LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 8 of total 8

Search options

  1. Book ; Online: PLANNING BY USING DIGITAL TECHNOLOGY IN THE RECONSTRUCTION OF CULTURAL HERITAGE SITES – A CASE STUDY OF QIONG-LIN SETTLEMENT IN KINMEN AREA

    Yang, W. B. / Ye, Y. N.

    eISSN: 2194-9034

    2017  

    Abstract: ICOMOS Florence Declaration in 2014, encourages an in-depth reflection on human values through cultural heritage and landscapes, which emphasizes the importance of historical heritage sites, in order to achieve the application of cultural heritage ... ...

    Abstract ICOMOS Florence Declaration in 2014, encourages an in-depth reflection on human values through cultural heritage and landscapes, which emphasizes the importance of historical heritage sites, in order to achieve the application of cultural heritage records through the public participation, sharing new technology platform and facilitation tools for knowledge diffusion, for instance. Nikos adopted digitized intangible cultural heritage within i-Treasures project to create a novel digital platform in 2016. Nowadays, the display platform developed based on geographic information system has been gradually accepted and widely used to distribute cultural heritage information, aiming to combine geography, time, events, issues, trends with the interactive maps to show the context of data changes from the consideration of planarity; for example, Burnaby City in Canada has cooperated with the Columbia University to create a navigation platform for guidance of tangible cultural heritage based on story maps in order to provide public recognition function. In this study, Qiong-Lin Settlement in Kinmen Area was taken as an example to illustrate the developing process of an overall planning framework for reappearing the glory of historic settlements of cultural heritage sites with digital technology, which included tangible and intangible cultural heritage preservation and transmission planning, community participation and digital navigation programs. The digital technology with the GIS-based digital platform can provide more diverse and interesting information while using an intuitive, graphical user story mapping interface. So that tangible cultural heritage can be effectively understood, interpreted and preserved with the value-added methods, and also intangible cultural heritage can be continuously transmitted to establish a complete system of cultural heritage preservation. The main contents include several navigation technologies, such as 3D laser scanning, UAV images, photogrammetry, panorama, audio/video, geographic information systems etc.
    Subject code 302
    Language English
    Publishing date 2017-08-23
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: There were no differences in serum HBV DNA level between HBeAg-positive and HBeAg-negative chronic hepatitis B with same liver histological necroinflammation grade but differences among grades 1, 2, 3 and 4 apportioned by the same hepatic parenchyma cell volume.

    Ke, W-M / Xie, S-B / Li, X-J / Zhang, S-Q / Lai, J / Ye, Y-N / Gao, Z-L / Chen, P-J

    Journal of viral hepatitis

    2011  Volume 18, Issue 9, Page(s) 637–645

    Abstract: Hepatitis B virus (HBV) DNA levels and liver histological necroinflammation grades are correlated with the antiviral efficacy. It is necessary to clarify the relationship between HBV replication levels apportioned by the same hepatic parenchyma cell ... ...

    Abstract Hepatitis B virus (HBV) DNA levels and liver histological necroinflammation grades are correlated with the antiviral efficacy. It is necessary to clarify the relationship between HBV replication levels apportioned by the same hepatic parenchyma cell volume and severity of liver histological necroinflammation grades in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative chronic hepatitis B. The serum HBV DNA levels apportioned by the same hepatic parenchyma cell volume were compared between HBeAg-positive and HBeAg-negative chronic hepatitis B as well as among liver histological necroinflammation grades 1, 2, 3 and 4, respectively. There were no differences in the serum HBV DNA levels between HBeAg-positive and HBeAg-negative chronic hepatitis B as well as among liver histological necroinflammation grades 1, 2, 3 and 4. However, there were differences in the serum HBV DNA levels apportioned by the same hepatic parenchyma cell volume among liver histological necroinflammation grades 1, 2, 3 and 4 in both HBeAg-positive and HBeAg-negative chronic hepatitis B, respectively. There were no differences in HBV DNA levels with the same liver histological necroinflammation grade activated by HBV wild-type and variant strains. After the differences in hepatic parenchyma cell volume for HBV replication of the same liver histological necroinflammation grade accompanied by different hepatic fibrosis stages were adjusted, the serum HBV DNA level apportioned by the same hepatic parenchyma cell volume was correlated with the severity of liver histological necroinflammation grade.
    MeSH term(s) Adult ; Alanine Transaminase/blood ; Analysis of Variance ; Biopsy ; Cell Size ; DNA, Viral/blood ; Female ; Hepatitis B e Antigens/blood ; Hepatitis B virus/pathogenicity ; Hepatitis B virus/physiology ; Hepatitis B, Chronic/pathology ; Hepatitis B, Chronic/virology ; Humans ; Inflammation/pathology ; Inflammation/virology ; Liver/pathology ; Liver/virology ; Liver Cirrhosis/pathology ; Liver Cirrhosis/virology ; Male ; Middle Aged ; Severity of Illness Index ; Virus Replication ; Young Adult
    Chemical Substances DNA, Viral ; Hepatitis B e Antigens ; Alanine Transaminase (EC 2.6.1.2)
    Language English
    Publishing date 2011-09
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1212497-7
    ISSN 1365-2893 ; 1352-0504
    ISSN (online) 1365-2893
    ISSN 1352-0504
    DOI 10.1111/j.1365-2893.2011.01444.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Effect of polysaccharides from Angelica sinensis on gastric ulcer healing.

