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Article ; Online: Social Well-Being, Psychological Factors, and Chronic Conditions Among Older Adults.

Min, J / Yeh, Y-C / Harvey, I S

JAR life

2022 Volume 11, Page(s) 14–19

Abstract: Background: Aging is characterized by the decline in physical health, functional status, and loss of social roles and relationships that can challenge the quality of life. Social well-being may help explain how aging individuals experience declining ... ...

Abstract	Background: Aging is characterized by the decline in physical health, functional status, and loss of social roles and relationships that can challenge the quality of life. Social well-being may help explain how aging individuals experience declining physical health and social relationships. Despite the high prevalence of chronic conditions among older adults, research exploring the relationship between social well-being and chronic disease is sparse. Objectives: The study aims were to investigate the relationship between social well-being and psychological factors (e.g., perceived control, life satisfaction, self-esteem, active coping, optimism, and religious coping) by chronic condition in older adults. Design: Cross-sectional study. Participants: The current study comprises older adults (N = 1,251, aged ≥ 65 y) who participated in the third wave of the National Survey of Midlife in the United States (i.e., MIDUS). Setting: MIDUS was conducted on a random-digit-dial sample of community-dwelling, English-speaking adults. Measurements: Six instruments representing psychological resources (life satisfaction, perceived control, self-esteem, optimism, active coping, and religious coping) and five dimensions of social well-being (social actualization, social coherence, social acceptance, social contribution, social integration) were measured. An index of chronic disease comprised of self-reported data whether they had received a physician's diagnosis for any chronic conditions over the past year. Results: The findings indicated that the individuals without chronic conditions had significantly higher social integration, social acceptance, and social contribution scores than the individuals with chronic conditions (t = 2.26, p < 0.05, t = 2.85, p < 0.01, and t = 2.23, p < 0.05, respectively). For individuals diagnosed with more than one chronic condition, perceived control, self-esteem, and optimism were positively related to their social well-being (β = .33, p < .001, β = .17, p < .001, and β = .33, p < .001, respectively). Conclusion: Findings suggested that older adults with multiple chronic conditions have a decrease in social well-being. Chronic disease management programs may help increase social well-being among individuals with multiple chronic conditions.
Language	English
Publishing date	2022-05-25
Publishing country	France
Document type	Journal Article
ISSN	2534-773X
ISSN (online)	2534-773X
DOI	10.14283/jarlife.2022.3
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Article ; Online: ROS-1 TKI for the treatment of concurrent sarcomatoid transformation and acquired ROS-1 F2004C mutation in a lung adenocarcinoma patient.

Ko, H-J / Hsu, C-K / Yeh, Y-C / Huang, H-C

Pulmonology

2021 Volume 28, Issue 1, Page(s) 76–79

MeSH term(s)	Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mutation ; Protein Kinase Inhibitors ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/genetics ; Proto-Oncogene Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins/genetics
Chemical Substances	Protein Kinase Inhibitors ; Proto-Oncogene Proteins ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; ROS1 protein, human (EC 2.7.10.1)
Language	English
Publishing date	2021-10-07
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	3009651-0
ISSN	2531-0437 ; 2531-0429
ISSN (online)	2531-0437
ISSN	2531-0429
DOI	10.1016/j.pulmoe.2021.08.009
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Article ; Online: COVID-19 ICU and mechanical ventilation patient characteristics and outcomes - A systematic review and meta-analysis

Chang, R. / Elhusseiny, K. M. / Yeh, Y.-C. / Sun, W.-z.

Abstract: Background Insight into COVID-19 intensive care unit (ICU) patient characteristics, rates and risks of invasive mechanical ventilation (IMV) and associated outcomes as well as any regional discrepancies is critical in this pandemic for individual case ... ...

