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Article ; Online: Effect of

Park, Musun / Yi, Jin-Mu / Kim, No Soo / Lee, Seo-Young / Lee, Haeseung

International journal of molecular sciences

2024 Volume 25, Issue 9

Abstract: We characterized the therapeutic biological modes of action of several terpenes ... ...

Abstract	We characterized the therapeutic biological modes of action of several terpenes in
MeSH term(s)	Molecular Docking Simulation ; Terpenes/pharmacology ; Terpenes/chemistry ; Transcriptome/drug effects ; Humans ; Wolfiporia/chemistry ; Gene Expression Profiling/methods ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Alzheimer Disease/genetics ; Microglia/drug effects ; Microglia/metabolism ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Computational Biology/methods ; Animals
Chemical Substances	Terpenes ; Antioxidants
Language	English
Publishing date	2024-04-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25094636
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Article ; Online: Comparative study of the mechanism of natural compounds with similar structures using docking and transcriptome data for improving in silico herbal medicine experimentations.

Park, Musun / Baek, Su-Jin / Park, Sang-Min / Yi, Jin-Mu / Cha, Seongwon

Briefings in bioinformatics

2023 Volume 24, Issue 6

Abstract: Natural products have successfully treated several diseases using a multi-component, multi-target mechanism. However, a precise mechanism of action (MOA) has not been identified. Systems pharmacology methods have been used to overcome these challenges. ... ...

Abstract	Natural products have successfully treated several diseases using a multi-component, multi-target mechanism. However, a precise mechanism of action (MOA) has not been identified. Systems pharmacology methods have been used to overcome these challenges. However, there is a limitation as those similar mechanisms of similar components cannot be identified. In this study, comparisons of physicochemical descriptors, molecular docking analysis and RNA-seq analysis were performed to compare the MOA of similar compounds and to confirm the changes observed when similar compounds were mixed and used. Various analyses have confirmed that compounds with similar structures share similar MOA. We propose an advanced method for in silico experiments in herbal medicine research based on the results. Our study has three novel findings. First, an advanced network pharmacology research method was suggested by partially presenting a solution to the difficulty in identifying multi-component mechanisms. Second, a new natural product analysis method was proposed using large-scale molecular docking analysis. Finally, various biological data and analysis methods were used, such as in silico system pharmacology, docking analysis and drug response RNA-seq. The results of this study are meaningful in that they suggest an analysis strategy that can improve existing systems pharmacology research analysis methods by showing that natural product-derived compounds with the same scaffold have the same mechanism.
MeSH term(s)	Molecular Docking Simulation ; Transcriptome ; Plants, Medicinal ; Biological Products/pharmacology ; Plant Extracts ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional
Chemical Substances	Biological Products ; Plant Extracts ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068142-2
ISSN	1477-4054 ; 1467-5463
ISSN (online)	1477-4054
ISSN	1467-5463
DOI	10.1093/bib/bbad344
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Article: Evaluation of the potential herb-drug interaction between Bojungikki-tang and PD-L1 immunotherapy in a syngeneic mouse model.

Yang, Sung-Yoon / Yi, Jin-Mu / Chun, Jaemoo / Park, Seongwon / Bui, Tham Thi / Yun, Hwi-Yeol / Chae, Jung-Woo / Jeong, Mi-Kyung

Frontiers in pharmacology

2023 Volume 14, Page(s) 1181263

Abstract: Atezolizumab (a PD-L1 inhibitor) has shown remarkable efficacy and tolerability in various cancer types. Despite its efficacy and safety, atezolizumab monotherapy has limitations, such as acquired resistance and adverse events. Bojungikki-tang (BJIKT) is ...

