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Article ; Online: Description of a new species of Pleciobates Esaki, 1930 (Hemiptera: Heteroptera: Gerridae) from Hainan Island, China.

Leng, Zhaoqi / Ye, Zhen

Zootaxa

2023 Volume 5382, Issue 1, Page(s) 87–96

Abstract: This paper provides the description of a new species, Pleciobates herczeki sp. nov., from Hainan Island, China. Photographs of the male and female habitus are provided, accompanied by line drawings of female structures, male genitalic structures, in situ ...

Abstract	This paper provides the description of a new species, Pleciobates herczeki sp. nov., from Hainan Island, China. Photographs of the male and female habitus are provided, accompanied by line drawings of female structures, male genitalic structures, in situ habitus and a distributional map for the newly described species.
MeSH term(s)	Female ; Male ; Animals ; Heteroptera ; Hemiptera ; China
Language	English
Publishing date	2023-12-07
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5382.1.10
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Blockchain Technology, Enterprise Risk and Enterprise Performance

Ye Zhen / Wen Qiao / Ruyuan Wang / Wenli Wang

Sustainability, Vol 16, Iss 1, p

2023 Volume 70

Abstract: In order to explore the impact of the application of blockchain technology on enterprise performance, as well as the mechanism of enterprise risk and the information disclosure quality on this impact process, and taking the data of A-share listed ... ...

Abstract	In order to explore the impact of the application of blockchain technology on enterprise performance, as well as the mechanism of enterprise risk and the information disclosure quality on this impact process, and taking the data of A-share listed companies in China’s manufacturing industry from 2015 to 2022 as a research sample, this paper adopts methods such as multi-period difference-in-differences (DID) modeling to conduct an empirical investigation. Findings: The application of blockchain technology can improve enterprise performance. Enterprise risk plays a partial mediating effect, because blockchain technology can reduce enterprise risk and thereby improve enterprise performance. Information disclosure quality has an inhibitory influence on the process by which blockchain technology affects enterprise risk and a facilitating influence on the process by which enterprise risk affects enterprise performance. The results show that manufacturing enterprises with low information disclosure quality can reduce enterprise risk by combining with blockchain technology in production, management, and other aspects, thus improving enterprise performance and promoting sustainable development of enterprise economy.
Keywords	blockchain technology ; enterprise risk ; enterprise performance ; information disclosure quality ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	670
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Astragaloside IV Mitigated Diabetic Nephropathy by Restructuring Intestinal Microflora and Ferroptosis.

Lyu, Xin / Zhang, Ting-Ting / Ye, Zhen / Chen, Ce

Molecular nutrition & food research

2024 Volume 68, Issue 6, Page(s) e2300734

Abstract: Scope: To investigate the underlying mechanism of Astragaloside IV (AS-IV) in ameliorating diabetic nephropathy (DN) by regulating intestinal microbiota ecology and intestinal mucosal barrier.: Methods and results: Genetically db/db mice are used to ... ...

Abstract	Scope: To investigate the underlying mechanism of Astragaloside IV (AS-IV) in ameliorating diabetic nephropathy (DN) by regulating intestinal microbiota ecology and intestinal mucosal barrier. Methods and results: Genetically db/db mice are used to establish DN mouse model to monitor the therapeutic effects of AS-IV and fecal microbiota transplantation (FMT) against DN. Supplementation with AS-IV dramatically attenuates several clinical indicators of DN in db/db mice. In addition, AS-IV markedly improves intestinal barrier function, modifies intestinal permeability, and reduces inflammation. Moreover, AS-IV treatment remarkably improves intestinal dysbiosis in db/db mice, characterized by an elevated abundance of Akkermansia, Ligilactobacillus, and Lactobacillus, indicating the fundamental role of the microbiome in DN progression. Furthermore, FMT derived from AS-IV-treated db/db mice is potentially efficient in antagonizing renal dysfunction, rebalancing gut microbiota, and improving intestinal permeability in recipient db/db mice. AS-IV-enriched Akkermansia muciniphila dramatically alleviates DN and intestinal mucosal barrier dysfunction in db/db mice. Intriguingly, AS-IV intervention dramatically diminishes ferroptosis in the kidney and colon tissues. CONCLUSION : Intestinal microbiome alterations and ferroptosis modulation by AS-IV may play instrumental roles in this mechanism, providing compelling evidence for the role of the gut-renal axis in DN.
MeSH term(s)	Mice ; Animals ; Diabetic Nephropathies/drug therapy ; Gastrointestinal Microbiome ; Ferroptosis ; Kidney ; Diabetes Mellitus ; Saponins ; Triterpenes
Chemical Substances	astragaloside A (3A592W8XKE) ; Saponins ; Triterpenes
Language	English
Publishing date	2024-02-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2160372-8
ISSN	1613-4133 ; 1613-4125
ISSN (online)	1613-4133
ISSN	1613-4125
DOI	10.1002/mnfr.202300734
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Article ; Online: 3D visualization technology for Learning human anatomy among medical students and residents: a meta- and regression analysis.