Abstract	Background Insight into COVID-19 intensive care unit (ICU) patient characteristics, rates and risks of invasive mechanical ventilation (IMV) and associated outcomes as well as any regional discrepancies is critical in this pandemic for individual case management and overall resource planning. Methods and Findings Electronic searches were performed for reports through May 1 2020 and reports on COVID-19 ICU admissions and outcomes were included using predefined search terms. Relevant data was subsequently extracted and pooled using fixed or random effects meta-analysis depending on heterogeneity. Study quality was assessed by the NIH tool and heterogeneity was assessed by I2 and Q tests. Baseline patient characteristics, ICU and IMV outcomes were pooled and meta-analyzed. Pooled odds ratios (pOR) were calculated for clinical features against ICU, IMV mortality. Subgroup analysis was carried out based on patient regions. A total of twenty-eight studies comprising 12,437 COVID-19 ICU admissions from seven countries were meta-analyzed. Pooled ICU admission rate was 21% [95% CI 0.12-0.34] and 69% of cases needed IMV [95% CI 0.61-0.75]. ICU and IMV mortality were 28.3% [95% CI 0.25-0.32], 43% [95% CI 0.29-0.58] and ICU, IMV duration was 7.78 [95% CI 6.99-8.63] and 10.12 [95% CI 7.08-13.16] days respectively. Besides confirming the significance of comorbidities and clinical findings of COVID-19 previously reported, we found the major correlates with ICU mortality were IMV [pOR 16.46, 95% CI 4.37-61.96], acute kidney injury (AKI) [pOR 12.47, 95% CI 1.52-102.7], and acute respiratory distress syndrome (ARDS) [pOR 6.52, 95% CI 2.66-16.01]. Subgroup analyses confirm significant regional discrepancies in outcomes. Conclusions This is the most comprehensive systematic review and meta-analysis of COVID-19 ICU and IMV cases and associated outcomes to date and the only analysis to implicate IMV's associtaion with COVID-19 ICU mortality. The significant association of AKI, ARDS and IMV with mortality has implications for ICU resource planning for AKI and ARDS as well as research into optimal ventilation strategies for patients. Regional differences in outcome implies a need to develop region specific protocols for ventilatory support as well as overall treatment.
Keywords	covid19
Publisher	MedRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.08.16.20035691
Database	COVID19

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Article ; Online: Comparison of clinical outcomes of edoxaban versus apixaban, dabigatran, rivaroxaban, and vitamin K antagonists in patients with atrial fibrillation in Germany: A real-world cohort study.

Marston, X L / Wang, R / Yeh, Y-C / Zimmermann, L / Ye, X / Gao, X / Brüggenjürgen, B / Unverdorben, M

International journal of cardiology

2021 Volume 346, Page(s) 93–99

Abstract: Background: The aim of the study was to compare the real-world effectiveness and safety in atrial fibrillation (AF) patients treated with edoxaban versus other oral anticoagulants (OACs) (apixaban, dabigatran, rivaroxaban, and vitamin K antagonists [VKA] ...