Abstract	Atezolizumab (a PD-L1 inhibitor) has shown remarkable efficacy and tolerability in various cancer types. Despite its efficacy and safety, atezolizumab monotherapy has limitations, such as acquired resistance and adverse events. Bojungikki-tang (BJIKT) is an herbal decoction widely prescribed in Asian countries and used to treat cancer-related symptoms including fatigue, appetite loss, gastrointestinal disorders, and other side effects from cancer therapy. Due to its immunomodulatory effects, Bojungikki-tang has been investigated as a combined treatment with anticancer agents. We evaluated the potential drug-drug interaction (DDI) between Bojungikki-tang and the anti-PD-L1 antibody based on the Food and Drug Administration (FDA) guidelines. In the study, we conducted an
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1181263
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Article ; Online: Jakyak-gamcho-tang, a decoction of Paeoniae Radix and Glycyrrhizae Radix et Rhizoma, ameliorates dexamethasone-induced muscle atrophy and muscle dysfunction.

Kim, Aeyung / Kim, Yu Ri / Park, Sang-Min / Lee, Haeseung / Park, Musun / Yi, Jin-Mu / Cha, Seongwon / Kim, No Soo

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 123, Page(s) 155057

Abstract: Background: Although chronic treatment with glucocorticoids, such as dexamethasone, is frequently associated with muscle atrophy, effective and safe therapeutics for treating muscle atrophy remain elusive. Jakyak-gamcho-tang (JGT), a decoction of ... ...

Abstract	Background: Although chronic treatment with glucocorticoids, such as dexamethasone, is frequently associated with muscle atrophy, effective and safe therapeutics for treating muscle atrophy remain elusive. Jakyak-gamcho-tang (JGT), a decoction of Paeoniae Radix and Glycyrrhizae Radix et Rhizoma, has long been used to relieve muscle tension and control muscle cramp-related pain. However, the effects of JGT on glucocorticoid-induced muscle atrophy are yet to be comprehensively clarified. Purpose: The objective of the current study was to validate the protective effect of JGT in dexamethasone-induced muscle atrophy models and elucidate its underlying mechanism through integrated in silico - in vitro - in vivo studies. Study design and methods: Differential gene expression was preliminarily analyzed using the RNA-seq data to determine the effects of JGT on C2C12 myotubes. The protective effects of JGT were further validated in dexamethasone-treated C2C12 myotubes by assessing cell viability, myotube integrity, and mitochondrial function or in C57BL/6 N male mice with dexamethasone-induced muscle atrophy by evaluating muscle mass and physical performance. Transcriptomic pathway analysis was also performed to elucidate the underlying mechanism. Results: Based on preliminary gene set enrichment analysis using the RNA-seq data, JGT regulated various pathways related to muscle differentiation and regeneration. Dexamethasone-treated C2C12 myotubes and muscle tissues of atrophic mice displayed substantial muscle protein degradation and muscle loss, respectively, which was efficiently alleviated by JGT treatment. Importantly, JGT-mediated protective effects were associated with observations such as preservation of mitochondrial function, upregulation of myogenic signaling pathways, including protein kinase B/mammalian target of rapamycin/forkhead box O3, inhibition of ubiquitin-mediated muscle protein breakdown, and downregulation of inflammatory and apoptotic pathways induced by dexamethasone. Conclusion: To the best of our knowledge, this is the first report to demonstrate that JGT could be a potential pharmaceutical candidate to prevent muscle atrophy induced by chronic glucocorticoid treatment, highlighting its known effects for relieving muscle spasms and pain. Moreover, transcriptomic pathway analysis can be employed as an efficient in silico tool to predict novel pharmacological candidates and elucidate molecular mechanisms underlying the effects of herbal medications comprising diverse biologically active ingredients.
MeSH term(s)	Male ; Mice ; Animals ; Glucocorticoids ; Paeonia ; Mice, Inbred C57BL ; Muscular Atrophy/chemically induced ; Muscular Atrophy/drug therapy ; Muscle Fibers, Skeletal ; Muscle Proteins/metabolism ; Muscle Proteins/pharmacology ; Muscle Proteins/therapeutic use ; Dexamethasone/pharmacology ; Pain ; Mammals ; Drugs, Chinese Herbal ; Glycyrrhiza
Chemical Substances	glycyrrhizae radix et rhizoma (2788Z9758H) ; Glucocorticoids ; Muscle Proteins ; Dexamethasone (7S5I7G3JQL) ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-09-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155057
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Article ; Online: Safety and Efficacy of

