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Article: Improving Cleaning Performance of Rice Combine Harvesters by DEM–CFD Coupling Technology

Ding, Bochuan / Liang, Zhenwei / Qi, Yongqi / Ye, Zhikang / Zhou, Jiahao

Agriculture (Basel). 2022 Sept. 13, v. 12, no. 9

2022

Abstract: The cleaning device is an important part of combine harvesters, as its superior or inferior performance directly affects the performance of the combine harvester greatly. With an increasing rice yield, the current single-duct cleaning performance ... ...

Abstract	The cleaning device is an important part of combine harvesters, as its superior or inferior performance directly affects the performance of the combine harvester greatly. With an increasing rice yield, the current single-duct cleaning performance declines greatly, and causes a large grain sieve loss level and a direct grain loss for the farms. To optimize the existing single-duct cleaning device to meet the large feeding rate requirement, firstly, the terminal velocity of rice grain and MOG (material other than grain) for different varieties was experimentally measured by the custom-made device. The effects of the moisture content of rice grains and the length of short straws on terminal velocity were studied in detail. Then, the gas–solid two-phase flow theory was comprehensively applied by utilizing the discrete element method (DEM) and computational fluid dynamics (CFD) to study the working mechanism of the existing single-duct cleaning unit, and the cleaning performance was evaluated from the view of the motion law of the threshing output within the cleaning shoe. At last, a multi-duct cleaning device was put forward, and a field experiment was performed to assess the performance of the newly developed cleaning device. The results showed that the grain sieve losses ratio and grain impurity ratio improved dramatically, proving that structure optimization of the cleaning device was feasible.
Keywords	agriculture ; combine harvesters ; field experimentation ; fluid mechanics ; rice ; terminal velocity ; water content
Language	English
Dates of publication	2022-0913
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture12091457
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Antidepressant Use and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis.

Wang, Ying / Ye, Zhikang / Liu, Lihong / Cui, Xiangli

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2019 Volume 22, Issue 1, Page(s) 57–71

Abstract: Purpose: Studies provided conflicting results on whether antidepressant use increased the risk of venous thromboembolism (VTE). Our aim was to examine the association between antidepressant use and the risk of VTE.: Methods: Pubmed, Embase, and the ... ...

Abstract	Purpose: Studies provided conflicting results on whether antidepressant use increased the risk of venous thromboembolism (VTE). Our aim was to examine the association between antidepressant use and the risk of VTE. Methods: Pubmed, Embase, and the Cochrane Library were searched up to March 13, 2018. Case-control studies and cohort studies that examined the association between antidepressant use and the risk of VTE, deep vein thrombosis or pulmonary embolism were included. Several subgroup analyses and sensitivity analyses were conducted. GRADE approach was used to assess the quality of evidence. Results: Nine studies (six case-control studies and three cohort studies) were included. Overall, antidepressant use may be associated with an increased risk of VTE (OR 1.27, 95% CI 1.09 to 1.49); however, no association was observed in studies with low risk of bias (OR 1.27, 95% CI 0.84 to 1.92). No association between selective serotonin reuptake inhibitor use and VTE risk was detected in the overall analysis (OR 1.10, 95% CI 0.90 to 1.34) and in subgroup analysis of studies with low risk of bias. Tricyclic antidepressant may be associated with an increased VTE risk (OR 1.26, 95% CI 1.02 to 1.57), and the quality of evidence was rated as very low by GRADE approach; however, no association was observed when we only included studies with low risk of bias. Conclusions: There was no association between selective serotonin reuptake inhibitor use and VTE risk. Tricyclic antidepressant may be associated with an increased VTE risk, but the quality of evidence was very low.
MeSH term(s)	Antidepressive Agents/adverse effects ; Case-Control Studies ; Cohort Studies ; Humans ; Risk ; Venous Thromboembolism/chemically induced ; Venous Thromboembolism/epidemiology
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2019-01-19
Publishing country	Canada
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	1482-1826
ISSN (online)	1482-1826
DOI	10.18433/jpps30129
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Article ; Online: Efficacy and Safety of Pharmacoprophylaxis for Venous Thromboembolism in Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-analysis.

