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  1. Article ; Online: Treatment of paradoxical eczematous eruption in psoriasis treated with secukinumab: A case report.

    Xiao, Yu / Peng, Shanshan / Li, Xiangjun / Mao, Tianyi / Fang, Muping / Hu, Youhong / Ye, Wenzheng

    Medicine

    2023  Volume 102, Issue 6, Page(s) e32844

    Abstract: Rationale: Eczematous eruption is an increasingly recognized form of drug-related eruption, typically reported in association with interleukin 17 (IL-17)A inhibitors. However, severe paradoxical eczematous eruption due to IL-17A inhibitors has been ... ...

    Abstract Rationale: Eczematous eruption is an increasingly recognized form of drug-related eruption, typically reported in association with interleukin 17 (IL-17)A inhibitors. However, severe paradoxical eczematous eruption due to IL-17A inhibitors has been rarely reported. Herein, we reported a case of a man with severe psoriasis with erythematous scaly plaques on the scalp, trunk, and arms and legs after the administration of secukinumab was initiated.
    Patient concerns: We reported a case of a 20-year-old man with severe psoriasis with erythematous scaly plaques on the scalp, trunk, and arms and legs after the administration of secukinumab was initiated. A skin biopsy was performed. It revealed spongiotic dermatitis consistent with eczematous reaction. Direct and indirect immunofluorescence assays were negative.
    Diagnoses: He was diagnosed with eczematous eruption.
    Interventions: Discontinuation of secukinumab and administration of cyclosporine and prednisone were considered.
    Outcomes: Significant improvement was observed, with no adverse events.
    Conclusion: Our case shows that eczematous eruption can paradoxically occur in patients on IL-17A inhibitors and this report is expected to increase awareness of the rising number of cutaneous eruptions related to biological agents.
    MeSH term(s) Humans ; Male ; Young Adult ; Antibodies, Monoclonal, Humanized/adverse effects ; Drug Eruptions/etiology ; Eczema/chemically induced ; Eczema/complications ; Erythema ; Exanthema/chemically induced ; Interleukin-17 ; Psoriasis/drug therapy ; Psoriasis/complications
    Chemical Substances Antibodies, Monoclonal, Humanized ; Interleukin-17 ; secukinumab (DLG4EML025)
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000032844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Anti-melanoma differentiation-associated gene 5 and anti-Ro52 antibody-dual positive dermatomyositis accompanied by rapidly lung disease: Three case reports.

    Ye, Wen-Zheng / Peng, Shan-Shan / Hu, You-Hong / Fang, Mu-Ping / Xiao, Yu

    World journal of clinical cases

    2023  Volume 11, Issue 23, Page(s) 5580–5588

    Abstract: Background: Clinically amyopathic deramatomyositis was manifested as the various cutaneous dermatomyositis (DM) manifestations without muscle weakness. Anti-melanoma differentiation-associated gene 5 (anti-MDA5) and anti-Ro52 antibody-dual positive ... ...

    Abstract Background: Clinically amyopathic deramatomyositis was manifested as the various cutaneous dermatomyositis (DM) manifestations without muscle weakness. Anti-melanoma differentiation-associated gene 5 (anti-MDA5) and anti-Ro52 antibody-dual positive clinically amyopathic DM patients are at a high risk of developing rapidly progressive interstitial lung disease, and they exhibit an immensely high half-year mortality.
    Case summary: We presented three patients with anti-MDA5 and anti-Ro52 antibody-dual positive DM patients and we reviewed the previous studies on the link between anti-MDA5 and anti-Ro52 antibody-dual positive DM. Although we aggressively treated these patients similarly, but they all exhibited different prognoses. We reviewed the importance of clinical cutaneous rashes as well as the pathogenesis and treatment in the dual positive anti-MDA5 and anti-Ro52 associated DM.
    Conclusion: Patients with anti-MDA5 anti-Ro52 antibody-dual positive DM should be accurately diagnosed at an early stage and should be treated aggressively, thus, the patient's prognosis can be significantly modified.
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v11.i23.5580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An unusual case report of porokeratosis ptychotropica on the buttocks.

    Xiao, Yu / Peng, Shanshan / Mao, Tianyi / Li, Xiangjun / Ye, Wenzheng / Fang, Muping

    Medicine

    2022  Volume 101, Issue 47, Page(s) e32074

    Abstract: Rationale: Porokeratosis ptychotropica represents an unusual form of porokeratosis characterized by symmetrical dyskeratotic skin lesions on the gluteal clefts. Herein, we report a case of porokeratosis ptychotropica.: Patient concerns: A 33-year-old ...

