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Article ; Online: Image registration method using representative feature detection and iterative coherent spatial mapping for infrared medical images with flat regions

Hao-Jen Wang / Chia-Yen Lee / Jhih-Hao Lai / Yeun-Chung Chang / Chung-Ming Chen

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 18

Abstract: Abstract In the registration of medical images, nonrigid registration targets, images with large displacement caused by different postures of the human body, and frequent variations in image intensity due to physiological phenomena are substantial ... ...

Abstract	Abstract In the registration of medical images, nonrigid registration targets, images with large displacement caused by different postures of the human body, and frequent variations in image intensity due to physiological phenomena are substantial problems that make medical images less suitable for intensity-based image registration modes. These problems also greatly increase the difficulty and complexity of feature detection and matching for feature-based image registration modes. This research introduces an automatic image registration algorithm for infrared medical images that offers the following benefits: effective detection of feature points in flat regions (cold patterns) that appear due to changes in the human body’s thermal patterns, improved mismatch removal through coherent spatial mapping for improved feature point matching, and large-displacement optical flow for optimal transformation. This method was compared with various classical gold standard image registration methods to evaluate its performance. The models were compared for the three key steps of the registration process—feature detection, feature point matching, and image transformation—and the results are presented visually and quantitatively. The results demonstrate that the proposed method outperforms existing methods in all tasks, including in terms of the features detected, uniformity of feature points, matching accuracy, and control point sparsity, and achieves optimal image transformation. The performance of the proposed method with four common image types was also evaluated, and the results verify that the proposed method has a high degree of stability and can effectively register medical images under a variety of conditions.
Keywords	Medicine ; R ; Science ; Q
Subject code	006
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The standardizing texture of thickened barium stimuli in the videofluoroscopic swallowing study at a medical center in Taiwan

Chien-Hui Cheng / Hui-Chuen Chen / Jo-Yu Chen / Yeun-Chung Chang / Tyng-Guey Wang

Journal of the Formosan Medical Association, Vol 121, Iss 2, Pp 563-

2022 Volume 565

Abstract: This study aimed to establish more practical standardized barium stimuli formulas for the videofluoroscopic swallowing study (VFSS) for clinical use. For clinical practice, we established the formula for preparing barium stimuli to comply with different ... ...

Abstract	This study aimed to establish more practical standardized barium stimuli formulas for the videofluoroscopic swallowing study (VFSS) for clinical use. For clinical practice, we established the formula for preparing barium stimuli to comply with different International Dysphagia Diet Standardization Initiative (IDDSI) levels. To comply with the definition of IDDSI levels 0–4, the gum-based thickener concentration of thickened barium was 0, 0.3, 0.6, 1.0, and 2.0 g/100 mL, respectively. The formulas established in this study may replace traditional barium stimuli for dysphagia assessment in clinical settings.
Keywords	Dysphagia ; Barium swallowing ; Viscosity ; Thickener ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Applying Compressed Sensing Volumetric Interpolated Breath-Hold Examination and Spiral Ultrashort Echo Time Sequences for Lung Nodule Detection in MRI

Yu-Sen Huang / Emi Niisato / Mao-Yuan Marine Su / Thomas Benkert / Ning Chien / Pin-Yi Chiang / Wen-Jeng Lee / Jin-Shing Chen / Yeun-Chung Chang

Diagnostics, Vol 12, Iss 93, p

2022 Volume 93

Abstract: This prospective study aimed to investigate the ability of spiral ultrashort echo time (UTE) and compressed sensing volumetric interpolated breath-hold examination (CS-VIBE) sequences in magnetic resonance imaging (MRI) compared to conventional VIBE and ... ...