Abstract	Background: The aim of the study was to compare the real-world effectiveness and safety in atrial fibrillation (AF) patients treated with edoxaban versus other oral anticoagulants (OACs) (apixaban, dabigatran, rivaroxaban, and vitamin K antagonists [VKA]) in Germany. Methods and results: Using a representative database of 3.5 million statutory health-insured lives in Germany, a retrospective cohort study was conducted to examine ischemic stroke (IS) or systemic embolism (SE) and major bleeding in AF patients initiating anticoagulant therapy from January 2014 through June 2017. Inverse probability of treatment weighting using propensity score was applied for baseline covariate adjustment. Cox proportional hazards models were used to estimate the adjusted risk (hazard ratio [HR]) of each outcome comparing edoxaban versus other OACs. Among 21,038 patients treated with OACs, 1236 edoxaban, 6053 apixaban, 1306 dabigatran, 7013 rivaroxaban, and 5430 VKA patients were included. The adjusted combined risks of IS or SE were lower (p < 0.05) for each edoxaban pairwise comparison with other OACs (HR: 0.83 vs. apixaban, 0.60 vs. dabigatran, 0.72 vs. rivaroxaban, 0.64 vs. VKA). Edoxaban favored lower risks of major bleeding compared with rivaroxaban (HR: 0.74) and VKA (HR: 0.47). No differences in the risk of major bleeding were found between edoxaban and apixaban (p = 0.33), and between edoxaban and dabigatran (p = 0.06). Conclusions: Edoxaban was associated with better effectiveness compared with other OACs in AF patients from Germany. Edoxaban also demonstrated a favorable safety profile.
MeSH term(s)	Administration, Oral ; Anticoagulants/adverse effects ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; Cohort Studies ; Dabigatran/adverse effects ; Humans ; Pyrazoles ; Pyridines ; Pyridones/adverse effects ; Retrospective Studies ; Rivaroxaban/adverse effects ; Stroke/drug therapy ; Stroke/epidemiology ; Stroke/prevention & control ; Thiazoles ; Vitamin K/therapeutic use
Chemical Substances	Anticoagulants ; Pyrazoles ; Pyridines ; Pyridones ; Thiazoles ; Vitamin K (12001-79-5) ; apixaban (3Z9Y7UWC1J) ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC) ; edoxaban (NDU3J18APO)
Language	English
Publishing date	2021-11-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2021.11.008
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Article ; Online: Budd-Chiara syndrome and chylothorax.

Wang, C-Y / Liao, C-Y / Huang, S-C / Yeh, Y-C

QJM : monthly journal of the Association of Physicians

2016 Volume 109, Issue 3, Page(s) 211–212

MeSH term(s)	Budd-Chiari Syndrome/complications ; Budd-Chiari Syndrome/diagnostic imaging ; Chylothorax/etiology ; Chylothorax/therapy ; Female ; Humans ; Middle Aged ; Phlebography ; Recurrence ; Vena Cava, Inferior/diagnostic imaging
Language	English
Publishing date	2016-03
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1199985-8
ISSN	1460-2393 ; 0033-5622 ; 1460-2725
ISSN (online)	1460-2393
ISSN	0033-5622 ; 1460-2725
DOI	10.1093/qjmed/hcv216
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Article ; Online: Risk of Myocardial Infarction and Ischemic Stroke after Dental Treatments.

Chen, T T / D'Aiuto, F / Yeh, Y C / Lai, M S / Chien, K L / Tu, Y K

Journal of dental research

2018 Volume 98, Issue 2, Page(s) 157–163

Abstract: The association between invasive dental treatments (IDTs) and a short-term risk of myocardial infarction (MI) and ischemic stroke (IS) remains controversial. Bacterial dissemination from the oral cavity and systemic inflammation linked to IDT can induce ... ...

Abstract	The association between invasive dental treatments (IDTs) and a short-term risk of myocardial infarction (MI) and ischemic stroke (IS) remains controversial. Bacterial dissemination from the oral cavity and systemic inflammation linked to IDT can induce a state of acute vascular dysfunction. The aim of study is to investigate the relation of IDTs to MI and IS by using case-only study designs to analyze data from a large Taiwanese cohort. A nationwide population-based study was undertaken by using the case-crossover and self-controlled case series design to analyze the Taiwanese National Health Care Claim database. Conditional logistic regression model and conditional Poisson regression model were used to estimate the risks of MI/IS. In addition, we used burn patients as negative controls to explore the potential effect of residual confounding. In total, 123,819 MI patients and 327,179 IS patients in the case-crossover design and 117,655 MI patients and 298,757 IS patients were included in the self-controlled case series design. Results from both study designs showed that the risk of MI within the first 24 wk after IDT was not significantly different from or close to unity except for a modest risk during the first week for patients without other comorbidities (odds ratios [95% confidence intervals] of 1.31 [1.08-1.58] and 1.15 [1.01-1.31] for 3 d and 7 d, respectively). We also observed no association between IDTs and IS, or the risk ratio was close to unity. IDTs did not appear to be associated with a transient risk of MI and IS in the Taiwanese population, with consistent findings from both case-only study designs. However, we cannot exclude that dental infections and diseases may yield a long-term risk of MI and IS.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Brain Ischemia/diagnosis ; Brain Ischemia/epidemiology ; Brain Ischemia/microbiology ; Case-Control Studies ; Cross-Over Studies ; Dental Care/adverse effects ; Female ; Humans ; Insurance, Health/statistics & numerical data ; Male ; Middle Aged ; Mouth/microbiology ; Mouth/surgery ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Myocardial Infarction/microbiology ; Oral Surgical Procedures/adverse effects ; Retrospective Studies ; Risk Factors ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/microbiology ; Taiwan/epidemiology
Language	English
Publishing date	2018-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80207-4
ISSN	1544-0591 ; 0022-0345
ISSN (online)	1544-0591
ISSN	0022-0345
DOI	10.1177/0022034518805745
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Ul III Zs.75: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 262: Show issues

