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  1. Article ; Online: Cost and quality-of-life impacts of community treatment orders (CTOs) for patients with psychosis: economic evaluation of the OCTET trial.

    Simon, Judit / Mayer, Susanne / Łaszewska, Agata / Rugkåsa, Jorun / Yeeles, Ksenija / Burns, Tom / Gray, Alastair

    Social psychiatry and psychiatric epidemiology

    2020  Volume 56, Issue 1, Page(s) 85–95

    Abstract: Purpose: Current RCT and meta-analyses have not found any effect of community treatment orders (CTOs) on hospital or social outcomes. Assumed positive impacts of CTOs on quality-of-life outcomes and reduced hospital costs are potentially in conflict ... ...

    Abstract Purpose: Current RCT and meta-analyses have not found any effect of community treatment orders (CTOs) on hospital or social outcomes. Assumed positive impacts of CTOs on quality-of-life outcomes and reduced hospital costs are potentially in conflict with patient autonomy. Therefore, an analysis of the cost and quality-of-life consequences of CTOs was conducted within the OCTET trial.
    Methods: The economic evaluation was carried out comparing patients (n = 328) with psychosis discharged from involuntary hospitalisation either to treatment under a CTO (CTO group) or voluntary status via Section 17 leave (non-CTO group) from the health and social care and broader societal perspectives (including cost implication of informal family care and legal procedures). Differences in costs and outcomes defined as quality-adjusted life years (QALYs) based on the EQ-5D-3L or capability-weighted life years (CWLYs) based on the OxCAP-MH were assessed over 12 months (£, 2012/13 tariffs).
    Results: Mean total costs from the health and social care perspective [CTO: £35,595 (SD: £44,886); non-CTO: £36,003 (SD: £41,406)] were not statistically significantly different in any of the analyses or cost categories. Mental health hospitalisation costs contributed to more than 85% of annual health and social care costs. Informal care costs were significantly higher in the CTO group, in which there were also significantly more manager hearings and tribunals. No difference in health-related quality of life or capability wellbeing was found between the groups.
    Conclusion: CTOs are unlikely to be cost-effective. No evidence supports the hypothesis that CTOs decrease hospitalisation costs or improve quality of life. Future decisions should consider impacts outside the healthcare sector such as higher informal care costs and legal procedure burden of CTOs.
    MeSH term(s) Community Mental Health Services ; Cost-Benefit Analysis ; Humans ; Involuntary Treatment ; Psychotic Disorders/therapy ; Quality of Life
    Language English
    Publishing date 2020-07-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 623071-4
    ISSN 1433-9285 ; 0037-7813 ; 0933-7954
    ISSN (online) 1433-9285
    ISSN 0037-7813 ; 0933-7954
    DOI 10.1007/s00127-020-01919-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recall of patients on community treatment orders over three years in the OCTET CTO cohort.

    Rugkåsa, Jorun / Yeeles, Ksenija / Koshiaris, Constantinos / Burns, Tom

    BMC psychiatry

    2016  Volume 16, Issue 1, Page(s) 392

    Abstract: Background: Randomised studies consistently show that Community Treatment Orders (CTOs) do not have the intended effect of preventing relapse and readmissions of patients with severe and enduring mental illness. Critics suggest this in part can be ... ...

    Abstract Background: Randomised studies consistently show that Community Treatment Orders (CTOs) do not have the intended effect of preventing relapse and readmissions of patients with severe and enduring mental illness. Critics suggest this in part can be explained by RCTs studying newly introduced CTO regimes and that patients therefore were not brought back to hospital for short-term observations ('recall') as frequently as intended. Our purpose was (i) to test the hypothesis that CTO practice as regards recall of patients to hospital in England and Wales was as rigorous under the OCTET trial period as in current routine use and (ii) to investigate the reasons for and outcomes of recalls and whether this changed over time.
    Method: Thirty six-month observational prospective study of 198 patients in the OCTET Follow-up Study.
    Results: Forty percent of patients were recalled, 19 % more than once. This is in line with current national use. Deterioration in clinical condition was the most common reason for recalls (49 %), and 68 % of recalls resulted in revocation of the order (i.e., retention in hospital under compulsion). This pattern remained stable over time.
    Conclusion: The use of recall cannot explain why RCTs have not confirmed any benefits from CTOs, and their continued use should be reconsidered.
    Trial registration: The OCTET Trial was retrospectively registered on 12 November 2009 ( ISRCTN73110773 ).
    MeSH term(s) Adolescent ; Adult ; Aged ; Community Mental Health Services/methods ; Community Mental Health Services/statistics & numerical data ; England ; Female ; Humans ; Male ; Mandatory Programs/statistics & numerical data ; Mental Disorders/therapy ; Middle Aged ; Patient Readmission/statistics & numerical data ; Prospective Studies ; Randomized Controlled Trials as Topic ; Wales ; Young Adult
    Language English
    Publishing date 2016-11-09
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-016-1102-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: What does being on a community treatment orders entail? A 3-year follow-up of the OCTET CTO cohort.

