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Article: Nanoparticle-based T cell immunoimaging and immunomodulatory for diagnosing and treating transplant rejection.

Ding, Mengdan / Gao, Tang / Song, Yishu / Yi, Luyang / Li, Wenqu / Deng, Cheng / Zhou, Wuqi / Xie, Mingxing / Zhang, Li

2024 Volume 10, Issue 2, Page(s) e24203

Abstract: T cells serve a pivotal role in the rejection of transplants, both by directly attacking the graft and by recruiting other immune cells, which intensifies the rejection process. Therefore, monitoring T cells becomes crucial for early detection of ... ...

Abstract	T cells serve a pivotal role in the rejection of transplants, both by directly attacking the graft and by recruiting other immune cells, which intensifies the rejection process. Therefore, monitoring T cells becomes crucial for early detection of transplant rejection, while targeted drug delivery specifically to T cells can significantly enhance the effectiveness of rejection therapy. However, regulating the activity of T cells within transplanted organs is challenging, and the prolonged use of immunosuppressive drugs is associated with notable side effects and complications. Functionalized nanoparticles offer a potential solution by targeting T cells within transplants or lymph nodes, thereby reducing the off-target effects and improving the long-term survival of the graft. In this review, we will provide an overview of recent advancements in T cell-targeted imaging molecular probes for diagnosing transplant rejection and the progress of T cell-regulating nanomedicines for treating transplant rejection. Additionally, we will discuss future directions and the challenges in clinical translation.
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24203
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A novel FK506-loading mesoporous silica nanoparticle homing to lymph nodes for transplant rejection treatment.

Song, Yishu / Jin, Qiaofeng / Zhou, Binqian / Deng, Cheng / Zhou, Wuqi / Li, Wenqu / Yi, Luyang / Ding, Mengdan / Chen, Yihan / Gao, Tang / Zhang, Li / Xie, Mingxing

International journal of pharmaceutics

2024 Volume 656, Page(s) 124074

Abstract: Tacrolimus (FK506) is an effective therapeutic for transplant rejection in clinical practice, primarily inhibiting rejection by suppressing the activation and proliferation of allogeneic T cells in the lymph nodes (LNs). However, conventional ... ...

Abstract	Tacrolimus (FK506) is an effective therapeutic for transplant rejection in clinical practice, primarily inhibiting rejection by suppressing the activation and proliferation of allogeneic T cells in the lymph nodes (LNs). However, conventional administration methods face challenges in directly delivering free FK506 to the LNs. In this study, we introduce a novel LN-targeted delivery system based on mesoporous silica nanoparticles (MSNs-FK506-MECA79). These particles were designed to selectively target high endothelial venules in LNs; this was achieved through surface modification with MECA79 antibodies. Their mean size and zeta potential were 201.18 ± 5.98 nm and - 16.12 ± 0.36 mV, respectively. Our findings showed that MSNs-FK506-MECA79 could accumulate in LNs and increase the local concentration of FK506 from 28.02 ± 7.71 ng/g to 123.81 ± 76.76 ng/g compared with the free FK506 treatment group. Subsequently, the therapeutic efficacy of MSNs-FK506-MECA79 was evaluated in a skin transplantation model. The treatment with MSNs-FK506-MECA79 could lead to a decrease in the infiltration of T cells in the grafts, a reduction in the grade of rejection, and a significant prolongation of survival. Consequently, this study presents a promising strategy for the active LN-targeted delivery of FK506 and improving the immunotherapeutic effects on transplant rejection.
MeSH term(s)	Tacrolimus/administration & dosage ; Tacrolimus/chemistry ; Silicon Dioxide/chemistry ; Graft Rejection/prevention & control ; Graft Rejection/immunology ; Animals ; Lymph Nodes/drug effects ; Lymph Nodes/immunology ; Nanoparticles ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/chemistry ; Immunosuppressive Agents/pharmacology ; Porosity ; Mice, Inbred BALB C ; Skin Transplantation/methods ; Male ; Mice ; Mice, Inbred C57BL ; Drug Delivery Systems/methods ; Drug Carriers/chemistry
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Silicon Dioxide (7631-86-9) ; Immunosuppressive Agents ; Drug Carriers
Language	English
Publishing date	2024-03-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2024.124074
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1409: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Granzyme B-responsive fluorescent probe for non-invasive early diagnosis of transplant rejection.

