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Article ; Online: Fasting blood glucose and insulin are not associated with atopic dermatitis in a pediatric population: A longitudinal cohort study from the Avon Longitudinal Study of Parents and Children.

Shan, Judy / Ye, Morgan / Ku, Elaine / McCulloch, Charles E / Langan, Sinéad M / Abuabara, Katrina

JAAD international

2023 Volume 15, Page(s) 12–14

Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ISSN	2666-3287
ISSN (online)	2666-3287
DOI	10.1016/j.jdin.2023.09.007
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Article ; Online: The impact of dermatitis on health-related quality of life: Data from the National Health and Nutrition Examination Survey.

Lee, Yong / Ye, Morgan / Tully, Janell / Salah, Samir / Kerob, Delphine / Abuabara, Katrina

Journal of the European Academy of Dermatology and Venereology : JEADV

2022

Language	English
Publishing date	2022-09-24
Publishing country	England
Document type	Letter
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.18600
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Pediatric ACEs and related life event screener (PEARLS) latent domains and child health in a safety-net primary care practice.

Ye, Morgan / Hessler, Danielle / Ford, Derek / Benson, Mindy / Koita, Kadiatou / Bucci, Monica / Long, Dayna / Harris, Nadine Burke / Thakur, Neeta

BMC pediatrics

2023 Volume 23, Issue 1, Page(s) 367

Abstract: Background: Research examining the connections between individual adverse childhood experiences (ACEs) and how groupings of interrelated adversities are linked with subsequent health is scarce, limiting our understanding of risk during a period of rapid ...

Abstract	Background: Research examining the connections between individual adverse childhood experiences (ACEs) and how groupings of interrelated adversities are linked with subsequent health is scarce, limiting our understanding of risk during a period of rapid expansion of ACE screening in clinical practice. The study objective was to conduct a psychometric analysis to derive latent domains of ACEs and related life events and assess the association between each domain and health outcome. Methods: Participants (3 months-11 years) were recruited from the University of California San Francisco Benioff's Children Hospital Oakland Primary Care Clinic. Children were screened with the Pediatric ACEs and Related Life Events Screener (PEARLS) (n = 340), which assessed 17 total ACEs and related life events, including forms of abuse, household challenges, and social risks. Domains were constructed using confirmatory factor analysis and associations between the three identified domains and 14 health outcomes were assessed using multivariable linear and logistic regression models. Results: Three PEARLS domains were identified: Maltreatment (ω = 0.73, ɑ=0.87), Household Challenges (ω = 0.70, ɑ=0.82), and Social Context (ω = 0.55, ɑ=0.70). Measurement invariance was supported across both gender and screening format. All domains were associated with poorer general and behavioral health and stomachaches. Maltreatment and Social Context were additionally associated with eczema while only Social Context was associated with increased odds of reporting headaches and somatic symptoms. Conclusion: In an underserved, urban west-coast pediatric population, the PEARLS found three adversity domains of Maltreatment, Household Challenges, and Social Context that all had an independent statistically significant association with poorer child health. The results provide a timely and more nuanced representation of risk that can inform clinical practice and policy using more targeted resources and interventions.
Language	English
Publishing date	2023-07-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-023-04163-2
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Article ; Online: The association between atopic eczema and lymphopenia: Results from a UK cohort study with replication in US survey data.

Hollestein, Loes M / Ye, Morgan Ya Fang / Ang, Ky-Leigh / Forbes, Harriet / Mansfield, Kathryn E / Abuabara, Katrina / Smeeth, Liam / Langan, Sinéad M

Journal of the European Academy of Dermatology and Venereology : JEADV

2023 Volume 37, Issue 6, Page(s) 1190–1198

Abstract: Background: Lymphocyte skin homing in atopic eczema (AE) may induce lymphopenia.: Objective: To determine if AE is associated with lymphopenia.: Methods: We used UK primary care electronic health records (Clinical Practice Research Datalink GOLD) ... ...