    Rugkåsa, Jorun / Yeeles, Ksenija / Koshiaris, Constantinos / Burns, Tom

    Social psychiatry and psychiatric epidemiology

    2016  Volume 52, Issue 4, Page(s) 465–472

    Abstract: Purpose: Community Treatment Orders lack evidence of effectiveness. Very little is known about how they are used in practice and over time in terms of what it obliges patients to do and the judicial threshold for remaining on an order.: Aims: To ... ...

    Abstract Purpose: Community Treatment Orders lack evidence of effectiveness. Very little is known about how they are used in practice and over time in terms of what it obliges patients to do and the judicial threshold for remaining on an order.
    Aims: To investigate CTO implementation in England in terms of the use of specified conditions, and judicial hearings; whether these change over time, and; the level of continued coercion.
    Method: 36-month observational prospective study of patients on CTO in the OCTET follow-up study.
    Results: The number of CTO conditions remained stable over time but consolidated around medication adherence and remaining in contact with services. Ten percent of Mental Health Tribunal Hearings and only 1 percent of Hospital Managers Hearings resulted in discharge. Twenty-seven percent of patients experienced more than one CTO episode and eighteen percent remained under compulsion until the end of follow-up.
    Conclusions: CTOs seem to be used primarily to oblige patients to take medication and stay in contact with services. There is agreement between clinical and legal judgements about their appropriateness and threshold for use. A pattern of continuous coercion for a significant group of patients raises concerns. If CTOs are to be continued to be imposed, their use should be carefully monitored with further cohort studies with long-term follow-up.
    MeSH term(s) Adult ; Coercion ; Community Mental Health Services/legislation & jurisprudence ; Community Mental Health Services/organization & administration ; Community Mental Health Services/standards ; England ; Female ; Follow-Up Studies ; Humans ; Male ; Mandatory Programs/legislation & jurisprudence ; Mandatory Programs/organization & administration ; Mandatory Programs/standards ; Mental Disorders/therapy ; Mentally Ill Persons/legislation & jurisprudence ; Middle Aged
    Language English
    Publishing date 2016-11-05
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 623071-4
    ISSN 1433-9285 ; 0037-7813 ; 0933-7954
    ISSN (online) 1433-9285
    ISSN 0037-7813 ; 0933-7954
    DOI 10.1007/s00127-016-1304-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Non-consent bias in OCTET--Authors' reply.

    Rugkåsa, Jorun / Yeeles, Ksenija / Molodynski, Andrew / Burns, Tom

    The lancet. Psychiatry

    2015  Volume 2, Issue 12, Page(s) e33–4

    Language English
    Publishing date 2015-12
    Publishing country England
    Document type Comment ; Letter
    ISSN 2215-0374
    ISSN (online) 2215-0374
    DOI 10.1016/S2215-0366(15)00497-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis.

    Lennox, Belinda / Xiong, Wenzheng / Waters, Patrick / Coles, Alasdair / Jones, Peter B / Yeo, Tianrong / May, Jeanne Tan May / Yeeles, Ksenija / Anthony, Daniel / Probert, Fay

    Molecular psychiatry

    2022  Volume 27, Issue 11, Page(s) 4722–4730

    Abstract: A range of studies suggest that a proportion of psychosis may have an autoimmune basis, but this has not translated through into clinical practice-there is no biochemical test able to accurately identify psychosis resulting from an underlying ... ...

