNAs/genetics ; Signal Transduction
    Chemical Substances MicroRNAs ; flotillins
    Language English
    Publishing date 2023-09-29
    Publishing country Greece
    Document type Review ; Journal Article
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2023.13099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The crosstalk between ubiquitination and endocrine therapy.

    Ge, Yidong / Zhan, Ziqing / Ye, Meng / Jin, Xiaofeng

    Journal of molecular medicine (Berlin, Germany)

    2023  Volume 101, Issue 5, Page(s) 461–486

    Abstract: Endocrine therapy (ET), also known as hormone therapy, refers to the treatment of tumors by regulating and changing the endocrine environment and hormone levels. Its related mechanism is mainly through reducing hormone levels and blocking the binding of ... ...

    Abstract Endocrine therapy (ET), also known as hormone therapy, refers to the treatment of tumors by regulating and changing the endocrine environment and hormone levels. Its related mechanism is mainly through reducing hormone levels and blocking the binding of hormones to corresponding receptors, thus blocking the signal transduction pathway to stimulate tumor growth. However, with the application of ET, some patients show resistance to ET, which is attributed to abnormal accumulation of hormone receptors (HRs) and the production of multiple mutants of HRs. The targeted degradation of abnormal accumulation protein mediated by ubiquitination is an important approach that regulates the protein level and function of intracellular proteins in eukaryotes. Here, we provide a brief description of the traditional and novel drugs available for ET in this review. Then, we introduce the link between ubiquitination and ET. In the end, we elaborate the clinical application of ET combined with ubiquitination-related molecules. KEY MESSAGES: • A brief description of the traditional and novel drugs available for endocrine therapy (ET). • The link between ubiquitination and ET. • The clinical application of ET combined with ubiquitination-related molecules.
    MeSH term(s) Humans ; Female ; Signal Transduction ; Ubiquitination ; Carrier Proteins ; Hormones ; Breast Neoplasms
    Chemical Substances Carrier Proteins ; Hormones
    Language English
    Publishing date 2023-03-24
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-023-02300-z
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.36: Show issues Location:
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  3. Article ; Online: Enhancing mechanical properties of composite solid electrolyte by ultra-high molecular weight polymers.

    Deng, Hongjie / He, Fa / Liu, Tongli / Ye, Meng / Wan, Fang / Guo, Xiaodong

    Nanotechnology

    2024  Volume 35, Issue 19

    Abstract: Composite solid electrolytes combining the advantages of inorganic and polymer electrolytes are considered as one of the promising candidates for solid-state lithium metal batteries. Compared with ceramic-in-polymer electrolyte, polymer-in-ceramic ... ...

    Abstract Composite solid electrolytes combining the advantages of inorganic and polymer electrolytes are considered as one of the promising candidates for solid-state lithium metal batteries. Compared with ceramic-in-polymer electrolyte, polymer-in-ceramic electrolyte displays excellent mechanical strength to inhibit lithium dendrite. However, polymer-in-ceramic electrolyte faces the challenges of lack of flexibility and severely blocked Li
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad27ad
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Karyotype and Phylogenetic Relationship Analysis of Five Varieties and Cultivars of

    He, Zhoujian / Lei, Yuting / Gong, Wei / Ye, Meng / Luo, Xiaomei

    Genes

    2023  Volume 14, Issue 7

    Abstract: Green prickly ash ( ...

    Abstract Green prickly ash (
    MeSH term(s) Phylogeny ; Zanthoxylum/genetics ; Karyotype ; Karyotyping ; DNA, Ribosomal/genetics
    Chemical Substances DNA, Ribosomal
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14071459
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  5. Article ; Online: Roles of estrogen receptor α in endometrial carcinoma (Review).

    Ge, Yidong / Ni, Xiaoqi / Li, Jingyun / Ye, Meng / Jin, Xiaofeng

    Oncology letters

    2023  Volume 26, Issue 6, Page(s) 530

    Abstract: Endometrial carcinoma (EC) is a group of endometrial epithelial malignancies, most of which are adenocarcinomas and occur in perimenopausal and postmenopausal women. It is one of the most common carcinomas of the female reproductive system. It has been ... ...

