Artikel ; Online: Cell-type specification in the retina: Recent discoveries from transcriptomic approaches.
Current opinion in neurobiology
2023 Band 81, Seite(n) 102752
Abstract: Understanding the formation of the complex nervous system hinges on decoding the mechanism that specifies a vast array of neuronal types, each endowed with a unique morphology, physiology, and connectivity. As a pivotal step towards addressing this ... ...
Abstract | Understanding the formation of the complex nervous system hinges on decoding the mechanism that specifies a vast array of neuronal types, each endowed with a unique morphology, physiology, and connectivity. As a pivotal step towards addressing this problem, seminal work has been devoted to characterizing distinct neuronal types. In recent years, high-throughput, single-cell transcriptomic methods have enabled a rapid inventory of cell types in various regions of the nervous system, with the retina exhibiting complete molecular characterization across many vertebrate species. This invaluable resource has furnished a fresh perspective for investigating the molecular principles of cell-type specification, thereby advancing our understanding of retinal development. Accordingly, this review focuses on the most recent transcriptomic characterizations of retinal cells, with a particular focus on amacrine cells and retinal ganglion cells. These investigations have unearthed new insights into their cell-type specification. |
---|---|
Mesh-Begriff(e) | Transcriptome ; Retina/physiology ; Retinal Ganglion Cells/physiology ; Amacrine Cells ; Gene Expression Profiling |
Sprache | Englisch |
Erscheinungsdatum | 2023-07-25 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Review ; Research Support, Non-U.S. Gov't |
ZDB-ID | 1078046-4 |
ISSN | 1873-6882 ; 0959-4388 |
ISSN (online) | 1873-6882 |
ISSN | 0959-4388 |
DOI | 10.1016/j.conb.2023.102752 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 3260: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.