    Abstract A range of studies suggest that a proportion of psychosis may have an autoimmune basis, but this has not translated through into clinical practice-there is no biochemical test able to accurately identify psychosis resulting from an underlying inflammatory cause. Such a test would be an important step towards identifying who might require different treatments and have the potential to improve outcomes for patients. To identify novel subgroups within patients with acute psychosis we measured the serum nuclear magnetic resonance (NMR) metabolite profiles of 75 patients who had identified antibodies (anti-glycine receptor [GlyR], voltage-gated potassium channel [VGKC], Contactin-associated protein-like 2 [CASPR2], leucine-rich glioma inactivated 1 [LGI1], N-methyl-D-aspartate receptor [NMDAR] antibody) and 70 antibody negative patients matched for age, gender, and ethnicity. Clinical symptoms were assessed using the positive and negative syndrome scale (PANSS). Unsupervised principal component analysis identified two distinct biochemical signatures within the cohort. Orthogonal partial least squared discriminatory analysis revealed that the serum metabolomes of NMDAR, LGI1, and CASPR2 antibody psychosis patients were indistinct from the antibody negative control group while VGKC and GlyR antibody patients had significantly decreased lipoprotein fatty acids and increased amino acid concentrations. Furthermore, these patients had more severe presentation with higher PANSS scores than either the antibody negative controls or the NMDAR, LGI1, and CASPR2 antibody groups. These results suggest that a proportion of patients with acute psychosis have a distinct clinical and biochemical phenotype that may indicate an inflammatory subtype.
    MeSH term(s) Humans ; Autoantibodies ; Intracellular Signaling Peptides and Proteins ; Potassium Channels, Voltage-Gated/blood ; Potassium Channels, Voltage-Gated/chemistry ; Psychotic Disorders/blood ; Psychotic Disorders/etiology ; Psychotic Disorders/metabolism ; Receptors, N-Methyl-D-Aspartate/blood ; Receptors, N-Methyl-D-Aspartate/chemistry ; Biomarkers ; Magnetic Resonance Spectroscopy ; Inflammation/blood ; Inflammation/complications ; Inflammation/metabolism
    Chemical Substances Autoantibodies ; Intracellular Signaling Peptides and Proteins ; Potassium Channels, Voltage-Gated ; Receptors, N-Methyl-D-Aspartate ; Biomarkers
    Language English
    Publishing date 2022-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01784-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association of symptom severity and cerebrospinal fluid alterations in recent onset psychosis in schizophrenia-spectrum disorders - An individual patient data meta-analysis.

    Campana, Mattia / Yakimov, Vladislav / Moussiopoulou, Joanna / Maurus, Isabel / Löhrs, Lisa / Raabe, Florian / Jäger, Iris / Mortazavi, Matin / Benros, Michael E / Jeppesen, Rose / Meyer Zu Hörste, Gerd / Heming, Michael / Giné-Servén, Eloi / Labad, Javier / Boix, Ester / Lennox, Belinda / Yeeles, Ksenija / Steiner, Johann / Meyer-Lotz, Gabriela /
    Dobrowolny, Henrik / Malchow, Berend / Hansen, Niels / Falkai, Peter / Siafis, Spyridon / Leucht, Stefan / Halstead, Sean / Warren, Nicola / Siskind, Dan / Strube, Wolfgang / Hasan, Alkomiet / Wagner, Elias

    Brain, behavior, and immunity

    2024  Volume 119, Page(s) 353–362

    Abstract: Neuroinflammation and blood-cerebrospinal fluid barrier (BCB) disruption could be key elements in schizophrenia-spectrum disorderś(SSDs) etiology and symptom modulation. We present the largest two-stage individual patient data (IPD) meta-analysis, ... ...

    Abstract Neuroinflammation and blood-cerebrospinal fluid barrier (BCB) disruption could be key elements in schizophrenia-spectrum disorderś(SSDs) etiology and symptom modulation. We present the largest two-stage individual patient data (IPD) meta-analysis, investigating the association of BCB disruption and cerebrospinal fluid (CSF) alterations with symptom severity in first-episode psychosis (FEP) and recent onset psychotic disorder (ROP) individuals, with a focus on sex-related differences. Data was collected from PubMed and EMBASE databases. FEP, ROP and high-risk syndromes for psychosis IPD were included if routine basic CSF-diagnostics were reported. Risk of bias of the included studies was evaluated. Random-effects meta-analyses and mixed-effects linear regression models were employed to assess the impact of BCB alterations on symptom severity. Published (6 studies) and unpublished IPD from n = 531 individuals was included in the analyses. CSF was altered in 38.8 % of individuals. No significant differences in symptom severity were found between individuals with and without CSF alterations (SMD = -0.17, 95 %CI -0.55-0.22, p = 0.341). However, males with elevated CSF/serum albumin ratios or any CSF alteration had significantly higher positive symptom scores than those without alterations (SMD = 0.34, 95 %CI 0.05-0.64, p = 0.037 and SMD = 0.29, 95 %CI 0.17-0.41p = 0.005, respectively). Mixed-effects and simple regression models showed no association (p > 0.1) between CSF parameters and symptomatic outcomes. No interaction between sex and CSF parameters was found (p > 0.1). BCB disruption appears highly prevalent in early psychosis and could be involved in positive symptomś severity in males, indicating potential difficult-to-treat states. This work highlights the need for considering BCB breakdownand sex-related differences in SSDs clinical trials and treatment strategies.
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2024.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A randomised controlled trial of time-limited individual placement and support: IPS-LITE trial.