    Ye, Y N / So, H L / Liu, E S L / Shin, V Y / Cho, C H

    Life sciences

    2003  Volume 72, Issue 8, Page(s) 925–932

    Abstract: Our previous study showed that a crude extract from Angelica sinensis (ASCE), which mainly consisted of polysaccharides, significantly promoted migration and proliferation of normal gastric epithelial cells. These results strongly suggest that ASCE has a ...

    Abstract Our previous study showed that a crude extract from Angelica sinensis (ASCE), which mainly consisted of polysaccharides, significantly promoted migration and proliferation of normal gastric epithelial cells. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa. However, there is no report concerning the effect of ASCE on gastric ulcer healing in animal models. In this study, we found that ASCE promoted ulcer healing. The area of the ulcer was reduced. This was accompanied with a significant increase in mucus synthesis when compared with the control. Angiogenesis was inhibited by the treatment of ASCE. Cell proliferation, ODC and EGFR protein expression was not affected in this process. Thus, the mechanism of how ASCE accelerates ulcer healing in addition to its effect on mucus synthesis remains to be investigated.
    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Animals ; Anti-Ulcer Agents/isolation & purification ; Anti-Ulcer Agents/therapeutic use ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/therapeutic use ; ErbB Receptors/metabolism ; Gastric Mucosa/drug effects ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Male ; Mucus/metabolism ; Neovascularization, Pathologic/pathology ; Ornithine Decarboxylase/metabolism ; Polysaccharides/isolation & purification ; Polysaccharides/therapeutic use ; Proliferating Cell Nuclear Antigen/metabolism ; Rats ; Rats, Sprague-Dawley ; Stomach Ulcer/drug therapy ; Stomach Ulcer/metabolism ; Stomach Ulcer/pathology ; Wound Healing/drug effects
    Chemical Substances Angiogenesis Inhibitors ; Anti-Ulcer Agents ; Drugs, Chinese Herbal ; Polysaccharides ; Proliferating Cell Nuclear Antigen ; angelicae sinensis extract ; ErbB Receptors (EC 2.7.10.1) ; Ornithine Decarboxylase (EC 4.1.1.17)
    Language English
    Publishing date 2003-01-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/s0024-3205(02)02332-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Angelica sinensis modulates migration and proliferation of gastric epithelial cells.

    Ye, Y N / Koo, M W / Li, Y / Matsui, H / Cho, C H

    Life sciences

    2001  Volume 68, Issue 8, Page(s) 961–968

    Abstract: A crude extract from Angelica sinensis (ASCE), which mainly consists of polysaccharides, prevents ethanol- or indomethacin-induced gastric mucosal damage and promotes ulcer healing. The aim of this study was to test the hypothesis that ASCE has a direct ... ...

    Abstract A crude extract from Angelica sinensis (ASCE), which mainly consists of polysaccharides, prevents ethanol- or indomethacin-induced gastric mucosal damage and promotes ulcer healing. The aim of this study was to test the hypothesis that ASCE has a direct stimulating effect on gastric epithelial cells for wound healing. We found that ASCE significantly promoted the migration of epithelial cells over an artificial wound on the surface of an RGM-1 monolayer. The extract also stimulated DNA synthesis in a dose-dependent manner and concomitantly increased EGF mRNA expression. Co-incubation of ASCE with anti-EGF antibody reduced the speed of migration and the DNA synthesis, which however were still higher than the control without ASCE. These results strongly suggest that ASCE has a direct wound healing effect on gastric mucosa, and this is acting partially through an EGF-mediated pathway.
    MeSH term(s) Animals ; Antibodies/pharmacology ; Cell Culture Techniques ; Cell Division/drug effects ; Cell Movement/drug effects ; Dose-Response Relationship, Drug ; Epidermal Growth Factor/immunology ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Gastric Mucosa/drug effects ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Gastrointestinal Agents/pharmacology ; Plant Extracts/pharmacology ; Plant Roots/chemistry ; Plants, Medicinal/chemistry ; Polysaccharides/pharmacology ; RNA, Messenger/biosynthesis ; Stomach Ulcer/drug therapy ; Stomach Ulcer/pathology ; Thymidine/metabolism ; Wound Healing/drug effects
    Chemical Substances Antibodies ; Gastrointestinal Agents ; Plant Extracts ; Polysaccharides ; RNA, Messenger ; Epidermal Growth Factor (62229-50-9) ; Thymidine (VC2W18DGKR)
    Language English
    Publishing date 2001-01-12
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/s0024-3205(00)00994-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke.