Abstract	This prospective study aimed to investigate the ability of spiral ultrashort echo time (UTE) and compressed sensing volumetric interpolated breath-hold examination (CS-VIBE) sequences in magnetic resonance imaging (MRI) compared to conventional VIBE and chest computed tomography (CT) in terms of image quality and small nodule detection. Patients with small lung nodules scheduled for video-assisted thoracoscopic surgery (VATS) for lung wedge resection were prospectively enrolled. Each patient underwent non-contrast chest CT and non-contrast MRI on the same day prior to thoracic surgery. The chest CT was performed to obtain a standard reference for nodule size, location, and morphology. The chest MRI included breath-hold conventional VIBE and CS-VIBE with scanning durations of 11 and 13 s, respectively, and free-breathing spiral UTE for 3.5–5 min. The signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and normal structure visualizations were measured to evaluate MRI quality. Nodule detection sensitivity was evaluated on a lobe-by-lobe basis. Inter-reader and inter-modality reliability analyses were performed using the Cohen κ statistic and the nodule size comparison was performed using Bland–Altman plots. Among 96 pulmonary nodules requiring surgery, the average nodule diameter was 7.7 ± 3.9 mm (range: 4–20 mm); of the 73 resected nodules, most were invasive cancer (74%) or pre-invasive carcinoma in situ (15%). Both spiral UTE and CS-VIBE images achieved significantly higher overall image quality scores, SNRs, and CNRs than conventional VIBE. Spiral UTE (81%) and CS-VIBE (83%) achieved a higher lung nodule detection rate than conventional VIBE (53%). Specifically, the nodule detection rate for spiral UTE and CS-VIBE reached 95% and 100% for nodules >8 and >10 mm, respectively. A 90% detection rate was achieved for nodules of all sizes with a part-solid or solid morphology. Spiral UTE and CS-VIBE under-estimated the nodule size by 0.2 ± 1.4 mm with 95% limits of agreement from −2.6 to 2.9 mm and by ...
Keywords	spiral UTE ; compressed sensing ; VIBE ; lung nodule ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Electromagnetic Navigation Bronchoscopy Localization Versus Percutaneous CT-Guided Localization for Lung Resection via Video-Assisted Thoracoscopic Surgery

Shuenn-Wen Kuo / Ying-Fan Tseng / Kuan-Yu Dai / Yeun-Chung Chang / Ke-Cheng Chen / Jang-Ming Lee

Journal of Clinical Medicine, Vol 8, Iss 3, p

A Propensity-Matched Study

2019 Volume 379

Abstract: Background: An ideal preoperative localization method is essential for the resection of small and deep-seated pulmonary nodules by video-assisted thoracoscopic surgery (VATS) in the era of low-dose computed tomography (CT) screening. This study describes ...

Abstract	Background: An ideal preoperative localization method is essential for the resection of small and deep-seated pulmonary nodules by video-assisted thoracoscopic surgery (VATS) in the era of low-dose computed tomography (CT) screening. This study describes a new localization method using electromagnetic navigation bronchoscopy (ENB) and compares it against conventional percutaneous CT-guided methods. Methods: Between January 2016 and May 2018, 18 consecutive patients with a total of 27 pulmonary nodules underwent ENB localization using patent blue vital dye before thoracoscopy for lung resection at the National Taiwan University Hospital. Over the same period, 268 patients had a total of 325 pulmonary nodules localized by a CT-guided method. Propensity analysis was applied to minimize bias during comparison. Results: Patients were selected using a propensity-score based process, matched for potential risk factors for localization failure, to ensure equal potential prognostic factors in both groups. After matching, the ENB group had 15 patients with a total of 24 pulmonary nodules, and the CT group had 30 patients with 48 pulmonary nodules. No major procedure-related complications occurred in either group. The target pulmonary nodule was not successfully localized for one patient in the ENB group and three in the CT group. The lesions were fully excised after conversion to mini-thoracotomy. Pathological examination confirmed the accuracy of the dye staining. Analysis found a non-significant difference in the success rate of these two localization methods. However, the following parameters were significantly different: interval between localization to surgery, global time, and rate of pneumothorax (p <0.05). Conclusions: In the era of minimally invasive surgery, surgeons need an efficient one-step way to manage pulmonary nodules. Patent blue vital injection with ENB guidance in the operating room is a new, effective approach to localize small, deep-seated and non-palpable pulmonary lesions, comparable with ...
Keywords	pulmonary nodules ; electromagnetic navigation bronchoscopy ; dye marking ; video-associated thoracic surgery ; CT-guided localization ; Medicine ; R
Subject code	610
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessing tumor angiogenesis using dynamic contrast-enhanced integrated magnetic resonance-positron emission tomography in patients with non-small-cell lung cancer

Yu-Sen Huang / Jenny Ling-Yu Chen / Hsin-Ming Chen / Li-Hao Yeh / Jin-Yuan Shih / Ruoh-Fang Yen / Yeun-Chung Chang

BMC Cancer, Vol 21, Iss 1, Pp 1-

2021 Volume 13

Abstract: Abstract Background Angiogenesis assessment is important for personalized therapeutic intervention in patients with non-small-cell lung cancer (NSCLC). This study investigated whether radiologic parameters obtained by dynamic contrast-enhanced (DCE)- ... ...