    Abstract Rationale: Porokeratosis ptychotropica represents an unusual form of porokeratosis characterized by symmetrical dyskeratotic skin lesions on the gluteal clefts. Herein, we report a case of porokeratosis ptychotropica.
    Patient concerns: A 33-year-old man, who complained of itching papules and plaques in the gluteal cleft and the buttocks for the last 7 years. Clinical examination showed a large well-defined reddish brown verrucous plaque located on both buttocks along with satellite papules on the inner thigh. Dermoscopy and histopathological findings were consistent with porokeratosis.
    Diagnosis: He was diagnosed with porokeratosis ptychotropica.
    Outcomes: No significant improvement was observed following treatment with oral acitretin and a topical retinoid.
    Lessons: The case report highlights the need for awareness amongst dermatologists for porokeratosis ptychotropica as a differential diagnosis for pruritic papules in the gluteal fold.
    MeSH term(s) Male ; Humans ; Adult ; Porokeratosis/diagnosis ; Porokeratosis/drug therapy ; Buttocks ; Thigh ; Acitretin ; Pruritus ; Plaque, Amyloid
    Chemical Substances Acitretin (LCH760E9T7)
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000032074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Nanoplasmonic Purcell Effect in Ultrafast and High-Light-Yield Perovskite Scintillators.

    Ye, Wenzheng / Yong, Zhihua / Go, Michael / Kowal, Dominik / Maddalena, Francesco / Tjahjana, Liliana / Wang, Hong / Arramel, Arramel / Dujardin, Christophe / Birowosuto, Muhammad Danang / Wong, Liang Jie

    Advanced materials (Deerfield Beach, Fla.)

    2024  , Page(s) e2309410

    Abstract: The development of X-ray scintillators with ultrahigh light yields and ultrafast response times is a long sought-after goal. In this work, a fundamental mechanism that pushes the frontiers of ultrafast X-ray scintillator performance is theoretically ... ...

    Abstract The development of X-ray scintillators with ultrahigh light yields and ultrafast response times is a long sought-after goal. In this work, a fundamental mechanism that pushes the frontiers of ultrafast X-ray scintillator performance is theoretically predicted and experimentally demonstrated: the use of nanoscale-confined surface plasmon polariton modes to tailor the scintillator response time via the Purcell effect. By incorporating nanoplasmonic materials in scintillator devices, this work predicts over tenfold enhancement in decay rate and 38% reduction in time resolution even with only a simple planar design. The nanoplasmonic Purcell effect is experimentally demonstrated using perovskite scintillators, enhancing the light yield by over 120% to 88 ± 11 ph/keV, and the decay rate by over 60% to 2.0 ± 0.2 ns for the average decay time, and 0.7 ± 0.1 ns for the ultrafast decay component, in good agreement with the predictions of our theoretical framework. Proof-of-concept X-ray imaging experiments are performed using nanoplasmonic scintillators, demonstrating 182% enhancement in the modulation transfer function at four line pairs per millimeter spatial frequency. This work highlights the enormous potential of nanoplasmonics in optimizing ultrafast scintillator devices for applications including time-of-flight X-ray imaging and photon-counting computed tomography.
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202309410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Polarization-Orthogonal Nondegenerate Plasmonic Higher-Order Topological States.

    Li, Yuanzhen / Xu, Su / Zhang, Zijian / Yang, Yumeng / Xie, Xinrong / Ye, Wenzheng / Liu, Feng / Xue, Haoran / Jing, Liqiao / Wang, Zuojia / Chen, Qi-Dai / Sun, Hong-Bo / Li, Erping / Chen, Hongsheng / Gao, Fei

    Physical review letters

    2023  Volume 130, Issue 21, Page(s) 213603

    Abstract: Photonic topological states, providing light-manipulation approaches in robust manners, have attracted intense attention. Connecting photonic topological states with far-field degrees of freedom (d.o.f.) has given rise to fruitful phenomena. Recently ... ...