    Ye, Y N / Wu, W K K / Shin, V Y / Bruce, I C / Wong, B C Y / Cho, C H

    Carcinogenesis

    2005  Volume 26, Issue 4, Page(s) 827–834

    Abstract: Previous studies indicate that the arachidonic acid-metabolizing enzymes COX-2 and 5-LOX are overexpressed during the process of colonic adenoma formation promoted by cigarette smoke. The aims of the present study were to investigate whether there exists ...

    Abstract Previous studies indicate that the arachidonic acid-metabolizing enzymes COX-2 and 5-LOX are overexpressed during the process of colonic adenoma formation promoted by cigarette smoke. The aims of the present study were to investigate whether there exists a relationship between COX-2 and 5-LOX, and whether dual inhibition of COX-2 and 5-LOX has an anticarcinogenic effect in the colonic tumorigenesis promoted by cigarette smoke. Results showed that pretreating colon cancer cells with cigarette smoke extract (CSE) promoted colon cancer growth in the nude mouse xenograft model. Inhibition of COX-2 or 5-LOX reduced the tumor size. In the group treated with COX-2-inhibitor, the PGE2 level decreased while the LTB4 level increased. In contrast, in the 5-LOX-inhibitor treated group, the LTB4 level was reduced and the PGE2 level was unchanged. However, combined treatment with both COX-2 and 5-LOX inhibitors further inhibited the tumor growth promoted by CSE over treatment with either COX-2-inhibitor or 5-LOX-inhibitor alone. This was accompanied by the downregulation of PGE2 and LTB4. In an in vitro study, we found that the action of CSE on colon cancer cells was mediated by 5-LOX DNA demethylation. In summary, these results indicate that inhibition of COX-2 may lead to a shunt of arachidonic acid metabolism towards the leukotriene pathway during colonic tumorigenesis promoted by CSE. Suppression of 5-LOX did not induce such a shunt and produced a better response. Therefore, 5-LOX inhibitor is more effective than COX-2 inhibitor, and blocker of both COX-2 and 5-LOX may present a superior anticancer profile in cigarette smokers.
    MeSH term(s) Adenocarcinoma/enzymology ; Adenocarcinoma/etiology ; Adenocarcinoma/prevention & control ; Animals ; Apoptosis/drug effects ; Arachidonate 5-Lipoxygenase/genetics ; Arachidonate 5-Lipoxygenase/metabolism ; Cell Proliferation/drug effects ; Colonic Neoplasms/enzymology ; Colonic Neoplasms/etiology ; Colonic Neoplasms/prevention & control ; Cyclooxygenase 2 ; Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors/therapeutic use ; DNA Methylation ; Dinoprostone/metabolism ; Female ; Leukotriene B4/metabolism ; Lipoxygenase Inhibitors/therapeutic use ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Neovascularization, Pathologic/prevention & control ; Prostaglandin-Endoperoxide Synthases/drug effects ; Prostaglandin-Endoperoxide Synthases/genetics ; Prostaglandin-Endoperoxide Synthases/metabolism ; RNA, Messenger/metabolism ; Smoke/adverse effects ; Nicotiana ; Tumor Cells, Cultured
    Chemical Substances Cyclooxygenase 2 Inhibitors ; Cyclooxygenase Inhibitors ; Lipoxygenase Inhibitors ; RNA, Messenger ; Smoke ; Leukotriene B4 (1HGW4DR56D) ; Arachidonate 5-Lipoxygenase (EC 1.13.11.34) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1) ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2005-01-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603134-1
    ISSN 1460-2180 ; 0143-3334
    ISSN (online) 1460-2180
    ISSN 0143-3334
    DOI 10.1093/carcin/bgi012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1558: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Protective role of heme oxygenase-1 on trinitrobenzene sulfonic acid-induced colitis in rats.