Abstract	Abstract Background Angiogenesis assessment is important for personalized therapeutic intervention in patients with non-small-cell lung cancer (NSCLC). This study investigated whether radiologic parameters obtained by dynamic contrast-enhanced (DCE)-integrated magnetic resonance-positron emission tomography (MR-PET) could be used to quantitatively assess tumor angiogenesis in NSCLC. Methods This prospective cohort study included 75 patients with NSCLC who underwent DCE-integrated MR-PET at diagnosis. The following parameters were analyzed: metabolic tumor volume (MTV), maximum standardized uptake value (SUVmax), reverse reflux rate constant (k ep), volume transfer constant (K trans), blood plasma volume fraction (v p ), extracellular extravascular volume fraction (v e ), apparent diffusion coefficient (ADC), and initial area under the time-to-signal intensity curve at 60 s post enhancement (iAUC60). Serum biomarkers of tumor angiogenesis, including vascular endothelial growth factor-A (VEGF-A), angiogenin, and angiopoietin-1, were measured by enzyme-linked immunosorbent assays simultaneously. Results Serum VEGF-A (p = 0.002), angiogenin (p = 0.023), and Ang-1 (p < 0.001) concentrations were significantly elevated in NSCLC patients compared with healthy individuals. MR-PET parameters, including MTV, K trans, and k ep, showed strong linear correlations (p < 0.001) with serum angiogenesis-related biomarkers. Serum VEGF-A concentrations (p = 0.004), MTV values (p < 0.001), and k ep values (p = 0.029) were significantly higher in patients with advanced-stage disease (stage III or IV) than in those with early-stage disease (stage I or II). Patients with initial higher values of angiogenesis-related MR-PET parameters, including MTV > 30 cm3 (p = 0.046), K trans > 200 10− 3/min (p = 0.069), and k ep > 900 10− 3/min (p = 0.048), may have benefited from angiogenesis inhibitor therapy, which thus led to significantly longer overall survival. Conclusions The present findings suggest that DCE-integrated ...
Keywords	Personalized medicine ; Radiologic biomarkers ; Angiogenesis inhibitors ; Survival ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Subject code	610 ; 616
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anaphylactic reaction to patent blue V used in preoperative computed tomography-guided dye localization of small lung nodules

Tsung-Ta Wu / Yeun-Chung Chang / Jan-Ming Lee / Ming-Hui Hung

Journal of the Formosan Medical Association, Vol 115, Iss 4, Pp 288-

2016 Volume 289

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2016-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preoperative non-stimulated adrenal venous sampling index for predicting outcomes of adrenalectomy for unilateral primary aldosteronism

Chien-Wei Huang / Bo-Ching Lee / Kao-Lang Liu / Yeun-Chung Chang / Vin-Cent Wu / Po-Tsang Lee / Chin-Chen Chang

Journal of the Formosan Medical Association, Vol 119, Iss 7, Pp 1185-

2020 Volume 1192

Abstract: Background/purpose: The aim of this study was to predict outcomes of adrenalectomy for unilateral primary aldosteronism (PA) using non-stimulated adrenal venous sampling (AVS) indices and the standardized Primary Aldosteronism Surgical Outcome (PASO) ... ...

Abstract	Background/purpose: The aim of this study was to predict outcomes of adrenalectomy for unilateral primary aldosteronism (PA) using non-stimulated adrenal venous sampling (AVS) indices and the standardized Primary Aldosteronism Surgical Outcome (PASO) criteria. Methods: Patients with unilateral PA who underwent adrenalectomy based on non-stimulated AVS and had follow-up data regarding surgical outcomes between 2011 and 2016 were enrolled. Demographic data and non-stimulated AVS indices, including lateralization index (LI) and contralateral suppression, were collected for analysis. Results: This study included 54 patients who underwent adrenalectomy. Clinical and biochemical outcomes were evaluated in all patients and in 52 (96.3%) patients, respectively. Complete clinical and biochemical success was achieved in 31 (57.4%) of 54 patients and 42 (80.8%) of 52 patients, respectively. An LI > 4 was significantly associated with complete clinical and biochemical success (OR = 4.30, 95% CI 1.18–15.68, p = 0.03, and OR = 7.55, 95% CI 1.28–44.47, p = 0.03, respectively). Contralateral suppression was an independent predictor of complete biochemical success (OR = 17.27, 95% CI 1.95–153.21, p = 0.01). Conclusion: Non-stimulated AVS indices including LI and contralateral suppression are reliable preoperative determinants for predicting the outcomes of adrenalectomy in patients with unilateral PA. Our findings provide more evidence and confidence to clinicians when applying non-stimulated AVS to determine PA treatment.
Keywords	Primary hyperaldosteronism ; Adrenalectomy ; Prognostic factors ; Venography ; Medicine (General) ; R5-920
Subject code	610 ; 616
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction

Mao-Yuan Su / Kuei-Yuan Hou / Ming-Hung Liu / Tien-Min Lin / Jyh-Ming Jimmy Juang / Lian-Yu Lin / Cho-Kai Wu / Hsi-Yu Yu / Shun-Chung Yang / Yu-Sen Huang / Emi Niisato / Yeun-Chung Chang

