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  1. Article ; Online: Antarctic krill extracts enhance muscle regeneration and muscle function via mammalian target of rapamycin regulation

    Lee, Seongmin / Baek, Mi-Ock / Abdul Khaliq, Sana / Parveen, Amna / Yeou Kim, Sun / Kim, Jin-Hyoung / Kim, Il-Chan / Yoon, Mee-Sup

    Journal of Functional Foods. , p.105483-

    2023  , Page(s) 105483–

    Abstract: Sarcopenia is a degenerative disease involving decreases in muscle mass and muscle strength. There is no effective therapeutic target or treatment for sarcopenia. Here, we isolated a new metabolite from Antarctic krill extracts (AKEs) and investigated ... ...

    Abstract Sarcopenia is a degenerative disease involving decreases in muscle mass and muscle strength. There is no effective therapeutic target or treatment for sarcopenia. Here, we isolated a new metabolite from Antarctic krill extracts (AKEs) and investigated whether AKEs promote muscle regeneration. The AKEs increased the muscle enhancer-reporter activity of insulin-like growth factor 2 as well as myogenic fusion during C2C12 myoblast differentiation in an mTOR-dependent manner but did not affect the cell cycle or apoptosis. When BaCl₂-injured tibialis anterior muscles were injected with the extracts, the central surface area of centrally nucleated regenerating muscle fibers and the grip strength of regenerated muscles were enhanced. Finally, we identified N-eicosapentanoyl phenylalanine as the bioactive compound in AKEs using mass spectrometry analysis. Our results suggest that AKEs augment muscle regeneration by increasing mTOR signaling. Thus, the extracts may be useful for developing treatments for sarcopenia.
    Keywords Euphausia superba ; apoptosis ; bioactive compounds ; cell cycle ; insulin-like growth factor II ; mammals ; mass spectrometry ; metabolites ; muscle development ; muscle strength ; muscle tissues ; muscles ; myoblasts ; phenylalanine ; rapamycin ; sarcopenia ; surface area ; therapeutics ; Antarctic krill extracts ; mTOR ; N-eicosapentanoyl phenylalanine
    Language English
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 2511964-3
    ISSN 1756-4646
    ISSN 1756-4646
    DOI 10.1016/j.jff.2023.105483
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: Lapachol-Induced Upregulation of Sirt1/Sirt3 is linked with Improved Skin Wound Healing in Alloxan-induced Diabetic Mice.

    Bibi, Shaheen / Ahmad, Fayyaz / Alam, Muhammad Rizwan / Ansar, Muhammad / Yeou, Kim Sun / Wahedi, Hussain Mustatab

    Iranian journal of pharmaceutical research : IJPR

    2021  Volume 20, Issue 3, Page(s) 419–430

    Abstract: Timely repair of damaged skin is very important to maintain the integrity and homeostasis of skin, but the wound healing process is compromised in diabetic patients due to several extrinsic and intrinsic factors thus lead to leg amputation and death ... ...

    Abstract Timely repair of damaged skin is very important to maintain the integrity and homeostasis of skin, but the wound healing process is compromised in diabetic patients due to several extrinsic and intrinsic factors thus lead to leg amputation and death eventually. Sirtuins, a family of seven conserved proteins are known to be associated with pathophysiological processes of the skin. The most important among them are sirt1and sirt3 involved in cell regeneration and cell survival. Naphthoquinone derivatives have a wide range of therapeutic properties, but the potential diabetic wound healing activity of lapachol has not been identified yet. The present study thus aimed to investigate the wound healing effects of lapachol in a diabetic mouse model. Diabetic wounded mice were divided into 3 groups; vehicle, lapachol 0.05%, and lapachol 0.1%. Skin samples collected from diabetic wounded mice on different time points after treatment for 10 consecutive days were subjected to downstream analysis by western blot, ELISA and histology. Lapachol treatment was found to enhance the expression of sirt1/sirt3 and other proteins involved in cell migration and blood vessel formation. The tissue development rate was increased by lapachol treatment with better collagen deposition. Interestingly, lapachol treatment also gave rise to a high concentration of growth factors resulting in speedy and timely recovery of injured skin. In summary, our findings suggest that lapachol promotes efficient wound healing in a diabetic mouse model by increasing the expression of sirt1 and sirt3 and other proteins related to wound repair and skin regeneration including α-PAK, RAC1/CDC42, VEGF and growth factors viz PDGF and VEGF. This research work finds a novel potential activator of sirtuins in the form of lapachol and depicts the role of activated sirtuins in diabetic wound healing.
    Language English
    Publishing date 2021-10-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2578271-X
    ISSN 1735-0328 ; 1726-6890
    ISSN 1735-0328 ; 1726-6890
    DOI 10.22037/ijpr.2021.112722.13914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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