Zhao, Ying / Ye, Zhikang / Lin, Jianrui / Zhang, Zhiqi / Tian, Peirong / Zhang, Zhongtao / Zhang, Peng / Cui, Xiangli

Obesity surgery

2022 Volume 32, Issue 5, Page(s) 1701–1718

Abstract: This study aims to assess the efficacy and safety of pharmacoprophylaxis regimens for venous thromboembolism (VTE) in patients undergoing bariatric surgery. A total of 15 studies were included. Low molecular-weight heparins (LMWH) and fondaparinux may be ...

Abstract	This study aims to assess the efficacy and safety of pharmacoprophylaxis regimens for venous thromboembolism (VTE) in patients undergoing bariatric surgery. A total of 15 studies were included. Low molecular-weight heparins (LMWH) and fondaparinux may be equally effective in reducing VTE risk (OR 1.02, 95% confidence interval [CI] 0.14-7.39). Pooled estimate suggested uncertain effects of augmented LMWH dosing on VTE prophylaxis compared with standard dosing (OR 0.57, 95% CI 0.07-4.39), but may increase major bleeding (OR 3.03, 95% CI 0.38-23.96). Very low-quality evidence showed an inconclusive effect of extended prophylaxis on VTE (OR 0.54, 95% CI 0.15-1.90) and major bleeding (OR 1.24, 95% CI 0.92-1.68) compared with restricted prophylaxis. Standard LMWH dosing may be effective and safe. Current evidences are insufficient to support extended prophylaxis.
MeSH term(s)	Anticoagulants/therapeutic use ; Bariatric Surgery/adverse effects ; Hemorrhage ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Obesity, Morbid/surgery ; Venous Thromboembolism/prevention & control
Chemical Substances	Anticoagulants ; Heparin, Low-Molecular-Weight
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-021-05825-9
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Article ; Online: Methodology for the Guidelines on Evaluation and Management of Hypoparathyroidism and Primary Hyperparathyroidism.

Yao, Liang / Guyatt, Gordon / Ye, Zhikang / Bilezikian, John P / Brandi, Maria Luisa / Clarke, Bart L / Mannstadt, Michael / Khan, Aliya A

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2022 Volume 37, Issue 11, Page(s) 2404–2410

Abstract: To develop guidelines for hypoparathyroidism and primary hyperparathyroidism, the panel assembled a panel of experts in parathyroid disorders, general endocrinologists, representatives of the Hypoparathyroidism Association, and systematic review and ... ...

Abstract	To develop guidelines for hypoparathyroidism and primary hyperparathyroidism, the panel assembled a panel of experts in parathyroid disorders, general endocrinologists, representatives of the Hypoparathyroidism Association, and systematic review and guideline methodologists. The guideline panel referred to a formal process following the Recommendations, Assessment, Development, and Evaluation Working Group (GRADE) methodology to issue GRADEd recommendations. In this approach, panelists and methodologists formatted the questions, conducted systematic reviews, evaluated risk of bias, assessed certainty of evidence, and presented a summary of findings in a transparent fashion. For most recommendations, the task forces used a less structured approach largely based on narrative reviews to issue non-GRADEd recommendations. The panel issued Eight GRADEd recommendations (seven for hypoparathyroidism and one for hyperparathyroidism). Each GRADEd recommendation is linked to the underlying body of evidence and judgments regarding the certainty of evidence and strength of recommendations, values and preferences, and costs, feasibility, acceptability and equity. This article summarizes the methodology for issuing GRADEd and non-GRADEd recommendations for patients with hypoparathyroidism or hyperparathyroidism. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
MeSH term(s)	Humans ; Hyperparathyroidism, Primary/diagnosis ; Hyperparathyroidism, Primary/therapy ; Hypoparathyroidism/diagnosis ; Hypoparathyroidism/therapy ; Systematic Reviews as Topic
Language	English
Publishing date	2022-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1002/jbmr.4687
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Article ; Online: Cost-effectiveness of endovascular thrombectomy with alteplase versus endovascular thrombectomy alone for acute ischemic stroke secondary to large vessel occlusion.

Ye, Zhikang / Zhou, Ting / Zhang, Mengmeng / Zhou, Junwen / Xie, Feng / Hill, Michael D / Smith, Eric E / Busse, Jason W / Zhang, Yi / Liu, Ying / Wang, Xin / Ma, Zhuo / An, Zhuoling

CMAJ open

2023 Volume 11, Issue 3, Page(s) E443–E450

Abstract: Background: Recent randomized trials have suggested that endovascular thrombectomy (EVT) alone may provide similar functional outcomes as the current standard of care, EVT combined with intravenous alteplase treatment, for acute ischemic stroke ... ...