Ko, Mi Mi / Jeong, Mi-Kyung / Choi, Chang Min / Lee, Seung Hyeun / Chun, Jaemoo / Yi, Jin-Mu / Jang, Ho / Lee, Sung Yong

International journal of environmental research and public health

2023 Volume 20, Issue 5

Abstract: Cancer immunotherapy with immune checkpoint inhibitors (ICIs) is a major treatment option for several types of cancer, including non-small cell lung cancer (NSCLC). The proposed study aims to investigate the safety and efficacy ... ...

Abstract	Cancer immunotherapy with immune checkpoint inhibitors (ICIs) is a major treatment option for several types of cancer, including non-small cell lung cancer (NSCLC). The proposed study aims to investigate the safety and efficacy of
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Lung Neoplasms/drug therapy ; Pilot Projects ; Plant Extracts/therapeutic use ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Chemical Substances	Immune Checkpoint Inhibitors ; Plant Extracts
Language	English
Publishing date	2023-03-03
Publishing country	Switzerland
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20054507
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Article: Systematic transcriptome analysis reveals molecular mechanisms and indications of bupleuri radix.

Park, Sang-Min / Kim, Aeyung / Lee, Haeseung / Baek, Su-Jin / Kim, No Soo / Park, Musun / Yi, Jin-Mu / Cha, Seongwon

Frontiers in pharmacology

2022 Volume 13, Page(s) 1010520

Abstract: Pharmacogenomic analysis based on drug transcriptomic signatures is widely used to identify mechanisms of action and pharmacological indications. Despite accumulating reports on the efficacy of medicinal herbs, related transcriptome-level analyses are ... ...

Abstract	Pharmacogenomic analysis based on drug transcriptomic signatures is widely used to identify mechanisms of action and pharmacological indications. Despite accumulating reports on the efficacy of medicinal herbs, related transcriptome-level analyses are lacking. The aim of the present study was to elucidate the underlying molecular mechanisms of action of Bupleuri Radix (BR), a widely used herbal medicine, through a systematic transcriptomic analysis. We analyzed the drug-responsive transcriptome profiling of A549 lung cancer cell line after treating them with multiple doses of BR water (W-BR) and ethanol (E-BR) extracts and their phytochemicals.
Language	English
Publishing date	2022-10-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1010520
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Article: Bojungikki-Tang Improves Response to PD-L1 Immunotherapy by Regulating the Tumor Microenvironment in MC38 Tumor-Bearing Mice.

Chun, Jaemoo / Park, Sang-Min / Yi, Jin-Mu / Ha, In Jin / Kang, Han Na / Jeong, Mi-Kyung

Frontiers in pharmacology

2022 Volume 13, Page(s) 901563

Abstract: Immune checkpoint blockage targeting PD-L1 has led to breakthroughs in cancer treatment. Although anti-PD-L1-based immunotherapy has been approved as standard therapy in various cancer types, its therapeutic efficacy in most colorectal cancers (CRC) is ... ...

