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  1. Article ; Online: Prothymosin α accelerates dengue virus-induced thrombocytopenia

    Mei-Lin Yang / Chia-Ling Lin / Yi-Cheng Chen / I-An Lu / Bing-Hua Su / Yen-Hsu Chen / Kuan-Ting Liu / Chao-Liang Wu / Ai-Li Shiau

    iScience, Vol 27, Iss 1, Pp 108422- (2024)

    1481  

    Abstract: Summary: Thrombocytopenia is the hallmark finding in dengue virus (DENV) infection. Prothymosin α (ProT) has both intracellular and extracellular functions involved in cell cycle progression, cell differentiation, gene regulation, oxidative stress ... ...

    Abstract Summary: Thrombocytopenia is the hallmark finding in dengue virus (DENV) infection. Prothymosin α (ProT) has both intracellular and extracellular functions involved in cell cycle progression, cell differentiation, gene regulation, oxidative stress response, and immunomodulation. In this study, we found that ProT levels were elevated in dengue patient sera as well as DENV-infected megakaryoblasts and their culture supernatants. ProT transgenic mice had reduced platelet counts with prolonged bleeding times. Upon treatment with DENV plus anti-CD41 antibody, they exhibited severe skin hemorrhage. Furthermore, overexpression of ProT suppressed megakaryocyte differentiation. Infection with DENV inhibited miR-126 expression, upregulated DNA (cytosine-5)-methyltransferase 1 (DNMT1), downregulated GATA-1, and increased ProT expression. Upregulation of ProT led to Nrf2 activation and reduced reactive oxygen species production, thereby suppressing megakaryopoiesis. We report the pathophysiological role of ProT in DENV infection and propose an involvement of the miR-126-DNMT1-GATA-1-ProT-Nrf2 signaling axis in DENV-induced thrombocytopenia.
    Keywords Virology ; Cell biology ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The preventive strategies of community hospital in the battle of fighting pandemic COVID-19 in Taiwan

    Chih-Jen Yang / Tun-Chieh Chen / Yen-Hsu Chen

    Journal of Microbiology, Immunology and Infection, Vol 53, Iss 3, Pp 381-

    2020  Volume 383

    Keywords COVID-19 ; Preventive strategies ; Community hospital ; Microbiology ; QR1-502 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Genetic Association Studies of MICB and PLCE1 with Severity of Dengue in Indonesian and Taiwanese Populations

    Imaniar Noor Faridah / Haafizah Dania / Rita Maliza / Wan-Hsuan Chou / Wen-Hung Wang / Yen-Hsu Chen / Dyah Aryani Perwitasari / Wei-Chiao Chang

    Diagnostics, Vol 13, Iss 21, p

    2023  Volume 3365

    Abstract: Dengue is an arboviral disease that has spread globally and become a major public health concern. A small proportion of patients may progress from symptomatic dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Findings ... ...

    Abstract Dengue is an arboviral disease that has spread globally and become a major public health concern. A small proportion of patients may progress from symptomatic dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Findings from a previous genome-wide association study (GWAS) demonstrated that variations in the major histocompatibility complex (MHC) class I chain-related B ( MICB ) and the phospholipase C epsilon 1 ( PLCE1 ) genes were related to DSS in a Vietnamese population. This study investigated associations of variations in MICB (rs3132468) and PLCE1 (rs3740360, rs3765524) with dengue severity and thrombocytopenia in both the Indonesian and Taiwanese populations. We sampled 160 patients from the Indonesian population and 273 patients from the Taiwanese population. None of the patients had DSS in the Taiwanese population. Based on age demographics, we found that dengue is more prevalent among younger individuals in the Indonesian population, whereas it has a greater impact on adults in the Taiwanese population. Our results showed the association between MICB rs3132468 and DSS. In addition, an association was identified between PLCE1 rs3740360 and DHF in secondary dengue in Indonesian patients. However, there is no association of MICB or PLCE1 variants with thrombocytopenia. This study highlights the value of genetic testing, which might be included in the clinical pathway for specific patients who can be protected from severe dengue.
    Keywords severe dengue ; MICB ; PLCE1 ; single-nucleotide polymorphism (SNP) ; Medicine (General) ; R5-920
    Subject code 616 ; 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Decline in invasive pneumococcus diseases while combating the COVID‐19 pandemic in Taiwan

    Jong‐Rung Tsai / Chih‐Jen Yang / Wei‐Ling Huang / Yen‐Hsu Chen

    Kaohsiung Journal of Medical Sciences, Vol 36, Iss 7, Pp 572-

    2020  Volume 573

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Mitigate risks of medication interruption due to COVID‐19 for elderly with chronic diseases