    Abstract Endometrial carcinoma (EC) is a group of endometrial epithelial malignancies, most of which are adenocarcinomas and occur in perimenopausal and postmenopausal women. It is one of the most common carcinomas of the female reproductive system. It has been shown that the occurrence and development of EC is closely associated with the interaction between estrogen (estradiol, E2) and estrogen receptors (ERs), particularly ERα. As a key nuclear transcription factor, ERα is a carcinogenic factor in EC. Its interactions with upstream and downstream effectors and co-regulators have important implications for the proliferation, metastasis, invasion and inhibition of apoptosis of EC. In the present review, the structure of ERα and the regulation of ERα in multiple dimensions are described. In addition, the classical E2/ERα signaling pathway and the crosstalk between ERα and other EC regulators are elucidated, as well as the therapeutic targeting of ERα, which may provide a new direction for clinical applications of ERα in the future.
    Language English
    Publishing date 2023-10-25
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2023.14117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Roles of NOLC1 in cancers and viral infection.

    Zhai, Fengguang / Wang, Jie / Luo, Xia / Ye, Meng / Jin, Xiaofeng

    Journal of cancer research and clinical oncology

    2023  Volume 149, Issue 12, Page(s) 10593–10608

    Abstract: Background: The nucleolus is considered the center of metabolic control and an important organelle for the biogenesis of ribosomal RNA (rRNA). Nucleolar and coiled-body phosphoprotein 1(NOLC1), which was originally identified as a nuclear localization ... ...

    Abstract Background: The nucleolus is considered the center of metabolic control and an important organelle for the biogenesis of ribosomal RNA (rRNA). Nucleolar and coiled-body phosphoprotein 1(NOLC1), which was originally identified as a nuclear localization signal-binding protein is a nucleolar protein responsible for nucleolus construction and rRNA synthesis, as well as chaperone shuttling between the nucleolus and cytoplasm. NOLC1 plays an important role in a variety of cellular life activities, including ribosome biosynthesis, DNA replication, transcription regulation, RNA processing, cell cycle regulation, apoptosis, and cell regeneration.
    Purpose: In this review, we introduce the structure and function of NOLC1. Then we elaborate its upstream post-translational modification and downstream regulation. Meanwhile, we describe its role in cancer development and viral infection which provide a direction for future clinical applications.
    Methods: The relevant literatures from PubMed have been reviewed for this article.
    Conclusion: NOLC1 plays an important role in the progression of multiple cancers and viral infection. In-depth study of NOLC1 provides a new perspective for accurate diagnosis of patients and selection of therapeutic targets.
    MeSH term(s) Humans ; Cell Nucleolus/genetics ; Cell Nucleolus/metabolism ; Nuclear Proteins/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Virus Diseases/metabolism ; Phosphoproteins/metabolism
    Chemical Substances Nuclear Proteins ; Phosphoproteins ; NOLC1 protein, human
    Language English
    Publishing date 2023-06-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-04934-5
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.10: Show issues Location:
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  7. Article ; Online: Six Express Sequence Tag-Simple Sequence Repeat Primers Reveal Genetic Diversity in the Cultivars of Three

    Deng, Yangchuan / He, Zhoujian / Li, Yanlin / Ye, Meng / Xiang, Li

    Current issues in molecular biology

    2023  Volume 45, Issue 9, Page(s) 7183–7196

    Abstract: ... ...

    Abstract Zanthoxylum
    Language English
    Publishing date 2023-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45090454
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article: The Impact of Partnerships and Information Sharing on Corporate Sustainable Performance: A Mediation Model Moderated by Government Support.

    Yue, Longfei / Ye, Meng / Chen, Qing

    Frontiers in psychology

    2022  Volume 13, Page(s) 942279

    Abstract: Based on the theory of strategic alliances and social networks, this article empirically studies the relationship between partnership, information sharing, and sustainable performance through a questionnaire survey of Chinese sports equipment ... ...