Abstract	Background: Recent randomized trials have suggested that endovascular thrombectomy (EVT) alone may provide similar functional outcomes as the current standard of care, EVT combined with intravenous alteplase treatment, for acute ischemic stroke secondary to large vessel occlusion. We conducted an economic evaluation of these 2 therapeutic options. Methods: We constructed a decision analytic model with a hypothetical cohort of 1000 patients to assess the cost-effectiveness of EVT with intravenous alteplase treatment versus EVT alone for acute ischemic stroke secondary to large vessel occlusion from both the societal and public health care payer perspectives. We used studies and data published in 2009-2021 for model inputs, and acquired cost data for Canada and China, representing high- and middle-income countries, respectively. We calculated incremental cost-effectiveness ratios (ICERs) using a lifetime horizon and accounted for uncertainty using 1-way and probabilistic sensitivity analyses. All costs are reported in 2021 Canadian dollars. Results: In Canada, the difference in quality-adjusted life-years (QALYs) gained between EVT with alteplase and EVT alone was 0.10 from both the societal and health care payer perspectives. The difference in cost was $2847 from a societal perspective and $2767 from the payer perspective. In China, the difference in QALYs gained was 0.07 from both perspectives, and the difference in cost was $1550 from the societal perspective and $1607 from the payer perspective. One-way sensitivity analyses showed that the distributions of modified Rankin Scale scores at 90 days after stroke were the most influential factor on ICERs. For Canada, compared to EVT alone, the probability that EVT with alteplase would be cost-effective at a willingness-to-pay threshold of $50 000 per QALY gained was 58.7% from a societal perspective and 58.4% from a payer perspective. The corresponding values for at a willingness-to-pay threshold of $47 185 (3 times the Chinese gross domestic product per capita in 2021) were 65.2% and 67.4%. Interpretation: For patients with acute ischemic stroke due to large vessel occlusion eligible for immediate treatment with both EVT alone and EVT with intravenous alteplase treatment, it is uncertain whether EVT with alteplase is cost-effective compared to EVT alone in Canada and China.
MeSH term(s)	Humans ; Tissue Plasminogen Activator/therapeutic use ; Cost-Benefit Analysis ; Ischemic Stroke/epidemiology ; Ischemic Stroke/etiology ; Ischemic Stroke/surgery ; Canada/epidemiology ; Thrombectomy
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2023-05-16
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2701622-5
ISSN	2291-0026 ; 2291-0026
ISSN (online)	2291-0026
ISSN	2291-0026
DOI	10.9778/cmajo.20220096
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Article ; Online: Analysis of volatile organic compounds and potential odour compounds in food contact paperboard using headspace two-dimensional GC-QTOF-MS.

Li, Dan / Zeng, Ying / Ye, Zhi-Kang / Li, Han-Ke / Li, Yu-Zhe / Dong, Ben / Su, Qi-Zhi / Lin, Qin-Bao / Xiao, Jing / Zhong, Huai-Ning

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

2023 Volume 40, Issue 11, Page(s) 1482–1493

Abstract: The objective was to establish a robust and reliable approach for the characterisation of volatile organic compounds (VOCs) present in food contact paperboard. This was achieved through the utilisation of headspace solid-phase microextraction in tandem ... ...

Abstract	The objective was to establish a robust and reliable approach for the characterisation of volatile organic compounds (VOCs) present in food contact paperboard. This was achieved through the utilisation of headspace solid-phase microextraction in tandem with comprehensive two-dimensional (2D) gas chromatography (GC) and quadrupole time-of-flight mass spectrometry (HS-SPME-GC × GC-QTOF-MS). The experimental parameters were optimised, involving the use of a DVB/C-WR/PDMS fibre at a temperature of 80 °C for a duration of 30 min. A total of 344 VOCs comprising aldehydes, ketones, alcohols, ethers, esters, alkanes and aromatic compounds, were tentatively identified in the samples. Twelve compounds believed to be from biogenic sources had a high odour impact making them major contributors to potential taint from the paperboard samples. Significant attention should be devoted to five compounds namely, 2-methylnaphthalene, 2-pentyl-furan, furfural, 1-octen-3-one and 1-octen-3-ol due to their potential adverse impact on the organoleptic qualities of packaged food items and their potential toxicity.
MeSH term(s)	Volatile Organic Compounds/analysis ; Odorants/analysis ; Solid Phase Microextraction/methods ; Gas Chromatography-Mass Spectrometry/methods ; Aldehydes/analysis
Chemical Substances	Volatile Organic Compounds ; Aldehydes
Language	English
Publishing date	2023-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2023.2259029
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Article ; Online: Authentication of recycled and virgin polyethylene terephthalate based on UPLC-Q-TOF-MS using non-volatile organic compounds and chemometrics.