Gao, Tang / Yi, Luyang / Wang, Yihui / Wang, Wenyuan / Zhao, Qianqian / Song, Yuan / Ding, Mengdan / Deng, Cheng / Chen, Yihan / Xie, Yuji / Wu, Wenqian / Jin, Qiaofeng / Zhang, Li / Xie, Mingxing

Biosensors & bioelectronics

2023 Volume 232, Page(s) 115303

Abstract: Allograft rejection has always been a major obstacle in organ transplantation. The current clinical diagnostic gold standard for allograft rejection is an invasive biopsy. However, biopsy has some limitations, such as sampling errors, risk of serious ... ...

Abstract	Allograft rejection has always been a major obstacle in organ transplantation. The current clinical diagnostic gold standard for allograft rejection is an invasive biopsy. However, biopsy has some limitations, such as sampling errors, risk of serious complications, and high cost. In this study, we have rationally developed an activatable fluorescent probe CYGB for imaging of granzyme B, which is a biomarker released by CD8
MeSH term(s)	Mice ; Animals ; Granzymes ; CD8-Positive T-Lymphocytes ; Fluorescent Dyes ; Graft Rejection/diagnosis ; Graft Rejection/pathology ; Biosensing Techniques
Chemical Substances	Granzymes (EC 3.4.21.-) ; Fluorescent Dyes
Language	English
Publishing date	2023-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2023.115303
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Zs.A 2275: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Electrospun polymer fibers modified with FK506 for the long-term treatment of acute cardiac allograft rejection in a heart transplantation model.

Deng, Cheng / Jin, Qiaofeng / Xu, Jia / Fu, Wenpei / He, Mengrong / Xu, Lingling / Song, Yishu / Wang, Wenyuan / Yi, Luyang / Chen, Yihan / Gao, Tang / Wang, Jing / Lv, Qing / Yang, Yali / Zhang, Li / Xie, Mingxing

Biomaterials science

2023 Volume 11, Issue 11, Page(s) 4032–4042

Abstract: FK506, a first-line immunosuppressant, is routinely administered orally and intravenously following heart transplantation. However, frequent administration can result in a substantial psychological burden to patients, resulting in non-adherence to ... ...

Abstract	FK506, a first-line immunosuppressant, is routinely administered orally and intravenously following heart transplantation. However, frequent administration can result in a substantial psychological burden to patients, resulting in non-adherence to medication. The purpose of our study is to overcome the disadvantages of systemic drug administration by developing a polymer-based delivery system that is tunable and biodegradable and that can release highly hydrophobic FK506 over extended periods to treat or prevent acute cardiac allograft rejection. Using an electrospinning method, long-acting microfibers were prepared, and FK506 appeared to be continuously released for up to 14 days based on the
MeSH term(s)	Animals ; Rats ; Allografts ; Graft Rejection/drug therapy ; Graft Rejection/prevention & control ; Heart Transplantation ; Polymers ; Tacrolimus ; Tissue Donors
Chemical Substances	Polymers ; Tacrolimus (WM0HAQ4WNM)
Language	English
Publishing date	2023-05-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d3bm00374d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Targeted microRNA delivery by lipid nanoparticles and gas vesicle-assisted ultrasound cavitation to treat heart transplant rejection.

Wang, Rui / Yi, Luyang / Zhou, Wuqi / Wang, Wenyuan / Wang, Lufang / Xu, Lingling / Deng, Cheng / He, Mengrong / Xie, Yuji / Xu, Jia / Chen, Yihan / Gao, Tang / Jin, Qiaofeng / Zhang, Li / Xie, Mingxing

Biomaterials science

2023 Volume 11, Issue 19, Page(s) 6492–6503

Abstract: Despite exquisite immune response modulation, the extensive application of microRNA therapy in treating heart transplant rejection is still impeded by poor stability and low target efficiency. Here we have developed a low-intensity pulsed ultrasound ( ... ...

Abstract	Despite exquisite immune response modulation, the extensive application of microRNA therapy in treating heart transplant rejection is still impeded by poor stability and low target efficiency. Here we have developed a low-intensity pulsed ultrasound (LIPUS) cavitation-assisted genetic therapy after executing the heart transplantation (LIGHT) strategy, facilitating microRNA delivery to target tissues through the LIPUS cavitation of gas vesicles (GVs), a class of air-filled protein nanostructures. We prepared antagomir-155 encapsulated liposome nanoparticles to enhance the stability. Then the murine heterotopic transplantation model was established, and antagomir-155 was delivered to murine allografted hearts
MeSH term(s)	Animals ; Mice ; MicroRNAs/genetics ; Liposomes ; Antagomirs ; Nanoparticles/chemistry ; Heart Transplantation
Chemical Substances	MicroRNAs ; Lipid Nanoparticles ; Liposomes ; Antagomirs
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d2bm02103j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Orally Administrable Aggregation-Induced Emission-Based Bionic Probe for Imaging and Ameliorating Dextran Sulfate Sodium-Induced Inflammatory Bowel Diseases.