    Burns, Tom / Yeeles, Ksenija / Langford, Oliver / Montes, Maria Vazquez / Burgess, Jennifer / Anderson, Catriona

    The British journal of psychiatry : the journal of mental science

    2015  Volume 207, Issue 4, Page(s) 351–356

    Abstract: Background: Individual placement and support (IPS) has been repeatedly demonstrated to be the most effective form of mental health vocational rehabilitation. Its no-discharge policy plus fixed caseloads, however, makes it expensive to provide.: Aims: ...

    Abstract Background: Individual placement and support (IPS) has been repeatedly demonstrated to be the most effective form of mental health vocational rehabilitation. Its no-discharge policy plus fixed caseloads, however, makes it expensive to provide.
    Aims: To test whether introducing a time limit for IPS would significantly alter its clinical effectiveness and consequently its potential cost-effectiveness.
    Method: Referrals to an IPS service were randomly allocated to either standard IPS or to time-limited IPS (IPS-LITE). IPS-LITE participants were referred back to their mental health teams if still unemployed at 9 months or after 4 months employment support. The primary outcome at 18 months was working for 1 day. Secondary outcomes comprised other vocational measures plus clinical and social functioning. The differential rates of discharge were used to calculate a notional increased capacity and to model potential rates and costs of employment.
    Results: A total of 123 patients were randomised and data were collected on 120 patients at 18 months. The two groups (IPS-LITE = 62 and IPS = 61) were well matched at baseline. Rates of employment were equal at 18 months (IPS-LITE = 24 (41%) and IPS = 27 (46%)) at which time 57 (97%) had been discharged from the IPS-LITE service and 16 (28%) from IPS. Only 11 patients (4 IPS-LITE and 7 IPS) obtained their first employment after 9 months. There were no significant differences in any other outcomes. IPS-LITE discharges generated a potential capacity increase of 46.5% compared to 12.7% in IPS which would translate into 35.8 returns to work in IPS-LITE compared to 30.6 in IPS over an 18-month period if the rates remained constant.
    Conclusions: IPS-LITE is equally effective to IPS and only minimal extra employment is gained by persisting beyond 9 months. If released capacity is utilised with similar outcomes, IPS-LITE results in an increase by 17% in numbers gaining employment within 18 months compared to IPS and will increase with prolonged follow-up. IPS-LITE may be more cost-effective and should be actively considered as an alternative within public services.
    MeSH term(s) Adult ; Cost-Benefit Analysis ; Employment/statistics & numerical data ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Mental Disorders/rehabilitation ; Middle Aged ; Proportional Hazards Models ; Psychiatric Status Rating Scales ; Rehabilitation, Vocational ; Time Factors
    Language English
    Publishing date 2015-10
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.bp.114.152082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Many patients do not participate in research. Can results still be generalised?

    Katsakou Christina / Priebe Stefan / Yeeles Ksenija

    BMC Psychiatry, Vol 7, Iss Suppl 1, p S

    2007  Volume 80

    Keywords Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Psychiatry ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2007-12-01T00:00:00Z
    Publisher BioMed Central
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Factorial structure and long-term stability of the Autonomy Preference Index.

    Morandi, Stephane / Golay, Philippe / Vazquez-Montes, Maria / Rugkåsa, Jorun / Molodynski, Andrew / Yeeles, Ksenija / Burns, Tom

    Psychological assessment

    2016  Volume 29, Issue 1, Page(s) 110–115

    Abstract: The autonomy preference index scale (API) has been designed to measure patient preference for 2 dimensions of autonomy: Their desire to take part in making medical decisions (decision making, [DM]) and their desire to be informed about their illness and ... ...