    Wang, W P / Guo, X / Koo, M W / Wong, B C / Lam, S K / Ye, Y N / Cho, C H

    American journal of physiology. Gastrointestinal and liver physiology

    2001  Volume 281, Issue 2, Page(s) G586–94

    Abstract: Preliminary studies showed that the inducible form of heme oxygenase (HO-1) was induced and played a protective role in the process of inflammation. The present study investigated the possible role of HO-1 in 2,4,6-trinitrobenzene sulfonic acid (TNBS)- ... ...

    Abstract Preliminary studies showed that the inducible form of heme oxygenase (HO-1) was induced and played a protective role in the process of inflammation. The present study investigated the possible role of HO-1 in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. We measured HO-1 activity in TNBS-induced colitis in rats and analyzed the severity of colitis along with altered HO activity by assessing lesion area and myeloperoxidase activity. HO-1 mRNA and protein expressions were determined at different time points after TNBS induction. Free radical production and inducible nitric oxide synthase (iNOS), which participate in oxidative injury, were also assayed. HO activity and HO-1 gene expression increased markedly after TNBS induction. Administration with tin mesoporphyrin (SnMP), a HO inhibitor, potentiated the colonic damage along with a reduction in HO-1 activity. Furthermore, the reduction of HO-1 expression by SnMP also enhanced reactive oxygen species and iNOS expression, both of which were dramatically increased after the TNBS enema. L-Arginine pretreatment further aggravated the injurious action of SnMP. Our results indicate that HO-1 plays a protective role in the colonic damage induced by the TNBS enema, and the preventive effects probably result from decreased free radical production and inhibition of iNOS expression in colonic tissues.
    MeSH term(s) Animals ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/enzymology ; Colitis, Ulcerative/pathology ; Enzyme Inhibitors/pharmacology ; Heme Oxygenase (Decyclizing)/biosynthesis ; Heme Oxygenase (Decyclizing)/genetics ; Heme Oxygenase (Decyclizing)/immunology ; Heme Oxygenase (Decyclizing)/physiology ; Heme Oxygenase-1 ; Immunohistochemistry ; Luminescent Measurements ; Male ; Metalloporphyrins/pharmacology ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase Type II ; Peroxidase/metabolism ; RNA, Messenger/biosynthesis ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Trinitrobenzenesulfonic Acid
    Chemical Substances Enzyme Inhibitors ; Metalloporphyrins ; RNA, Messenger ; Reactive Oxygen Species ; tin mesoporphyrin (0KAE1U0G7Q) ; Trinitrobenzenesulfonic Acid (8T3HQG2ZC4) ; Peroxidase (EC 1.11.1.7) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, rat (EC 1.14.13.39) ; Heme Oxygenase (Decyclizing) (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18) ; heme oxygenase-2 (EC 1.14.14.18)
    Language English
    Publishing date 2001-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603840-2
    ISSN 1522-1547 ; 0193-1857
    ISSN (online) 1522-1547
    ISSN 0193-1857
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury.

    Ye, Y N / Liu, E S / Li, Y / So, H L / Cho, C C / Sheng, H P / Lee, S S / Cho, C H

    Life sciences

    2001  Volume 69, Issue 6, Page(s) 637–646

    Abstract: A polysaccharides-enriched fraction from the root of Angelica sinensis, which is known for its antiulcer action on the gastrointestinal tract, was isolated and studied for its hepato-protective effect in rodents. Intra-gastric administration of Angelica ... ...

