Article ; Online: ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.
2017 Volume 357, Issue 6352, Page(s) 707–713
Abstract: Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular etiology is still unclear. Here, we show that ELABELA ( ... ...
| Abstract | Preeclampsia (PE) is a gestational hypertensive syndrome affecting between 5 and 8% of all pregnancies. Although PE is the leading cause of fetal and maternal morbidity and mortality, its molecular etiology is still unclear. Here, we show that ELABELA (ELA), an endogenous ligand of the apelin receptor (APLNR, or APJ), is a circulating hormone secreted by the placenta. |
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| MeSH term(s) | Animals ; Apelin/genetics ; Apelin/metabolism ; Birth Weight ; Cardiovascular Abnormalities/genetics ; Carrier Proteins/administration & dosage ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Carrier Proteins/pharmacology ; Female ; Mice ; Mice, Knockout ; Neovascularization, Physiologic/genetics ; Peptide Hormones ; Placenta/blood supply ; Placenta/metabolism ; Placental Hormones/genetics ; Placentation/genetics ; Pre-Eclampsia/genetics ; Pregnancy ; Proteinuria ; Signal Transduction | ||||||||||
| Chemical Substances | Apela protein, mouse ; Apelin ; Apln protein, mouse ; Carrier Proteins ; Peptide Hormones ; Placental Hormones | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2017-06-29 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 128410-1 | ||||||||||
| ISSN | 1095-9203 ; 0036-8075 | ||||||||||
| ISSN (online) | 1095-9203 | ||||||||||
| ISSN | 0036-8075 | ||||||||||
| DOI | 10.1126/science.aam6607 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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