Wang, Wenyuan / Wu, Ya / Wang, Yihui / Wang, Rui / Deng, Cheng / Yi, Luyang / Wang, Lufang / He, Mengrong / Zhou, Wuqi / Xie, Yuji / Jin, Qiaofeng / Chen, Yihan / Gao, Tang / Zhang, Li / Xie, Mingxing

Advanced healthcare materials

2023 Volume 12, Issue 9, Page(s) e2202420

Abstract: As macrophage infiltration is significantly related to the progression of inflammatory bowel disease (IBD), monitoring the macrophages is a valuable strategy for IBD diagnosis. However, owing to the harsh physiological environment of the gastrointestinal ...

Abstract	As macrophage infiltration is significantly related to the progression of inflammatory bowel disease (IBD), monitoring the macrophages is a valuable strategy for IBD diagnosis. However, owing to the harsh physiological environment of the gastrointestinal tract and enzymatic degradation, the development of orally administrable imaging probes for tracking macrophages remains a considerable challenge. Accordingly, herein, an orally administrable aggregation-induced emission biomimetic probe (HBTTPIP/β-glucan particles [GPs]) is developed for tracing macrophages; HBTTPIP/GPs can diagnose and alleviate dextran sulfate sodium (DSS)-induced colonic inflammation and self-report the treatment efficiency. The fluorophore HBTTPIP can effectively aggregate in GPs, restricting intramolecular rotation and activating the fluorescence of HBTTPIP. After being orally administrated, HBTTPIP/GPs are phagocytosed by intestinal macrophages, which then migrate to colonic lesions, enabling non-invasive monitoring of the severity of IBD via in vivo fluorescence imaging. Notably, oral HBTTPIP/GPs ameliorate DSS-induced IBD by inhibiting the expressions of pro-inflammatory factors and improving colonic mucosal barrier function. Furthermore, these HBTTPIP/GPs realize self-feedback of the therapeutic effects of GPs on DSS-induced colitis. The oral biomimetic probe HBTTPIP/GPs reported herein provide a novel theranostic platform for IBD, integrating non-invasive diagnosis of IBD in situ and the corresponding treatment.
MeSH term(s)	Humans ; Animals ; Mice ; Dextran Sulfate/pharmacology ; Bionics ; Cytokines/metabolism ; Inflammatory Bowel Diseases/chemically induced ; Inflammatory Bowel Diseases/diagnostic imaging ; Inflammatory Bowel Diseases/drug therapy ; Colitis/chemically induced ; Colitis/diagnostic imaging ; Colitis/drug therapy ; Colon/diagnostic imaging ; Colon/metabolism ; Mice, Inbred C57BL ; Disease Models, Animal
Chemical Substances	Dextran Sulfate (9042-14-2) ; Cytokines
Language	English
Publishing date	2023-01-15
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202202420
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6966: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Granzyme B-responsive fluorescent probe for non-invasive early diagnosis of transplant rejection

Gao, Tang / Yi, Luyang / Wang, Yihui / Wang, Wenyuan / Zhao, Qianqian / Song, Yuan / Ding, Mengdan / Deng, Cheng / Chen, Yihan / Xie, Yuji / Wu, Wenqian / Jin, Qiaofeng / Zhang, Li / Xie, Mingxing

Biosensors and Bioelectronics. 2023 July, v. 232 p.115303-

2023

Abstract	Allograft rejection has always been a major obstacle in organ transplantation. The current clinical diagnostic gold standard for allograft rejection is an invasive biopsy. However, biopsy has some limitations, such as sampling errors, risk of serious complications, and high cost. In this study, we have rationally developed an activatable fluorescent probe CYGB for imaging of granzyme B, which is a biomarker released by CD8⁺T cells attacking the graft. Moreover, the ability of CYGB to detect rejection early in mouse heart and skin transplantation models was evaluated. The probe CYGB consists of a caged hemicyanine-based fluorophore and a GzmB-specifically cleaved peptide substrate linked via a self-immolating spacer, p-aminobenzyl alcohol. Endogenous GzmB in CD8⁺ T cells specifically activated the near-infrared fluorescence (NIRF) signal of CYGB. In vivo imaging in mice skin and heart graft models, showed that CYGB preferentially accumulates in grafts, enabling early diagnosis of rejection. Moreover, CYGB enables non-invasive assessment of the level of immunosuppression in allogeneic mice treated with FK506. This study provides an alternative method for monitoring the status of allografts without biopsy.
Keywords	alcohols ; allografting ; biomarkers ; biopsy ; biosensors ; early diagnosis ; fluorescence ; fluorescent dyes ; graft rejection ; heart ; immunosuppression ; mice ; organ transplantation ; peptides ; risk ; skin grafting ; Granzyme B ; Fluorescent probe ; Allograft rejection
Language	English
Dates of publication	2023-07
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2023.115303
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2275: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Three-Dimensional Echocardiography Assessment of Right Ventricular Volumes and Function: Technological Perspective and Clinical Application.