Abstract	Background: Lymphocyte skin homing in atopic eczema (AE) may induce lymphopenia. Objective: To determine if AE is associated with lymphopenia. Methods: We used UK primary care electronic health records (Clinical Practice Research Datalink GOLD) for a matched cohort study in adults (18 years+) (1997-2015) with at least one recorded lymphocyte count. We matched people with AE to up to five people without. We used multivariable logistic regression to estimate the association between AE and lymphopenia (two low lymphocyte counts within 3 months) and linear mixed effects regression to estimate the association with absolute lymphocyte counts using all available counts. Cox proportional hazard models were used to investigate the effect of lymphopenia on common infections. We replicated the study using US survey data (National Health and Nutrition Examination Survey [NHANES]). Results: Among 71,731 adults with AE and 126,349 adults without AE, we found an adjusted odds ratio (OR) for lymphopenia of 1.16 (95% CI: 1.09-1.23); the strength of association increased with increasing eczema severity. When comparing all recorded lymphocyte counts from adults with AE (n = 1,497,306) to those of people without AE (n = 4,035,870) we saw a lower mean lymphocyte (adjusted mean difference -0.047 × 10 Conclusion: Atopic eczema, including increasing AE severity, is associated with a decreased lymphocyte count, regardless of immunosuppressive drug use. Whether the lower lymphocyte count has wider health implications for people with severe eczema warrants further investigation.
MeSH term(s)	Adult ; Male ; Humans ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/therapy ; Cohort Studies ; Nutrition Surveys ; Eczema/complications ; Lymphopenia/complications ; Lymphopenia/epidemiology ; United Kingdom/epidemiology
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.18841
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Article ; Online: Adverse Childhood Experiences and Related Events are Associated with Asthma Symptoms in Children.

Martinez, Adali / Ye, Morgan / Hessler, Danielle / de la Rosa, Rosemarie / Benson, Mindy / Gilgoff, Rachel / Koita, Kadiatou / Bucci, Monica / Harris, Nadine Burke / Long, Dayna / Thakur, Neeta

Academic pediatrics

2024 Volume 24, Issue 4, Page(s) 669–676

Abstract: Objective: To examine the association between adverse childhood experiences (ACEs) and related events and asthma symptom burden in children.: Methods: This is a cross-sectional study of baseline data from 147 participants with asthma from a cohort of ...

Abstract	Objective: To examine the association between adverse childhood experiences (ACEs) and related events and asthma symptom burden in children. Methods: This is a cross-sectional study of baseline data from 147 participants with asthma from a cohort of children enrolled in the Pediatric ACEs Screening and Resiliency Study. Participants completed the PEdiatric ACEs and Related Life Events Screener (PEARLS) tool, a 17-item questionnaire, capturing 3 domains of childhood adversity-child maltreatment, household challenges, and social context. Asthma symptom burden was assessed using the International Study of Asthma and Allergies in Childhood core questionnaire, which asks participants to identify the presence and frequency of severe wheezing that limits speech, wheezing with exercise, nocturnal wheezing, and nocturnal cough in the last 12 months. Using multivariable logistical regression models, we examined the relationship between reported PEARLS and asthma symptoms. Results: Of children with asthma, 86% reported at least 1 adversity, with 48% reporting 4 or more. The odds of severe wheeze limiting speech increased by 19% with each additional reported adversity captured by the PEARLS tool (95% confidence intervals (CI) 1.01-1.41). Increasing PEARLS scores were also associated with 16% increased odds of reporting wheeze with exercise (95% CI 1.03-1.31). Wheezing with exercise was associated with the household challenges domain (odds ratio (OR) 1.34; 95% CI 1.05-1.72), while severe wheeze limiting speech was associated with the social context domain (OR 1.75; 95%CI 1.02-3.02). Conclusions: Childhood adversities are associated with increased asthma symptom burden, suggesting the tool may be helpful in identifying children at risk for poorly controlled asthma.
MeSH term(s)	Humans ; Asthma/epidemiology ; Female ; Male ; Child ; Cross-Sectional Studies ; Respiratory Sounds ; Adverse Childhood Experiences/statistics & numerical data ; Logistic Models ; Adolescent ; Surveys and Questionnaires ; Child Abuse/statistics & numerical data ; Cough/epidemiology ; Cough/etiology ; Child, Preschool ; Multivariate Analysis
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2483385-X
ISSN	1876-2867 ; 1876-2859
ISSN (online)	1876-2867
ISSN	1876-2859
DOI	10.1016/j.acap.2024.01.010
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Article ; Online: Associations Between Early-Life Adversity, Ambient Air Pollution, and Telomere Length in Children.

