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Article ; Online: Geniposide Causes Idiopathic Mesenteric Phlebosclerosis.

Young Chuah, Yoen / Yeh Lee, Yeong

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2023 Volume 34, Issue 8, Page(s) 890–891

MeSH term(s)	Humans ; Iridoids ; Tomography, X-Ray Computed ; Sclerosis/chemically induced
Chemical Substances	geniposide (145295QLXY) ; Iridoids
Language	English
Publishing date	2023-07-11
Publishing country	Turkey
Document type	Letter ; Comment
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
DOI	10.5152/tjg.2023.23208
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Article ; Online: Molecular Epidemiology and its Role in Translational Medicine

Yeh Lee Yeong

Journal of International Translational Medicine, Vol 4, Iss 1, Pp 21-

2016 Volume 27

Abstract: The primary definition of translational medicine is to develop new clinical therapeutic methods for the diagnosis, treatment and prognosis of diseases by the therapeutic mechanism and new pathological cognition obtained in laboratory. Since the 21st ... ...

Abstract	The primary definition of translational medicine is to develop new clinical therapeutic methods for the diagnosis, treatment and prognosis of diseases by the therapeutic mechanism and new pathological cognition obtained in laboratory. Since the 21st century, most developed countries worldwide have made great adjustment in the strategies of translational medicine, but so far, only a few basic research results have been successfully translated into clinical practice. Research of translational medicine requires the team work of interdisciplinary groups, including medical experts, molecular biologists, and epidemiologists. With the rapid development of biological techniques and extensive application of molecular biology, epidemiology has become a real interdisciplinary discipline from conventional population survey, and stepped into genetic and molecular era, an era of molecular epidemiology. Molecular epidemiology not only provides research findings to translational medicine, but also bridges between basic science and medical research, so as to improve the effective translation of basic scientific results. This article, focusing on molecular epidemiology and translational medicine, mainly summarized the history and current status of translational medicine and emphatically interpreted the importance of molecular epidemiology to translational medicine.
Keywords	Molecular epidemiology ; Translational medicine ; Phenotype ; Whole-gene polymorphism ; Medicine ; R
Language	English
Publishing date	2016-03-01T00:00:00Z
Publisher	Third Party Medicine International Publishing Group Co. Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Overlap of disorders of gut-brain interaction: a systematic review and meta-analysis.

Fairlie, Thomas / Shah, Ayesha / Talley, Nicholas J / Chey, William D / Koloski, Natasha / Yeh Lee, Yeong / Gwee, Kok-Ann / Jones, Michael P / Holtmann, Gerald

The lancet. Gastroenterology & hepatology

2023 Volume 8, Issue 7, Page(s) 646–659

Abstract: Background: Rome criteria differentiate distinct types of disorders of gut-brain interaction (DGBI); also known as functional gastrointestinal disorders. Overlap of symptom categories frequently occurs. This systematic review and meta-analysis aimed to ... ...

Abstract	Background: Rome criteria differentiate distinct types of disorders of gut-brain interaction (DGBI); also known as functional gastrointestinal disorders. Overlap of symptom categories frequently occurs. This systematic review and meta-analysis aimed to define the prevalence of DGBI overlap and compare overlap in population-based, primary care or tertiary care health settings. Furthermore, we aimed to compare symptom severity of psychological comorbidities in DGBI with and without overlap. Methods: For this systematic review and meta-analysis we searched MEDLINE (PubMed) and Embase electronic databases from inception until March 1, 2022, for original articles and conference abstracts of observational cross-sectional, case-controlled, or cohort design studies that reported the prevalence of DGBI overlap in adult participants (aged ≥18 years). We included only those studies where the diagnosis of DGBI was based on clinical assessment, questionnaire data, or specific symptom-based criteria. Studies were excluded if reporting on mixed populations of DGBI and organic diseases. Aggregate patient data were extracted from eligible published studies. The prevalence of DGBI overlap in all studies was pooled using the DerSimonian and Laird random effects model, and further analysis stratified by subgroups (care setting, diagnostic criteria, geographic region, and gross domestic product per capita). We also assessed the relationship between DGBI overlap with anxiety, depression, and quality of life symptom scores. This study was registered with PROSPERO (CRD42022311101). Findings: 46 of 1268 screened studies, reporting on 75 682 adult DGBI participants, were eligible for inclusion in this systematic review and meta-analysis. Overall, 24 424 (pooled prevalence 36·5% [95% CI 30·7 to 42·6]) participants had a DGBI overlap, with considerable between-study heterogeneity (I Interpretation: Overlap of DGBI subtypes is frequent, and is more prevalent in tertiary care settings and associated with more severe symptom manifestations or psychological comorbidities. Despite the large sample size, the comparative analyses revealed substantial heterogeneity, and the results should be interpreted with caution. Funding: National Health and Medical Research Council and Centre for Research Excellence.
MeSH term(s)	Adult ; Humans ; Adolescent ; Cross-Sectional Studies ; Quality of Life ; Anxiety/epidemiology ; Comorbidity ; Brain ; Observational Studies as Topic
Language	English
Publishing date	2023-05-18
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ISSN	2468-1253
ISSN (online)	2468-1253
DOI	10.1016/S2468-1253(23)00102-4
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Article ; Online: Uniting the global gastroenterology community to meet the challenge of climate change and non-recyclable waste.