Scientific Reports, Vol 11, Iss 1, Pp 1-

CMR-derived ECVs vary with myocardial region and associate with the regional wall thickness

2021 Volume 1

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

Abstract	An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: First Asian population study of stereotactic body radiation therapy for ventricular arrhythmias

Li-Ting Ho / Jenny Ling-Yu Chen / Hsing-Min Chan / Yu-Cheng Huang / Mao-Yuan Su / Sung-Hsin Kuo / Yeun-Chung Chang / Jiunn-Lee Lin / Wen-Jone Chen / Wen-Jeng Lee / Lian-Yu Lin

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract We report the first Asian series on stereotactic body radiation (SBRT) for refractory ventricular arrhythmia (VA) in Taiwanese patients. Three-dimensional electroanatomic maps, delayed-enhancement magnetic resonance imaging (DE-MRI), and dual- ... ...

Abstract	Abstract We report the first Asian series on stereotactic body radiation (SBRT) for refractory ventricular arrhythmia (VA) in Taiwanese patients. Three-dimensional electroanatomic maps, delayed-enhancement magnetic resonance imaging (DE-MRI), and dual-energy computed tomography (CT) were used to identify scar substrates. The main target volume was treated with a single radiation dose of 25 Gy and the margin volume received 20 Gy using simultaneous integrated boost delivered by the Varian TrueBeam system. Efficacy was assessed according to VA events recorded by an implantable cardioverter-defibrillator (ICD) or a 24-h Holter recorder. Pre- and post-radiation therapy imaging studies were performed. From February 2019 to December 2019, seven patients (six men, one woman; mean age, 55 years) were enrolled and treated. One patient died of hepatic failure. In the remaining six patients, at a median follow-up of 14.5 months, the VA burden and ICD shocks significantly decreased (only one patient with one ICD shock after treatment). Increased intensity on DE-MRI might be associated with a lower risk for VA recurrence, whereas dual-energy CT had lower detection sensitivity. No acute or minimal late adverse events occurred. In patients with refractory VA, SBRT is associated with a marked reduction in VA burden and ICD shocks, and DE-MRI might be useful for monitoring treatment effects.
Keywords	Medicine ; R ; Science ; Q
Subject code	616 ; 610
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predictive Modelling of Lung Function using Emphysematous Density Distribution

Kuo-Lung Lor / Cheng-Pei Liu / Yeun-Chung Chang / Chong-Jen Yu / Cheng-Yi Wang / Ming-Jui Chung / Fan-Ya Lin / Chung-Ming Chen

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 13

Abstract: Abstract Target lung tissue selection remains a challenging task to perform for treating severe emphysema with lung volume reduction (LVR). In order to target the treatment candidate, the percentage of low attenuation volume (LAV%) representing the ... ...

Abstract	Abstract Target lung tissue selection remains a challenging task to perform for treating severe emphysema with lung volume reduction (LVR). In order to target the treatment candidate, the percentage of low attenuation volume (LAV%) representing the proportion of emphysema volume to whole lung volume is measured using computed tomography (CT) images. Although LAV% have shown to have a correlation with lung function in patients with chronic obstructive pulmonary disease (COPD), similar measurements of LAV% in whole lung or lobes may have large variations in lung function due to emphysema heterogeneity. The functional information of regional emphysema destruction is required for supporting the choice of optimal target. The purpose of this study is to develop an emphysema heterogeneity descriptor for the three-dimensional emphysematous bullae according to the size variations of emphysematous density (ED) and their spatial distribution. The second purpose is to derive a predictive model of airflow limitation based on the regional emphysema heterogeneity. Deriving the bullous representation and grouping them into four scales in the upper and lower lobes, a predictive model is computed using the linear model fitting to estimate the severity of lung function. A total of 99 subjects, 87 patients with mild to very severe COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I~IV) and 12 control participants with normal lung functions (forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) > 0.7) were evaluated. The final model was trained with stratified cross-validation on randomly selected 75% of the dataset (n = 76) and tested on the remaining dataset (n = 23). The dispersed cases of LAV% inconsistent with their lung function outcome were evaluated, and the correlation study suggests that comparing to LAV of larger bullae, the widely spread smaller bullae with equivalent LAV has a larger impact on lung function. The testing dataset has the correlation of r = −0.76 (p < 0.01) between the whole lung LAV% and FEV1/FVC, whereas using two ED % of scales and location-dependent variables to predict the emphysema-associated FEV1/FVC, the results shows their correlation of 0.82 (p < 0.001) with clinical FEV1/FVC.
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 000
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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