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Article ; Online: Purple Urine Bag Syndrome Amelioration without Antibiotic Therapy.

Ye, Xiao-Qing / Bi, Wei-Hong / Wang, Ting

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

2024 Volume 34, Issue 2, Page(s) 248

Abstract: Null. ...

Abstract	Null.
MeSH term(s)	Humans ; Urinary Tract Infections/drug therapy ; Syndrome ; Anti-Bacterial Agents/therapeutic use ; Urine
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-02-11
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2276646-7
ISSN	1681-7168 ; 1022-386X
ISSN (online)	1681-7168
ISSN	1022-386X
DOI	10.29271/jcpsp.2024.02.248
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Article ; Online: Effects of pharmaceutical and personal care products on pubertal development: Evidence from human and animal studies.

Wang, Linping / Ye, Xiaoqing / Liu, Jing

Environmental pollution (Barking, Essex : 1987)

2024 Volume 346, Page(s) 123533

Abstract: Pharmaceutical and personal care products (PPCPs) include a wide range of drugs, personal care products and household chemicals that are produced and used in significant quantities. The safety of PPCPs has become a growing concern in recent decades due ... ...

Abstract	Pharmaceutical and personal care products (PPCPs) include a wide range of drugs, personal care products and household chemicals that are produced and used in significant quantities. The safety of PPCPs has become a growing concern in recent decades due to their ubiquitous presence in the environment and potential risks to human health. PPCPs have been detected in various human biological samples, including those from children and adolescents, at concentrations ranging from several ng/L to several thousand μg/L. Epidemiological studies have shown associations between exposure to PPCPs and changes in the timing of puberty in children and adolescents. Animal studies have shown that exposure to PPCPs results in advanced or delayed pubertal onset. Mechanisms by which PPCPs regulate pubertal development include alteration of the hypothalamic kisspeptin and GnRH networks, disruption of steroid hormones, and modulation of metabolic function and epigenetics. Gaps in knowledge and further research needs include the assessment of environmental exposure to pharmaceuticals in children and adolescents, low-dose and long-term effects of exposure to PPCPs, and the modes of action of PPCPs on pubertal development. In summary, this comprehensive review examines the potential effects of exposure to PPCPs on pubertal development based on evidence from human and animal studies.
MeSH term(s)	Animals ; Child ; Humans ; Adolescent ; Environmental Monitoring/methods ; Water Pollutants, Chemical/analysis ; Cosmetics/analysis ; Environmental Exposure ; Pharmaceutical Preparations
Chemical Substances	Water Pollutants, Chemical ; Cosmetics ; Pharmaceutical Preparations
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2024.123533
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Article: Editorial: Endocrine-active substances in food: identification, evaluation, and control.

Luo, Yu-Syuan / Ye, Xiaoqing / Yin, Shanshan

Frontiers in nutrition

2023 Volume 10, Page(s) 1252122

Language	English
Publishing date	2023-08-11
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1252122
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Article: Preparation strategy of hydrogel microsphere and its application in skin repair.

Chi, Honggang / Qiu, Yunqi / Ye, Xiaoqing / Shi, Jielin / Li, Ziyi

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1239183

Abstract: In recent years, hydrogel microsphere has attracted much attention due to its great potential in the field of skin repair. This paper reviewed the recent progress in the preparation strategy of hydrogel microsphere and its application in skin repair. In ... ...

Abstract	In recent years, hydrogel microsphere has attracted much attention due to its great potential in the field of skin repair. This paper reviewed the recent progress in the preparation strategy of hydrogel microsphere and its application in skin repair. In this review, several preparation methods of hydrogel microsphere were summarized in detail. In addition, the related research progress of hydrogel microspheres for skin repair was reviewed, and focused on the application of bioactive microspheres, antibacterial microspheres, hemostatic microspheres, and hydrogel microspheres as delivery platforms (hydrogel microspheres as a microcarrier of drugs, bioactive factors, or cells) in the field of skin repair. Finally, the limitations and future prospects of the development of hydrogel microspheres and its application in the field of skin repair were presented. It is hoped that this review can provide a valuable reference for the development of the preparation strategy of hydrogel microspheres and promote the application of hydrogel microspheres in skin repair.
Language	English
Publishing date	2023-07-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1239183
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Article: Multi-arm covariate-adaptive randomization.

Hu, Feifang / Ye, Xiaoqing / Zhang, Li-Xin

Science China. Mathematics

2022 , Page(s) 1–28

Abstract: Simultaneously investigating multiple treatments in a single study achieves considerable efficiency in contrast to the traditional two-arm trials. Balancing treatment allocation for influential covariates has become increasingly important in today's ... ...