Abstract	Immune checkpoint blockage targeting PD-L1 has led to breakthroughs in cancer treatment. Although anti-PD-L1-based immunotherapy has been approved as standard therapy in various cancer types, its therapeutic efficacy in most colorectal cancers (CRC) is still limited due to the low response to immunotherapy. Therefore, combining treatment with herbal medicines could be an alternative approach for treating CRC to overcome this limitation. Bojungikki-Tang (BJIKT), a herbal formula used in traditional Chinese medicine, clinically improves the quality of life for cancer patients and has been associated with antitumor and immune-modulating activities. However, the regulatory effect of BJIKT on the immune response in the tumor microenvironment remains largely uninvestigated. In this study, we verified the inhibitory effect of BJIKT on tumor growth and investigated the regulatory effect of combination therapy with BJIKT and anti-PD-L1 on antitumor immune responses in an MC38 CRC-bearing C57BL/6 mouse model. Immune profiling analysis by flow cytometry was used to characterize the exact cell types contributing to anticancer activities. Combination treatment with BJIKT and anti-PD-L1 therapy significantly suppressed tumor growth in MC38-bearing mice and increased the proportion of cytotoxic T lymphocytes and natural killer cells in tumor tissues. Furthermore, BJIKT suppressed the population of myeloid-derived suppressor cells, suggesting that this combination treatment effectively regulates the immunological function of T-cells by improving the tumor microenvironment. The herbal formula BJIKT can be a novel therapeutic option for improving anti-PD-L1-based immunotherapy in patients with CRC.
Language	English
Publishing date	2022-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.901563
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Article ; Online: Identification of a novel anticancer mechanism of Paeoniae Radix extracts based on systematic transcriptome analysis.

Baek, Su-Jin / Lee, Haeseung / Park, Sang-Min / Park, Musun / Yi, Jin-Mu / Kim, No Soo / Kim, Aeyung / Cha, Seongwon

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 148, Page(s) 112748

Abstract: Paeoniae Radix (PR) has a great therapeutic value in many clinical applications; however, the presence of various bioactive compounds and its complicated effects on human health makes its precise mechanisms of action unclear. This study investigated the ... ...

Abstract	Paeoniae Radix (PR) has a great therapeutic value in many clinical applications; however, the presence of various bioactive compounds and its complicated effects on human health makes its precise mechanisms of action unclear. This study investigated the effects of PR at the molecular pathway level by profiling genome-wide gene expression changes following dose-dependent treatment of human lung cancer cells (A549) with PR water extract (WPR), PR ethanol extracts (EPR), as well as their individual components. We found that PR exerts anticancer effects in A549 cells by regulating numerous pathways. Specifically, EPR and two compounds, namely, hederagenin (HG) and oleanolic acid (OA), significantly downregulate the Aurora B pathway. Furthermore, we generated an integrated PR extracts-compounds-target genes network in the Aurora B pathway to understand their interactions. Our findings reinforce that inhibiting Aurora kinase activity is a therapeutic target for treating cancers, providing the potential for novel mechanisms of action for PR and its components against lung cancer.
MeSH term(s)	A549 Cells ; Antineoplastic Agents, Phytogenic/pharmacology ; Aurora Kinase B/metabolism ; Gene Expression Profiling/methods ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Oleanolic Acid/analogs & derivatives ; Oleanolic Acid/metabolism ; Paeonia/chemistry ; Plant Extracts/pharmacology ; Plant Roots/chemistry
Chemical Substances	Antineoplastic Agents, Phytogenic ; Plant Extracts ; Oleanolic Acid (6SMK8R7TGJ) ; Aurora Kinase B (EC 2.7.11.1) ; hederagenin (RQF57J8212)
Language	English
Publishing date	2022-02-24
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.112748
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Article ; Online: Neuroprotective Effects of an Aqueous Extract of

Yi, Jin-Mu / Shin, Sarah / Kim, No Soo / Bang, Ok-Sun

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 6

Abstract: The dried fruits ... ...