Wang, Junming / Li, Wenjun / Dun, Aishe / Zhong, Ning / Ye, Zhen

BMC medical education

2024 Volume 24, Issue 1, Page(s) 461

Abstract: Background: 3D visualization technology applies computers and other devices to create a realistic virtual world for individuals with various sensory experiences such as 3D vision, touch, and smell to gain a more effective understanding of the ... ...

Abstract	Background: 3D visualization technology applies computers and other devices to create a realistic virtual world for individuals with various sensory experiences such as 3D vision, touch, and smell to gain a more effective understanding of the relationships between real spatial structures and organizations. The purpose of this study was to comprehensively evaluate the effectiveness of 3D visualization technology in human anatomy teaching/training and explore the potential factors that affect the training effects to better guide the teaching of classroom/laboratory anatomy. Methods: We conducted a meta-analysis of randomized controlled studies on teaching human anatomy using 3D visualization technology. We extensively searched three authoritative databases, PubMed, Web of Science, and Embase; the main outcomes were the participants' test scores and satisfaction, while the secondary outcomes were time consumption and enjoyment. Heterogeneity by I² was statistically determined because I²> 50%; therefore, a random-effects model was employed, using data processing software such as RevMan, Stata, and VOSviewer to process data, apply standardized mean difference and 95% confidence interval, and subgroup analysis to evaluate test results, and then conduct research through sensitivity analysis and meta-regression analysis. Results: Thirty-nine randomized controlled trials (2,959 participants) were screened and included in this study. The system analysis of the main results showed that compared with other methods, including data from all regions 3D visualization technology moderately improved test scores as well as satisfaction and enjoyment; however, the time that students took to complete the test was not significantly reduced. Meta-regression analysis also showed that regional factorsaffected test scores, whereas other factors had no significant impact. When the literature from China was excluded, the satisfaction and happiness of the 3D virtual-reality group were statistically significant compared to those of the traditional group; however, the test results and time consumption were not statistically significant. Conclusion: 3D visualization technology is an effective way to improve learners' satisfaction with and enjoyment of human anatomical learning, but it cannot reduce the time required for testers to complete the test. 3D visualization technology may struggle to improve the testers' scores. The literature test results from China are more prone to positive results and affected by regional bias.
MeSH term(s)	Humans ; Anatomy/education ; Students, Medical/psychology ; Imaging, Three-Dimensional ; Internship and Residency ; Randomized Controlled Trials as Topic ; Virtual Reality ; Regression Analysis ; Computer-Assisted Instruction/methods
Language	English
Publishing date	2024-04-26
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-024-05403-4
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Article: The roles of protein ubiquitination in tumorigenesis and targeted drug discovery in lung cancer.

Ye, Zhen / Yang, Jingru / Jiang, Hanming / Zhan, Xianquan

Frontiers in endocrinology

2023 Volume 14, Page(s) 1220108

Abstract: The malignant lung cancer has a high morbidity rate and very poor 5-year survival rate. About 80% - 90% of protein degradation in human cells is occurred through the ubiquitination enzyme pathway. Ubiquitin ligase (E3) with high specificity plays a ... ...