Ahmad, Ashfaq / Li, He / Zhang, Yanting / Liu, Juanjuan / Gao, Ying / Qian, Mingzhu / Lin, Yixia / Yi, Luyang / Zhang, Li / Li, Yuman / Xie, Mingxing

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: Right ventricular (RV) function has important prognostic value in a variety of cardiovascular diseases. Due to complex anatomy and mode of contractility, conventional two-dimensional echocardiography does not provide sufficient and accurate RV function ... ...

Abstract	Right ventricular (RV) function has important prognostic value in a variety of cardiovascular diseases. Due to complex anatomy and mode of contractility, conventional two-dimensional echocardiography does not provide sufficient and accurate RV function assessment. Currently, three-dimensional echocardiography (3DE) allows for an excellent and reproducible assessment of RV function owing to overcoming these limitations of traditional echocardiography. This review focused on 3DE and discussed the following points: (i) acquisition of RV dataset for 3DE images, (ii) reliability, feasibility, and reproducibility of RV volumes and function measured by 3DE with different modalities, (iii) the clinical application of 3DE for RV function quantification.
Language	English
Publishing date	2022-03-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12040806
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biomimetic Glucan Particles with Aggregation-Induced Emission Characteristics for Noninvasive Monitoring of Transplant Immune Response.

Gao, Tang / Wu, Ya / Wang, Wenyuan / Deng, Cheng / Chen, Yihan / Yi, Luyang / Song, Yishu / Li, Wenqu / Xu, Lingling / Xie, Yuji / Fang, Lingyun / Jin, Qiaofeng / Zhang, Li / Tang, Ben Zhong / Xie, Mingxing

ACS nano

2021 Volume 15, Issue 7, Page(s) 11908–11928

Abstract: Real-time monitoring of post-transplant immune response is critical to prolong the survival of grafts. The current gold standard for assessing the immune response to graft is biopsy. However, such a method is invasive and prone to false negative results ... ...

Abstract	Real-time monitoring of post-transplant immune response is critical to prolong the survival of grafts. The current gold standard for assessing the immune response to graft is biopsy. However, such a method is invasive and prone to false negative results due to limited tissue size available and the heterogeneity of the rejection site. Herein, we report biomimetic glucan particles with aggregation-induced emission (AIE) characteristics (HBTTPEP/GPs) for real-time noninvasive monitoring of post-transplant immune response. We have found that the positively charged near-infrared AIEgens can effectively aggregate in the confined space of glucan particles (GPs), thereby turning on the fluorescence emission. HBTTPEP/GPs can track macrophages for 7 days without hampering the bioactivity. Oral administration of HBTTPEP/GPs can specially target macrophages by mimicking yeast, which then migrate to the transplant rejection site. The fluorescence emitted from HBTTPEP/GPs correlated well with the infiltration of macrophages and the degree of allograft rejection. Furthermore, a single oral HBTTPEP/GPs dose can dynamically evaluate the therapeutic response to immunosuppressive therapy. Consequently, the biomimetic AIE-active glucan particles can be developed as a promising probe for immune-monitoring in solid organ transplantation.
MeSH term(s)	Glucans ; Biomimetics ; Graft Rejection ; Transplantation, Homologous ; Immunity
Chemical Substances	Glucans
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.1c03029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Feasibility and Accuracy of a Fully Automated Right Ventricular Quantification Software With Three-Dimensional Echocardiography: Comparison With Cardiac Magnetic Resonance.

Ahmad, Ashfaq / Li, He / Wan, Xiaojing / Zhong, Yi / Zhang, Yanting / Liu, Juanjuan / Gao, Ying / Qian, Mingzhu / Lin, Yixia / Yi, Luyang / Zhang, Li / Li, Yuman / Xie, Mingxing

Frontiers in cardiovascular medicine

2021 Volume 8, Page(s) 732893

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-10-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.732893
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