Hao, Tian-Ying / Lin, Qin-Bao / Wu, Xue-Feng / Wu, Si-Liang / Zhong, Huai-Ning / Dong, Ben / Chen, Zhi-Feng / Ye, Zhi-Kang / Wang, Zhi-Wei / Xu, Xiaowen

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

2023 Volume 40, Issue 8, Page(s) 1114–1130

Abstract: Plastic packaging waste, such as polyethylene terephthalate (PET) has increased significantly in recent decades, arousing a considerable and serious public concern regarding the environment, economy, and policy. Plastic recycling is a useful tool to ... ...

Abstract	Plastic packaging waste, such as polyethylene terephthalate (PET) has increased significantly in recent decades, arousing a considerable and serious public concern regarding the environment, economy, and policy. Plastic recycling is a useful tool to mitigate this issue. Here, a feasible study was performed to investigate the potential of a novel method for identifying virgin and recycled PET. Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was combined with various chemometrics, as a simple and reliable method that achieved a high discrimination rate for 105 batches of virgin PET (v-PET) and recycled PET (r-PET) based on 202 non-volatile organic compounds (NVOCs). Making use of orthogonal partial least-squares discrimination analysis (OPLS-DA) together with non-parametric tests, 26 marker compounds (i.e. 12 intentionally added substances (IAS) and 14 non-intentionally added substances (NIAS) as well as 31 marker compounds (i.e. 11 IAS and 20 NIAS) obtained from positive and combination of positive and negative ionization modes of UPLC-Q-TOF-MS, respectively, were successfully identified. Moreover, 100% accuracy was obtained using a decision tree (DT). Cross-discrimination based on misclassified samples using various chemometrics allowed the prediction accuracy to be improved and to identify a large sample set, thus greatly enhancing the application scope of this method. The possible origins of these detected compounds can be the plastic itself, as well as contamination from food, medicine, pesticides, industry-related substances, and degradation and polymerization products. As many of these compounds are toxic, especially those pesticide related, this indicates an urgent requirement for closed loop recycling. Overall, this analytical method provides a quick, accurate, and robust way to distinguish virgin from recycled PET and thus addresses the issue of potential virgin PET adulteration thereby detecting fraud in the area of PET recycling.
MeSH term(s)	Polyethylene Terephthalates/analysis ; Chemometrics ; Mass Spectrometry/methods ; Chromatography, Liquid ; Plastics/analysis ; Chromatography, High Pressure Liquid/methods
Chemical Substances	Polyethylene Terephthalates ; Plastics
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2023.2227732
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Article ; Online: Authentication of recycled and virgin polyethylene terephthalate based on UPLC-Q-TOF-MS using non-volatile organic compounds and chemometrics

Hao, Tian-Ying / Lin, Qin-Bao / Wu, Xue-Feng / Wu, Si-Liang / Zhong, Huai-Ning / Dong, Ben / Chen, Zhi-Feng / Ye, Zhi-Kang / Wang, Zhi-Wei / Xu, Xiaowen