Abstract	The dried fruits of
MeSH term(s)	Animals ; Apoptosis/drug effects ; Cell Line ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Forsythia/chemistry ; Humans ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mice ; Neuroprotective Agents/chemistry ; Neuroprotective Agents/pharmacology ; Oxaliplatin/adverse effects ; Peripheral Nervous System Diseases/drug therapy ; Peripheral Nervous System Diseases/etiology ; Peripheral Nervous System Diseases/pathology ; Phytochemicals/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Rats ; Reactive Oxygen Species/metabolism
Chemical Substances	Neuroprotective Agents ; Phytochemicals ; Plant Extracts ; Reactive Oxygen Species ; Oxaliplatin (04ZR38536J)
Language	English
Publishing date	2019-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24061177
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Article ; Online: Ameliorative effects of aqueous extract of Forsythiae suspensa fruits on oxaliplatin-induced neurotoxicity in vitro and in vivo.

Yi, Jin-Mu / Shin, Sarah / Kim, No Soo / Bang, Ok-Sun

BMC complementary and alternative medicine

2019 Volume 19, Issue 1, Page(s) 339

Abstract: Background: The dried fruits of Forsythia suspensa has generally been used to clear heat and detoxify in traditional Korean and Chinese medicine. Oxaliplatin is a first-line treatment chemotherapeutic agent for advanced colorectal cancer, but it induces ...

Abstract	Background: The dried fruits of Forsythia suspensa has generally been used to clear heat and detoxify in traditional Korean and Chinese medicine. Oxaliplatin is a first-line treatment chemotherapeutic agent for advanced colorectal cancer, but it induces peripheral neuropathy as an adverse side effect affecting the treatment regimen and the patient's quality of life. The present study was conducted to evaluate the neuroprotective effects of an aqueous extract of F. suspensa fruits (EFSF) on oxaliplatin-induced peripheral neuropathy. Methods: The chemical components from EFSF were characterized and quantified using the ultra-high performance liquid chromatography-diode array detector system. The cytotoxicities of anticancer drugs in cancer cells and PC12 cells were assessed by the Ez-Cytox viability assay. To measure the in vitro neurotoxicity, the neurite outgrowth was analyzed in the primary dorsal root ganglion (DRG) cells, and neural PC12 cells that were differentiated with nerve growth factor. To evaluate the in vivo neuroprotective activity, the von Frey test was performed in six-week-old male mice (C57BL/6) receiving EFSF (60-600 mg/kg) in the presence of 20-30 mg/kg cumulative doses of oxaliplatin. Thereafter, the mice were euthanized for immunohistochemical staining analysis with an antibody against PGP9.5. Results: EFSF attenuated the cytotoxic activities of the various anticancer drugs in neural PC12 cells, but did not affect the anticancer activity of oxaliplatin in human cancer cells. Oxaliplatin remarkably induced neurotoxicities including cytotoxicity and the inhibited neurite outgrowth of DRG and neural PC12 cells. However, the co-treatment of EFSF (100 μg/ml) with oxaliplatin completely reversed the oxaliplatin-induced neurotoxicity. Forsythoside A, the major component of EFSF, also exerted remarkable neuroprotective effects against the oxaliplatin-induced neurotoxicity. In addition, EFSF (60-200 mg/kg) significantly alleviated the oxaliplatin-induced mechanical allodynia and loss of intra-epidermal nerve fiber to the levels of the vehicle control in the mouse peripheral neuropathy model. Conclusions: EFSF could be considered a useful herbal medicine for the treatment of peripheral neuropathy in cancer patients receiving chemotherapy with oxaliplatin.
MeSH term(s)	Animals ; Antineoplastic Agents/toxicity ; Cell Survival/drug effects ; Forsythia ; Fruit/chemistry ; HCT116 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Neurites/drug effects ; Neuroprotective Agents/pharmacology ; Neurotoxins/toxicity ; Oxaliplatin/toxicity ; PC12 Cells ; Plant Extracts/pharmacology ; Rats
Chemical Substances	Antineoplastic Agents ; Neuroprotective Agents ; Neurotoxins ; Plant Extracts ; Oxaliplatin (04ZR38536J)
Language	English
Publishing date	2019-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-019-2761-8
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