Abstract	Simultaneously investigating multiple treatments in a single study achieves considerable efficiency in contrast to the traditional two-arm trials. Balancing treatment allocation for influential covariates has become increasingly important in today's clinical trials. The multi-arm covariate-adaptive randomized clinical trial is one of the most powerful tools to incorporate covariate information and multiple treatments in a single study. Pocock and Simon's procedure has been extended to the multi-arm case. However, the theoretical properties of multi-arm covariate-adaptive randomization have remained largely elusive for decades. In this paper, we propose a general framework for multi-arm covariate-adaptive designs which also includes the two-arm case, and establish the corresponding theory under widely satisfied conditions. The theoretical results provide new insights about balance properties of covariate-adaptive randomization procedures and make foundations for most existing statistical inferences under two-arm covariate-adaptive randomization. Furthermore, these open a door to study the theoretical properties of statistical inferences for clinical trials based on multi-arm covariate-adaptive randomization procedures.
Language	English
Publishing date	2022-07-21
Publishing country	China
Document type	Journal Article
ZDB-ID	2546737-2
ISSN	1869-1862 ; 1674-7283
ISSN (online)	1869-1862
ISSN	1674-7283
DOI	10.1007/s11425-020-1954-y
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Article: Dynamic asymmetric impact of equity market uncertainty on energy markets: A time-varying causality analysis

Hong, Yanran / Wang, Lu / Ye, Xiaoqing / Zhang, Yaojie

Renewable energy. 2022 Aug., v. 196

2022

Abstract: This paper aims to investigate the dynamic asymmetric impact of equity market uncertainty on the energy market. For that reason, we first apply the asymmetric Granger causality test to capture both positive and negative EMV and oil shocks. We find the ... ...

Abstract	This paper aims to investigate the dynamic asymmetric impact of equity market uncertainty on the energy market. For that reason, we first apply the asymmetric Granger causality test to capture both positive and negative EMV and oil shocks. We find the existence of the asymmetric effect, displaying as negative EMV shocks are the primary driving factors of positive oil shocks, while positive EMV shocks can affect negative oil shocks. Further, on the basis of three rolling-window procedures, we extend the asymmetric causality test to detect the structural breakpoints and time-varying characteristics of the causal relationships running from EMV shocks to oil shocks. Results show that some extreme events may lead to a structural breakpoint in their relationships. In particular, the negative effects of EMV shocks on oil shocks seem to be more lasting than the positive ones. Our findings may provide a new perspective on asset allocation, energy portfolio construction, and risk management.
Keywords	assets ; energy ; markets ; oils ; renewable energy sources ; risk management ; uncertainty
Language	English
Dates of publication	2022-08
Size	p. 535-546.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001449-1
ISSN	1879-0682 ; 0960-1481
ISSN (online)	1879-0682
ISSN	0960-1481
DOI	10.1016/j.renene.2022.07.027
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Perinatal exposure to low doses of cypermethrin induce the puberty-related hormones and decrease the time to puberty in the female offspring

Gan, Hongya / Zhu, Bingqi / Zhou, Fangmei / Jung, Jisun / Liu, Jing / Ye, Xiaoqing

Environ Sci Pollut Res. 2023 Jan., v. 30, no. 2 p.2665-2675

2023

Abstract: Pyrethroid insecticides are ubiquitously detected in environmental media, food, and urine samples. Our previous epidemiological study reported a correlation between increased pyrethroid exposure and delayed pubertal development in Chinese girls. In this ... ...

Abstract	Pyrethroid insecticides are ubiquitously detected in environmental media, food, and urine samples. Our previous epidemiological study reported a correlation between increased pyrethroid exposure and delayed pubertal development in Chinese girls. In this study, we further investigated the effects of perinatal exposure to low doses of cypermethrin (CP) on pubertal onset and hypothalamic-pituitary-ovarian axis in the female mice offspring. The treatment of CP with 60 μg/kg/day from gestation day 6 (GD6) to postnatal day 21 (PND21) significantly decreased the time to puberty in the female offspring. Exposure of CP increased the serum levels of gonadotropin-releasing hormone (GnRH) and the expression of GnRH genes in a dose-dependent manner in the female offspring. CP also induced the serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the expression of gonadotropin subunit genes [LHβ, FSHβ, and chorionic gonadotropin α (Cgα)]. Furthermore, CP induced serum estradiol (E₂) levels and the expression of steroidogenesis-related genes [steroidogenic acute regulatory (StAR) and Cytochrome p 450, family 11, subfamily A, polypeptide 1 (CYP11A1)] in the ovary. In accordance with the in vivo tests, administration of CP (6.7, 20, and 60 μg/L) stimulated a dose-dependent increase in the synthesis and secretion of the puberty-related hormones in the explants of hypothalamus, pituitary, and ovary. The interference with calcium channels in the ovary may be responsible for CP-induced pubertal onset. Our study provided evidence that perinatal exposure to low doses of CP induced puberty-related hormones and decreased the time to puberty in the female offspring.
Keywords	blood serum ; calcium ; cypermethrin ; dose response ; epidemiological studies ; estradiol ; females ; follicle-stimulating hormone ; gonadotropin-releasing hormone ; hypothalamus ; luteinizing hormone ; polypeptides ; pregnancy ; progeny ; puberty ; pyrethrins ; secretion ; urine
Language	English
Dates of publication	2023-01
Size	p. 2665-2675.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22328-x
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: DrivingDiffusion

Li, Xiaofan / Zhang, Yifu / Ye, Xiaoqing

Layout-Guided multi-view driving scene video generation with latent diffusion model

2023

Abstract: With the increasing popularity of autonomous driving based on the powerful and unified bird's-eye-view (BEV) representation, a demand for high-quality and large-scale multi-view video data with accurate annotation is urgently required. However, such ... ...