    Abstract Based on the theory of strategic alliances and social networks, this article empirically studies the relationship between partnership, information sharing, and sustainable performance through a questionnaire survey of Chinese sports equipment manufacturers. The findings show that partnerships have a positive impact on sustainable performance; that information sharing plays a role in mediating the relationships between trust, cooperation, and sustainable performance; and that government support can positively impact the effect of partnerships on sustainable performance. Through empirical research, this article proves the mechanism of the impact of partnership on alliance performance, further expands the theoretical basis for enterprises' establishment of strategic alliances, and has important enlightening significance for enterprises within alliances aiming to rationally use the networks inside and outside their alliances to obtain knowledge and resources and improve their sustainable performance.
    Language English
    Publishing date 2022-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.942279
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  9. Article: The Impact of eSports Industry Knowledge Alliances on Innovation Performance: A Mediation Model Based on Knowledge Sharing.

    Yue, Longfei / Zheng, Yiwen / Ye, Meng

    Frontiers in psychology

    2022  Volume 13, Page(s) 902473

    Abstract: This study investigates the associations among member ability, member relationships, knowledge sharing, and innovation performance in eSports industry knowledge alliance. A survey strategy and purposive sampling were applied, and the analysis was ... ...

    Abstract This study investigates the associations among member ability, member relationships, knowledge sharing, and innovation performance in eSports industry knowledge alliance. A survey strategy and purposive sampling were applied, and the analysis was conducted on a sample of 311 senior managers from the China eSports Association. The hypotheses were tested using SPSS 24.0 software and AMOS 24.0 software. This study shows that member ability and member relationships have both a direct and indirect effect on innovation performance. Firstly, member ability, member relationships, and member knowledge sharing significantly impact the innovation performance of eSports industry knowledge alliances. Secondly, member knowledge sharing plays a mediating role in the effect of member ability and membership relationship on innovation performance. This pioneering article explores the interaction mechanisms between member ability, member relationships, and innovation performance in eSports industry knowledge alliance. The research results are conducive to the development of the eSports industry toward deep integration and sustainable development and provide a reference for similar knowledge-intensive enterprise alliance behaviors.
    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.902473
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  10. Article ; Online: Coordinated development of high-quality agricultural transformation and technological innovation: a case study of main grain-producing areas, China.

    Deng, Fumin / Jia, Siyuan / Ye, Meng / Li, Zhi

    Environmental science and pollution research international

    2022  Volume 29, Issue 23, Page(s) 35150–35164

    Abstract: The high-quality development of agriculture is closely related to technological innovation, but the evolutionary characteristics of the relationship between agricultural transformation and technological innovation have received little study. This study ... ...

    Abstract The high-quality development of agriculture is closely related to technological innovation, but the evolutionary characteristics of the relationship between agricultural transformation and technological innovation have received little study. This study takes 13 main grain-producing areas of China as the research object. Data collection was from 2004 to 2019. Based on the coupling coordination and responsiveness models, we analyze the spatio-temporal agriculture comprehensive level and the associated response degree of agricultural transformation to technological innovation. The results showed that (1) the comprehensive development of technological innovation showed a growth trend, while the agricultural transformation showed a U-shaped growth trend; (2) the coordinated development of these two systems has been significantly improved, but there are differences in the development speed of each province; (3) the coordinated gravity center moved southward in the spatial pattern, eventually presenting the characteristics of "higher level in the east and lower level in the west, while the higher level in the south and lower level in the north"; (4) the influence of technological innovation on agricultural transformation gradually changed from inhibition to positive promotion. In the end, this paper puts forward suggestions on the high-quality development of agriculture from the relationship of technological innovation and agricultural transformation.
    MeSH term(s) Agriculture ; China ; Economic Development ; Edible Grain ; Inventions ; Technology
    Language English
    Publishing date 2022-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-021-18020-1
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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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