Leddin, Desmond / Omary, M Bishr / Veitch, Andrew / Metz, Geoffrey / Amrani, Naima / Aabakken, Lars / Raja Ali, Raja Affendi / Alvares-Da-Silva, Mario Reis / Armstrong, David / Boyacioglu, Sedat / Chen, Ye / Elwakil, Reda / Fock, Kwong-Ming / Hamid, Saeed S / Makharia, Govind / Macrae, Finlay / Malekzadeh, Reza / Mulder, Chris J / Piscoya, Alejandro /

Perman, Mai Ling / Sadeghi, Anahita / Saenz, Roque / Saurin, Jean-Christophe / Butt, Amna Subhan / Wu, Kaichun / Yeh Lee, Yeong

Gut

2021 Volume 70, Issue 11, Page(s) 2025–2029

MeSH term(s)	Climate Change ; Conservation of Natural Resources ; Gastroenterology/organization & administration ; Global Health ; Humans ; Medical Waste
Chemical Substances	Medical Waste
Language	English
Publishing date	2021-09-25
Publishing country	England
Document type	Journal Article
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2021-325789
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Article ; Online: Germline mutation and protein expression analysis of mismatch repair genes MSH6 and PMS2 in Malaysian Lynch syndrome patients.

Zahary, Mohd Nizam / Kaur, Gurjeet / Hassan, Muhammad Radzi Abu / Sidek, Ahmad Shanwani Mohd / Singh, Harjinder / Yeh, Lee Yeong / Ankathil, Ravindran

International journal of colorectal disease

2013 Volume 29, Issue 2, Page(s) 261–262

MeSH term(s)	Adenosine Triphosphatases/genetics ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; DNA Mismatch Repair/genetics ; DNA Repair Enzymes/genetics ; DNA-Binding Proteins/genetics ; Germ-Line Mutation/genetics ; Humans ; Malaysia ; Mismatch Repair Endonuclease PMS2
Chemical Substances	DNA-Binding Proteins ; G-T mismatch-binding protein ; Adenosine Triphosphatases (EC 3.6.1.-) ; PMS2 protein, human (EC 3.6.1.-) ; Mismatch Repair Endonuclease PMS2 (EC 3.6.1.3) ; DNA Repair Enzymes (EC 6.5.1.-)
Language	English
Publishing date	2013-09-27
Publishing country	Germany
Document type	Letter
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-013-1770-1
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Article ; Online: In healthy volunteers, immunohistochemistry supports squamous to columnar metaplasia as mechanism of expansion of cardia, aggravated by central obesity.

Derakhshan, Mohammad H / Robertson, Elaine V / Yeh Lee, Yeong / Harvey, Tim / Ferrier, Rod K / Wirz, Angela A / Orange, Clare / Ballantyne, Stuart A / Hanvey, Scott L / Going, James J / McColl, Kenneth E L

Gut

2015 Volume 64, Issue 11, Page(s) 1705–1714

Abstract: Introduction: Recently, we showed that the length of cardiac mucosa in healthy volunteers correlated with age and obesity. We have now examined the immunohistological characteristics of this expanded cardia to determine whether it may be due to columnar ...