Food Additives & Contaminants: Part A. 2023 Aug. 3, v. 40, no. 8 p.1114-1130

2023

Abstract	Plastic packaging waste, such as polyethylene terephthalate (PET) has increased significantly in recent decades, arousing a considerable and serious public concern regarding the environment, economy, and policy. Plastic recycling is a useful tool to mitigate this issue. Here, a feasible study was performed to investigate the potential of a novel method for identifying virgin and recycled PET. Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was combined with various chemometrics, as a simple and reliable method that achieved a high discrimination rate for 105 batches of virgin PET (v-PET) and recycled PET (r-PET) based on 202 non-volatile organic compounds (NVOCs). Making use of orthogonal partial least-squares discrimination analysis (OPLS-DA) together with non-parametric tests, 26 marker compounds (i.e. 12 intentionally added substances (IAS) and 14 non-intentionally added substances (NIAS) as well as 31 marker compounds (i.e. 11 IAS and 20 NIAS) obtained from positive and combination of positive and negative ionization modes of UPLC-Q-TOF-MS, respectively, were successfully identified. Moreover, 100% accuracy was obtained using a decision tree (DT). Cross-discrimination based on misclassified samples using various chemometrics allowed the prediction accuracy to be improved and to identify a large sample set, thus greatly enhancing the application scope of this method. The possible origins of these detected compounds can be the plastic itself, as well as contamination from food, medicine, pesticides, industry-related substances, and degradation and polymerization products. As many of these compounds are toxic, especially those pesticide related, this indicates an urgent requirement for closed loop recycling. Overall, this analytical method provides a quick, accurate, and robust way to distinguish virgin from recycled PET and thus addresses the issue of potential virgin PET adulteration thereby detecting fraud in the area of PET recycling.
Keywords	adulterated products ; chemometrics ; decision support systems ; fraud ; ionization ; issues and policy ; least squares ; mass spectrometry ; medicine ; pesticides ; plastics ; polyethylene terephthalates ; polymerization ; prediction ; toxicity ; wastes ; UPLC-Q-TOF-MS ; recycled polyethylene terephthalate ; non-volatile organic compounds
Language	English
Dates of publication	2023-0803
Size	p. 1114-1130.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2023.2227732
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Treatment of critical bleeding events in patients with immune thrombocytopenia: a protocol for a systematic review and meta-analysis.

Systematic reviews

2024 Volume 13, Issue 1, Page(s) 21

Abstract: Background: Critical bleeding events in adults and children with ITP are medical emergencies; however, evidence-based treatment protocols are lacking. Due to the severe thrombocytopenia, (typically platelet count less than 20 × 10: Methods: ... ...

Abstract	Background: Critical bleeding events in adults and children with ITP are medical emergencies; however, evidence-based treatment protocols are lacking. Due to the severe thrombocytopenia, (typically platelet count less than 20 × 10 Methods: Literature searches will be conducted in four electronic databases: Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and PubMed. Eligible studies will be randomized controlled trials or observational studies that enrolled patients with ITP describing one or more interventions for the management of critical bleeding. Title and abstract screening, full-text screening, data extraction, and risk of bias evaluation will be conducted independently and in duplicate using Covidence and Excel. Outcomes will be pooled for meta-analysis where appropriate or summarized descriptively. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology will be used to evaluate the certainty of the evidence. Primary outcomes of interest will include frequency of critical bleeds, mortality and bleeding-related mortality, bleeding resolution, platelet count, and disability. Discussion: Evidence-based treatments for critical bleeding in patients with ITP are needed to improve patient outcomes and standardize care in the emergency setting. Systematic review registration: CRD42020161206.
MeSH term(s)	Adult ; Child ; Humans ; Hemorrhage/therapy ; Meta-Analysis as Topic ; Purpura, Thrombocytopenic, Idiopathic/complications ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Systematic Reviews as Topic ; Thrombocytopenia/complications ; Thrombocytopenia/therapy
Language	English
Publishing date	2024-01-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2662257-9
ISSN	2046-4053 ; 2046-4053
ISSN (online)	2046-4053
ISSN	2046-4053
DOI	10.1186/s13643-023-02436-6
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Article ; Online: [No title information]

Devasenapathy, Niveditha / Ye, Zhikang / Loeb, Mark / Fang, Fang / Najafabadi, Borna Tadayon / Xiao, Yingqi / Couban, Rachel / Bégin, Philippe / Guyatt, Gordon

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2020 Volume 192, Issue 47, Page(s) E1559–E1570

Title translation	Efficacité et innocuité du plasma de convalescent en cas de forme grave de COVID-19, extrapolée de données relatives à d’autres formes graves d’infections respiratoires virales : revue systématique et méta-analyse.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/therapy ; Pandemics ; Plasma ; SARS-CoV-2 ; Treatment Outcome
Language	French
Publishing date	2020-09-19
Publishing country	Canada
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.200642-f
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