de la Rosa, Rosemarie / Le, Austin / Holm, Stephanie / Ye, Morgan / Bush, Nicole R / Hessler, Danielle / Koita, Kadiatou / Bucci, Monica / Long, Dayna / Thakur, Neeta

Psychosomatic medicine

2024

Abstract: Objective: Examine the independent associations and interaction between early-life adversity and residential ambient air pollution exposure on relative buccal telomere length (rBTL).: Methods: Experiences of abuse, neglect, household challenges, and ... ...

Abstract	Objective: Examine the independent associations and interaction between early-life adversity and residential ambient air pollution exposure on relative buccal telomere length (rBTL). Methods: Experiences of abuse, neglect, household challenges, and related life events were identified in a cross-sectional sample of children ages 1-11 years (n = 197) using the 17-item Pediatric ACEs and Related Life Event Screener (PEARLS) tool. The PEARLS tool was analyzed both as a total score and across established domains (Maltreatment, Household Challenges, and Social Context). Ground-level fine particulate matter (PM 2.5 ) concentrations were matched to residential locations for the one and twelve months prior to biospecimen collection. We used multivariable linear regression models to examine for independent associations between continuous PM 2.5 exposure and PEARLS score/domains with rBTL. Additionally, effect modification by PEARLS scores and domains on associations between PM 2.5 exposure and rBTL was examined. Results: Study participants were 47% girls, with mean age = 5.9 years [standard deviation: 3.4] median reported PEARLS score of 2 [interquartile range (IQR): 4], median 12-month prior PM 2.5 concentrations of 11.8 μg/m 3 [IQR: 2.7], median 1-month prior PM 2.5 concentrations of 10.9 μg/m 3 [IQR: 5.8], and rBTL of 0.1 [IQR: 0.03]. Mean 12-month prior PM 2.5 exposure was inversely associated with rBTL (ß = -0.02, 95% CI: -0.04, -0.01). While reported PEARLS scores and domains were not independently associated with rBTL, we observed a greater decrement in rBTL with increment of average annual PM 2.5 as reported Social Context domain items increased (p-interaction<0.05). Conclusion: Our results suggest that adverse Social Context factors may accelerate the association between chronic PM 2.5 exposure on telomere shortening during childhood.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	3469-1
ISSN	1534-7796 ; 0033-3174
ISSN (online)	1534-7796
ISSN	0033-3174
DOI	10.1097/PSY.0000000000001276
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Article ; Online: Adult atopic eczema and the risk of dementia: A population-based cohort study.

Magyari, Alexa / Ye, Morgan / Margolis, David J / McCulloch, Charles E / Cummings, Steven R / Yaffe, Kristine / Langan, Sinéad M / Abuabara, Katrina

Journal of the American Academy of Dermatology

2022 Volume 87, Issue 2, Page(s) 314–322

Abstract: Background: Chronic inflammatory conditions have been linked to dementia, but little is known about the role of atopic eczema, an inflammatory condition recently recognized to be common among older adults.: Objective: To determine whether active ... ...