Abstract	Introduction: Recently, we showed that the length of cardiac mucosa in healthy volunteers correlated with age and obesity. We have now examined the immunohistological characteristics of this expanded cardia to determine whether it may be due to columnar metaplasia of the distal oesophagus. Methods: We used the squamocolumnar junction (SCJ), antral and body biopsies from the 52 Helicobacter pylori-negative healthy volunteers who had participated in our earlier physiological study and did not have hiatus hernia, transsphincteric acid reflux, Barrett's oesophagus or intestinal metaplasia (IM) at cardia. The densities of inflammatory cells and reactive atypia were scored at squamous, cardiac and oxyntocardiac mucosa of SCJ, antrum and body. Slides were stained for caudal type homeobox 2 (CDX-2), villin, trefoil factor family 3 (TFF-3) and liver-intestine (LI)-cadherin, mucin MUC1, Muc-2 and Muc-5ac. In addition, biopsies from 15 Barrett's patients with/without IM were stained and scored as comparison. Immunohistological characteristics were correlated with parameters of obesity and high-resolution pH metry recording. Results: Cardiac mucosa had a similar intensity of inflammatory infiltrate to non-IM Barrett's and greater than any of the other upper GI mucosae. The immunostaining pattern of cardiac mucosa most closely resembled non-IM Barrett's showing only slightly weaker CDX-2 immunostaining. In distal oesophageal squamous mucosa, expression of markers of columnar differentiation (TFF-3 and LI-cadherin) was apparent and these correlated with central obesity (correlation coefficient (CC)=0.604, p=0.001 and CC=0.462, p=0.002, respectively). In addition, expression of TFF-3 in distal oesophageal squamous mucosa correlated with proximal extension of gastric acidity within the region of the lower oesophageal sphincter (CC=-0.538, p=0.001). Conclusions: These findings are consistent with expansion of cardia in healthy volunteers occurring by squamo columnar metaplasia of distal oesophagus and aggravated by central obesity. This metaplastic origin of expanded cardia may be relevant to the substantial proportion of cardia adenocarcinomas unattributable to H. pylori or transsphincteric acid reflux.
MeSH term(s)	Biopsy ; Cardia/pathology ; Esophagogastric Junction/pathology ; Female ; Healthy Volunteers ; Humans ; Immunohistochemistry ; Male ; Metaplasia/complications ; Metaplasia/pathology ; Middle Aged ; Obesity, Abdominal/complications ; Severity of Illness Index
Language	English
Publishing date	2015-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2014-308914
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Article ; Online: Contribution of the MLH1 -93G>a promoter polymorphism in modulating susceptibility risk in Malaysian colorectal cancer patients.

Nizam, Zahary Mohd / Abdul Aziz, Ahmad Aizat / Kaur, Gurjeet / Abu Hassan, Muhammad Radzi / Mohd Sidek, Ahmad Shanwani / Yeh, Lee Yeong / Mazuwin, Maya / Ankathil, Ravindran

Asian Pacific journal of cancer prevention : APJCP

2013 Volume 14, Issue 2, Page(s) 619–624

Abstract: Background: Colorectal cancer (CRC) exists in a more common sporadic form and less common hereditary forms, associated with the Lynch syndrome, familial adenomatous polyposis (FAP) and other rare syndromes. Sporadic CRC is believed to arise as a result ... ...

Abstract	Background: Colorectal cancer (CRC) exists in a more common sporadic form and less common hereditary forms, associated with the Lynch syndrome, familial adenomatous polyposis (FAP) and other rare syndromes. Sporadic CRC is believed to arise as a result of close interaction between environmental factors, including dietary and lifestyle habits, and genetic predisposition factors. In contrast, hereditary forms such as those related to the Lynch syndrome result from inheritance of germline mutations of mismatch repair (MMR) genes. However, in certain cases, the influence of low penetrance alleles in familial colorectal cancer susceptibility is also undeniable. Aim: To investigate the genotype frequencies of MLH1 promoter polymorphism -93G>A and to determine whether it could play any role in modulating familial and sporadic CRC susceptibility risk. Methods: A case-control study comprising of 104 histopathologically confirmed CRC patients as cases (52 sporadic CRC and 52 Lynch syndrome patients) and 104 normal healthy individuals as controls was undertaken. DNA was extracted from peripheral blood and the polymorphism was genotyped employing PCR-RFLP methods. The genotypes were categorized into homozygous wild type, heterozygous and homozygous variants. The risk association between these polymorphisms and CRC susceptibility risk was calculated using binary logistic regression analysis and deriving odds ratios (ORs). Results: When risk association was investigated for all CRC patients as a single group, the heterozygous (G/A) genotype showed a significantly higher risk for CRC susceptibility with an OR of 2.273, (95%CI: 1.133-4.558 and p-value=0.021). When analyzed specifically for the 2 types of CRC, the heterozygous (G/A) genotype showed significantly higher risk for sporadic CRC susceptibility with and OR of 3.714, (95%CI: 1.416-9.740 and p-value=0.008). Despite high OR value was observed for Lynch syndrome (OR: 1.600, 95%CI: 0.715-3.581), the risk was not statistically significant (P=0.253). Conclusion: Our results suggest an influence of MLH1 promoter polymorphism -93G>A in modulating susceptibility risk in Malaysian CRC patients, especially those with sporadic disease.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Case-Control Studies ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Malaysia ; Male ; Middle Aged ; MutL Protein Homolog 1 ; Nuclear Proteins/genetics ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic/genetics ; Risk ; Risk Assessment
Chemical Substances	Adaptor Proteins, Signal Transducing ; MLH1 protein, human ; Nuclear Proteins ; MutL Protein Homolog 1 (EC 3.6.1.3)
Language	English
Publishing date	2013-04-25
Publishing country	Thailand
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218955-5
ISSN	2476-762X ; 1513-7368
ISSN (online)	2476-762X
ISSN	1513-7368
DOI	10.7314/apjcp.2013.14.2.619
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Article ; Online: Chronic atrophic antral gastritis and risk of metaplasia and dysplasia in an area with low prevalence of Helicobacter pylori.