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Article ; Online: Education and imaging. Gastrointestinal: gastric hematoma with bleeding in a patient with primary amyloidosis.

Yeh, Y-C / Lin, C-H / Huang, S-C / Tsou, Y-K

Journal of gastroenterology and hepatology

2013 Volume 29, Issue 3, Page(s) 419

MeSH term(s)	Aged ; Amyloidosis/complications ; Amyloidosis/diagnosis ; Amyloidosis/pathology ; Biopsy ; Endoscopy, Digestive System ; Female ; Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/pathology ; Hematoma/etiology ; Hematoma/pathology ; Humans ; Immunoglobulin Light-chain Amyloidosis ; Rupture, Spontaneous/etiology ; Stomach Diseases/etiology ; Stomach Diseases/pathology
Language	English
Publishing date	2013-12-27
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.12528
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: New Late Gene, dar, Involved in DNA Replication of Bacteriophage T4 I. Isolation, Characterization, and Genetic Location.

Wu, J R / Yeh, Y C

Journal of virology

2006 Volume 15, Issue 5, Page(s) 1096–1106

Abstract: Suppressors of gene 59-defective mutants were isolated by screening spontaneous, temperature-sensitive (ts) revertants of the amber mutant, amC5, in gene 59. Six ts revertants were isolated. No gene 59-defective ts recombinant was obtained by crossing ... ...

Abstract	Suppressors of gene 59-defective mutants were isolated by screening spontaneous, temperature-sensitive (ts) revertants of the amber mutant, amC5, in gene 59. Six ts revertants were isolated. No gene 59-defective ts recombinant was obtained by crossing each ts revertant with the wild type, T4D. However, suppressors of gene 59-defective mutants were obtained from two of these ts revertants. These suppressor mutants are referred to as dar (DNA arrested restoration). dar mutants specifically restored the abnormalities, both in DNA synthesis and burst size, caused by gene 59-defective mutants to normal levels. It is unlikely that dar mutants are nonsense suppressors since theý failed to suppress amber mutations in 11 other genes investigated. The genetic expression of dar is controlled by gene 55; therefore, dar is a late gene. The genetic location of dar has been mapped between genes 24 and 25, a region contiguous to late genes. dar appears to be another nonessential gene of T4 since burst sizes of dar were almost identical to those of the wild type. Mutations in dar did not affect genetic recombination and repair of UV-damaged DNA, but caused a sensitivity to hydroxyurea in progeny formation. The effect of the dar mutation on host DNA degradation cannot account for its hydroxyurea sensitivity. dar mutant alleles were recessive to the wild-type allele as judged by restoration of arrested DNA synthesis. The possible mechanisms for the suppression of defects in gene 59 are discussed.
Language	English
Publishing date	2006-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.15.5.1096-1106.1975
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Article ; Online: Hepatobiliary and Pancreatic: Obstructive jaundice after transarterial chemoembolization of hepatocellular carcinoma related to intraductal tumor necrotic fragment.