Abstract	Background: Chronic inflammatory conditions have been linked to dementia, but little is known about the role of atopic eczema, an inflammatory condition recently recognized to be common among older adults. Objective: To determine whether active atopic eczema is associated with incident dementia. Methods: A longitudinal cohort study of 1,767,667 individuals aged 60 to 99 years registered with The Health Improvement Network, a primary care cohort in the United Kingdom. The diagnoses of atopic eczema and dementia were identified using medical record codes. Results: The incidence of dementia was 57 per 10,000 person-years among those with atopic eczema during follow-up (12.1% of the population) compared with 44 per 10,000 person-years in the control group. This translated to a 27% increased risk of dementia (hazard ratio, 1.27; 95% CI, 1.23-1.30) in adjusted Cox proportional hazard models. Similar associations were observed in subgroup analyses of vascular dementia and Alzheimer's disease. The association persisted after additionally adjusting for the use of systemic corticosteroids (hazard ratio, 1.29; 95% CI, 1.26-1.33) and potential mediators (hazard ratio, 1.19; 95% CI, 1.16-1.22). More severe eczema was associated with a higher risk of dementia. Limitations: Lack of detailed data on severity. Conclusion: Atopic eczema was associated with a small but increased risk of incident dementia. The association increased with the severity of atopic eczema.
MeSH term(s)	Aged ; Alzheimer Disease/epidemiology ; Cohort Studies ; Dermatitis, Atopic/complications ; Dermatitis, Atopic/epidemiology ; Eczema/epidemiology ; Humans ; Incidence ; Longitudinal Studies
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2022.03.049
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Article ; Online: Biological Burden of Adverse Childhood Experiences in Children.

de la Rosa, Rosemarie / Zablotny, David / Ye, Morgan / Bush, Nicole R / Hessler, Danielle / Koita, Kadiatou / Bucci, Monica / Long, Dayna / Thakur, Neeta

Psychosomatic medicine

2023 Volume 85, Issue 2, Page(s) 108–117

Abstract: Objective: This study aimed to examine relationships between adverse childhood experiences (ACEs) and related life events and allostatic load (AL)-"wear and tear" from chronic stress-in a pediatric population.: Methods: Children were screened with ... ...

Abstract	Objective: This study aimed to examine relationships between adverse childhood experiences (ACEs) and related life events and allostatic load (AL)-"wear and tear" from chronic stress-in a pediatric population. Methods: Children were screened with the PEdiatric ACEs and Related Life Event Screener (PEARLS) tool, a 17-item questionnaire capturing experiences of abuse, neglect, household challenges, and related life events. Biological data were available for 207 participants, and AL was operationalized using clinical or empirical cutoff points across 4 physiological systems (i.e., cardiac, metabolic, inflammatory, neurologic). Covariate-adjusted multivariable regression models were used to examine associations between AL with adversity and health. Results: Children (mean age = 6.5 years, range = 1-11 years) had an average AL score of 1.9 (standard deviation = 1.7), and a U-shaped relationship was observed with child's age. Continuous PEARLS and original ACE scores were not associated with AL. However, children with a reported PEARLS score of 1 to 2 or original ACEs score of 1 to 3 had 1.5 (incidence rate ratio [IRR] = 1.50, 95% confidence interval [CI] = 1.09-2.08) and 1.4 (IRR = 1.41, 95% CI = 1.08-1.84) times greater AL, respectively, compared with participants with none reported. In secondary analyses, caregiver mental illness was associated with higher child AL (adjusted IRR = 1.27, 95% CI = 1.01-1.58). AL was also associated with poorer perceived child general health (adjusted β = -0.87, 95% CI = -1.58 to -0.15) and greater odds of child obesity (adjusted odds ratio = 1.51, 95% CI = 1.23-1.89). Conclusions: Measuring AL in a pediatric population requires careful consideration of age. Higher AL was associated with a greater number of reported adversities and worse child health.
MeSH term(s)	Child ; Humans ; Infant ; Child, Preschool ; Adverse Childhood Experiences ; Child Abuse ; Mental Disorders/epidemiology ; Surveys and Questionnaires
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3469-1
ISSN	1534-7796 ; 0033-3174
ISSN (online)	1534-7796
ISSN	0033-3174
DOI	10.1097/PSY.0000000000001167
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Article ; Online: Atopic Dermatitis and Cardiovascular Risk in Pediatric Patients: A Systematic Review and Meta-Analysis.

Kern, Chloe / Ortiz, Camila / Johanis, Michael / Ye, Morgan / Tahir, Peggy / Mulick, Amy / Allen, Isabel E / McCulloch, Charles E / Langan, Sinéad M / Abuabara, Katrina

The Journal of investigative dermatology

2023 Volume 144, Issue 5, Page(s) 1038–1047.e16

Abstract: Cardiovascular guidelines recommend early screening and preventative treatment for children with chronic inflammatory diseases. Atopic dermatitis (AD) is associated with cardiovascular risk in adults, but data in children are limited. We systematically ... ...