Abstract	With the increasing popularity of autonomous driving based on the powerful and unified bird's-eye-view (BEV) representation, a demand for high-quality and large-scale multi-view video data with accurate annotation is urgently required. However, such large-scale multi-view data is hard to obtain due to expensive collection and annotation costs. To alleviate the problem, we propose a spatial-temporal consistent diffusion framework DrivingDiffusion, to generate realistic multi-view videos controlled by 3D layout. There are three challenges when synthesizing multi-view videos given a 3D layout: How to keep 1) cross-view consistency and 2) cross-frame consistency? 3) How to guarantee the quality of the generated instances? Our DrivingDiffusion solves the problem by cascading the multi-view single-frame image generation step, the single-view video generation step shared by multiple cameras, and post-processing that can handle long video generation. In the multi-view model, the consistency of multi-view images is ensured by information exchange between adjacent cameras. In the temporal model, we mainly query the information that needs attention in subsequent frame generation from the multi-view images of the first frame. We also introduce the local prompt to effectively improve the quality of generated instances. In post-processing, we further enhance the cross-view consistency of subsequent frames and extend the video length by employing temporal sliding window algorithm. Without any extra cost, our model can generate large-scale realistic multi-camera driving videos in complex urban scenes, fueling the downstream driving tasks. The code will be made publicly available. Comment: 11 pages
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence
Subject code	004
Publishing date	2023-10-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: IST-Net

Liu, Jianhui / Chen, Yukang / Ye, Xiaoqing / Qi, Xiaojuan

Prior-free Category-level Pose Estimation with Implicit Space Transformation

2023

Abstract: Category-level 6D pose estimation aims to predict the poses and sizes of unseen objects from a specific category. Thanks to prior deformation, which explicitly adapts a category-specific 3D prior (i.e., a 3D template) to a given object instance, prior- ... ...

Abstract	Category-level 6D pose estimation aims to predict the poses and sizes of unseen objects from a specific category. Thanks to prior deformation, which explicitly adapts a category-specific 3D prior (i.e., a 3D template) to a given object instance, prior-based methods attained great success and have become a major research stream. However, obtaining category-specific priors requires collecting a large amount of 3D models, which is labor-consuming and often not accessible in practice. This motivates us to investigate whether priors are necessary to make prior-based methods effective. Our empirical study shows that the 3D prior itself is not the credit to the high performance. The keypoint actually is the explicit deformation process, which aligns camera and world coordinates supervised by world-space 3D models (also called canonical space). Inspired by these observations, we introduce a simple prior-free implicit space transformation network, namely IST-Net, to transform camera-space features to world-space counterparts and build correspondence between them in an implicit manner without relying on 3D priors. Besides, we design camera- and world-space enhancers to enrich the features with pose-sensitive information and geometrical constraints, respectively. Albeit simple, IST-Net achieves state-of-the-art performance based-on prior-free design, with top inference speed on the REAL275 benchmark. Our code and models are available at https://github.com/CVMI-Lab/IST-Net. Comment: Accepted by ICCV2023
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	006
Publishing date	2023-03-23
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dimer Peptide Ligands of Vascular Endothelial Growth Factor: Optimizing Linker Length for High Affinity and Antiangiogenic Activity.

Ye, Xiaoqing / Gaucher, Jean-François / Hu, Haofeng / Wang, Lei / Broussy, Sylvain

Journal of medicinal chemistry

2023 Volume 66, Issue 14, Page(s) 9753–9765

Abstract: Macromolecular ligands targeting vascular endothelial growth factor A (VEGF) to inhibit pathological angiogenesis are used in the clinic for the treatment of cancers and ocular diseases. To develop smaller ligands retaining high affinity through an ... ...

Abstract	Macromolecular ligands targeting vascular endothelial growth factor A (VEGF) to inhibit pathological angiogenesis are used in the clinic for the treatment of cancers and ocular diseases. To develop smaller ligands retaining high affinity through an avidity effect, here we design homodimer peptides targeting the two symmetrical binding sites of the VEGF homodimer. A series of 11 dimers were synthesized with flexible poly(ethylene glycol) (PEG) linkers of increasing lengths. The binding mode was determined by size exclusion chromatography, and analytical thermodynamic parameters were measured by isothermal titration calorimetry and compared to the antibody bevacizumab. The effect of linker length was qualitatively correlated to a theoretical model. With the optimal length in PEG
MeSH term(s)	Humans ; Vascular Endothelial Growth Factor A/metabolism ; Ligands ; Peptides/chemistry ; Binding Sites ; Human Umbilical Vein Endothelial Cells ; Angiogenesis Inhibitors/chemistry
Chemical Substances	Vascular Endothelial Growth Factor A ; Ligands ; Peptides ; Angiogenesis Inhibitors
Language	English
Publishing date	2023-07-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c00561
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