Yeh, Lee Yeong / Raj, Mahendra / Hassan, Syed / Aziz, Syed Abdul / Othman, Nor Hayati / Mutum, Samarendra Singh / Naik, Ventakesh R

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology

2009 Volume 28, Issue 2, Page(s) 49–52

Abstract: Introduction: The Northeastern region of Peninsular Malaysia is an area with exceptionally low prevalence for Helicobacter pylori infection. The risk of intestinal metaplasia and dysplasia in patients with chronic atrophic gastritis (CAG) and its ... ...

Abstract	Introduction: The Northeastern region of Peninsular Malaysia is an area with exceptionally low prevalence for Helicobacter pylori infection. The risk of intestinal metaplasia and dysplasia in patients with chronic atrophic gastritis (CAG) and its association with Helicobacter pylori is unknown in this region. Methods: This was a cross-sectional study on gastric biopsies from 234 consecutive patients (mean age 53.5 [14.8] years) who underwent upper gastrointestinal endoscopy between January 2006 and December 2006. Results: There were 137 (59%) men and 185 (79%) Malay patients. Among 234 biopsies, CAG was found in 99 and non-atrophic gastritis in 135. Intestinal metaplasia and dysplasia were detected in 8 and 6 atrophic gastritis biopsies, respectively, and in 10 and 3 of non-atrophic gastritis biopsies, respectively. H. pylori were detected in 16 (9 Malays, 7 non- Malays) biopsies (p=0.024); intestinal metaplasia was detected in 4 biopsies (p=0.3) and dysplasia in 5 biopsies (p=0.3). Of the 218 biopsies negative for H. pylori, intestinal metaplasia was found in 14 and dysplasia in 4. The risk of intestinal metaplasia as well as dysplasia was associated with presence of H. pylori infection (p=0.029 and p<0.001 respectively). Conclusion: Even in a setting of low prevalence of H. pylori, intestinal metaplasia and dysplasia were significantly associated with H. pylori infection. The frequency of intestinal metaplasia and dysplasia was similar different between biopsies with atrophic gastritis and non-atrophic gastritis.
MeSH term(s)	Biopsy ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Gastritis, Atrophic/complications ; Gastritis, Atrophic/pathology ; Helicobacter Infections/epidemiology ; Helicobacter Infections/microbiology ; Helicobacter pylori/isolation & purification ; Humans ; Intestinal Diseases/epidemiology ; Intestinal Diseases/etiology ; Intestinal Diseases/pathology ; Intestine, Small/pathology ; Malaysia/epidemiology ; Male ; Metaplasia ; Middle Aged ; Prevalence ; Prognosis ; Pyloric Antrum/microbiology ; Pyloric Antrum/pathology ; Retrospective Studies ; Risk Factors ; Rural Population ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/etiology ; Stomach Neoplasms/pathology
Language	English
Publishing date	2009-08-21
Publishing country	India
Document type	Comparative Study ; Journal Article
ZDB-ID	632595-6
ISSN	0975-0711 ; 0254-8860
ISSN (online)	0975-0711
ISSN	0254-8860
DOI	10.1007/s12664-009-0017-0
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