    Abstract Photonic topological states, providing light-manipulation approaches in robust manners, have attracted intense attention. Connecting photonic topological states with far-field degrees of freedom (d.o.f.) has given rise to fruitful phenomena. Recently emerged higher-order topological insulators (HOTIs), hosting boundary states two or more dimensions lower than those of bulk, offer new paradigms to localize or transport light topologically in extended dimensionalities. However, photonic HOTIs have not been related to d.o.f. of radiation fields yet. Here, we report the observation of polarization-orthogonal second-order topological corner states at different frequencies on a designer-plasmonic kagome metasurface in the far field. Such phenomenon stands on two mechanisms, i.e., projecting the far-field polarizations to the intrinsic parity d.o.f. of lattice modes and the parity splitting of the plasmonic corner states in spectra. We theoretically and numerically show that the parity splitting originates from the underlying interorbital coupling. Both near-field and far-field experiments verify the polarization-orthogonal nondegenerate second-order topological corner states. These results promise applications in robust optical single photon emitters and multiplexed photonic devices.
    MeSH term(s) Female ; Pregnancy ; Humans ; Fruit ; Photons
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.130.213603
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  6. Article ; Online: Association analyses identify six new psoriasis susceptibility loci in the Chinese population.

    Sun, Liang-Dan / Cheng, Hui / Wang, Zai-Xing / Zhang, An-Ping / Wang, Pei-Guang / Xu, Jin-Hua / Zhu, Qi-Xing / Zhou, Hai-Sheng / Ellinghaus, Eva / Zhang, Fu-Ren / Pu, Xiong-Ming / Yang, Xue-Qin / Zhang, Jian-Zhong / Xu, Ai-E / Wu, Ri-Na / Xu, Li-Min / Peng, Lin / Helms, Cynthia A / Ren, Yun-Qing /
    Zhang, Chi / Zhang, Shu-Mei / Nair, Rajan P / Wang, Hong-Yan / Lin, Guo-Shu / Stuart, Philip E / Fan, Xing / Chen, Gang / Tejasvi, Trilokraj / Li, Pan / Zhu, Jun / Li, Zhi-Ming / Ge, Hong-Mei / Weichenthal, Michael / Ye, Wen-Zheng / Zhang, Cheng / Shen, Song-Ke / Yang, Bao-Qi / Sun, Yuan-Yuan / Li, Shan-Shan / Lin, Yan / Jiang, Jian-Hua / Li, Cun-Tao / Chen, Ri-Xin / Cheng, Juan / Jiang, Xin / Zhang, Peng / Song, Wei-Min / Tang, Jin / Zhang, Hao-Qin / Sun, Li / Cui, Jing / Zhang, Li-Jun / Tang, Biao / Huang, Fei / Qin, Qian / Pei, Xiao-Ping / Zhou, Ai-Min / Shao, Li-Mei / Liu, Jian-Lan / Zhang, Feng-Yu / Du, Wei-Dong / Franke, Andre / Bowcock, Anne M / Elder, James T / Liu, Jian-Jun / Yang, Sen / Zhang, Xue-Jun

    Nature genetics

    2010  Volume 42, Issue 11, Page(s) 1005–1009

    Abstract: We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the ... ...

    Abstract We extended our previous genome-wide association study for psoriasis with a multistage replication study including 8,312 individuals with psoriasis (cases) and 12,919 controls from China as well as 3,293 cases and 4,188 controls from Germany and the United States and 254 nuclear families from the United States. We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10⁻⁸) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10⁻²¹) in the European studies. Two of these loci showed evidence for association in the German study at ZNF816A and GJB2 with P = 3.6 × 10⁻³ and P = 7.9 × 10⁻³, respectively. ERAP1 and ZNF816A were associated with type 1 (early onset) psoriasis in the Chinese Han population (test for heterogeneity P = 6.5 × 10⁻³ and P = 1.5 × 10⁻³, respectively). Comparisons with the results of previous GWAS of psoriasis highlight the heterogeneity of disease susceptibility between the Chinese and European populations. Our study identifies new genetic susceptibility factors and suggests new biological pathways in psoriasis.
    MeSH term(s) Aminopeptidases/genetics ; Asian Continental Ancestry Group/genetics ; Connexin 26 ; Connexins/genetics ; DNA Replication ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Germany/epidemiology ; Humans ; Membrane Proteins/genetics ; Minor Histocompatibility Antigens ; Neoplasm Proteins/genetics ; Polymorphism, Single Nucleotide ; Psoriasis/genetics ; Securin ; Serpins/genetics ; Tumor Suppressor Proteins ; United States/epidemiology
    Chemical Substances CSMD1 protein, human ; Connexins ; GJB2 protein, human ; Membrane Proteins ; Minor Histocompatibility Antigens ; Neoplasm Proteins ; SERPINB8 protein, human ; Securin ; Serpins ; Tumor Suppressor Proteins ; pituitary tumor-transforming protein 1, human ; Connexin 26 (127120-53-0) ; Aminopeptidases (EC 3.4.11.-) ; ERAP1 protein, human (EC 3.4.11.-)
    Language English
    Publishing date 2010-10-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng.690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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