    Abstract The autonomy preference index scale (API) has been designed to measure patient preference for 2 dimensions of autonomy: Their desire to take part in making medical decisions (decision making, [DM]) and their desire to be informed about their illness and the treatment (information seeking; [IS]). The DM dimension is measured by 6 general items together with 9 items related to 3 clinical vignettes (3 × 3 items). The IS dimension is measured by 8 items. While the API is widely used, a review of literature has identified several inconsistencies in the way it is scored. The first aim of this study was to determine the best scoring structure of the API on the basis of validity and reliability evidence. The second aim was to investigate the long-term stability of API scores. Two-hundred and 85 patients with a diagnosis of psychosis were assessed as they were about to be discharged from involuntary psychiatric hospitalization and they were reassessed after 6 and 12 months. Confirmatory factor analysis (CFA) revealed that a 3-factor solution was most adequate and that 2 distinct DM subscales should be preferred to 1 total DM score. While internal consistency estimates of the 3 subscales were good, the long-term stability of API scores was only modest. Multigroup-CFA revealed scalar invariance indicating API scores kept the same meaning longitudinally. In conclusion, a 3-factor structure seemed to be most adequate for the API scale. Long-term stability estimates suggested that clinicians should regularly assess patients' preferences for autonomy because API scores fluctuate over time. (PsycINFO Database Record
    MeSH term(s) Adult ; Decision Making ; Factor Analysis, Statistical ; Female ; Humans ; Information Seeking Behavior ; Male ; Middle Aged ; Patient Participation/psychology ; Patient Preference/psychology ; Personal Autonomy ; Psychotic Disorders/psychology ; Psychotic Disorders/therapy ; Reproducibility of Results ; Schizophrenia/therapy ; Schizophrenic Psychology ; Surveys and Questionnaires
    Language English
    Publishing date 2016-04-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1000939-5
    ISSN 1939-134X ; 1040-3590
    ISSN (online) 1939-134X
    ISSN 1040-3590
    DOI 10.1037/pas0000327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Operationalising the capability approach for outcome measurement in mental health research.

    Simon, Judit / Anand, Paul / Gray, Alastair / Rugkåsa, Jorun / Yeeles, Ksenija / Burns, Tom

    Social science & medicine (1982)

    2013  Volume 98, Page(s) 187–196

    Abstract: Amartya Sen's multidimensional capability approach focuses on the importance of freedoms to be or do things people have reason to value. It is an alternative to standard utilitarian welfarism, the theoretical approach to quality-adjusted life years ( ... ...

    Abstract Amartya Sen's multidimensional capability approach focuses on the importance of freedoms to be or do things people have reason to value. It is an alternative to standard utilitarian welfarism, the theoretical approach to quality-adjusted life years (QALYs) and cost-utility analyses. Despite the limitations of the utility approach in capturing non-health benefits and broader welfare inequalities, there have been very limited applications of the capability approach in the mental health context where these issues are imperative. We report the development and application of a multidimensional instrument, the OxCAP-MH, which aims to operationalise the capability approach for outcome measurement in mental health research. The study was carried out as part of an ongoing programme on community coercion experienced by service users with severe and enduring mental illness being treated using Community Treatment Orders. Capabilities data were collected at baseline in the OCTET RCT for 333 'revolving door' mental health service users who were in involuntary hospital treatment at the time of recruitment in England (2008-2011). The research focused on the identification of capabilities domains most affected by mental illness and their association with socio-demographic and clinical factors and other measures of well-being such as the EQ-5D and Global Assessment of Functioning (GAF) scales. The OxCAP-MH item response rate was 90%-68%. There were significant correlations between service users' overall capability scores and the GAF, EQ-5D VAS and EQ-5D-3L utilities (corr = 0.249, 0.514, 0.415, respectively). The most affected capability domains were: 'Daily activities', 'Influencing local decisions', 'Enjoying recreation', 'Planning one's life' and 'Discrimination'. Age had a mixed effect, while female service users and those with a primary diagnosis of schizophrenia or longer illness duration reported significantly lower capability scores. The results support the feasibility and validity of directly measuring human capabilities for the mentally ill and the potential for applying the approach to outcome measurement.
    MeSH term(s) Activities of Daily Living ; Adult ; Aged ; England ; Feasibility Studies ; Female ; Health Services Research ; Humans ; Male ; Mental Disorders/psychology ; Mental Disorders/therapy ; Mental Health Services ; Middle Aged ; Outcome Assessment, Health Care/methods ; Reproducibility of Results ; Surveys and Questionnaires ; Young Adult
    Language English
    Publishing date 2013-10-02
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2013.09.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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