    Abstract A polysaccharides-enriched fraction from the root of Angelica sinensis, which is known for its antiulcer action on the gastrointestinal tract, was isolated and studied for its hepato-protective effect in rodents. Intra-gastric administration of Angelica sinensis polysaccharides-enriched fraction (AP) at the doses of 50 or 75 mg/kg dose-dependently prevented liver toxicity induced by acetaminophen in mice but did not affect the serum acetaminophen concentration. It normalized the rises of serum alanine transferase (ALT) and hepatic nitric oxide synthase (NOS) activities and the decrease of glutathione level in the liver. It also reduced the hepatic malondialdehyde (MDA) concentration. The protective effect was less evident in the carbon tetrachloride (CCl4)-treated animals including mice and rats. In the rat the elevated serum ALT level was unaffected though the MDA level was similarly reduced by the higher dose of AP. In these animals, CCl4 increased the hepatic glutathione level instead while the NOS activity remained unchanged. These findings suggest that the pathogenic mechanisms of both acetaminophen and CCl4 are different. AP is more effective in the protection against liver damage induced by acetaminophen, which is associated with the glutathione depletion and nitric oxide synthase activation in the liver.
    MeSH term(s) Acetaminophen/blood ; Acetaminophen/toxicity ; Administration, Oral ; Alanine Transaminase/blood ; Animals ; Carbon Tetrachloride/toxicity ; Chemical and Drug Induced Liver Injury/blood ; Chemical and Drug Induced Liver Injury/prevention & control ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal ; Glutathione/metabolism ; Glycosaminoglycans/therapeutic use ; Liver/drug effects ; Liver/metabolism ; Male ; Malondialdehyde/metabolism ; Mice ; Mice, Inbred ICR ; Nitric Oxide Synthase/blood ; Nitric Oxide Synthase Type II ; Plant Extracts/therapeutic use ; Plant Roots/chemistry ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Drugs, Chinese Herbal ; Glycosaminoglycans ; Plant Extracts ; Acetaminophen (362O9ITL9D) ; Malondialdehyde (4Y8F71G49Q) ; Carbon Tetrachloride (CL2T97X0V0) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, mouse (EC 1.14.13.39) ; Nos2 protein, rat (EC 1.14.13.39) ; Alanine Transaminase (EC 2.6.1.2) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2001-06-29
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/s0024-3205(01)01153-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.368: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line.

    Ye, Y N / Liu, E S / Shin, V Y / Koo, M W / Li, Y / Wei, E Q / Matsui, H / Cho, C H

    Biochemical pharmacology

    2001  Volume 61, Issue 11, Page(s) 1439–1448

    Abstract: It has been reported that an extract from Angelica sinensis mainly consisting of polysaccharides (95%) prevented ethanol- or indomethacin-induced gastric mucosal damage (Cho CH et al. Planta Med 2000;66:348-51). However, it is not known whether Angelica ... ...

    Abstract It has been reported that an extract from Angelica sinensis mainly consisting of polysaccharides (95%) prevented ethanol- or indomethacin-induced gastric mucosal damage (Cho CH et al. Planta Med 2000;66:348-51). However, it is not known whether Angelica sinensis has a direct stimulatory effect on the healing of gastric mucosal lesions. To study the hypothesis that Angelica sinensis has a direct mucosal healing effect in rats and in isolated gastric epithelial cells, we assessed the wound repair in both animals and normal cell culture (RGM-1), as well as [3H]thymidine incorporation, ornithine decarboxylase (ODC) activity, and ODC protein and c-Myc protein expression after different treatments in RGM-1 cells. We found that Angelica sinensis crude extract (ASCE) dose-dependently enhanced gastric ulcer healing in rats and promoted wound repair in RGM-1 cells. It also significantly stimulated [3H]thymidine incorporation and ODC activity in RGM-1 cells in a concentration-dependent manner. ODC and c-Myc protein expression was also increased as a result of this process. DL-alpha-difluoromethyl-ornithine repressed the [3H]thymidine incorporation and ODC activity induced by ASCE. Pretreatment with c-Myc antisense oligodeoxynucleotides blocked the stimulatory action of ASCE on [3H]thymidine incorporation and ODC protein expression. These data suggest that ASCE has a direct mucosal healing effect on gastric epithelial cells, while ODC and c-Myc are closely associated with this effect.
    MeSH term(s) Animals ; Apiaceae/chemistry ; Cell Division/drug effects ; Cells, Cultured ; DNA/biosynthesis ; DNA/drug effects ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Eflornithine/pharmacology ; Enzyme Inhibitors/pharmacology ; Intestinal Mucosa/cytology ; Intestinal Mucosa/drug effects ; Ornithine Decarboxylase/drug effects ; Ornithine Decarboxylase/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Proto-Oncogene Proteins c-myc/metabolism ; Rats ; Rats, Wistar ; Stomach Ulcer/drug therapy ; Thymidine/metabolism ; Tritium ; Wound Healing/drug effects
    Chemical Substances Drugs, Chinese Herbal ; Enzyme Inhibitors ; Plant Extracts ; Proto-Oncogene Proteins c-myc ; angelicae sinensis extract ; Tritium (10028-17-8) ; DNA (9007-49-2) ; Ornithine Decarboxylase (EC 4.1.1.17) ; Thymidine (VC2W18DGKR) ; Eflornithine (ZQN1G5V6SR)
    Language English
    Publishing date 2001-06-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/s0006-2952(01)00625-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 19: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top