Abstract	The malignant lung cancer has a high morbidity rate and very poor 5-year survival rate. About 80% - 90% of protein degradation in human cells is occurred through the ubiquitination enzyme pathway. Ubiquitin ligase (E3) with high specificity plays a crucial role in the ubiquitination process of the target protein, which usually occurs at a lysine residue in a substrate protein. Different ubiquitination forms have different effects on the target proteins. Multiple short chains of ubiquitination residues modify substrate proteins, which are favorable signals for protein degradation. The dynamic balance adapted to physiological needs between ubiquitination and deubiquitination of intracellular proteins is beneficial to the health of the organism. Ubiquitination of proteins has an impact on many biological pathways, and imbalances in these pathways lead to diseases including lung cancer. Ubiquitination of tumor suppressor protein factors or deubiquitination of tumor carcinogen protein factors often lead to the progression of lung cancer. Ubiquitin proteasome system (UPS) is a treasure house for research and development of new cancer drugs for lung cancer, especially targeting proteasome and E3s. The ubiquitination and degradation of oncogene proteins with precise targeting may provide a bright prospect for drug development in lung cancer; Especially proteolytic targeted chimerism (PROTAC)-induced protein degradation technology will offer a new strategy in the discovery and development of new drugs for lung cancer.
MeSH term(s)	Humans ; Proteasome Endopeptidase Complex/metabolism ; Lung Neoplasms/drug therapy ; Ubiquitination ; Ubiquitin/metabolism ; Proteins/metabolism ; Cell Transformation, Neoplastic ; Drug Discovery
Chemical Substances	Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Ubiquitin ; Proteins
Language	English
Publishing date	2023-09-19
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1220108
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Article: Taxonomic notes of subgenus

Jin, Zezhong / Fu, Siying / Ye, Zhen

ZooKeys

2023 Volume 1149, Page(s) 37–52

Abstract: Velia (Cesavelia) ... ...

Abstract	Velia (Cesavelia) bui
Language	English
Publishing date	2023-02-22
Publishing country	Bulgaria
Document type	Journal Article
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.1149.96680
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Article ; Online: Causal Relationship Between Estimated Glomerular Filtration Rate and Inflammatory Bowel Disease: Genetic Evidence From Bidirectional Mendelian Randomization Analysis.

Liu, Mengsi / Ye, Zhen / Sun, Zhen

Inflammatory bowel diseases

2023 Volume 29, Issue 6, Page(s) e25–e27

MeSH term(s)	Humans ; Adult ; Mendelian Randomization Analysis ; Glomerular Filtration Rate/genetics ; Sweden ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Inflammatory Bowel Diseases/genetics
Language	English
Publishing date	2023-04-17
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izad067
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Article ; Online: Taxonomic notes of subgenus Velia (Cesavelia) Koçak & Kemal, 2010 (Hemiptera, Heteroptera, Veliidae) from China, with description of one new species

Jin, Zezhong / Fu, Siying / Ye, Zhen

ZooKeys. 2023 Feb. 22, v. 1149 p.37-52

2023

Abstract: AbstractVelia (Cesavelia) buisp. nov. from Hubei Province, China is described, and Velia (Cesavelia) tonkina Polhemus & Polhemus, 2003 is newly recorded from China. In addition, new distribution data for three species of Velia (Cesavelia), V. ... ...

Abstract	AbstractVelia (Cesavelia) buisp. nov. from Hubei Province, China is described, and Velia (Cesavelia) tonkina Polhemus & Polhemus, 2003 is newly recorded from China. In addition, new distribution data for three species of Velia (Cesavelia), V. longiconnexiva Tran, Zettel & Buzzetti, 2009, V. sinensis Andersen, 1981 and V. tonkina Polhemus & Polhemus, 2003 are provided. Photographs of the habitus in dorsal and lateral views, metafemora of males, genitalic structures and habitats, along with a distribution map of this subgenus, are provided.
Keywords	Veliidae ; new species ; China ; Distribution ; morphology ; new record ; range extension ; semiaquatic bugs ; taxonomy
Language	English
Dates of publication	2023-0222
Size	p. 37-52.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2445640-8
ISSN	1313-2970 ; 1313-2989
ISSN (online)	1313-2970
ISSN	1313-2989
DOI	10.3897/zookeys.1149.96680
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Article ; Online: Geomorphic impacts within Red River Fault and island shifting as witnessed by the phylogeography of the largest water strider.

