Article ; Online: Effect of β-blockers on mortality in patients with sepsis: A propensity-score matched analysis.
Frontiers in cellular and infection microbiology
2023 Volume 13, Page(s) 1121444
Abstract: Objectives: We aimed to evaluate the association between β-blocker therapy and mortality in patients with sepsis.: Methods: Patients with sepsis were selected from the Medical Information Mart for Intensive Care (MIMIC)-III. Propensity score matching ...
| Abstract | Objectives: We aimed to evaluate the association between β-blocker therapy and mortality in patients with sepsis. Methods: Patients with sepsis were selected from the Medical Information Mart for Intensive Care (MIMIC)-III. Propensity score matching (PSM) was used to balance the baseline differences. A multivariate Cox regression model was used to assess the relationship between β-blocker therapy and mortality. The primary outcome was the 28-day mortality. Results: A total of 12,360 patients were included in the study, involving 3,895 who received β-blocker therapy and 8,465 who did not. After PSM, 3,891 pairs of patients were matched. The results showed that β-blockers were associated with improved 28- (hazards ratio (HR) 0.78) and 90-day (HR 0.84) mortality. Long-acting β-blockers were associated with improved 28-day survival (757/3627 [20.9%] vs. 583/3627 [16.1%], Conclusions: β-blockers were associated with improved 28- and 90-day mortality in patients with sepsis and septic shock. Long-acting β-blocker therapy may have a protective role in patients with sepsis, reducing the 28-day and 90-day mortality. However, short-acting β-blocker (esmolol) treatment did not reduce the mortality in sepsis. |
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| MeSH term(s) | Humans ; Propensity Score ; Sepsis/drug therapy ; Adrenergic beta-Antagonists/therapeutic use ; Shock, Septic/drug therapy ; Retrospective Studies |
| Chemical Substances | Adrenergic beta-Antagonists |
| Language | English |
| Publishing date | 2023-03-28 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2619676-1 |
| ISSN | 2235-2988 ; 2235-2988 |
| ISSN (online) | 2235-2988 |
| ISSN | 2235-2988 |
| DOI | 10.3389/fcimb.2023.1121444 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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