    Shih‐Huai Hsiao / Hsiu‐Mei Chang / Ya‐Ting Kang / Yen‐Hsu Chen

    Kaohsiung Journal of Medical Sciences, Vol 36, Iss 8, Pp 661-

    2020  Volume 662

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Association between renal function and cardiovascular mortality

    Ta-Chien Chan / Yen-Hsu Chen / Ying-Jhen Huang / Yu-Lin Hsu / Yung-Hsin Chuang / Hugo Y -H Lin

    BMJ Open, Vol 11, Iss

    a retrospective cohort study of elderly from health check-up

    2021  Volume 9

    Keywords Medicine ; R
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Ambient Cumulative PM2.5 Exposure and the Risk of Lung Cancer Incidence and Mortality

    Hung-Ling Huang / Yung-Hsin Chuang / Tzu-Hsuan Lin / Changqing Lin / Yen-Hsu Chen / Jen-Yu Hung / Ta-Chien Chan

    International Journal of Environmental Research and Public Health, Vol 18, Iss 12400, p

    A Retrospective Cohort Study

    2021  Volume 12400

    Abstract: Smoking, sex, air pollution, lifestyle, and diet may act independently or in concert with each other to contribute to the different outcomes of lung cancer (LC). This study aims to explore their associations with the carcinogenesis of LC, which will be ... ...

    Abstract Smoking, sex, air pollution, lifestyle, and diet may act independently or in concert with each other to contribute to the different outcomes of lung cancer (LC). This study aims to explore their associations with the carcinogenesis of LC, which will be useful for formulating further preventive strategies. This retrospective, longitudinal follow-up cohort study was carried out by connecting to the MJ Health Database, Taiwan Cancer Registry database, and Taiwan cause of death database from 2000 to 2015. The studied subjects were persons attending the health check-ups, distributed throughout the main island of Taiwan. Cox proportional hazards regression models were used to investigate the risk factors associated with LC development and mortality after stratifying by smoking status, with a special emphasis on ambient two-year average PM 2.5 exposure, using a satellite-based spatiotemporal model at a resolution of 1 km 2 , and on dietary habit including consumption of fruits and vegetables. After a median follow-up of 12.3 years, 736 people developed LC, and 401 people died of LC-related causes. For never smokers, the risk of developing LC (aHR: 1.32, 95%CI: 1.12–1.56) and dying from LC-related causes (aHR: 1.28, 95%CI: 1.01–1.63) rises significantly with every 10 μg/m 3 increment of PM 2.5 exposure, but not for ever smokers. Daily consumption of more than two servings of vegetables and fruits is associated with lowering LC risk in ever smokers (aHR: 0.68, 95%CI: 0.47–0.97), and preventing PM 2.5 exposure is associated with lowering LC risk for never smokers.
    Keywords fine particulate matter ; lung cancer ; health behaviors ; diet ; Medicine ; R
    Subject code 333
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Dynamic Changes of Platelet and Factors Related Dengue Haemorrhagic Fever

    Imaniar Noor Faridah / Haafizah Dania / Yen-Hsu Chen / Woro Supadmi / Barkah Djaka Purwanto / Mochammad Junaidy Heriyanto / Mahda Adil Aufa / Wei-Chiao Chang / Dyah Aryani Perwitasari

    Diagnostics, Vol 12, Iss 950, p

    A Retrospective Study in Indonesian

    2022  Volume 950

    Abstract: Dengue is a viral infection caused by the dengue virus (DENV). Dengue infection is a self-limited acute febrile illness caused by four serotypes of DENV (DENV-1~4). Early recognition of high-risk patients would be helpful to reduce mortality rates and ... ...

    Abstract Dengue is a viral infection caused by the dengue virus (DENV). Dengue infection is a self-limited acute febrile illness caused by four serotypes of DENV (DENV-1~4). Early recognition of high-risk patients would be helpful to reduce mortality rates and prevent severe dengue. Our study aimed to identify factors related to dengue hemorrhagic fever (DHF) based on admission-day data, and further to understand the distribution of biochemical laboratory data in dengue patients. This retrospective study was conducted in hospitals in Yogyakarta city, Indonesia, and involved febrile patients who were admitted to the hospital with a diagnosis of dengue during 2018 and 2020. Logistic regression models were used to identify variables related to DHF. In this study, 1087 patients were included as suspected dengue patients, among them 468 had dengue fever (DF) and 619 had DHF. Over half of the DHF patients were males (55.9%) with an average age of 17.9 years, and with a secondary infection (71.3%). By a multivariate analysis, on-admission laboratory data of thrombocytopenia and hemoglobin showed significant association with DHF. Furthermore, DHF patients had significantly prolonged hospitalizations compared to DF patients. In conclusion, on-admission platelet counts and hemoglobin laboratory data are useful as predictors of DHF especially for suspected dengue patients with the limitations of diagnostic tests.
    Keywords dengue hemorrhagic fever ; platelet ; risk factor ; Medicine (General) ; R5-920
    Subject code 616 ; 610
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Association between the occurrence of albuminuria and the risk of early dementia among older people upon health examination