Sun, Xiaoya / Pan, Qiqi / Hubley, Brad / Ye, Zhen / Zhang, Peng / Xie, Qiang

Molecular phylogenetics and evolution

2024 Volume 195, Page(s) 108062

Abstract: Palaeogeological events and climate oscillations profoundly impact the demographics and distributions of small-range species, increasing the extinction risk. The largest water strider worldwide, Gigantometra gigas (Hemiptera: Gerridae), exhibits ... ...

Abstract	Palaeogeological events and climate oscillations profoundly impact the demographics and distributions of small-range species, increasing the extinction risk. The largest water strider worldwide, Gigantometra gigas (Hemiptera: Gerridae), exhibits restricted distributions in Vietnam and southern China. Herein, we generated three genomic datasets (mitogenomes, 146 nuclear protein-coding genes and single nucleotide polymorphisms) with ecological niche modelling (ENM) to explicitly test whether the present-day distribution of G. gigas actually resulted from geographical and climatic effects. We found that the origin of this largest water strider reached the divergence time of the genus within Gerridae, providing a greater opportunity to explore its response to geographic movements. The right-lateral motion of the Red River Fault facilitated the divergence of two phylogeographic lineages, resulting in the "north-south component" genetic pattern in G. gigas. The Hainan and southeast Vietnam populations of the southern linage were completely separated by the Beibu Gulf but exhibited similar genetic compositions, confirming that Hainan had a continental origin and that Hainan Island joined with the Indo-China Peninsula to promote gene exchange among populations. Additionally, we noticed the low genetic diversity but long demographic history of the northern lineage, which displayed population dynamics opposite to those of other organisms. Integrating the demographic changes and ENM findings revealed that suitable habitat contraction and rapid demographic decline during the Last Glacial Maximum (LGM) triggered the low genetic diversity of the northern lineage. Overall, the demographic history of the largest water strider was mainly shaped by geographical features, and first provided evidence from the phylogeographic perspective of aquatic insects to support the hypothesis of Hainan Island shifting.
MeSH term(s)	Phylogeography ; Phylogeny ; Water ; China ; Rivers ; Genetic Variation ; DNA, Mitochondrial/genetics
Chemical Substances	Water (059QF0KO0R) ; DNA, Mitochondrial
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	33610-5
ISSN	1095-9513 ; 1055-7903
ISSN (online)	1095-9513
ISSN	1055-7903
DOI	10.1016/j.ympev.2024.108062
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Article ; Online: H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation.

Kubo, Naoki / Chen, Poshen B / Hu, Rong / Ye, Zhen / Sasaki, Hiroyuki / Ren, Bing

Molecular cell

2024

Abstract: Histone H3 lysine 4 mono-methylation (H3K4me1) marks poised or active enhancers. KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase activities are largely dispensable for transcription during early embryogenesis in ... ...

Abstract	Histone H3 lysine 4 mono-methylation (H3K4me1) marks poised or active enhancers. KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase activities are largely dispensable for transcription during early embryogenesis in mammals. To better understand the role of H3K4me1 in enhancer function, we analyze dynamic enhancer-promoter (E-P) interactions and gene expression during neural differentiation of the mouse embryonic stem cells. We found that KMT2C/D catalytic activities were only required for H3K4me1 and E-P contacts at a subset of candidate enhancers, induced upon neural differentiation. By contrast, a majority of enhancers retained H3K4me1 in KMT2C/D catalytic mutant cells. Surprisingly, H3K4me1 signals at these KMT2C/D-independent sites were reduced after acute depletion of KMT2B, resulting in aggravated transcriptional defects. Our observations therefore implicate KMT2B in the catalysis of H3K4me1 at enhancers and provide additional support for an active role of H3K4me1 in enhancer-promoter interactions and transcription in mammalian cells.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2024.02.030
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