Abstract	Cardiovascular guidelines recommend early screening and preventative treatment for children with chronic inflammatory diseases. Atopic dermatitis (AD) is associated with cardiovascular risk in adults, but data in children are limited. We systematically searched for studies that examined the association between childhood AD and cardiovascular risk factors and outcomes. Data from 10 publications, including 577,148 individuals, revealed an association between AD and ischemic heart disease (n = 3, OR = 1.68, 95% confidence interval [CI] = 1.29-2.19) and diabetes (n = 4, OR = 1.31, 95% CI = 1.12-1.53), but this did not persist among studies that adjusted for potential confounders (n = 2, OR = 0.98, 95% CI = 0.35-2.75). Similarly, there was an association with lipid disorders but not across the entire population distribution (n = 7, OR = 1.24, 95% CI = 1.13-1.36, 95% prediction interval = 0.95-1.61). AD was not associated with hypertension (n = 5, OR = 1.15, 95% CI = 0.98-1.34, 95% prediction interval = 0.81-1.62) or stroke (n = 2, OR = 1.24, 95% CI = 0.94-1.62). Studies lacked detail on AD severity and important confounders such as body mass index, and the certainty of evidence was very low to low on the basis of GRADE (Grading of Recommendations, Assessment, Development and Evaluation) assessments. Currently, data do not support a clinically meaningful increase in cardiovascular risk for children with AD.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Dermatitis, Atopic/epidemiology ; Dermatitis, Atopic/complications ; Heart Disease Risk Factors ; Risk Factors
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2023.09.285
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Article ; Online: Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study.

Ye, Morgan / Warner, Marcella / Mocarelli, Paolo / Brambilla, Paolo / Eskenazi, Brenda

Environmental health : a global access science source

2018 Volume 17, Issue 1, Page(s) 22

Abstract: Background: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental contaminant that can bioaccumulate in humans, cross the placenta, and cause immunological effects in children, including altering their risk of developing allergies. On July ...

Abstract	Background: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental contaminant that can bioaccumulate in humans, cross the placenta, and cause immunological effects in children, including altering their risk of developing allergies. On July 10, 1976, a chemical explosion in Seveso, Italy, exposed nearby residents to a high amount of TCDD. In 1996, the Seveso Women's Health Study (SWHS) was established to study the effects of TCDD on women's health. Using data from the Seveso Second Generation Health Study, we aim to examine the effect of prenatal exposure to TCDD on the risk of atopic conditions in SWHS children born after the explosion. Methods: Individual-level TCDD was measured in maternal serum collected soon after the accident. In 2014, we initiated the Seveso Second Generation Health Study to follow-up the children of the SWHS cohort who were born after the explosion or who were exposed in utero to TCDD. We enrolled 677 children, and cases of atopic conditions, including eczema, asthma, and hay fever, were identified by self-report during personal interviews with the mothers and children. Log-binomial and Poisson regressions were used to determine the association between prenatal TCDD and atopic conditions. Results: A 10-fold increase in 1976 maternal serum TCDD (log Conclusions: Our results suggest that maternal serum TCDD near the time of explosion is associated with lower risk of eczema, which supports other evidence pointing to the dysregulated immune effects of TCDD.
MeSH term(s)	Adolescent ; Adult ; Asthma/chemically induced ; Asthma/epidemiology ; Child ; Child, Preschool ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/epidemiology ; Environmental Pollutants/adverse effects ; Female ; Humans ; Italy/epidemiology ; Polychlorinated Dibenzodioxins/adverse effects ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/epidemiology ; Prospective Studies ; Rhinitis, Allergic, Seasonal/chemically induced ; Rhinitis, Allergic, Seasonal/epidemiology ; Sex Factors ; Young Adult
Chemical Substances	Environmental Pollutants ; Polychlorinated Dibenzodioxins
Language	English
Publishing date	2018-02-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2092232-2
ISSN	1476-069X ; 1476-069X
ISSN (online)	1476-069X
ISSN	1476-069X
DOI	10.1186/s12940-018-0365-2
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