Hwang, H E / Tseng, H S / Liu, C A / Chiou, Y Y / Yeh, Y C / Chiu, N C

Journal of gastroenterology and hepatology

2017 Volume 32, Issue 3, Page(s) 546

MeSH term(s)	Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic/adverse effects ; Chemoembolization, Therapeutic/methods ; Cholangiopancreatography, Endoscopic Retrograde ; Common Bile Duct/diagnostic imaging ; Common Bile Duct/pathology ; Humans ; Jaundice, Obstructive/diagnostic imaging ; Jaundice, Obstructive/etiology ; Liver Neoplasms/complications ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy ; Middle Aged ; Necrosis ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local/complications ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/therapy ; Tomography, X-Ray Computed
Language	English
Publishing date	2017-03-14
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.13609
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Association between thyroid dysfunction and dysglycaemia: a prospective cohort study.

Chang, C-H / Yeh, Y-C / Shih, S-R / Lin, J-W / Chuang, L-M / Caffrey, J L / Tu, Y-K

Diabetic medicine : a journal of the British Diabetic Association

2017 Volume 34, Issue 11, Page(s) 1584–1590

Abstract: Aims: To compare the incidence of hyperglycaemia among participants with low, elevated and normal serum thyroid-stimulating hormone concentration, as well as the incidence of abnormal thyroid function test results among participants with normal blood ... ...

Abstract	Aims: To compare the incidence of hyperglycaemia among participants with low, elevated and normal serum thyroid-stimulating hormone concentration, as well as the incidence of abnormal thyroid function test results among participants with normal blood glucose and those with hyperglycaemia. Methods: In a prospective study, a cohort of 72 003 participants with normal, low and elevated serum thyroid-stimulating hormone concentration were followed from the study beginning to the first report of diabetes and prediabetes. A proportional hazards regression model was used to calculate the hazard ratios and 95% CIs for each outcome, adjusting for age, sex, education level, smoking, alcohol consumption and obesity. Analyses for the association between dysglycaemia and incident abnormal thyroid function test were also conducted. Results: During a median 2.6 year follow-up, the incident rates for dysglycaemia, particularly prediabetes, were substantially higher in participants with elevated thyroid-stimulating hormone concentrations at baseline, while the rates for participants with normal and low thyroid-stimulating hormone were similar. After controlling for risk factors, participants with elevated thyroid-stimulating hormone retained a 15% increase in risk of prediabetes (adjusted hazard ratio 1.15, 95% CI 1.04-1.26), but were not at greater risk of diabetes (adjusted hazard ratio 0.96, 95% CI 0.64-1.44). By contrast, participants with normal and low thyroid-stimulating hormone concentrations had similar dysglycaemia risks. Participants with diabetes and prediabetes were not at greater risks of developing abnormal thyroid function test results when compared with participants with euglycaemia. Conclusions: People with elevated serum thyroid-stimulating hormone concentration are at greater risk of developing prediabetes. Whether this includes a greater risk of developing frank diabetes may require an extended period of follow-up to clarify.
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Glucose Metabolism Disorders/blood ; Glucose Metabolism Disorders/complications ; Glucose Metabolism Disorders/epidemiology ; Glucose Metabolism Disorders/physiopathology ; Humans ; Incidence ; Male ; Middle Aged ; Prediabetic State/blood ; Prediabetic State/complications ; Prediabetic State/epidemiology ; Prediabetic State/physiopathology ; Thyroid Diseases/blood ; Thyroid Diseases/complications ; Thyroid Diseases/diagnosis ; Thyroid Diseases/epidemiology ; Thyroid Function Tests ; Thyroid Gland/physiopathology ; Thyrotropin/blood
Chemical Substances	Thyrotropin (9002-71-5)
Language	English
Publishing date	2017
Publishing country	England
Document type	Journal Article
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.13420
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