    Ta-Chien Chan / Yen-Hsu Chen / Tzu-Jung Tseng / Yun-Ting Yen / Yuan-Han Yang

    BMJ Open, Vol 10, Iss

    a community-based cohort study in Taiwan

    2020  Volume 12

    Abstract: Objectives This study aimed to investigate the associations between biochemical markers, renal function, health behaviours and dementia among older people.Design A retrospective cohort study.Setting Community-based health examination database from Taipei ...

    Abstract Objectives This study aimed to investigate the associations between biochemical markers, renal function, health behaviours and dementia among older people.Design A retrospective cohort study.Setting Community-based health examination database from Taipei city.Participants In total, 35 434 older people were included from February 2005 to December 2012. To assess changes in renal function, we selected participants who attended health examinations at least twice and responded to the AD8 questionnaire in 2012. We excluded those with dementia at baseline.Primary outcome measures Early dementia was assessed using the AD8 questionnaire in 2012. Explanatory variables included demographic factors, health behaviours, biochemical markers and renal function. We used a Cox proportional hazard model to estimate the HR for early dementia onset.Results Individuals with mild albuminuria (HR 1.228; 95% CI 1.066 to 1.414), lower eGFR (HR 1.549; 95% CI 1.319 to 1.820) and higher age (HR 1.022; 95% CI 1.015 to 1.028) were associated with a high risk of early dementia. Older people with no alcohol intake (HR 0.872; 95% CI 0.794 to 0.958), and higher education levels (HR 0.647; 95% CI 0.589 to 0.710) were at a low risk of early dementia.Conclusions Elevated mild albuminuria and low eGFR were associated with a high risk of early dementia in this community-based cohort. Routine health examinations for older people can help screen out the high-risk population, and clinical management might reduce or delay the risk of early dementia.
    Keywords Medicine ; R
    Subject code 360
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Lipopolysaccharide-Induced Nitric Oxide and Prostaglandin E2 Production Is Inhibited by Tellimagrandin II in Mouse and Human Macrophages

    Chun-Yu Lin / Shih-Han Kao / Ling-Chien Hung / Hsin-Ju Chien / Wen-Hung Wang / Yu-Wei Chang / Yen-Hsu Chen

    Life, Vol 11, Iss 411, p

    2021  Volume 411

    Abstract: Sepsis develops from a serious microbial infection that causes the immune system to go into overdrive. The major microorganisms that induce sepsis are Gram-negative bacteria with lipopolysaccharide (LPS) in their cell walls. Nitric oxide (NO) and ... ...

    Abstract Sepsis develops from a serious microbial infection that causes the immune system to go into overdrive. The major microorganisms that induce sepsis are Gram-negative bacteria with lipopolysaccharide (LPS) in their cell walls. Nitric oxide (NO) and cyclooxygenase-2 (COX-2) are the key factors involved in the LPS-induced pro-inflammatory process. This study aimed to evaluate the effects of polyphenol Tellimagrandin II (TGII) on anti-inflammatory activity and its underlying basic mechanism in murine macrophage cell line RAW 264.7 and human monocyte-derived macrophages. Macrophages with more than 90% cell viability were found in the cytotoxicity assay under 50 μM TGII. Pre- or post-treatment with TGII significantly reduced LPS-induced inducible nitric oxide synthase (NOS2) protein and mRNA expression, reducing LPS-induced COX-2 protein. Downstream of NOS2 and COX-2, NO and prostaglandin E2 (PGE2) were significantly inhibited by TGII. Upstream of NOS2 and COX-2, phospho-p65, c-fos and phospho-c-jun were also reduced after pre-treatment with TGII. Mitogen-activated protein kinases (MAPKs) are also critical to nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) stimulation, and phospho-p38 expression was found to have been blocked by TGII. TGII efficiently reduces LPS-induced NO production and its upstream regulatory factors, suggesting that TGII may be a potential therapeutic agent for sepsis and other inflammatory diseases.
    Keywords Tellimagrandin II ; macrophage ; inflammation ; nitric oxide ; cyclooxygenase-2 ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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